xanthoangelol profile

xanthoangelol: from Angelica keiskei; structure given in first source; RN given refers to (E,E)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Angelica	genus	A plant genus of the family Apiaceae.[MeSH]	Apiaceae	A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH]

ID Source	ID
PubMed CID	643007
CHEMBL ID	494083
SCHEMBL ID	454823
SCHEMBL ID	5519362
MeSH ID	M0186718

Synonym
xanthoangelol
(e)-1-[3-[(2e)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxy-phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
2-propen-1-one, 1-[3-[(2e)-3,7-dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-, (2e)-
inchi=1/c25h28o4/c1-17(2)5-4-6-18(3)7-13-21-24(28)16-14-22(25(21)29)23(27)15-10-19-8-11-20(26)12-9-19/h5,7-12,14-16,26,28-29h,4,6,13h2,1-3h3/b15-10+,18-7
2',4,4'-trihydroxy-3'-geranylchalcone
1-[3-(3,7-dimethyl-octa-2,6-dienyl)-2,4-dihydroxy-phenyl]-3-(4-hydroxy-phenyl)-propenone
(2e)-1-{3-[(2e)-3,7-dimethylocta-2,6-dien-1-yl]-2,4-dihydroxyphenyl}-3-(4-hydroxyphenyl)prop-2-en-1-one
smr000156234
MLS000574837 ,
62949-76-2
LMPK12120053
(e)-1-[3-[(2e)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
CHEMBL494083
NCGC00247541-01
91d4gn26z1 ,
unii-91d4gn26z1
2-propen-1-one, 1-(3-(3,7-dimethyl-2,6-octadienyl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (e,e)-
SCHEMBL454823
SCHEMBL5519362
AC-34303
cid_643007
bdbm70842
(e)-1-[3-[(2e)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
(e)-1-[3-[(2e)-3,7-dimethylocta-2,6-dienyl]-2,4-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
cc(c)=cccc(c)=ccc1c(o)ccc(c(=o)c=cc2ccc(o)cc2)c1o
HY-111588
CS-0087769
(2e)-1-(3-((2e)-3,7-dimethyl-2,6-octadien-1-yl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
2-propen-1-one, 1-(3-((2e)-3,7-dimethyl-2,6-octadien-1-yl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2e)-
MS-26569
E88642
DTXSID301317693
AKOS040740579

Excerpt	Reference	Relevance
"Xanthoangelol is a geranylated chalcone isolated from fruits of Amorpha fructicosa that exhibits antibacterial effects at low micromolar concentration against Gram-positive bacterial pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecium and Enterococcus faecalis. "	( The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria. Bandow, JE; Hernández, MV; Kalscheuer, R; Meier, D; Muharini, R; Proksch, P; van Geelen, L, 2019)	2.25

Excerpt	Reference	Relevance
"Treatments of xanthoangelol D but not xanthoangelol, xanthoangelol E and F markedly suppressed both of basal and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in PAECs."	( Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB. Baba, K; Kawai, Y; Matsumura, Y; Ohkita, M; Sugii, M; Tahara, C; Takaoka, M; Taniguchi, M, 2005)	2.12

