An exogenous or endogenous compound which inhibits serine endopeptidases.
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 20.0409 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 12.5893 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 0.6172 | 2 | 5 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 4.4668 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.0054 | 3 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 11.5982 | 4 | 4 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 11.9955 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 5.8479 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 4.7360 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 14.5500 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 100.0000 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 13.7295 | 3 | 7 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 5.6294 | 1 | 2 |
| Chain A, PAPAIN | Carica papaya (papaya) | Potency | 15.8489 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.1861 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 4.9019 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 40.8708 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.5221 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 16.9330 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 4.2534 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 20.7491 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 6.7902 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 7.1181 | 2 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 1.4951 | 1 | 3 |
| endonuclease IV | Escherichia coli | Potency | 7.0795 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 29.0848 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 14.8040 | 4 | 11 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 4.7763 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 29.2778 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 9.5221 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 7.1700 | 3 | 5 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 32.8851 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 19.9526 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 20.2593 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.5221 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 31.6228 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.5221 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 16.2710 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 16.2982 | 2 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.0078 | 2 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 15.8489 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.7008 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 16.2710 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.3974 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 25.6651 | 2 | 2 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 10.9472 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 67.8334 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 5.0119 | 1 | 1 |
| polyprotein | Zika virus | Potency | 35.4813 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 73.0780 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 12.6511 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 19.7511 | 4 | 4 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 11.9173 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.5481 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.6555 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 3.8832 | 2 | 2 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 23.3507 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 42.9840 | 2 | 4 |
| Thrombopoietin | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.0119 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.0119 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.8208 | 3 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 10.1830 | 5 | 7 |
| WRN | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |