Roles > defoliant
Page last updated: 2024-08-05 15:00:14

defoliant

A herbicide which when sprayed or dusted on plants causes its leaves to fall off.

ChEBI ID: 23582

Members (4)

MemberDefinitionClass
2,4-dichlorophenoxyacetic acidA chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.2,4-D
2,4,5-trichlorophenoxyacetic acidA chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2, 4 and 5 are substituted by chlorines.(2,4,5-trichlorophenoxy)acetic acid
butyl phosphorotrithioatetribufos
diquatThe organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.diquat

Research

Studies (3,741)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,105 (29.54)18.7374
1990's563 (15.05)18.2507
2000's910 (24.33)29.6817
2010's821 (21.95)24.3611
2020's342 (9.14)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials12 (0.26%)5.53%
Reviews180 (3.94%)6.00%
Case Studies125 (2.73%)4.05%
Observational0 (0.00%)0.25%
Other4,256 (93.07%)84.16%

Protein Targets (31)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency17.358447
AR proteinHomo sapiens (human)Potency35.201157
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency17.740711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency3.548111
estrogen nuclear receptor alphaHomo sapiens (human)Potency36.107837
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency56.939623
farnesoid X nuclear receptorHomo sapiens (human)Potency21.875111
Guanine nucleotide-binding protein GHomo sapiens (human)Potency22.387211
LuciferasePhotinus pyralis (common eastern firefly)Potency84.532012
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency52.547136
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency13.800611
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency12.625224
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency41.728622
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency37.646012
pregnane X nuclear receptorHomo sapiens (human)Potency29.465424
pregnane X receptorRattus norvegicus (Norway rat)Potency7.943311
progesterone receptorHomo sapiens (human)Potency16.116113
RAR-related orphan receptor gammaMus musculus (house mouse)Potency4.085611
retinoid X nuclear receptor alphaHomo sapiens (human)Potency31.102747
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency29.934911
SMAD family member 2Homo sapiens (human)Potency35.277225
SMAD family member 3Homo sapiens (human)Potency35.277225
thioredoxin reductaseRattus norvegicus (Norway rat)Potency1.122011
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency42.654025
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.012611
thyroid stimulating hormone receptorHomo sapiens (human)Potency29.311347
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency30.330422
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency35.650133

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Androgen receptorRattus norvegicus (Norway rat)IC50457.088011
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPisum sativum (garden pea)IC504,530.000022
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialPisum sativum (garden pea)IC504,530.000022