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	3.9811	0.0032	45.4673	12,589.2998	AID2517
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	39.8107	0.6310	35.7641	100.0000	AID504339
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	50.1187	5.6234	17.2929	31.6228	AID485281
Chain A, Cruzipain	Trypanosoma cruzi	Potency	39.8107	0.0020	14.6779	39.8107	AID1476
glp-1 receptor, partial	Homo sapiens (human)	Potency	10.0000	0.0184	6.8060	14.1254	AID624417
TDP1 protein	Homo sapiens (human)	Potency	24.8446	0.0008	11.3822	44.6684	AID686978; AID686979
Microtubule-associated protein tau	Homo sapiens (human)	Potency	13.9480	0.1800	13.5574	39.8107	AID1460; AID1468
Smad3	Homo sapiens (human)	Potency	31.6228	0.0052	7.8098	29.0929	AID588855
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	3.9811	0.0112	12.4002	100.0000	AID1030
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	11.2202	0.2818	9.7212	35.4813	AID2326
67.9K protein	Vaccinia virus	Potency	22.3872	0.0001	8.4406	100.0000	AID720579
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.1187	0.7079	36.9043	89.1251	AID504333
alpha-galactosidase	Homo sapiens (human)	Potency	50.1187	4.4668	18.3916	35.4813	AID1467
IDH1	Homo sapiens (human)	Potency	25.9290	0.0052	10.8652	35.4813	AID686970
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	50.1187	0.0355	20.9770	89.1251	AID504332
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	0.1778	0.0366	19.6376	50.1187	AID1466; AID2242
flap endonuclease 1	Homo sapiens (human)	Potency	79.4328	0.1337	25.4129	89.1251	AID588795
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	35.4813	0.0079	8.2332	1,122.0200	AID2546
geminin	Homo sapiens (human)	Potency	25.4995	0.0046	11.3741	33.4983	AID624296; AID624297
Vpr	Human immunodeficiency virus 1	Potency	39.8107	1.5849	19.6264	63.0957	AID651644
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	0.1259	0.0041	9.9625	28.1838	AID2675
lamin isoform A-delta10	Homo sapiens (human)	Potency	14.1254	0.8913	12.0676	28.1838	AID1487
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	0.1778	3.5481	18.0395	35.4813	AID1466
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	0.1778	3.5481	18.0395	35.4813	AID1466
Alpha-synuclein	Homo sapiens (human)	Potency	35.4813	0.5623	9.3985	25.1189	AID652106
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	35.4813	1.7783	16.2081	35.4813	AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
recombinase A	Mycobacterium tuberculosis H37Rv	EC50 (µMol)	234.2000	0.0180	23.2882	287.6000	AID434968; AID435010
streptokinase A precursor	Streptococcus pyogenes M1 GAS	EC50 (µMol)	1.0190	0.0600	8.9128	130.5170	AID1902
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
replicative DNA helicase	Mycobacterium tuberculosis H37Rv	AC50	9.8030	0.0570	30.7482	325.3000	AID449749; AID449750
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
calcium ion homeostasis	Alpha-synuclein	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Alpha-synuclein	Homo sapiens (human)
microglial cell activation	Alpha-synuclein	Homo sapiens (human)
positive regulation of receptor recycling	Alpha-synuclein	Homo sapiens (human)
positive regulation of neurotransmitter secretion	Alpha-synuclein	Homo sapiens (human)
negative regulation of protein kinase activity	Alpha-synuclein	Homo sapiens (human)
fatty acid metabolic process	Alpha-synuclein	Homo sapiens (human)
neutral lipid metabolic process	Alpha-synuclein	Homo sapiens (human)
phospholipid metabolic process	Alpha-synuclein	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Alpha-synuclein	Homo sapiens (human)
mitochondrial membrane organization	Alpha-synuclein	Homo sapiens (human)
adult locomotory behavior	Alpha-synuclein	Homo sapiens (human)
response to xenobiotic stimulus	Alpha-synuclein	Homo sapiens (human)
response to iron(II) ion	Alpha-synuclein	Homo sapiens (human)
regulation of phospholipase activity	Alpha-synuclein	Homo sapiens (human)
negative regulation of platelet-derived growth factor receptor signaling pathway	Alpha-synuclein	Homo sapiens (human)
regulation of glutamate secretion	Alpha-synuclein	Homo sapiens (human)
regulation of dopamine secretion	Alpha-synuclein	Homo sapiens (human)
synaptic vesicle exocytosis	Alpha-synuclein	Homo sapiens (human)
synaptic vesicle priming	Alpha-synuclein	Homo sapiens (human)
regulation of transmembrane transporter activity	Alpha-synuclein	Homo sapiens (human)
negative regulation of microtubule polymerization	Alpha-synuclein	Homo sapiens (human)
receptor internalization	Alpha-synuclein	Homo sapiens (human)
protein destabilization	Alpha-synuclein	Homo sapiens (human)
