Any substance that inhibits the synthesis of DNA.
| Member | Definition | Class |
|---|
| 9-arabinofuranosylguanine | A purine nucleoside in which guanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. It inhibits DNA synthesis and causes cell death. | 9-beta-D-arabinofuranosylguanine |
| adefovir | A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. | adefovir |
| adefovir dipivoxil | An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection. | adefovir pivoxil |
| anisomycin | An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. | (-)-anisomycin |
| aphidicolin | A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. | aphidicolin |
| azathioprine | A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS. | azathioprine |
| ciprofloxacin | A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. | ciprofloxacin zwitterion; ciprofloxacin |
| coumermycin | A hydroxycoumarin antibiotic that is obtained from Streptomyces rishiriensis and exhibits potent antibacterial and anticancer activity. | coumermycin A1 |
| cyc 682 | A nucleoside analogue resulting from the formal condensation of the carboxy group of hexadecanoic acid with the amino group of CNDAC. It is the prodrug of CNDAC and is currently in clinical development for the treatment of acute myeloid leukemia (AML). | sapacitabine |
| enoxacin | A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea. | enoxacin |
| etoposide | | etoposide |
| fludarabine phosphate | A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. | fludarabine phosphate |
| gemcitabine | A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. | gemcitabine |
| guanazole | An aromatic amine that is 1,2,4-triazole substituted at positions 3 and 5 by amino groups. | guanazole |
| hydroxyurea | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. | hydroxyurea |
| idoxuridine | A pyrimidine 2'-deoxyribonucleoside compound having 5-iodouracil as the nucleobase; used as an antiviral agent. | 5-iodo-2'-deoxyuridine |
| levofloxacin | An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase. | levofloxacin |
| methotrexate | | methotrexate |
| nalidixic acid | A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species. | nalidixic acid |
| nelarabine | A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G). | nelarabine |
| norfloxacin | A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase. | norfloxacin |
| pefloxacin | A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively. | pefloxacin |
| pipemidic acid | A pyridopyrimidine that is 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid substituted at position 2 by a piperazin-1-yl group and at position 8 by an ethyl group. A synthetic broad-spectrum antibacterial, it is used for treatment of gastrointestinal, biliary, and urinary infections. | pipemidic acid |
| piromidic acid | A pyridopyrimidine that is 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid, substituted at position 2 by a pyrrolidin-1-yl group and at position 8 by an ethyl group. A synthetic antibacterial which is used for the treatment of urinary tract and intestinal infections. | piromidic acid |
| rifampin | A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei). | rifampicin zwitterion; rifampicin |
| rx-3117 | A triol that is (1S,2R)-4-fluoro-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol which is substituted by a 4-amino-2-oxopyrimidin-1(2H)-yl group at position 5. It is a cytidine analog which exhibits anticancer activity in several cancers, including gemcitabine-resistant tumours. | roducitabine |
| streptozocin | An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. | streptozocin |
| t-2 toxin | A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. | T-2 toxin |
| tosufloxacin, 4-toluene sulfonate | A racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate. | tosufloxacin tosylate |
| u-47929 | | ficellomycin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 21.1456 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 20.8114 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 1.9659 | 2 | 8 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 39.5498 | 3 | 7 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 27.3918 | 2 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.9402 | 1 | 8 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 19.6222 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 21.2791 | 11 | 43 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 35.3275 | 2 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0757 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.0791 | 8 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 6.2811 | 1 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 28.4797 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 6.2811 | 1 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 23.4236 | 2 | 6 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 53.8703 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 20.4839 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 76.8806 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 53.8703 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 76.8806 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 16.1382 | 3 | 16 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 1.0392 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.9036 | 1 | 8 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 18.8541 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.9869 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 30.9584 | 1 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 69.6219 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 17.9025 | 2 | 9 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 65.6297 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 30.9584 | 1 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 86.9672 | 2 | 4 |
