A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Reference |
|---|
| "In conclusion, osteoarthritis is associated with a thickening of the subchondral bone with an abnormally low mineralization pattern." | ( Alpert, B; Grynpas, MD; Katz, I; Lieberman, I; Pritzker, KP, 1991) |
| "Because osteoarthritis is a focal disease, histologic controls were used to measure the severity in different areas of the cartilage and in different specimens." | ( Ehrlich, MG, 1985) |
| "The treatment of osteoarthritis is predicated upon an understanding of the anatomy and pathomechanics of the disease process." | ( Dray, GJ; Jablon, M, 1987) |
| "The term 'osteoarthritis' is preferred to 'osteoarthrosis'." | ( de Groot Swanson, G; Swanson, AB, 1985) |
| "Thus some forms of osteoarthritis are closely associated with apatite type crystal deposition and may imply abnormal mineral formation in articular cartilage as a pathogenic mechanism." | ( Ali, SY, 1985) |
| "When osteoarthritis is seen with subluxation, it probably represents congenital subluxation and not displacement of the femoral head secondary to remodelling." | ( Gofton, JP, 1971) |
| "Osteoarthritis is a good indication for these medications whose effectiveness is well documented." | ( Gougeon, J, 1983) |
| "Osteoarthritis is one of the oldest and most common forms of arthritis afflicting human beings." | ( Brandt, KD; Eyanson, S, 1984) |
| "The term "osteoarthritis" is preferred over "osteoarthrosis." | ( Swanson, AB; Swanson, GD, 1983) |
| "Although hand osteoarthritis is common, it has been the focus of few therapeutic trials." | ( Caspard, H; Dreiser, RL; Grouin, JM; Guillou, GB; Maheu, E, 1995) |
| "Hand osteoarthritis is only beginning to be considered a potentially useful model for therapeutic trials and clinical research, in addition to the two widely-used models, knee and hip osteoarthritis." | ( Dreiser, RL; Lequesne, M; Maheu, E, 1995) |
| "Osteoarthritis is the most common joint disease and the second highest ranking cause of disability in the US." | ( Jennings, MB, 1994) |
| "Osteoarthritis is the most frequently encountered form of arthritis worldwide." | ( Brocks, DR; Skeith, KJ, 1994) |
| "Osteoarthritis is a chronic disease that has exacerbations and remissions." | ( Schnitzer, TJ, 1993) |
| "Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage." | ( Bijlsma, JW; Huber-Bruning, O; Lafeber, FP; Vanden Berg, WB; Vander Kraan, PM, 1993) |
| "Osteoarthritis is a common disease of the cartilage in a joint for which the general practitioner (GP) is frequently consulted." | ( de Bock, GH, 1996) |
| "Osteoarthritis is associated with elevated keratan sulfate levels; however, the elevation of keratan sulfate is less in patients with concomitant synovitis." | ( Diamond, BE; Israel, HA; Ratcliffe, A; Saed-Nejad, F, 1997) |
| "The prevalence of osteoarthritis is higher in women than men, and in women it increases dramatically in the years after menopause." | ( Felson, DT; Nevitt, MC, 1998) |
| "Osteoarthritis is a joint disease that is characterized by focal degradation of articular cartilage." | ( van den Berg, WB; van der Kraan, PM, 2000) |
| "Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States." | ( Berman, BM; Blair, SN; Dieppe, PA; Felson, DT; Fries, JF; Goldberg, V; Hochberg, MC; Jacobs, JJ; Lawrence, RC; Lorig, KR; McAlindon, T; Minor, MA; Weinberger, M, 2000) |
| "Although osteoarthritis is characterized by a progressive loss of the extracellular cartilage matrix, very little is known about the fate of articular chondrocytes during the progression of the disease." | ( Kirsch, T; Pfander, D; Swoboda, B, 2001) |
| "Osteoarthritis is a common rheumatologic disorder." | ( Davis, AW; Hinton, R; Moody, RL; Thomas, SF, 2002) |
| "Osteoarthritis is a degenerative joint disorder characterized by breakdown of articular cartilage." | ( Ijiri, K; Komiya, S; Liu, RQ; Malfait, AM; Tortorella, MD, 2002) |
| "Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age." | ( Jaovisidha, K; Rosenthal, AK, 2002) |
| "Osteoarthritis is one of the most common joint disorders in the elderly, yet few studies have targeted symptomatic osteoarthritis, especially symptomatic hand osteoarthritis." | ( Aliabadi, P; Chaisson, CE; Felson, DT; Kelly-Hayes, M; Niu, J; Zhang, Y, 2002) |
| "Osteoarthritis is treated with a variety of pharmacologic therapies, including acetaminophen, traditional nonsteroidal anti-inflammatory drugs, cyclo-oxygenase-2 inhibitors, intra-articular steroids, viscosupplements, glucosamine, chondroitin sulfate, capsaicin, and vitamins." | ( Goldberg, SH; Lonner, JH; Von Feldt, JM, 2002) |
| "Osteoarthritis is a frequent sequela of joint disease, especially with severe injuries or if attempts at therapy are unsuccessful." | ( Baxter, GM; Dechant, JE; Frisbie, DD; McIlwraith, CW; Trotter, GW, 2003) |
| "Osteoarthritis is characterized mainly by degenerative changes in joint cartilage, ultimately resulting in loss of cartilage, and alterations in the subchondral bone." | ( Laufer, S, 2003) |
| "Osteoarthritis is the most widespread form of arthritis in the United States." | ( Duryea, J; Gupta, KB; Weissman, BN, 2004) |
| "However, secondary osteoarthritis is a frequent cause of disability in chronic disease." | ( Seitz, M, 2004) |
| "Osteoarthritis is a major public health burden." | ( Bertin, P; Jolivet-Landreau, I; Keddad, K, 2004) |
| "Osteoarthritis is the most common form of human arthritis." | ( Fukuda, A; Iida, A; Ikegawa, S; Kawakami, A; Kizawa, H; Kotani, A; Kou, I; Mabuchi, A; Miyamoto, Y; Nakamura, K; Nakamura, Y; Notoya, K; Sudo, A; Uchida, A; Yamamoto, S, 2005) |
| "Osteoarthritis is a chronic disease of the joints, characterised by joint pain, stiffness and loss of physical function." | ( Fidan, DD; Frankish, R; Garner, SE; Maxwell, L, 2005) |
| "Osteoarthritis is the most common degenerative disorder of the modern world." | ( Aigner, T; Bartnik, E; Dietz, U; Gebauer, M; Haag, J; Saas, J; Takigawa, M, 2005) |
| "Primary osteoarthritis is mostly related to aging, whereas, secondary osteoarthritis is caused by another disease or condition." | ( Mahajan, A; Tandon, V; Verma, S, 2005) |
| "Progression of knee osteoarthritis is associated with progression of lumbar spine and hip osteoarthritis." | ( Doyle, DV; Hart, DJ; Hassett, G; March, L; Spector, TD, 2006) |