response to magnesium ion	Alpha-synuclein	Homo sapiens (human)
negative regulation of transporter activity	Alpha-synuclein	Homo sapiens (human)
response to lipopolysaccharide	Alpha-synuclein	Homo sapiens (human)
negative regulation of monooxygenase activity	Alpha-synuclein	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Alpha-synuclein	Homo sapiens (human)
response to type II interferon	Alpha-synuclein	Homo sapiens (human)
cellular response to oxidative stress	Alpha-synuclein	Homo sapiens (human)
SNARE complex assembly	Alpha-synuclein	Homo sapiens (human)
positive regulation of SNARE complex assembly	Alpha-synuclein	Homo sapiens (human)
regulation of locomotion	Alpha-synuclein	Homo sapiens (human)
dopamine biosynthetic process	Alpha-synuclein	Homo sapiens (human)
mitochondrial ATP synthesis coupled electron transport	Alpha-synuclein	Homo sapiens (human)
regulation of macrophage activation	Alpha-synuclein	Homo sapiens (human)
positive regulation of apoptotic process	Alpha-synuclein	Homo sapiens (human)
negative regulation of apoptotic process	Alpha-synuclein	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Alpha-synuclein	Homo sapiens (human)
negative regulation of neuron apoptotic process	Alpha-synuclein	Homo sapiens (human)
positive regulation of endocytosis	Alpha-synuclein	Homo sapiens (human)
negative regulation of exocytosis	Alpha-synuclein	Homo sapiens (human)
positive regulation of exocytosis	Alpha-synuclein	Homo sapiens (human)
regulation of long-term neuronal synaptic plasticity	Alpha-synuclein	Homo sapiens (human)
synaptic vesicle endocytosis	Alpha-synuclein	Homo sapiens (human)
synaptic vesicle transport	Alpha-synuclein	Homo sapiens (human)
positive regulation of inflammatory response	Alpha-synuclein	Homo sapiens (human)
regulation of acyl-CoA biosynthetic process	Alpha-synuclein	Homo sapiens (human)
protein tetramerization	Alpha-synuclein	Homo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosol	Alpha-synuclein	Homo sapiens (human)
neuron apoptotic process	Alpha-synuclein	Homo sapiens (human)
dopamine uptake involved in synaptic transmission	Alpha-synuclein	Homo sapiens (human)
negative regulation of dopamine uptake involved in synaptic transmission	Alpha-synuclein	Homo sapiens (human)
negative regulation of serotonin uptake	Alpha-synuclein	Homo sapiens (human)
regulation of norepinephrine uptake	Alpha-synuclein	Homo sapiens (human)
negative regulation of norepinephrine uptake	Alpha-synuclein	Homo sapiens (human)
excitatory postsynaptic potential	Alpha-synuclein	Homo sapiens (human)
long-term synaptic potentiation	Alpha-synuclein	Homo sapiens (human)
positive regulation of inositol phosphate biosynthetic process	Alpha-synuclein	Homo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathway	Alpha-synuclein	Homo sapiens (human)
response to interleukin-1	Alpha-synuclein	Homo sapiens (human)
cellular response to copper ion	Alpha-synuclein	Homo sapiens (human)
cellular response to epinephrine stimulus	Alpha-synuclein	Homo sapiens (human)
positive regulation of protein serine/threonine kinase activity	Alpha-synuclein	Homo sapiens (human)
supramolecular fiber organization	Alpha-synuclein	Homo sapiens (human)
negative regulation of mitochondrial electron transport, NADH to ubiquinone	Alpha-synuclein	Homo sapiens (human)
positive regulation of glutathione peroxidase activity	Alpha-synuclein	Homo sapiens (human)
positive regulation of hydrogen peroxide catabolic process	Alpha-synuclein	Homo sapiens (human)
regulation of synaptic vesicle recycling	Alpha-synuclein	Homo sapiens (human)
regulation of reactive oxygen species biosynthetic process	Alpha-synuclein	Homo sapiens (human)
positive regulation of protein localization to cell periphery	Alpha-synuclein	Homo sapiens (human)
negative regulation of chaperone-mediated autophagy	Alpha-synuclein	Homo sapiens (human)
regulation of presynapse assembly	Alpha-synuclein	Homo sapiens (human)
amyloid fibril formation	Alpha-synuclein	Homo sapiens (human)
synapse organization	Alpha-synuclein	Homo sapiens (human)
chemical synaptic transmission	Alpha-synuclein	Homo sapiens (human)
negative regulation of protein phosphorylation	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA processing	TAR DNA-binding protein 43	Homo sapiens (human)
RNA splicing	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of protein stability	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of insulin secretion	TAR DNA-binding protein 43	Homo sapiens (human)
