A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
| Member | Definition | Class |
|---|
| 4-hydroxyphenylethanol | A phenol substituted at position 4 by a 2-hydroxyethyl group. | 2-(4-hydroxyphenyl)ethanol |
| acebutolol | An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol. | acebutolol |
| acebutolol hydrochloride | The hydrochloride salt of acebutolol, prepared using equimolar amounts of acebutolol and hydrogen chloride. | acebutolol hydrochloride |
| acecainide | A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine. | N-acetylprocainamide |
| acetyldigitoxin | A cardenolide glycoside compound consisting of digitoxin having an acetyl substituent at the 3-position on the D-ribo-hexopyranosyl residue at the non-reducing end. | 3'''-O-acetyldigitoxin |
| acetylstrophanthidin | An acetate ester that is strophanidin acetylated at the 3beta-hydroxy group. | acetylstrophanthidin |
| adenosine | A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond. | adenosine |
| alprenolol | A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent. | alprenolol |
| asl 8052 | The hydrochloride salt of esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. | esmolol hydrochloride |
| atenolol | An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. | atenolol |
| beclomethasone dipropionate | A steroid ester comprising beclomethasone having propionyl groups at the 17- and 21-positions. | beclomethasone dipropionate |
| bepridil | A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl. | bepridil |
| bevantolol | A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension. | bevantolol |
| bisoprolol | | bisoprolol |
| bretylium | A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. | bretylium |
| bretylium tosylate | The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. | bretylium tosylate |
| carteolol | | carteolol |
| carteolol hydrochloride | | carteolol hydrochloride |
| cinalukast | 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in the human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma. | cinalukast |
| d 888 | A nitrile that acts as an L-type calcium channel blocker. | devapamil |
| deslanoside | A cardenolide glycoside that is lanatoside C with the acetoxy group replaced by a hydroxy group. | deslanoside |
| digoxin | A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small. | digoxin |
| disopyramide | A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug. | disopyramide |
| dronedarone | A member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias. | dronedarone |
| encainide | 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. | encainide |
| enprofylline | Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. | enprofylline |
| ethylisopropylamiloride | A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. | ethylisopropylamiloride |
| felodipine | The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris. | felodipine |
| flecainide | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). | flecainide |
| flecainide acetate | An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). | flecainide acetate |
| glyburide | An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group. | glyburide |
| lidocaine | The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. | lidocaine |
| lidocaine hydrochloride | The anhydrous form of the hydrochloride salt of lidocaine. | lidocaine hydrochloride |
| lidocaine hydrochloride | The monohydrate form of lidocaine hydrochloride. | lidocaine hydrochloride monohydrate |
| losartan | A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position | losartan |
| magnesium sulfate | A magnesium salt having sulfate as the counterion. | magnesium sulfate |
| metipranolol | 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma. | metipranolol |
| mexiletine | An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol. | mexiletine |
| mexiletine hydrochloride | A hydrochloride composed of equimolar amounts of mexiletine and hydrogen chloride. | mexiletine hydrochloride |
| montelukast | | montelukast |
| moricizine | A phenothiazine substituted on the nitrogen by a 3-(morpholin-4-yl)propanoyl group, and at position 2 by an (ethoxycarbonyl)amino group. | moricizine |
| moricizine hydrochloride | A hydrochloride salt obtained from equimola amounts of moricizine and hydrogen chloride. | moricizine hydrochloride |
| or 1259 | | levosimendan |
| ouabain | A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus. | ouabain |
| pilsicainide | A secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. | pilsicainide |
| polydatin | A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. | trans-piceid |
| practolol | N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias. | practolol |
| procainamide | A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias. | procainamide |
| procainamide hydrochloride | A hydrochloride which has procainamide as the amino component. | procainamide hydrochloride |
| propafenone | An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. | propafenone |
| propafenone hydrochloride | A hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. | propafenone hydrochloride |
| propranolol | A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3. | propranolol |
| quinidine | A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | quinidine |
| sotalol | A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. | sotalol |
| sotalol hydrochloride | A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. | sotalol hydrochloride |
| timolol | The (S)-(-) (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine. | (S)-timolol (anhydrous) |
| timolol maleate | The maleic acid salt of the active (S)-enantiomer of timolol, comprising equimolar amounts of (S)-timolol and maleic acid. | (S)-timolol maleate |
| tocainide | A monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic. | tocainide |
| uk 68798 | A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug. | dofetilide |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 12.9676 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 16.5709 | 2 | 6 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.3475 | 4 | 17 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 13.2428 | 2 | 10 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.2861 | 1 | 7 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 15.9003 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 7.2334 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 10.7354 | 12 | 122 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 17.7330 | 2 | 12 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.4683 | 1 | 11 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.9781 | 3 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 12.7528 | 2 | 15 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 12.8319 | 1 | 9 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 7.0954 | 2 | 18 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 18.1179 | 2 | 14 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 28.9165 | 1 | 4 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 23.4124 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 28.9165 | 1 | 4 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 23.4124 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 8.2674 | 3 | 17 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.3314 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 27.5942 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 15.0696 | 2 | 12 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 29.4091 | 1 | 5 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 41.4374 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 14.6726 | 2 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 155.0383 | 1 | 11 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 19.0728 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 11.2192 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 14.6726 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 55.1107 | 2 | 14 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 4.1502 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.2259 | 1 | 13 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 12.9336 | 1 | 18 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 20.9002 | 1 | 6 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 8.6287 | 2 | 24 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.9319 | 2 | 15 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.4522 | 1 | 15 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 9.5357 | 3 | 6 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 16.4816 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 91.5366 | 1 | 5 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 35.1675 | 1 | 5 |
| endonuclease IV | Escherichia coli | Potency | 19.9526 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 8.9657 | 12 | 106 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 12.5670 | 2 | 17 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 15.3915 | 10 | 85 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 9.8163 | 2 | 20 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 24.4288 | 4 | 23 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 10.3777 | 5 | 17 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 31.3874 | 1 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 24.8755 | 1 | 6 |