| "Osteoarthritis is a common malady of the musculoskeletal system affecting the articular cartilage." | ( Reddi, AH, 2006) |
| "Osteoarthritis is the most common form of arthritis and is a leading cause of disability in the elderly." | ( Issa, SN; Sharma, L, 2006) |
| "Osteoarthritis is considered an illness in which a complex interaction between the tissues of the joint plays a significant role in the initiation and/or progression of this pathophysiology." | ( Fahmi, H; Lajeunesse, D; Martel-Pelletier, J; Pelletier, JP; Tardif, G, 2006) |
| "Osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to over-production under undesirable physiological conditions." | ( Hwang, HJ; Kang, KJ; Lee, BH; Shin, HC, 2006) |
| "Osteoarthritis is one of the most common forms of arthritis seen in primary care." | ( Chandanwale, AS; Jain, UK; Kapoor, S; Oak, J; Pareek, A, 2006) |
| "The etiology of osteoarthritis is multifactorial, with inflammatory, metabolic, and mechanical causes." | ( Beyreuther, B; Callizot, N; Stöhr, T, 2007) |
| "Erosive osteoarthritis is usually considered as an inflammatory subset of osteoarthritis (OA)." | ( Emery, P; Farrant, JM; Grainger, AJ; McGonagle, D; O'Connor, PJ; Tan, AL; Tanner, S, 2007) |
| "Osteoarthritis is a chronic disease characterised by irreversible damage to joint structures, including loss of articular cartilage, osteophyte formation, alterations in the subchondral bone and synovial inflammation." | ( Garcia-Giralt, N; Martel-Pelletier, J; Monfort, J; Pelletier, JP, 2008) |
| "Osteoarthritis is the most common disease of the joints, and joint replacement surgery is often performed on the major lower extremity joints to relieve pain and improve function." | ( Milner, CE, 2008) |
| "Osteoarthritis is the most common form of arthritis." | ( Cicero, AF; Laghi, L, 2007) |
| "Osteoarthritis is the most common arthritis in the world." | ( Fox, BA; Stephens, MM, 2007) |
| "Osteoarthritis is influenced by genetic and environment factors, including mechanical stress; however, the relationship between running and the development of osteoarthritis remains a matter of controversy." | ( Ju, YJ; Masuda, H; Miyazaki, K; Mochizuki, T; Muneta, T; Nimura, A; Sekiya, I; Tang, T, 2008) |
| "Osteoarthritis is a chronic, painful condition that is now recognised as affecting a large proportion of cats." | ( Gunew, MN; Marshall, RD; Menrath, VH, 2008) |
| "Osteoarthritis is a chronic joint disease characterized by pain and immobility due to a gradual loss of cartilage." | ( Hosea Blewett, HJ, 2008) |
| "Osteoarthritis is an inflammatory disease of load-bearing synovial joints that is currently treated with drugs that exhibit numerous side effects and are only temporarily effective on pain, the main symptom of the disease." | ( Csaki, C; Mobasheri, A; Nebrich, S; Shakibaei, M, 2008) |
| "Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis." | ( du Souich, P; Dumais, G; Iovu, M, 2008) |
| "Osteoarthritis is a chronic and progressive joint disease." | ( Brizuela, NY; Demurtas, SL; Meirovich, CI; Montrull, HL, 2007) |
| "Osteoarthritis is characterized by joint pain, stiffness and limited range of motion and has been designated an international health burden by the World Health Organization." | ( McDonald, DD; Merkle, D, 2009) |
| "Patients with hand osteoarthritis are commonly treated by health care professionals (allied to medicine)." | ( Hagen, KB; Kjeken, I; Moe, RH; Uhlig, T, 2009) |
| "Osteoarthritis is a multifactorial disease characterized by loss of articular cartilage and subchondral plate thickening." | ( Baek, YH; Choi, DY; Huh, JE; Lee, JD; Park, DS; Seo, DM, 2010) |
| "Osteoarthritis is a chronic disease characterized by irreversible damage to joint structures, including loss of articular cartilage, inflammation of the synovial membrane, and alterations in the subchondral bone." | ( Kwan Tat, S; Martel-Pelletier, J; Pelletier, JP, 2010) |
| "Osteoarthritis is a disabling disease of the aging generation, which results in loss of quality of life and increased healthcare costs." | ( Creemers, LB; Dhert, WJ; Rutgers, M; Saris, DB; Yang, KG, 2009) |
| "Idiopathic osteoarthritis is the most common form of osteoarthritis (OA) world-wide and remains the leading cause of disability and the associated socio-economic burden in an increasing aging population." | ( de Andrés, MC; Goldring, MB; Hashimoto, K; Imagawa, K; Itoi, E; Oreffo, RO; Pitt, D; Roach, HI, 2011) |
| "Osteoarthritis is characterized by progressive breakdown of articular cartilage." | ( van den Berg, WB, 2011) |
| "Osteoarthritis is the leading cause of physical disability among Americans, and tissue engineered cartilage grafts have emerged as a promising treatment option for this debilitating condition." | ( Jiang, J; Khanarian, NT; Lu, HH; Mow, VC; Wan, LQ, 2012) |
| "Osteoarthritis is one of the most common chronic inflammatory conditions seen in the general population." | ( Grundmann, O; Sanders, M, 2011) |
| "Osteoarthritis is a degenerative joint disease with pain and loss of joint function as major pathological features." | ( Ahmed, AS; Ahmed, M; Bakalkin, G; Erlandsson-Harris, H; Li, J; Stark, A, 2012) |
| "Osteoarthritis is associated with cell death and extracellular matrix degradation in articular cartilage." | ( Blanco, FJ; Caramés, B; Hasegawa, A; Lotz, M; Miyaki, S; Taniguchi, N, 2012) |
| "Osteoarthritis is a progressive joint disease characterized by cartilage degradation and bone remodelling." | ( Arcuri, G; Ferlosio, A; Orlandi, A; Spagnoli, LG; Tarantino, U, 2013) |
| "Osteoarthritis is a highly prevalent disease, age being the main risk factor." | ( Barten-van Rijbroek, AD; Bijlsma, JW; DeGroot, J; Lafeber, FP; Mastbergen, SC; Vos, PA; Zuurmond, AM, 2012) |
| "Osteoarthritis is a degenerative joint disease characterized by a progressive and irreversible loss of the articular cartilage, due in main part to the cleavage of type II collagen within the matrix by the enzyme matrix metalloproteinase (MMP)13." | ( Barter, MJ; Bui, C; Galler, M; Reynard, LN; Rowan, AD; Scott, JL; Xu, Y; Young, DA, 2012) |
| "Osteoarthritis is one of the most frequent and chronic conditions that affect the U." | ( Hameed, F; Ihm, J, 2012) |