response to endoplasmic reticulum stress	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of protein import into nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of circadian rhythm	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of apoptotic process	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation by host of viral transcription	TAR DNA-binding protein 43	Homo sapiens (human)
rhythmic process	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of cell cycle	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA destabilization	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear inner membrane organization	TAR DNA-binding protein 43	Homo sapiens (human)
amyloid fibril formation	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
fatty acid binding	Alpha-synuclein	Homo sapiens (human)
phospholipase D inhibitor activity	Alpha-synuclein	Homo sapiens (human)
SNARE binding	Alpha-synuclein	Homo sapiens (human)
magnesium ion binding	Alpha-synuclein	Homo sapiens (human)
transcription cis-regulatory region binding	Alpha-synuclein	Homo sapiens (human)
actin binding	Alpha-synuclein	Homo sapiens (human)
protein kinase inhibitor activity	Alpha-synuclein	Homo sapiens (human)
copper ion binding	Alpha-synuclein	Homo sapiens (human)
calcium ion binding	Alpha-synuclein	Homo sapiens (human)
protein binding	Alpha-synuclein	Homo sapiens (human)
phospholipid binding	Alpha-synuclein	Homo sapiens (human)
ferrous iron binding	Alpha-synuclein	Homo sapiens (human)
zinc ion binding	Alpha-synuclein	Homo sapiens (human)
lipid binding	Alpha-synuclein	Homo sapiens (human)
oxidoreductase activity	Alpha-synuclein	Homo sapiens (human)
kinesin binding	Alpha-synuclein	Homo sapiens (human)
Hsp70 protein binding	Alpha-synuclein	Homo sapiens (human)
histone binding	Alpha-synuclein	Homo sapiens (human)
identical protein binding	Alpha-synuclein	Homo sapiens (human)
alpha-tubulin binding	Alpha-synuclein	Homo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Alpha-synuclein	Homo sapiens (human)
tau protein binding	Alpha-synuclein	Homo sapiens (human)
phosphoprotein binding	Alpha-synuclein	Homo sapiens (human)
molecular adaptor activity	Alpha-synuclein	Homo sapiens (human)
dynein complex binding	Alpha-synuclein	Homo sapiens (human)
cuprous ion binding	Alpha-synuclein	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
double-stranded DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
RNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA 3'-UTR binding	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
lipid binding	TAR DNA-binding protein 43	Homo sapiens (human)
identical protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
pre-mRNA intronic binding	TAR DNA-binding protein 43	Homo sapiens (human)
molecular condensate scaffold activity	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
platelet alpha granule membrane	Alpha-synuclein	Homo sapiens (human)
extracellular region	Alpha-synuclein	Homo sapiens (human)
extracellular space	Alpha-synuclein	Homo sapiens (human)
nucleus	Alpha-synuclein	Homo sapiens (human)
cytoplasm	Alpha-synuclein	Homo sapiens (human)
mitochondrion	Alpha-synuclein	Homo sapiens (human)
lysosome	Alpha-synuclein	Homo sapiens (human)
cytosol	Alpha-synuclein	Homo sapiens (human)
plasma membrane	Alpha-synuclein	Homo sapiens (human)
cell cortex	Alpha-synuclein	Homo sapiens (human)
actin cytoskeleton	Alpha-synuclein	Homo sapiens (human)
membrane	Alpha-synuclein	Homo sapiens (human)
inclusion body	Alpha-synuclein	Homo sapiens (human)
axon	Alpha-synuclein	Homo sapiens (human)
growth cone	Alpha-synuclein	Homo sapiens (human)
synaptic vesicle membrane	Alpha-synuclein	Homo sapiens (human)
perinuclear region of cytoplasm	Alpha-synuclein	Homo sapiens (human)
postsynapse	Alpha-synuclein	Homo sapiens (human)
supramolecular fiber	Alpha-synuclein	Homo sapiens (human)
protein-containing complex	Alpha-synuclein	Homo sapiens (human)
cytoplasm	Alpha-synuclein	Homo sapiens (human)
axon terminus	Alpha-synuclein	Homo sapiens (human)
neuronal cell body	Alpha-synuclein	Homo sapiens (human)
intracellular non-membrane-bounded organelle	TAR DNA-binding protein 43	Homo sapiens (human)
nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
perichromatin fibrils	TAR DNA-binding protein 43	Homo sapiens (human)
mitochondrion	TAR DNA-binding protein 43	Homo sapiens (human)
cytoplasmic stress granule	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear speck	TAR DNA-binding protein 43	Homo sapiens (human)
interchromatin granule	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
chromatin	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (117)