| ClpP | Bacillus subtilis | Potency | 23.7358 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 20.8834 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 21.8959 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.6936 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 29.5555 | 1 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 74.3111 | 1 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 46.7791 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 4.6109 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.5394 | 10 | 45 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.1589 | 3 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 12.9252 | 9 | 53 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.1172 | 1 | 12 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 7.0667 | 4 | 23 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 11.2624 | 3 | 5 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 44.9647 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 21.1684 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 20.8834 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 21.8959 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 2.7914 | 3 | 13 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 12.2419 | 2 | 9 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.2472 | 4 | 8 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 18.3368 | 1 | 4 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 4.1095 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 46.0682 | 2 | 3 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 1.9377 | 5 | 8 |
| hepatitis C virus polyprotein | | Potency | 7.0456 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 18.5700 | 2 | 8 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 22.1473 | 1 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 37.1935 | 2 | 12 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 20.8834 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 2.0896 | 2 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 48.4211 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.9953 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 6.1892 | 1 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 80.7345 | 2 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 20.8834 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 18.2766 | 2 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 69.5421 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.5636 | 2 | 13 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 59.6218 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 26.5353 | 2 | 8 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 11.9939 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.5119 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 21.0277 | 3 | 19 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 5.5779 | 2 | 5 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 34.7092 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 2.8184 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 8.2107 | 3 | 19 |
| P53 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 12.5816 | 2 | 6 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 47.7548 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 24.7397 | 4 | 9 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.7188 | 4 | 8 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 79.8801 | 3 | 5 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 4.6553 | 1 | 2 |
| polyprotein | Zika virus | Potency | 21.1684 | 1 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 9.0532 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 16.5388 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 26.3572 | 3 | 8 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.7920 | 2 | 7 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.0415 | 2 | 14 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 28.8521 | 3 | 18 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 12.4531 | 4 | 15 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 15.3900 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 15.3900 | 2 | 4 |
| Smad3 | Homo sapiens (human) | Potency | 0.1365 | 4 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 80.7345 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 21.7986 | 2 | 6 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.0429 | 1 | 10 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 19.3605 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 8.8075 | 2 | 38 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 10.0000 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 26.9998 | 4 | 14 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 17.9118 | 2 | 17 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.4778 | 4 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 4.6553 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 4.6553 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.5607 | 1 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 26.7395 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 24.2921 | 4 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 61.7233 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 18.3369 | 1 | 4 |