| "Erosive hand osteoarthritis is a form of hand osteoarthritis." | ( Maheu, E, 2012) |
| "Osteoarthritis is a condition caused in part by injury, loss of cartilage structure and function, and an imbalance in inflammatory and anti-inflammatory pathways." | ( Chen, CH; Chyu, MC; Dunn, DM; Kwun, IS; Lo, DF; Shen, CL; Smith, BJ, 2012) |
| "Osteoarthritis is a chronic disease with a major impact on quality of life for a large proportion of the population." | ( Burdett, N; McNeil, JD, 2012) |
| "Osteoarthritis is characterized by degenerative alterations of articular cartilage including both the degradation of extracellular matrix and the death of chondrocytes." | ( Chen, J; Crawford, R; Xiao, Y, 2013) |
| "Osteoarthritis is a chronic disease characterized by irreversible damage to joint structures, including loss of articular cartilage, osteophyte formation, alterations in the subchondral bone and synovial inflammation." | ( Chevalier, X; Henrotin, Y; Hochberg, M; Hunter, DJ; Uebelhart, D, 2013) |
| "Osteoarthritis is one of the most frequent, disabling, and costly pathologies of modern society." | ( Lluch Girbés, E; López Cubas, C; Nijs, J; Torres-Cueco, R, 2013) |
| "Erosive hand osteoarthritis is common and debilitating." | ( Gabay, C; So, AK; Van Linthoudt, D, 2013) |
| "Osteoarthritis is characterized by slow degenerative processes in the articular cartilage within synovial joints." | ( Amighi, K; De Vriese, C; Gaignaux, A; Goole, J; Jerome, C; Réeff, J; Siepmann, F; Siepmann, J; Thomassin, JM, 2013) |
| "Osteoarthritis is a highly prevalent and debilitating joint disorder." | ( Artemov, D; Askin, FB; Cao, X; Carrino, JA; Chang, W; Chen, Q; Cosgarea, A; Crane, JL; Frassica, FJ; Jia, X; Li, Y; Lu, WW; Mears, SC; Riley, L; Sponseller, P; Wan, M; Wen, C; Yao, J; Zhao, Z; Zhen, G; Zhou, X, 2013) |
| "Osteoarthritis is the most common, multi component joint disease mainly characterized by destruction of articular cartilage which leads up to subchondral bone." | ( Jain, A; Singh, S; Singh, SK; Singh, Y, 2013) |
| "Osteoarthritis is the most common form of arthritis and includes manifestations of both nociceptive and neuropathic mechanisms." | ( Ashford, RL; Dimitroulas, T; Duarte, RV; Kitas, GD; Raphael, JH; Southall, JL; Sparkes, E, 2014) |
| "Osteoarthritis is clinically defined mainly by pains upon movement and joint stiffness." | ( Zwolak, P, 2014) |
| "Osteoarthritis is the most common form of arthritis and is a major cause of pain and disability in the elderly." | ( Arden, NK; Beekman, M; Bierma-Zeinstra, S; Bomer, N; Eiriksson, FF; Evangelou, E; Frigge, ML; Gudjonsson, SA; Hart, D; Helgadottir, HT; Hofman, A; Ingvarsson, T; Jonasdottir, A; Jonsdottir, I; Jonsson, H; Kloppenburg, M; Kong, A; Lohmander, S; Magnusson, OT; Masson, G; Metrustry, S; Meulenbelt, I; Nelissen, RG; Rivadeneira, F; Sigurdsson, A; Slagboom, PE; Spector, T; Stefansson, K; Strijbosch, AM; Styrkarsdottir, U; Thorleifsson, G; Thorsteinsdottir, M; Thorsteinsdottir, U; Uitterlinden, A; Valdes, AM; van Meurs, J, 2014) |
| "Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases; 12% associated with traumatic injury resulting in post-traumatic osteoarthritis (PTOA)." | ( Carson, WL; Cook, JL; Pfeiffer, FM; Stoker, AM; Waters, NP, 2014) |
| "Osteoarthritis is the most prevalent rheumatic disease and the leading cause of physical disability and reduced quality of life of the population over 65 years." | ( Aikawa, P; Cintra, DE; Sartori-Cintra, AR, 2014) |
| "Osteoarthritis is a progressive joint disease and a major cause of disability for which no curative therapies are yet available." | ( Cavaleiro, C; Judas, F; Mendes, AF; Ribeiro, M; Rufino, AT; Salgueiro, L; Sousa, C, 2015) |
| "Osteoarthritis is a common, progressive joint disease, and treatments generally aim for symptomatic improvement." | ( Farran, A; Martel-Pelletier, J; Montell, E; Pelletier, JP; Vergés, J, 2015) |
| "Osteoarthritis is thought to be the most prevalent chronic and disabling joint disease in animals and humans and its treatment is a major orthopaedic challenge because there is no ideal drug treatment to preserve joint structure and function, as well as to ameliorate the symptomatology of the disease." | ( Caeiro, JR; González-Cantalapiedra, A; Guede, D; López-Peña, M; Muñoz, F; Permuy, M, 2015) |
| "Osteoarthritis is thought to be the most prevalent chronic and disabling joint disease in animals and humans." | ( Caeiro, JR; González-Cantalapiedra, A; Guede, D; López-Peña, M; Muñoz, F; Permuy, M, 2015) |
| "Osteoarthritis is a chronic degenerative disease that affects the articular cartilage." | ( Knight, MM; Poole, CA; Thompson, CL; Varone, A; Wiles, A; Yasmin, H, 2015) |
| "Osteoarthritis is a progressive joint disease that results in degradation of cartilage in load-bearing joints." | ( Agarwal, R; García, AJ; Lee, LA; Volkmer, TM; Wang, P; Wang, Q, 2016) |
| "The therapy of osteoarthritis is based on conservative therapeutic approaches, depending on the disease's severity." | ( Baerwald, C; Krasselt, M, 2015) |
| "Osteoarthritis is a long-term complication of acute articular infections." | ( Beck, S; Kubosch, EJ; Langenmair, ER; Salzmann, GM; Schmal, H, 2015) |
| "Age-related osteoarthritis is a common form of arthritis that has been associated with mitochondrial dysfunction and oxidative stress." | ( Carlson, CS; Chubinskaya, S; Collins, JA; Furdui, CM; Loeser, RF; Nelson, KJ; Poole, LB; Rowe, MA; Wood, ST, 2016) |
| "Osteoarthritis is a disabling affliction expected to increase in the coming decades, and disease- modifying osteoarthritis drugs (DMOADs) would be highly desirable adjuncts to symptomatic relief and structure reconstruction as they may delay the disease process." | ( Maccari, F; Mantovani, V; Volpi, N, 2016) |
| "Osteoarthritis is a degenerative joint disease that is characterized by the inflammation of synovium." | ( Jun, F; Li, D; Liao, S; Wang, J; Xie, X; Zhou, K, 2016) |
| "Knee osteoarthritis is a disabling disease that costs billions of dollars to treat." | ( Bellamy, JL; Goff, BJ; Sayeed, SA, 2016) |
| "Osteoarthritis is a degenerative disease of the joint affecting aging populations worldwide." | ( Chin, KY, 2016) |
