A statin that is derived from a naturally occurring statin by partial chemical synthesis.
ChEBI ID: 87633
Member | Definition | Role |
---|---|---|
pravastatin | A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. | pravastatin |
pravastatin sodium | An organic sodium salt that is the sodium salt of pravastatin. A reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), it is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. | pravastatin sodium |
simvastatin | A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. | simvastatin |
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 96 (0.90) | 18.7374 |
1990's | 1,762 (16.45) | 18.2507 |
2000's | 4,095 (38.22) | 29.6817 |
2010's | 3,944 (36.81) | 24.3611 |
2020's | 817 (7.63) | 2.80 |
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 2,766 (22.99%) | 5.53% |
Reviews | 878 (7.30%) | 6.00% |
Case Studies | 615 (5.11%) | 4.05% |
Observational | 58 (0.48%) | 0.25% |
Other | 7,716 (64.12%) | 84.16% |