Assay ID	Title	Year	Journal	Article
AID1611025	Induction of ClpC protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611021	Induction of SufD protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID422533	Cytotoxicity against NHEM cells assessed as cell viability 24 hrs by WST-8 assay	2009	Journal of natural products, Jan, Volume: 72, Issue:1	Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
AID1611023	Induction of YqiG protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437926	Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1610998	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611043	Induction of DnaK.2 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437920	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1611033	Induction of DnaK.1 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610985	Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611053	Induction of YkgB protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611005	Selectivity index, ratio of IC50 for human HEK293 cells to MIC90 for methicillin-resistant Staphylococcus aureus ATCC 700699	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID343716	Superoxide-scavenging activity assessed as inhibition of formation of WST1 formazan	2008	Journal of natural products, Jul, Volume: 71, Issue:7	C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.
AID1611010	Induction of membrane integrity impairment in methicillin resistant Staphylococcus aureus Mu50 harboring GFP reporter plasmid assessed as increase in release of GFP at 1 to 16 times MIC incubated for 3 to 6 hrs by BacTiter-Glo Assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437922	Antibacterial activity against Enterococcus faecium ATCC 700221 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1611050	Induction of PdhA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1197165	Induction of apoptosis in human K562 cells assessed as cell shrinkage/blebbing at 30 uM after 48 hrs	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.
AID422532	Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation	2009	Journal of natural products, Jan, Volume: 72, Issue:1	Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
AID1611001	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611006	Selectivity index, ratio of IC50 for human HepG2 cells to MIC90 for methicillin-resistant Staphylococcus aureus ATCC 700699	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID378959	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 10 molar ratio relative to TPA	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1611031	Induction of ClpP protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610990	Antibacterial activity against Acinetobacter baumannii ATCC BAA-747 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611037	Induction of YvlB protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611056	Induction of SodA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611042	Induction of HisI protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611008	Induction of membrane integrity impairment in methicillin-resistant Staphylococcus aureus ATCC 700699 at 0.5 to 4 times MIC measured for 30 mins by DiOC2(3) probe based fluorescence assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611036	Induction of Hag protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID378956	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio relative to TPA	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1611007	Selectivity index, ratio of IC50 for human CLS54 cells to MIC90 for methicillin-resistant Staphylococcus aureus ATCC 700699	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611020	Induction of FabG protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611016	Induction of LiaH.1 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610995	Antibacterial activity against mid-exponential growth phase of methicillin-resistant Staphylococcus aureus ATCC 700699 assessed as increase in cell lysis at 12.5 to 25 uM	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611018	Induction of LiaH.2 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610984	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1197163	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.
AID1611029	Induction of BdhA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1197166	Induction of apoptosis in human K562 cells assessed as apoptotic rate at 30 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based FACS analysis (Rvb = 5%)	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.
AID1611026	Induction of ArgB protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611046	Induction of SerA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437917	Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1611000	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437921	Antibacterial activity against Enterococcus faecium ATCC 35667 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID378957	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 molar ratio relative to TPA	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1610983	Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID378958	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 100 molar ratio relative to TPA	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1611057	Induction of AhpF protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611009	Induction of membrane integrity impairment in methicillin resistant Staphylococcus aureus Mu50 assessed as increase in release of ATP at 1 to 16 times MIC incubated for 1 hr by BacTiter-Glo Assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID378962	Scavenging activity against (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide-induced NO generation in human Chang liver cells	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1611027	Induction of YhfK protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611015	Hemolytic activity against human erythrocytes at =>100 uM measured up to 24 hrs	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611041	Induction of PpaC protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611045	Induction of CysK protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611002	Cytotoxicity against human CLS54 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611048	Induction of Tpx protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611052	Induction of TrxA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610994	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 assessed as delay in growth at 6.25 uM measured for 24 hrs relative to control	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611044	Induction of Cah protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610988	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 700221 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611055	Induction of YwfI protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610993	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 assessed as delay in growth at 1.56 uM measured for 6 hrs	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610999	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611035	Induction of AroA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611030	Induction of Hom protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611024	Induction of YdjE protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610986	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437924	Antibacterial activity against Acinetobacter baumannii ATCC BAA1605 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1611054	Induction of HisG protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611011	Induction of membrane integrity impairment in methicillin-resistant Staphylococcus aureus ATCC 700699 at 12.5 to 25 uM measured for 3 hrs by PI staining based fluorescence assay	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610992	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611039	Induction of GroES protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID391883	Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay	2008	Journal of natural products, Oct, Volume: 71, Issue:10	Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