| "Osteoarthritis is the most common form of arthritis, and pain relief with opioid-like drugs is a commonly used therapeutic for osteoarthritic patients." | ( Ba, K; Eliasberg, CD; Evseenko, D; Gullo, F; Lee, S; Lin, Y; Petrigliano, FA; Shkhyan, R; Wang, J; Wu, L; Zhang, S, 2017) |
| "Osteoarthritis is an age-related disease and cellular senescence is predicted to be a significant component of the pathological process." | ( Archer, CW; Baird, DM; Davies, IR; Fairclough, J; Fellows, CR; Gohil, K; Khan, IM; Rooney, P; Williams, R, 2017) |
| "Osteoarthritis is a common progressive disease in older adults, and those affected often have impaired physical function, co-existing disease states, and reduced quality of life." | ( Cooke, J; Cooper, G; Lee, K; Shield, A, 2017) |
| "Osteoarthritis is the most prevalent chronic articular disease, in which pain is one of the main symptoms and a major determinant of functional loss." | ( Harrison-Muñoz, S; Irarrázaval, S; Rojas-Briones, V, 2017) |
| "Osteoarthritis is the most prevalent chronic articular disease, in which pain is one of the main symptoms and the major determinant of functional loss." | ( Harrison-Muñoz, S; Irarrázaval, S; Rojas-Briones, V, 2017) |
| "Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear." | ( Aznar-Lopez, C; Cailotto, F; Carmeliet, P; Cornelis, FMF; Guns, LA; Lories, RJ; Monteagudo, S; Yibmantasiri, P, 2017) |
| "Osteoarthritis is the most prevalent form of arthritis, affecting a large part of population." | ( Guo, C; Hua, L; Lei, M; Wang, D; Xue, S; Yu, D; Zhang, C, 2017) |
| "Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available." | ( Bambridge, G; Chanalaris, A; Doherty, C; Marsden, BD; Nagase, H; Troeberg, L; Wren, SP, 2017) |
| "Osteoarthritis is a chronic progressive joint disease, characterized by complex mechanisms related to inflammation and degeneration of articular cartilage." | ( Choi, MS; Chun, HS; Han, SH; Kim, CS; Kim, DK; Kim, HJ; Kim, JS; Kim, SG; Lee, SA; Moon, SM; Park, BR, 2018) |
| "Osteoarthritis is a severe and debilitating joint disease, which is characterized as results from damage and degeneration of the articular cartilage of the joint surfaces." | ( Carbone, EJ; Jiang, T; Kan, HM; Li, Y; Lo, KW; Rajpura, K, 2018) |
| "Osteoarthritis is a type of joint disease that results from the breakdown of joint cartilage and underlying bone and is believed to be caused by mechanical stress on the joint and low-grade inflammatory processes." | ( Jin, R; Pan, J; Shen, M; Wu, R; Xu, S, 2018) |
| "Osteoarthritis is the leading cause of pain and disability worldwide." | ( Callanan, A; Munir, N, 2018) |
| "Osteoarthritis is the most common degenerative joint disease and causes major pain and disability in adults." | ( Pan, C; Shan, H; Wang, B; Wang, F; Wang, L; Wang, N; Zhou, Z, 2018) |
| "Osteoarthritis is a chronic degenerative joint disease involving both articular cartilage and subchondral bone." | ( Chen, G; Chen, X; He, F; Lin, J; Liu, T; Pan, G; Pei, M; Wang, Y; Yan, J; Yang, H; Yu, J; Zhang, J; Zhu, C, 2018) |
| "Osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and a chondrocyte inflammatory response that induces an inflammatory environment closely linked to extracellular matrix (ECM) degradation." | ( Ding, X; Feng, Z; Hu, Z; Li, X; Ni, W; Wu, A; Wu, D; Xuan, J; Zheng, G, 2018) |
| "Osteoarthritis is a prevalent chronic disease that impacts quality of life and imposes a heavy economic burden." | ( Bright, B; Bright, P; Bright, R; Limaye, A, 2018) |
| "Hand osteoarthritis is a prevalent disease with limited treatment options." | ( Bobacz, K; Elewaut, D; Huizinga, TWJ; Kloppenburg, M; Kroon, FPB; Kwok, WY; Punzi, L; Ramonda, R; Smolen, JS; Vander Cruyssen, B; Verbruggen, G; Wittoek, R; Wolterbeek, R, 2018) |
| "Patients with osteoarthritis are often affected by a number of cardiovascular comorbidities, including hypertension, which is present in about 40% of cases." | ( Angeli, F; Reboldi, G; Signorotti, S; Trapasso, M; Verdecchia, P, 2018) |
| "Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient." | ( Krasnokutsky, S; Neogi, T; Pillinger, MH, 2019) |
| "Osteoarthritis is associated with excess mortality, which may be explained by reduced levels of physical activity owing to lower limb pain, presence of comorbid conditions, and the adverse effects of anti-osteoarthritis medications especially NSAIDs." | ( Al-Daghri, N; Bruyère, O; Chapurlat, R; Cooper, C; Herrero-Beaumont, G; Rannou, F; Reginster, JY; Roth, R; Uebelhart, D, 2019) |
| "Osteoarthritis is one of the most common orthopedic diseases in elderly people who have lost their mobility." | ( Chen, Z; Hu, B; Huang, H; Li, S; Ma, Y; Pan, X; Shi, P; Sun, X; Wang, J; Xie, Z, 2019) |
| "Osteoarthritis is a form of chronic joint inflammation caused by the deterioration of the joint cartilage, accompanied by chronic pain, lameness and stiffness, particularly after prolonged activity." | ( Calabrò, S; Cortese, L; Cutrignelli, MI; Della Rocca, G; Lombardi, P; Mastellone, V; Molinari, ML; Musco, N; Tudisco, R; Vassalotti, G, 2019) |
| "Osteoarthritis is a degenerative joint disease which primarily affects the articular cartilage and subchondral bones." | ( Abas, NH; Abdul Hamid, J; Afian Mokhtar, S; Chin, KY; Ima Nirwana, S; Japar Sidik, FZ; Mohd Ramli, ES; Rajalingham, S; Wong, SK, 2019) |
| "OA (Osteoarthritis) is a predominant degenerative disease, characterized by the synovial inflammation and cartilage destruction." | ( Gong, Z; Hu, S; Wang, C; Zhang, G, 2019) |
| "Osteoarthritis is a common debilitating condition affecting a substantial portion of the population and is an accepted consequence of ageing and overuse." | ( Oettinger, J; Yip, K, 2020) |
| "Osteoarthritis is the disease connected with aging which is characterised by progressive degeneration of all elements building the joint but also influencing the muscles constituting motor unit with the affected joint." | ( Jarecki, J, 2019) |
| "Osteoarthritis is one of the leading causes of a chronic pain in elderly people." | ( Khovasova, NO; Moroz, VI; Naumov, AV; Tkacheva, ON, 2019) |
| "Hand osteoarthritis is a prevalent joint condition that has a high burden of disease and an unmet medical need for effective therapeutic options." | ( Allaart, CF; Böhringer, S; Boonen, A; Kloppenburg, M; Kortekaas, MC; Kroon, FPB; Reijnierse, M; Riyazi, N; Rosendaal, FR; Starmans, M; Turkstra, F; van Zeben, J, 2019) |