| Vpr | Human immunodeficiency virus 1 | Potency | 12.5893 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0011 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0146 | 2 | 2 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 136.7000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Adenosine deaminase | Bos taurus (cattle) | Ki | 800.0000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 26.6500 | 2 | 2 |
| Arylacetamide deacetylase | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 128.4286 | 1 | 14 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Ki | 90.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 50.0000 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 50.0000 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 522.0000 | 2 | 2 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 49.7510 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 0.0840 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | IC50 | 5.7614 | 29 | 39 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | IC50 | 0.1100 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Leishmania major | Ki | 0.0001 | 1 | 1 |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | IC50 | 10.0050 | 2 | 2 |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | Ki | 0.8800 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 324.0552 | 5 | 29 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 758.6750 | 1 | 4 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 11.9000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 127.2857 | 1 | 14 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Ki | 756.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 341.3333 | 3 | 3 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 19.0000 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 15.5654 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 49.7510 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 8.3190 | 1 | 1 |
| Caspase-3 | Homo sapiens (human) | IC50 | 28.2222 | 9 | 9 |
| Chain A, DEOXYNUCLEOSIDE KINASE | Drosophila melanogaster (fruit fly) | IC50 | 0.7600 | 1 | 1 |
| Chain A, Proto-oncogene Serine/threonine Protein Kinase Pim-1 | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 3 |
| Chain A, Proto-oncogene Serine/threonine-protein Kinase Pim-1 | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | IC50 | 0.0012 | 2 | 5 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 37.6464 | 4 | 4 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 2.5600 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 34.5089 | 4 | 4 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Deoxynucleoside kinase | Drosophila melanogaster (fruit fly) | IC50 | 500.0000 | 1 | 1 |
| Diacylglycerol kinase 1 | Drosophila melanogaster (fruit fly) | IC50 | 133.0000 | 1 | 1 |
| Dihydrofolate reductase | Enterococcus faecium | IC50 | 0.0014 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 4.1688 | 24 | 34 |
| Dihydrofolate reductase | Gallus gallus (chicken) | IC50 | 0.0545 | 2 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 1.5079 | 80 | 94 |
| Dihydrofolate reductase | Lacticaseibacillus casei | IC50 | 0.0138 | 29 | 30 |
| Dihydrofolate reductase | Mus musculus (house mouse) | IC50 | 0.0331 | 11 | 11 |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | IC50 | 0.0174 | 3 | 3 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 0.0717 | 12 | 13 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 0.0047 | 10 | 11 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 34.5460 | 5 | 5 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 0.4019 | 11 | 11 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 0.0000 | 1 | 1 |
| Dihydrofolate reductase | Mus musculus (house mouse) | Ki | 0.2167 | 17 | 18 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 0.0000 | 1 | 1 |
| Dihydrofolate reductase | Staphylococcus aureus | Ki | 0.0005 | 2 | 2 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 0.0136 | 1 | 2 |
| Dihydrofolate reductase | Bos taurus (cattle) | IC50 | 722.1480 | 11 | 11 |
| DNA gyrase subunit A | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 77.6500 | 1 | 2 |
| DNA gyrase subunit A | Escherichia coli K-12 | IC50 | 15.9235 | 28 | 31 |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | IC50 | 629.5917 | 8 | 9 |
| DNA gyrase subunit A | Staphylococcus aureus | IC50 | 103.4485 | 20 | 20 |
| DNA gyrase subunit B | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 77.6500 | 1 | 2 |
| DNA gyrase subunit B | Escherichia coli K-12 | IC50 | 13.8472 | 23 | 26 |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | IC50 | 1,000.8651 | 4 | 5 |
| DNA gyrase subunit B | Staphylococcus aureus | IC50 | 57.9980 | 15 | 15 |
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | IC50 | 5.1500 | 6 | 6 |
| DNA polymerase beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase beta | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human alphaherpesvirus 1 strain 17 | IC50 | 0.5000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human alphaherpesvirus 1 strain KOS | IC50 | 0.4380 | 1 | 1 |
| DNA polymerase catalytic subunit | Human herpesvirus 3 strain Dumas | IC50 | 1.6000 | 1 | 2 |
| DNA polymerase catalytic subunit | Human herpesvirus 5 strain AD169 | IC50 | 0.4435 | 2 | 2 |
| DNA polymerase catalytic subunit | Human herpesvirus 6 (strain Uganda-1102) | IC50 | 0.4000 | 1 | 1 |
| DNA polymerase delta catalytic subunit | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| DNA polymerase lambda | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| DNA polymerase subunit gamma-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 75.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 460.0000 | 2 | 3 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 83.8400 | 25 | 26 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | IC50 | 22.3150 | 4 | 4 |