AID1611038	Induction of YuaE protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610997	Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 700699 assessed as reduction in bacterial CFU at 4 times MIC measured for 30 mins	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1610991	Antibacterial activity against multidrug-resistant Acinetobacter baumannii ATCC BAA-1605 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611003	Selectivity index, ratio of IC50 for human THP1 cells to MIC90 for methicillin-resistant Staphylococcus aureus ATCC 700699	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1437923	Antibacterial activity against Mycobacterium tuberculosis by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1611019	Induction of PspA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611004	Selectivity index, ratio of IC50 for human MRC5 cells to MIC90 for methicillin-resistant Staphylococcus aureus ATCC 700699	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID378961	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1437919	Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID391884	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay	2008	Journal of natural products, Oct, Volume: 71, Issue:10	Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
AID1437925	Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1611034	Induction of PepF protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611017	Induction of GroEL.3 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1423397	Inhibition of Staphylococcus aureus USA300 GFP-fused SaeRS at 20 uM after 8 hrs by fluorescence-based assay	2018	Journal of medicinal chemistry, 12-13, Volume: 61, Issue:23	Total Synthesis of Xanthoangelol B and Its Various Fragments: Toward Inhibition of Virulence Factor Production of Staphylococcus aureus.
AID1610987	Antibacterial activity against Enterococcus faecalis ATCC 35667 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1195522	Inhibition of PTP1B (unknown origin) at 20 ug/ml using pNPP substrate measured after 3 mins by colorimetric assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).
AID1611028	Induction of NfrA protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1195523	Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assay	2015	Bioorganic & medicinal chemistry letters, , Volume: 25, Issue:10	PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).
AID1437918	Antibacterial activity against methicilin-resistant Staphylococcus aureus ATCC 700699 by broth microdilution method	2017	Journal of natural products, 01-27, Volume: 80, Issue:1	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
AID1610989	Antibacterial activity against Bacillus subtilis 168 by broth micro dilution method	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611049	Induction of MenB protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611047	Induction of YfmJ protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1197892	Induction of GLUT4 translocation in rat L6 cells assessed as increase in 2-deoxyglucose uptake relative to control	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
AID1197164	Toxicity against HUVEC incubated for 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.
AID378960	Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1611051	Induction of YqjE protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611022	Induction of GroEL.2 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611032	Induction of GroEL.1 protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1611040	Induction of YceH protein expression in Bacillus subtilis 168 at 2.3 uM incubated for 15 mins by 35S-methionine pulse labeling based 2D-PAGE analysis	2019	Bioorganic & medicinal chemistry, 12-01, Volume: 27, Issue:23	The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	4 (8.00)	18.2507
2000's	10 (20.00)	29.6817
2010's	30 (60.00)	24.3611
2020's	6 (12.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (3.92%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	49 (96.08%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydroquinone [no description available]	2.05	1	benzenediol; hydroquinones	antioxidant; carcinogenic agent; cofactor; Escherichia coli metabolite; human xenobiotic metabolite; mouse metabolite; skin lightening agent
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2.1	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
5-methoxypsoralen 5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.	2.11	1	5-methoxyfurocoumarin; organic heterotricyclic compound; psoralens	hepatoprotective agent; plant metabolite
carbonyl cyanide m-chlorophenyl hydrazone Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.	2.21	1	hydrazone; monochlorobenzenes; nitrile	antibacterial agent; geroprotector; ionophore
methoxsalen Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.	2.46	2	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite
rotenone Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.	2.15	1	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin
ethyl acetate ethyl acetate : The acetate ester formed between acetic acid and ethanol.	2.01	1	acetate ester; ethyl ester; volatile organic compound	EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor; metabolite; polar aprotic solvent; Saccharomyces cerevisiae metabolite
thiazoles [no description available]	2.04	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
oleanolic acid [no description available]	2.11	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
glycyrrhizic acid glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.	2.03	1	enone; glucosiduronic acid; pentacyclic triterpenoid; tricarboxylic acid; triterpenoid saponin	EC 3.4.21.5 (thrombin) inhibitor; plant metabolite
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.11	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.01	1	benzenes; phenyl acetates
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.04	1	organic bromide salt	colorimetric reagent; dye
isopimpinellin isopimpinellin: from Ruta graveolens & Heracleum lanatum; structure	2.03	1	psoralens
deguelin deguelin: a natural product from Mundulea sericea; RN refers to (7aS-cis)-isomer; structure given in first source. deguelin : A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.	2.48	2	aromatic ether; diether; organic heteropentacyclic compound; rotenones	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; mitochondrial NADH:ubiquinone reductase inhibitor; plant metabolite