| "Osteoarthritis is associated with intrauterine growth retardation (IUGR) and abnormal glucose metabolism." | ( Hui, H; Hui, W; Liang, L; Liao-Bin, C; Lin-Long, W; Qing-Xian, L; Yi-Zhong, W, 2020) |
| "Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain." | ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| "Osteoarthritis is the most common degenerative cartilage disease." | ( Du, X; Ouyang, H, 2019) |
| "BACKGROUND Osteoarthritis is a chronic degenerative disease of the joints that is common in older people worldwide." | ( He, J; Zheng, S, 2020) |
| "Osteoarthritis is a major problem in elder people." | ( Abdelkhalek, AA; Elkasabgy, NA; Salama, AH, 2020) |
| "BACKGROUND Osteoarthritis is a joint disorder characterized by articular cartilage degradation leading to joint stiffness and pain." | ( Chen, G; Wang, X; Yang, K, 2020) |
| "Osteoarthritis is the most common type of arthritis and one of the leading causes of job loss and motor disabilities." | ( Arabi, I; Eliaspour, D; Lari, A; Raeissadat, SA; Seif Barghi, T; Sheikhpour, M, 2020) |
| "Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis." | ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| "Osteoarthritis is characterized by chronic joint pain, swelling, stiffness, limited movement or joint deformity, all of which seriously affect the quality of life and health of the affected individuals." | ( Sun, T; Wang, XF; Xue, JB; Zhou, YL, 2020) |
| "Osteoporotic-osteoarthritis is an incapacitating musculoskeletal illness of the aged." | ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| "Osteoarthritis is a typical degenerative joint disease related to a lubrication deficiency of articular cartilage, which is characterized by increased friction at the joint surface and severe inflammation of the joint capsule." | ( Cui, W; Deng, L; He, M; Liang, J; Luo, J; Sun, Y; Wang, B; Xu, X; Yang, J; Zhang, H; Zhang, K, 2020) |
| "Osteoarthritis is the single greatest cause of chronic pain, has no cure, and affects 8." | ( Blain, EJ; Bonnet, CS; Gilbert, SJ; Mason, DJ; Williams, AS, 2020) |
| "Osteoarthritis is a degenerative joint disease." | ( Botchway, BOA; Hu, S; Jiang, J; Liu, X; Meng, Y; Zhang, Y, 2020) |
| "Osteoarthritis is a common joint disease affecting a large population especially the elderly where cartilage degeneration is one of its hallmark symptoms." | ( Huang, YP; Zheng, YP, 2020) |
| "Osteoarthritis is the leading cause of disability worldwide; cartilage degeneration and defects are the central features." | ( Chen, C; Chen, P; Chen, Y; Li, M; Lu, H; Zhu, S, 2020) |
| "Osteoarthritis is the most common joint disorder worldwide and one of the leading causes of disability in the elderly." | ( Ishii, S; Morita, D; Yoshioka, K, 2020) |
| "Osteoarthritis is a common degenerative disease that most frequently involves the hand." | ( Han, EY; Im, SH; Jeon, YT; Kim, J; Kim, YH; Seo, KB, 2020) |
| "Osteoarthritis is a chronic degenerative disease characterized by cartilage destruction." | ( Bei, C; Chen, X; Gao, W; Gu, M; Jin, J; Pan, Z; Ren, C; Sun, L; Tian, N; Wang, X; Wu, A; Wu, Y; Zhang, X; Zhou, Y, 2020) |
| "Osteoarthritis is the most prevalent joint disease in the United States, with many patients requiring surgical replacement of the affected joint." | ( Heinrichs, DE; Iglesias, SL; Vasarhelyi, EM; Watson, DW, 2021) |
| "Osteoarthritis is currently one of the most common chronic diseases." | ( Feng, Y; Huang, Z; Lu, W; Wang, L; Zhu, X, 2021) |
| "Osteoarthritis is the most common joint disease and a major cause of functional limitation and pain in adults." | ( Li, Y; Liu, J; Liu, S; Pan, W, 2021) |
| "Osteoarthritis is a progressive degenerative joint disease which is high prevalent in dogs." | ( Aragosa, F; Caterino, C; Costanza, D; Della Valle, G; Fatone, G; Lamagna, F; Nieddu, A; Piscitelli, A, 2021) |
| "Osteoarthritis is most frequent disease of the joints and prescription of the SYSADOA should be main principle of that treatment." | ( Materkowski, M, 2021) |
| "Osteoarthritis is the most prevalent musculoskeletal disease, affecting 250 million people worldwide." | ( Graham, HK; Keppie, SJ; Mansfield, JC; McLean, C; Önnerfjord, P; Pavlovskaya, GE; Philp, CJ; Sherratt, MJ; Tang, X; Vincent, TL; Wall, A; Winlove, CP, 2021) |
| "Osteoarthritis is a common chronic disease associated with chondrocyte inflammation and cartilage matrix hydrolyzation." | ( Pan, X; Wang, W; Xia, B; Xu, Y; Yang, W; Zhang, M, 2021) |
| "The Osteoarthritis is a chronic disease characterized by a progressive deterioration of the articular cartilage producing a strong inflammatory activity and chronic pain in patients." | ( Del Campo, M; Lagos, N; Montero, C; Riquelme, G, 2021) |
| "Osteoarthritis is a chronic inflammatory disease of the joints associated with significant morbidity and lower quality of life." | ( Hou, D; Huang, Z; Li, J; Liu, N; Wang, W, 2021) |
| "Hand osteoarthritis is a common and disabling problem without effective therapies." | ( Cicuttini, FM; Hill, CL; Jones, G; Kasza, J; Keen, HI; Teichtahl, AJ; Wang, Y; Wluka, AE, 2021) |
| "Osteoarthritis is a chronic joint disease characterized by chronic inflammation, progressive destruction of articular cartilage, and subchondral bone sclerosis." | ( He, K; Huang, G; Huang, X; Shan, R; Song, R; Xie, F; Yang, X, 2021) |
| "Osteoarthritis is a common multifactorial chronic disease that occurs in articular cartilage, subchondral bone, and periarticular tissue." | ( Chen, L; Gao, M; Guan, F; He, K; Li, J; Liu, M; Lv, Y; Shi, T; Zhang, H; Zhang, M; Zhao, J; Zhao, Y, 2021) |
| "Hand osteoarthritis is a common and disabling chronic joint disease with a lack of effective therapies." | ( Cicuttini, FM; Estee, MM; Gan, D; Heritier, S; Hussain, SM; Lim, YZ; Wang, Y; Wluka, AE, 2021) |
| "Osteoarthritis is a type of age-related, chronic, and degenerative joint disease." | ( Han, J; Hu, T; Luo, J; Shen, X; Weng, Q; Zhang, Y, 2022) |
| "Osteoarthritis is one of the usual chronic musculoskeletal dysfunctions." | ( Wei, Q, 2022) |
| "Osteoarthritis is an inflammatory disease of the musculoskeletal system characterized by damaged articular cartilage." | ( Qu, L; Wang, C, 2022) |