| DNA topoisomerase 4 subunit A | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 545.8500 | 1 | 2 |
| DNA topoisomerase 4 subunit A | Escherichia coli K-12 | IC50 | 51.0000 | 1 | 1 |
| DNA topoisomerase 4 subunit A | Staphylococcus aureus | IC50 | 5.4282 | 10 | 11 |
| DNA topoisomerase 4 subunit B | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 545.8500 | 1 | 2 |
| DNA topoisomerase 4 subunit B | Staphylococcus aureus | IC50 | 6.4850 | 6 | 6 |
| DNA-directed RNA polymerase subunit beta | Escherichia coli O127:H6 str. E2348/69 | IC50 | 511.3333 | 3 | 3 |
| DNA-directed RNA polymerase subunit beta | Mycobacterium tuberculosis H37Rv | IC50 | 0.0100 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | IC50 | 0.0300 | 1 | 1 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| exodeoxyribonuclease V subunit RecB | Escherichia coli str. K-12 substr. MG1655 | IC50 | 0.1000 | 1 | 1 |
| exodeoxyribonuclease V subunit RecC | Escherichia coli str. K-12 substr. MG1655 | IC50 | 0.1000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | IC50 | 0.0800 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 1,600.0000 | 2 | 2 |
| Folate receptor alpha | Homo sapiens (human) | IC50 | 0.2262 | 4 | 4 |
| Folate receptor beta | Homo sapiens (human) | IC50 | 0.1585 | 4 | 4 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Ki | 166.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 28.3575 | 2 | 8 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Glucose transporter | Leishmania mexicana | IC50 | 0.2250 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 91.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| Hexose transporter 1 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.3260 | 1 | 1 |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 17.9000 | 1 | 1 |
| Multidrug resistance associated protein | Homo sapiens (human) | Ki | 1,200.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 121.1000 | 1 | 14 |
| NH(3)-dependent NAD(+) synthetase | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.0000 | 1 | 1 |
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | Homo sapiens (human) | IC50 | 21.2170 | 2 | 4 |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | IC50 | 9.7367 | 2 | 4 |
| Phosphoribosyl pyrophosphate synthase-associated protein 2 | Homo sapiens (human) | Ki | 3,000.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 3.0680 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 1,551.0003 | 13 | 17 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 125.0000 | 1 | 2 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 9,050.0000 | 1 | 2 |
| Proton-coupled folate transporter | Homo sapiens (human) | IC50 | 0.1208 | 2 | 2 |
| Pteridine reductase 1 | Leishmania major | Ki | 0.1095 | 2 | 2 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 53.0000 | 1 | 1 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 49.7510 | 1 | 1 |
| Reduced folate transporter | Homo sapiens (human) | IC50 | 0.0120 | 2 | 2 |
| Reduced folate transporter | Homo sapiens (human) | Ki | 3.5000 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 7.6000 | 1 | 1 |
| Ribonucleoside-diphosphate reductase large subunit | Homo sapiens (human) | IC50 | 997.0000 | 1 | 1 |
| Serum paraoxonase/arylesterase 1 | Homo sapiens (human) | Ki | 131.0000 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 60.0000 | 1 | 2 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 0.3210 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 599.7800 | 1 | 2 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 20.7500 | 2 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 896.1255 | 1 | 2 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 18.2000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A2 | Homo sapiens (human) | Ki | 51.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 1.4300 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 1.5000 | 4 | 4 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 9.0500 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 2.8400 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 6.6333 | 3 | 3 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 63.0000 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Thymidine kinase | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 500.0000 | 1 | 1 |
| Thymidine kinase | Human herpesvirus 3 strain Dumas | IC50 | 500.0000 | 1 | 1 |
| Thymidine kinase | Macacine alphaherpesvirus 1 | IC50 | 1.5000 | 1 | 1 |
| Thymidine kinase 2, mitochondrial | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Thymidine kinase, cytosolic | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Thymidine kinase, cytosolic | Homo sapiens (human) | Ki | 0.0900 | 1 | 1 |
| Thymidylate synthase | Escherichia coli K-12 | IC50 | 11.4303 | 3 | 12 |
| Thymidylate synthase | Homo sapiens (human) | IC50 | 33.6082 | 12 | 21 |
| Thymidylate synthase | Lacticaseibacillus casei | IC50 | 158.1000 | 10 | 10 |
| Thymidylate synthase | Mus musculus (house mouse) | IC50 | 20.0000 | 2 | 2 |
| Thymidylate synthase | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Thymidylate synthase | Mus musculus (house mouse) | Ki | 45.0000 | 1 | 1 |
| Thymidylate synthase | Escherichia coli | IC50 | 60.6000 | 3 | 3 |
| Thymidylate synthase | Escherichia coli LF82 | IC50 | 18.0000 | 1 | 1 |
| Toll-like receptor 4 | Homo sapiens (human) | IC50 | 1.0400 | 1 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 35.8755 | 2 | 4 |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | IC50 | 10.0050 | 2 | 2 |