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	2.06	1
liquiritigenin liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.	2.05	1	4',7-dihydroxyflavanone	hormone agonist; plant metabolite
tephrosin tephrosin: RN given for (7aR-cis)-isomer; has insecticidal activity; structure in first source. tephrosin : A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.	2.04	1	aromatic ether; cyclic ketone; organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; pesticide
phaseollidin phaseollidin: from Erythrina burana; RN refers to (6aR-cis)-isomer; structure given in first source. phaseollidin : A member of the class of pterocarpans that is (6aR,11aR)-pterocarpan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 10.	2.05	1	pterocarpans
celastrol [no description available]	2.04	1	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite
glabridin [no description available]	2.25	1	hydroxyisoflavans	antiplasmodial drug
moxifloxacin Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.	2.58	2	aromatic ether; cyclopropanes; fluoroquinolone antibiotic; pyrrolidinopiperidine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug
isobavachin isobavachin: RN given for (S)-isomer; structure in first source	2.44	2	flavanones
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.05	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.05	1	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
alpha-toxicarol alpha-toxicarol: from the roots of Derris trifoliata; structure in first source	2.15	1	isoflavanones
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	2.03	1	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	6.98	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
farnesol Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.	2.04	1	farnesol	plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.04	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
oleic acid Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.	2.1	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent
visnadin [no description available]	2.11	1
chalcone trans-chalcone : The trans-isomer of chalcone.	6.06	35	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
isoliquiritigenin [no description available]	2.78	3	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
xanthohumol xanthohumol: from hop plant, Humulus lupulus. xanthohumol : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.	3.21	1	aromatic ether; chalcones; polyphenol	anti-HIV-1 agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor; metabolite
cardamonin cardamonin: found in Zingiberaceae; structure in first source	2.1	1	chalcones
epalrestat epalrestat : A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.	3.21	1	monocarboxylic acid; thiazolidines	EC 1.1.1.21 (aldehyde reductase) inhibitor
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole: intermediate in the synthesis of imidazolineoxyl N-oxides; partial structure given in first source	2.03	1	benzoic acid; imidazolines; organic radical	apoptosis inhibitor; radical scavenger
Dehydrodeguelin,7a,13a-Didehydrodeguelin [no description available]	2.15	1	rotenones
leachianone g leachianone G: structure in first source. leachianone G : A tetrahydroxyflavanone having the hydroxy groups at the 2'-, 4'-, 5- and 7-positions and a prenyl group at 8-position.	2.05	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; tetrahydroxyflavanone
quercitrin [no description available]	2.11	1	alpha-L-rhamnoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	antileishmanial agent; antioxidant; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
luteolin-7-glucoside luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.11	1	beta-D-glucoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antioxidant; plant metabolite
genistein [no description available]	2.05	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2.75	3	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.21	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
hyperoside quercetin 3-O-beta-D-galactopyranoside : A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.	2.11	1	beta-D-galactoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	hepatoprotective agent; plant metabolite
thromboxane b2 Thromboxane B2: A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).. thromboxane B2 : A member of the class of thromboxanes B that is (5Z,13E)-thromboxa-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.	1.98	1	thromboxanes B	human metabolite; mouse metabolite
12-hydroxy-5,8,10-heptadecatrienoic acid 12-hydroxy-5,8,10-heptadecatrienoic acid: metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation	1.98	1	hydroxy polyunsaturated fatty acid; long-chain fatty acid; trienoic fatty acid	metabolite
neobavaisoflavone neobavaisoflavone: isolated from Psoralea corylifolia; structure in first source. neobavaisoflavone : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation.	2.05	1	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; plant metabolite; platelet aggregation inhibitor
osthenol osthenol: structure in first source. osthenol : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group.	2.03	1	hydroxycoumarin	antifungal agent; plant metabolite
12-hydroxy-5,8,10,14-eicosatetraenoic acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)	1.98	1
flavokawain b flavokawain B: from Piper methysticum Forst (Kava Kava) roots; structure in first source. flavokawain B : A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.	2.1	1	chalcones; dimethoxybenzene; phenols	anti-inflammatory agent; antileishmanial agent; antineoplastic agent; apoptosis inducer; metabolite
Isoliquiritigenin 4,4'-dimethyl ether [no description available]	3.21	1	chalcones
guajavarin guajavarin: from leaves of Psidium guajava	2.11	1
4-hydroxyderricin 4-hydroxyderricin: from Angelica keiskei; RN given refers to (E)-isomer; structure in first source	6.03	20	chalcones
broussochalcone a broussochalcone A: RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source	3.21	1
amorphastilbol amorphastilbol: dual PPARalpha/gamma agonist from Amorpha species	2.48	2
bavachalcone bavachalcone: structure in first source	3.61	2	chalcones
sophoraflavanone a sophoraflavanone A: structure in first source. sophoraflavanone A : A trihydroxyflavanone that is (S)-naringenin substituted by a geranyl group at position 8. Isolated from Macaranga bicolor, it exhibits antibacterial and antineoplastic activities.	2.03	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; trihydroxyflavanone	antibacterial agent; antineoplastic agent; metabolite
(6aS,12aS)-9-hydroxy-2,3-dimethoxy-8-(3-methylbut-2-enyl)-6a,12a-dihydro-6H-[1]benzopyrano[3,4-b][1]benzopyran-12-one [no description available]	2.15	1	rotenones
Xanthoangelol D [no description available]	2.11	1	chalcones
scopolamine hydrobromide [no description available]	2.41	1
bavachin bavachin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; do not confuse with bavachinin	2.05	1
endothelin-1 Endothelin-1: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)	7.02	1
hoe 33342 bisbenzimide ethoxide trihydrochloride: benzimidazole fluorescent dye	2.04	1
amorfrutin a amorfrutin A: an antidiabetic agent that inhibits NF-kappaB activation; structure in first source	2.48	2	stilbenoid
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.04	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.43	2	benzenes; hydroxycoumarin; methyl ketone