| "Osteoarthritis is a progressive disease characterized by cartilage destruction in the joints." | ( Ando, R; Hatipoglu, OF; Hirohata, S; Ikemura, K; Inagaki, J; Katsuyama, E; Kodama, S; Miki, A; Nakano, A; Ohtsuki, T; Ooka, Y; Opoku, G; Tani, Y; Watanabe, S; Yamaji, H; Yamamoto, S, 2022) |
| "Osteoarthritis is a common disease in dogs and cats, and the search for novel treatment options is needed." | ( Corbee, RJ, 2022) |
| "Osteoarthritis is associated with an increase in mechanical friction of the joint, which causes irreversible damage to articular cartilage." | ( Han, J; Sun, Y; Wang, H; Yan, Y; Zhang, H; Zhao, W; Zheng, Y, 2022) |
| "Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions." | ( Abu-Amer, Y; Adapala, NS; Arra, M; Brophy, R; Cai, L; Mbalaviele, G; Naqvi, SK; Rai, MF; Singamaneni, S; Swarnkar, G, 2022) |
| "Fetal-originated osteoarthritis is relative to poor cartilage quality and may exhibit transgenerational genetic effects." | ( Chen, L; Gao, H; Gu, H; Han, H; Li, B; Li, Q; Liu, L; Wang, H; Wu, Z; Zhou, S; Zhu, J, 2023) |
| "Osteoarthritis is a common disease characterized by degenerative lesions of articular cartilage in the elderly." | ( Chen, ZJ; Huo, XQ; Ren, Y; Shu, Z; Zhang, YL, 2022) |
| "Osteoarthritis is the most common human joint disease in the world." | ( Aleebrahim-Dehkordi, E; Arian, AS; Hamedanchi, NF; Hasanpour-Dehkordi, A; Rafieian-Kopaei, M; Soveyzi, F, 2023) |
| "Osteoarthritis is the most common human joint disease in the world." | ( Aleebrahim-Dehkordi, E; Arian, AS; Hamedanchi, NF; Hasanpour-Dehkordi, A; Rafieian-Kopaei, M; Soveyzi, F, 2023) |
| "Osteoarthritis is a common cause of morbidity in an increasingly aging population." | ( DeFroda, SF; Hartnett, DA; Milner, JD, 2023) |
| "Osteoarthritis is a heterogeneous joint disorder that lacks a clinically meaningful disease modifying drug." | ( Beier, F; Hadzic, E, 2023) |
| "Osteoarthritis is a common degenerative disease, the cause of it is still unknown, and the treatment mainly focuses on improving symptoms." | ( Jiang, J; Li, J; Liu, T; Xiong, C; Zhou, X, 2023) |
| "Osteoarthritis is a disease that affects females more than males and causes poor quality of life." | ( Al-Qazaz, H; Thabit, Z, 2023) |
| "Osteoarthritis is one of the most common diseases of the joints and spine and is characterized by degenerative changes starting in the cartilage." | ( Šléglová, O, 2023) |
| "Osteoarthritis is a major contributor to pain and disability worldwide." | ( Cornel, JH; Eikelboom, JW; Fiolet, ATL; Heijman, MWJ; Mosterd, A; Nidorf, SM; Popa, CD; Schut, A; Thompson, PL; Tijssen, JGP; van den Bemt, BJF; van den Ende, CHM, 2023) |
| "Osteoarthritis is a degenerative knee joint disease featured with articular cartilage degeneration and inflammation." | ( He, Z; Liu, Y; Xu, G, 2023) |
| "Osteoarthritis is the most prevalent joint disease worldwide and the primary cause of musculoskeletal dysfunction." | ( Aydin, M; Betul Celik, Z; Eseoglu, I; Gunaydin, C; Kehribar, L; Yalcin Kehribar, D, 2023) |
| "Osteoarthritis is a chronic degenerative joint disease affecting millions of people worldwide, with no disease-modifying drugs currently available to treat the disease." | ( Betts, JHJ; Green, J; Pelut, A; Piras, M; Searcey, M; Steverding, D; Tinson, RAJ; Troeberg, L; Wren, SP, 2023) |
| "Osteoporotic osteoarthritis is primarily associated with low subchondral bone mass." | ( Chen, L; Jiang, T; Wang, H; Wu, Z; Xiao, H; Xie, X; Zhou, S; Zhu, J, 2023) |
| "Osteoarthritis is a significant global health problem." | ( Dohnalek, MH; Ha, Y; Hill, WS; Jung, JC; Kang, SB; Kim, SJ, 2023) |
| "Osteoarthritis is a multifactorial joint disease characterized by degeneration, and aging stands as a significant risk factor." | ( Arias, C; Salazar, LA, 2023) |
| "Osteoarthritis is a substantial burden for patients with the disease." | ( Abd El-Karim, SS; Al-Mokaddem, AK; Alkahtani, HM; Anwar, MM; Ibrahim, NE; Mahmoud, AH; Zen, AA, 2023) |
| "Hand osteoarthritis is a disabling condition with few effective therapies." | ( Antony, B; Cicuttini, FM; Hill, CL; Jones, G; Kasza, J; Keen, HI; O'Sullivan, R; Teichtahl, AJ; Wang, Y; Wluka, AE, 2023) |
| "Osteoarthritis is a common chronic degenerative disease, of which the essence is the degenerative changes of bone and joint cartilage, involving damage in multiple structures such as bone, synovium and joints." | ( Hu, W; Ji, R; Li, X; Pan, H; Qian, W; Ye, Q; Zhou, L, 2023) |
| "Osteoarthritis is a worldwide prevalent disease that imposes a significant socioeconomic burden on individuals and healthcare systems." | ( Chen, X; Cheng, Y; Wang, S; Yang, A; Yang, Y; Zhang, Y; Zhao, X, 2023) |
| Excerpt | Reference |
|---|
| "One important point in the treatment of osteoarthritis is to control the pain that accompanies the persistent inflammatory conditions." | ( Auteri, A; Blardi, P; Di Perri, T; Gatti, F, 1992) |
| "In short-term, symptomatic treatment of osteoarthritis of the knee, the efficacy of acetaminophen was similar to that of ibuprofen, whether the latter was administered in an analgesic or an antiinflammatory dose." | ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| "We reviewed the result of treatment of knee osteoarthritis with intraarticular injection of betamethasone derivatives in 100 patients over a 5 year period." | ( Ballesteros, F; Gordillo, E; Gordillo, H; Saffie, F, 1989) |
| "This trial shows that long-term treatment of osteoarthritis with tenoxicam and with piroxicam is beneficial." | ( Andersen, RB; Fossgreen, J; Holm, P; Jensen, EM; Kirchheiner, B; Kryger, J; Lund, B; Pichard, J, 1987) |
| "This study indicates that in the treatment of osteoarthritis, piroxicam is as effective as naproxen and poses no greater risk of serious gastrointestinal side effects." | ( Husby, G, 1986) |
| "Sixty-two patients requiring regular treatment for osteoarthritis were entered into a 6-month open assessment of 1." | ( Berry, H; Nicholls, A, 1985) |
| "A new method of treating osteoarthritis of the knee involving the intraneural injection of a depot steroid is described." | ( Pybus, PK, 1984) |
| "One of the mainstays of treatment for osteoarthritis is the use of nonsteroidal anti-inflammatory drugs." | ( Jennings, MB, 1994) |