| Trifunctional purine biosynthetic protein adenosine-3 | Mus musculus (house mouse) | IC50 | 20.0000 | 2 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 60.0000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 11.2700 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
| V-type proton ATPase subunit B, brain isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | ID50 | 0.0500 | 1 | 1 |
| AAA family ATPase | Staphylococcus aureus | Km | 192.0000 | 1 | 1 |
| Adenosine deaminase | Bos taurus (cattle) | Km | 430.0000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Homo sapiens (human) | Km | 6,000.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Homo sapiens (human) | Km | 6,000.0000 | 1 | 1 |
| Arylacetamide deacetylase | Homo sapiens (human) | Km | 200.0000 | 1 | 2 |
| ATP-binding cassette sub-family C member 11 | Homo sapiens (human) | Km | 957.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Km | 8.1000 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 2,951.6533 | 3 | 3 |
| Bcl-2-like protein 11 | Homo sapiens (human) | AC50 | 99.9300 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Km | 2,560.0000 | 3 | 3 |
| CAAX prenyl protease 2 isoform 2 | Homo sapiens (human) | AC50 | 41.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Km | 616.5400 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Km | 296.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 28.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 23.0000 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | AC50 | 150.3397 | 3 | 3 |
| Cytidine deaminase | Homo sapiens (human) | Km | 600.6667 | 3 | 3 |
| Deoxycytidine kinase | Homo sapiens (human) | Km | 1.7750 | 2 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | IC80 | 1.4400 | 1 | 1 |
| Dihydrofolate reductase | Lacticaseibacillus casei | ID50 | 0.0130 | 5 | 5 |
| Dihydrofolate reductase | Mus musculus (house mouse) | ID50 | 0.0171 | 6 | 6 |
| DNA gyrase subunit A | Escherichia coli K-12 | Activity | 10.7200 | 4 | 4 |
| DNA gyrase subunit A | Staphylococcus aureus | CC50 | 101.6667 | 3 | 3 |
| DNA gyrase subunit A | Escherichia coli K-12 | EC | 1.2000 | 1 | 1 |
| DNA gyrase subunit B | Escherichia coli K-12 | Activity | 0.4000 | 1 | 1 |
| DNA gyrase subunit B | Staphylococcus aureus | CC50 | 5.0000 | 1 | 1 |
| DNA gyrase subunit B | Escherichia coli K-12 | EC | 1.2000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | MIC | 100.0000 | 1 | 1 |
| DNA topoisomerase 2 | Drosophila melanogaster (fruit fly) | IC90 | 85.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | Activity | 78.6667 | 3 | 3 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | CC50 | 150.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | EC2 | 150.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC100 | 100.0000 | 2 | 2 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC90 | 68.0000 | 2 | 2 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | ID50 | 50.0000 | 9 | 9 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | Inhibition | 100.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Mus musculus (house mouse) | Activity | 25.0000 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | Activity | 100.0000 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | IC100 | 100.0000 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | IC90 | 68.0000 | 2 | 2 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | ID50 | 50.0000 | 7 | 7 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | Inhibition | 100.0000 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | MIC | 0.1000 | 1 | 1 |
| DNA topoisomerase 4 subunit A | Staphylococcus aureus | CC50 | 0.4000 | 1 | 1 |
| DNA topoisomerase 4 subunit B | Staphylococcus aureus | CC50 | 0.4000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | MIC | 5.4850 | 2 | 2 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Concentration | 47.0000 | 1 | 2 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Km | 71.3333 | 3 | 3 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Km | 165.0000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Vmax | 0.8200 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | ID50 | 50.0000 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | AC50 | 0.3610 | 3 | 3 |
| LMP1 [Human herpesvirus 4] | human gammaherpesvirus 4 (Epstein-Barr virus) | AC50 | 9.1427 | 3 | 3 |
| Multidrug resistance associated protein | Homo sapiens (human) | Km | 768.6667 | 3 | 3 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Km | 1,540.0000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | Km | 1,300.0000 | 1 | 1 |
| PAX8 | Homo sapiens (human) | AC50 | 0.2600 | 1 | 1 |
| Phosphoribosyl pyrophosphate synthase-associated protein 2 | Homo sapiens (human) | Km | 1,500.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | INH | 18.0000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | MIC | 0.1000 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | Km | 17.8000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | Km | 157.8500 | 4 | 4 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Km | 270.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Km | 417.3333 | 3 | 3 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Km | 1.6333 | 3 | 3 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Km | 7.2500 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Km | 13.5000 | 2 | 2 |
| Thymidine kinase | Vaccinia virus WR | Km | 31.0000 | 1 | 1 |
| Thymidine phosphorylase | Homo sapiens (human) | Km | 157.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Km | 503.0000 | 1 | 1 |