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.78	3
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.78	3
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	3.03	1
Germinoblastoma [description not available]	2.15	1
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	2.15	1
Infections, Staphylococcal [description not available]	2.21	1
Bacterial Infections, Gram-Positive [description not available]	2.21	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.21	1
Gram-Positive Bacterial Infections Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.	2.21	1
Acute Confusional Senile Dementia [description not available]	2.41	1
Amnesia-Memory Loss [description not available]	2.41	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.41	1
Amnesia Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)	7.41	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.6	1
Atrophy, Muscle [description not available]	2.25	1
Muscular Atrophy Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.	2.25	1
Cerebral Infarction, Middle Cerebral Artery [description not available]	2.31	1
Injury, Ischemia-Reperfusion [description not available]	2.31	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	7.31	1
Infarction, Middle Cerebral Artery NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.	2.31	1
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.17	1
B16 Melanoma [description not available]	2.17	1
Cancer of Skin [description not available]	2.17	1
Skin Neoplasms Tumors or cancer of the SKIN.	2.17	1
Hepatocellular Carcinoma [description not available]	2.61	2
Cancer of Liver [description not available]	2.78	3
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.61	2
Liver Neoplasms Tumors or cancer of the LIVER.	2.78	3
Hypospermatogenesis [description not available]	2.21	1
Metastase [description not available]	2.21	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.21	1
Benign Neoplasms [description not available]	2.08	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.08	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.11	1
Osteogenic Sarcoma [description not available]	2.11	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	2.11	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	7.13	1
Leucocythaemia [description not available]	2.47	2
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	7.47	2
Hyperglycemia, Postprandial Abnormally high BLOOD GLUCOSE level after a meal.	2.06	1
Hyperglycemia Abnormally high BLOOD GLUCOSE level.	2.06	1
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	2.01	1
Cancer of Lung [description not available]	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.44	2
Apoplexy [description not available]	2.03	1
Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)	7.03	1
Benign Neoplasms, Brain [description not available]	2.04	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.04	1

xanthoangelol

Description

Cross-References

Synonyms (33)

Research Excerpts

Overview

Treatment

Protein Targets (30)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (94)

Molecular Functions (33)

Ceullar Components (29)

Bioassays (117)

Research

Studies (50)

Market Indicators

Research Demand Index: 22.75

Study Types

xanthoangelol

Description

Related Flora

Cross-References

Synonyms (33)

Research Excerpts

Overview

Treatment

Protein Targets (30)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (94)

Molecular Functions (33)

Ceullar Components (29)

Bioassays (117)

Research

Studies (50)

Market Indicators

Research Demand Index: 22.75

Study Types

Related Drugs (68)

Related Conditions (49)