| "A 59-year-old man, under treatment for osteoarthritis of the right hip joint, was admitted to the Department of Orthopedic Surgery of Health Insurance Nankai Hospital with complaints of high fever and severe right hip joint pain." | ( Goto, Y; Hiroiwa, K; Kuroda, Y; Nagai, H; Nagaoka, H; Nasu, M; Tashiro, T, 1993) |
| "Successful treatment of osteoarthritis must effectively control pain, and should slow down or reverse progression of the disease." | ( Kelly, GS, 1998) |
| "Successful treatment of osteoarthritis must effectively control pain and should slow down or reverse the progression of the degeneration." | ( , 1999) |
| "To analyze results of treatment of osteoarthritis (OA) with acetaminophen and the nonsteroidal antiinflammatory drugs (NSAID) through a patient survey." | ( Callahan, LF; Cummins, P; Pincus, T; Swearingen, C, 2000) |
| "(1) The treatment of osteoarthritis is symptomatic, and relies first and foremost on physical therapy." | ( , 2000) |
| "Cat's claw is an effective treatment for osteoarthritis." | ( Bustamante, SA; Miller, MJ; Okuhama, NN; Piscoya, J; Rodriguez, Z; Sandoval, M, 2001) |
| "The use of drugs for the treatment of osteoarthritis, with a view to obtain a long-term symptomatic as well as structural benefit, is still in a preliminary state." | ( Reginster, JY, 2004) |
| "It is indicated for the symptomatic treatment of osteoarthritis or rheumatoid arthritis (10 to 20 mg once a day) and for the treatment of primary dysmenorrhea (40 mg once a day)." | ( Malaise, M; Scheen, AJ, 2004) |
| "We evaluated their use in the treatment of osteoarthritis by general practitioners, with special attention to concomitant prescription of gastroprotective agents." | ( Bouée, S; Charlemagne, A; Fagnani, F; Lancry, PJ; Le Jeunne, P; Naudin, F; Sermet, C, 2004) |
| "The current treatment of osteoarthritis associated with calcium-containing crystals should involve nonsteroidal anti-inflammatory drugs, intra-articular steroids, and in resistant cases, joint irrigation can be considered." | ( Kalunian, KC; Terkeltaub, R; Wu, CW, 2005) |
| "The medical treatment of osteoarthritis (OA) in the horse is one of the most utilized therapeutic regimens in the equine practice." | ( Goodrich, LR; Nixon, AJ, 2006) |
| "In the treatment of osteoarthritis, celecoxib is as effective as the nonspecific NSAIDs naproxen and diclofenac, but has significantly fewer serious upper gastrointestinal events." | ( Agrawal, NM; Andrade-Ortega, L; Bello, AE; Eisen, GM; Fort, JG; Goldstein, JL; Hanrahan, PS; Levy, RA; Singh, G; Stenson, WF; Triadafilopoulos, G; Wallemark, C, 2006) |
| "Although common treatments for osteoarthritis (OA) pain, such as nonsteroidal antiinflammatory drugs (NSAIDs), simple analgesics, and weak opioids, provide relief in some cases, they fail to control pain or are poorly tolerated in many cases." | ( Langford, R; McKenna, F; Ratcliffe, S; Richarz, U; Vojtassák, J, 2006) |
| "Glucosamine is commonly used for the treatment of osteoarthritis, and its use is increasing in the general population." | ( Anastassiades, T; Berger, C; Carran, J; Gao, Y; Hanley, DA; Hopman, WM; Joseph, L; Towheed, TE; Vik, SA, 2006) |
| "Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage." | ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2006) |
"Annual costs of treating osteoarthritis in ambulatory care amounted to 756 with selective NSAIDs and 416 with non-selective NSAIDs."| ( De Coster, S; De Ruyck, B; Laekeman, G; Simoens, S; Stutz, P, 2006) | |
| "Tramadol is increasingly used for the treatment of osteoarthritis (OA) because it does not produce gastrointestinal bleeding or renal problems and does not affect articular cartilage." | ( Camargo, F; Cepeda, MS; Valencia, L; Zea, C, 2007) |
| "The pharmacological treatment of osteoarthritis is traditionally accomplished with nonspecific symptomatic agents, which are generally effective only for acute symptom relief." | ( Förster, KK; Heisel, J, 2007) |
| "Glucosamine is used to treat osteoarthritis." | ( Blick, KE; Cornea, A; Jenkins, A; Pham, T; Scofield, RH, 2007) |
| "Pharmacologic treatment of osteoarthritis has been confined mostly to analgesic or nonsteroidal antiinflammatory drugs that only modify the symptoms." | ( Aloisi, R; Fioravanti, A; Leo, G; Mian, M; Savarino, L, 2007) |
| "Complementary treatments for osteoarthritis (OA) are sought by patients for symptomatic relief and to avoid the iatrogenic effects of non-steroidal anti-inflammatories." | ( Bashir, N; Brien, S; Coghlan, B; Lewith, G; Prescott, P, 2008) |
| "Conventional treatment of osteoarthritis (OA) with non-steroidal anti-inflammatory drugs is associated with serious gastrointestinal side effects and in view of the recent withdrawal of some cyclo-oxygenase-2 inhibitors, identifying safer alternative treatment options is needed." | ( Bashir, N; Brien, S; Lewith, G; Lewith, H; Prescott, P, 2008) |
| "Symptomatic slow-acting drugs for the treatment of osteoarthritis (SYSADOA; OA) are compounds which are prescribed as drugs in European countries since many years, whereas they are sold as nutraceuticals in USA." | ( Uebelhart, D, 2008) |
| "The prevailing chronic treatment for osteoarthritis--oral administration of NSAIDs--is accompanied by severe adverse effects and risks of gastrointestinal (GI) toxicity." | ( Biton, IE; Elron-Gross, I; Glucksam, Y; Margalit, R, 2009) |
| "Aminosugars are commonly used to treat osteoarthritis; however, molecular mechanisms mediating their anti-arthritic activities are still poorly understood." | ( Brinson, DC; Lotz, MK; Shikhman, AR; Valbracht, J, 2009) |
| "Glucosamine sulfate (GS) is used in treatment of human osteoarthritis, but no data for(99m)TcGS scintigraphy are available." | ( Menzel, J; Sinzinger, H; Sobal, G, 2009) |
| "The piroxicam patch is effective in the treatment of lumbar osteoarthritis and has demonstrated to be well tolerated and it improves patients compliance." | ( Allegrini, A; Bonani, S; Bucci, M; Comuzio, S; Di Grigoli, M; Giangreco, D; Martinotti, S; Mezzetti, A; Nuzzo, L; Pavone, D; Tavella-Scaringi, A; Toniato, E, 2009) |
| "The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks." | ( Forest, K; Girodet, PO; Jacquet, A; Mallet, L; Moore, N; Pariente, A, 2009) |
