Any monocarboxylic acid having a 2-oxo substituent.
ChEBI ID: 35910
| Member | Definition | Role |
|---|---|---|
| 2-keto-4-methylvalerate | A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease. | 4-methyl-2-oxopentanoic acid |
| 2-ketoarginine | A 2-oxo monocarboxylic acid that is 2-oxopentanoic acid in which one of the methyl hydrogens is substituted by a carbamimidamido group. | 5-guanidino-2-oxopentanoic acid zwitterion; 5-guanidino-2-oxopentanoic acid |
| 2-ketopentanoic acid | An oxopentanoic acid carrying an oxo group at position 2. | 2-oxopentanoic acid |
| 2-oxo-3-methylvalerate | A 2-oxo monocarboxylic acid that is valeric acid carrying oxo- and methyl substituents at C-2 and C-3, respectively. An alpha-keto acid analogue and metabolite of isoleucine in man, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD). | 3-methyl-2-oxovaleric acid |
| 3-fluoropyruvate | A pyruvic acid derivative having a 3-fluoro substituent. | 3-fluoropyruvic acid |
| 3-mercaptopyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid substituted by a sulfanyl group at position 3. | 3-mercaptopyruvic acid |
| 3,4-dihydroxyphenylpyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 3,4-dihydroxyphenyl group. | 3,4-dihydroxyphenylpyruvic acid |
| 4-hydroxyphenylpyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. | 4-hydroxyphenylpyruvic acid |
| alpha-keto-delta-guanidinovaleric acid | A 2-oxo monocarboxylic acid that is 2-oxopentanoic acid in which one of the methyl hydrogens is substituted by a carbamimidamido group. | 5-guanidino-2-oxopentanoic acid zwitterion; 5-guanidino-2-oxopentanoic acid |
| alpha-ketobutyric acid | A 2-oxo monocarboxylic acid that is the 2-oxo derivative of butanoic acid. | 2-oxobutanoic acid |
| alpha-ketocaproic acid | A straight-chain fatty acid consisting of hexanoic acid having an oxo group at position 2. | 2-oxohexanoic acid |
| alpha-ketoglutaramate | 2-oxoglutaramic acid | |
| alpha-ketoisovalerate | A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid. | 3-methyl-2-oxobutanoic acid |
| bromopyruvate | A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug | 3-bromo-2-oxopropanoic acid; 3-bromopyruvic acid |
| glyoxylic acid | A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom. | glyoxylic acid |
| hydroxypyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism. | 3-hydroxypyruvic acid |
| indol-3-yl pyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid substituted by a 1H-indol-3-yl group at position 3. It has been found in Lycopersicon esculentum | 3-(indol-3-yl)pyruvic acid |
| oxaluric acid | A 2-oxo monocarboxylic acid that is amino(oxo)acetic acid substituted by a carbamoylamino group at the nitrogen atom. | oxaluric acid |
| phenylglyoxylic acid | A 2-oxo monocarboxylic acid that is glyoxylic acid in which the aldehyde hydrogen is substituted by a phenyl group. | phenylglyoxylic acid |
| phenylpyruvic acid | A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway. | keto-phenylpyruvic acid |
| pyruvic acid | A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis. | pyruvic acid |
| vanillactic acid | Vanillactic acid |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,973 (28.58) | 18.7374 |
| 1990's | 1,804 (17.34) | 18.2507 |
| 2000's | 2,242 (21.55) | 29.6817 |
| 2010's | 2,644 (25.42) | 24.3611 |
| 2020's | 739 (7.10) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 231 (2.04%) | 5.53% |
| Reviews | 438 (3.88%) | 6.00% |
| Case Studies | 155 (1.37%) | 4.05% |
| Observational | 17 (0.15%) | 0.25% |
| Other | 10,461 (92.56%) | 84.16% |