| "Hyaluronic acid is widely used in the treatment of osteoarthritis and exerts significant chondroprotective effects." | ( Hu, QJ; Liu, SQ; Ming, JH; Peng, H; Qiu, B; Zhou, JL, 2010) |
| "Current treatment for osteoarthritis (OA) is limited." | ( Dennis, L; Doré, CJ; Julius, A; Mackworth-Young, CG; Smith, AS, 2010) |
| "Glucosamine is commonly used for the treatment of osteoarthritis." | ( Anastassiades, TP; Dostrovsky, NR; Hudson, RW; Towheed, TE, 2011) |
| "Recommended pain treatments for osteoarthritis (OA) and chronic low back pain (CLBP) are suboptimal, and limited information is available regarding patterns of pharmacotherapy among patients with these conditions." | ( Emery, P; Gore, M; Leslie, DL; Sadosky, AB; Tai, KS, 2012) |
| "It has been approved for the treatment of osteoarthritis (OA) in Europe to promote cartilage and joint health and is sold over the counter as a dietary supplement in the United States." | ( Henrotin, Y; Marty, M; Mobasheri, A, 2012) |
| "Conventional medical treatment of osteoarthritis often successfully relieves pain but can also produce adverse gastrointestinal and cardiovascular effects, especially with long-term use." | ( Fouladbakhsh, J, 2012) |
| "In the treatment of osteoarthritis, small clinical trials and case series to date suggest safety, symptomatic improvement, and functional improvement at up to a year of follow-up; however, most of these studies are uncontrolled." | ( Borg-Stein, J; Nguyen, RT; Vora, A, 2012) |
| "Exogenous hyaluronan has been used to treat osteoarthritis (OA), a degenerative joint disease involving inflammatory changes." | ( Chang, CC; Chen, CH; Chen, YH; Cheng, CW; Hsieh, MS; Huang, PT; Liao, ST; Lin, YF, 2012) |
| "Glucosamine is a popular treatment for osteoarthritis." | ( Maesschalck, J, 2012) |
| "Most conventional treatments for osteoarthritis, such as non-steroidal anti-inflammatory drugs (NSAIDs) and simple analgesics, have side effects." | ( Janosch, C; Szechinski, J; Zawadzki, M, 2013) |
| "Current available drugs to treat osteoarthritis are predominantly directed towards the symptomatic relief of pain and inflammation but they do little to reduce joint destruction." | ( Pan, XM; Quan, Y; Xie, QG; Zhang, B, 2013) |
| "grandiflorum in the treatment of osteoarthritis, rabbit osteoarthritis model combined with D-galactose was used." | ( Jia, P; Li, R; Mu, F; Wang, S; Zhang, W, 2013) |
| "Various perspective targets for the treatment of osteoarthritis and rheumatoid arthritis are also discussed." | ( Laev, SS; Salakhutdinov, NF, 2015) |
| "The polysaccharides used in the treatment of osteoarthritis (OA) mainly include sodium hyaluronate, chondroitin sulfate, chitosan, xanthan gum, Low molecular weight heparin, alginate and other polysaccharides." | ( Chen, Q; Han, G; Ling, P; Liu, F; Shao, X; Wang, F, 2017) |
| "However, its effect on treatment of osteoarthritis remains elusive so far." | ( Jiang, S; Jiang, T; Li, H; Liu, J; Liu, W; Sun, Y; Zhang, F; Zhang, H, 2017) |
| "In vivo, the cartilage lesions in AECF-treated osteoarthritis rats exhibited less proteoglycan loss and lower OARSI scores." | ( Choi, MS; Chun, HS; Han, SH; Kim, CS; Kim, DK; Kim, HJ; Kim, JS; Kim, SG; Lee, SA; Moon, SM; Park, BR, 2018) |
| "An efficient treatment for osteoarthritis (OA) can benefit from the local release of a high therapeutic dose over an extended period of time." | ( Allémann, E; Gabay, C; Jordan, O; Maudens, P; Seemayer, CA; Thauvin, C, 2018) |
| "We can use from escin for the treatment of osteoarthritis as an anti-inflammatory agent in the latter but further studies to support the results from such a model are needed." | ( Hallajzadeh, J; Maghsoudi, H; Rezaeipour, M, 2018) |
| "The successful use of rose hip for the treatment of osteoarthritis is well documented." | ( Gruenwald, J; Moré, MI; Uebelhack, R, 2019) |
| "It is of great significance to treat osteoarthritis by regulating the immune response." | ( Deng, C; Li, X; Lin, R; Liu, Y; Qin, C; Wang, L; Wu, C; Yao, Q; Zhang, M, 2019) |
| "Intra-articular (IA) drug delivery to treat osteoarthritis (OA) is limited by the short retention time of drugs in the joints due to poor specific targeting and non-responsiveness under acidic environment." | ( Chen, H; He, M; He, Y; Liu, G; Lu, Z; Qin, Z; Ren, E; Wang, J; Zhao, J; Zheng, L, 2020) |
| "Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used." | ( Araújo, RLTM; Barbosa Neto, JO; Cartagenes, MDSS; Czeczko, NG; Garcia, JBS; Gomes, LMRS, 2021) |
| "Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs)." | ( Doherty, M; Lei, G; Persson, MSM; van Middelkoop, M; Wei, J; Xiong, Y; Zeng, C; Zhang, W, 2021) |
| "Strategies for treating osteoarthritis (OA) have become a research focus because an effective treatment for OA is unavailable." | ( Cao, L; Fan, HT; Li, JL; Song, R; Yang, HT; Yang, XF; Zhong, L; Zhou, HX, 2022) |
| "Conventional treatments for osteoarthritis (OA), including drug delivery and tissue engineering approaches, could not offer a high yield of cartilage repair due to the compact and exclusive structure of cartilage." | ( Bagheri, F; Eslaminejad, MB; Moghadam, NA, 2022) |
| "Current treatments for osteoarthritis, including nonsteroidal antiinflammatory drugs, glucocorticoids, and hyaluronic acid, are mainly based on reducing pain and inflammation." | ( Aleebrahim-Dehkordi, E; Arian, AS; Hamedanchi, NF; Hasanpour-Dehkordi, A; Rafieian-Kopaei, M; Soveyzi, F, 2023) |
| "Current treatments for osteoarthritis, including nonsteroidal antiinflammatory drugs, glucocorticoids, and hyaluronic acid, are mainly based on reducing pain and inflammation." | ( Aleebrahim-Dehkordi, E; Arian, AS; Hamedanchi, NF; Hasanpour-Dehkordi, A; Rafieian-Kopaei, M; Soveyzi, F, 2023) |
| "It is also available for the treatment of osteoarthritis, rheumatoid arthritis, tendonitis, etc." | ( Çalışıcı, D; Goktas, B; Yılmaz, S, 2023) |
| "Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians." | ( Gu, J; Hao, B; Hong, W; Jaspers, RT; Lan, H; Li, H; Pathak, JL; Peng, G; Qian, D; Shao, M; Wang, H; Wu, G; Yan, Y; Zeng, J, 2023) |
| "It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain unclear." | ( Bai, X; Chen, J; Chen, L; Cheng, W; Hu, C; Liang, J; Liao, J; Liu, B; Liu, L; Liu, Q; Song, B; Wang, JD; Wang, Y; Xie, Q; Yang, K; Zhang, P; Zhao, N; Zheng, F, 2023) |