| G | Vesicular stomatitis virus | Potency | 12.2259 | 1 | 13 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 8.7277 | 1 | 13 |
| geminin | Homo sapiens (human) | Potency | 6.6711 | 3 | 34 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 17.8572 | 3 | 31 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.6086 | 3 | 9 |
| GLS protein | Homo sapiens (human) | Potency | 10.2841 | 2 | 10 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.3784 | 5 | 37 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 12.2210 | 1 | 10 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 16.0414 | 2 | 4 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.0355 | 2 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.7498 | 2 | 13 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 24.7732 | 1 | 7 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 19.9826 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 36.2520 | 2 | 9 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.2259 | 1 | 13 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 21.0722 | 2 | 6 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.2475 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 13.6607 | 1 | 5 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.2259 | 1 | 26 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 12.7399 | 1 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.6592 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.6592 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 12.8803 | 3 | 32 |
| interleukin 8 | Homo sapiens (human) | Potency | 0.2985 | 1 | 1 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.6314 | 2 | 26 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.0316 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 12.3861 | 3 | 7 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 31.7545 | 3 | 6 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 29.1096 | 1 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 30.7505 | 2 | 6 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 21.2031 | 2 | 6 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 12.5434 | 2 | 9 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.6375 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 29.8911 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 29.8911 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 7.7401 | 1 | 3 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.5060 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 24.7097 | 1 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 46.4497 | 1 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.2313 | 4 | 30 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 11.6759 | 2 | 5 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 7.8365 | 2 | 9 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 9.4392 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 14.2653 | 2 | 9 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 14.6999 | 1 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.0750 | 3 | 36 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 61.4308 | 1 | 4 |
| Parkin | Homo sapiens (human) | Potency | 5.8964 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 26.2869 | 2 | 5 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.1340 | 2 | 9 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 56.9578 | 1 | 8 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 11.1176 | 5 | 36 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 7.9744 | 5 | 31 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 4.3299 | 1 | 3 |
| polyprotein | Zika virus | Potency | 24.8755 | 1 | 6 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 11.6552 | 1 | 19 |
| PPM1D protein | Homo sapiens (human) | Potency | 14.2807 | 1 | 10 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 14.0181 | 3 | 20 |
| progesterone receptor | Homo sapiens (human) | Potency | 16.0563 | 3 | 17 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.2473 | 2 | 25 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 7.4311 | 1 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 4.7645 | 1 | 15 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 17.4339 | 3 | 20 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 13.3324 | 4 | 31 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 21.1174 | 2 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 1.2589 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 11.2837 | 2 | 19 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 11.2837 | 2 | 19 |
| Smad3 | Homo sapiens (human) | Potency | 19.9546 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 18.3098 | 1 | 12 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 4.2113 | 1 | 9 |
| T cell receptor, partial | Homo sapiens (human) | Potency | 7.0509 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 5 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.5591 | 2 | 61 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 21.8959 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 20.3748 | 4 | 17 |
| Thrombopoietin | Homo sapiens (human) | Potency | 11.2947 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.2969 | 2 | 22 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 1.0071 | 3 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 9.7635 | 6 | 24 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 0.3758 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 4.3299 | 1 | 3 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 4.3299 | 1 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 72.7305 | 2 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 14.4432 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 5.6819 | 4 | 25 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 12.2210 | 1 | 10 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 2.3055 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 11.6337 | 6 | 9 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0216 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 3.3369 | 2 | 7 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.5307 | 1 | 3 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.6685 | 2 | 4 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 2.3773 | 2 | 3 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.3030 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 2.5680 | 2 | 5 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.2452 | 1 | 4 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.5633 | 2 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.7015 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.3390 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.7015 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 3.3133 | 2 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 1.1440 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 67.4500 | 1 | 8 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 1.0000 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 1.0000 | 1 | 2 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 0.5000 | 1 | 1 |
| Adenosine kinase | Toxoplasma gondii | Ki | 8.9000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 0.0023 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 28.9376 | 3 | 3 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 32.5460 | 8 | 9 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 0.0032 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 42.4375 | 8 | 8 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 72.7858 | 7 | 9 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 35.1271 | 7 | 7 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 89.0060 | 5 | 7 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 1.6260 | 3 | 4 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 50.3464 | 4 | 5 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 32.5500 | 2 | 2 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 89,500.0000 | 2 | 2 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Ki | 33,860.0000 | 3 | 3 |
| Albumin | Homo sapiens (human) | Ki | 354,813,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 35.2350 | 2 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.8290 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 2.6209 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 33.8303 | 2 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.4210 | 1 | 2 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 33.8303 | 2 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.4210 | 1 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 4.4654 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.4700 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 5.1454 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.7670 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 0.0190 | 1 | 1 |
| ATP synthase subunit beta, mitochondrial | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| ATP synthase subunit delta, mitochondrial | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| ATP synthase subunit epsilon, mitochondrial | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| ATP synthase subunit gamma, mitochondrial | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 126.3333 | 1 | 15 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | IC50 | 0.0043 | 1 | 1 |
| ATP-binding cassette sub-family C member 9 | Homo sapiens (human) | IC50 | 1.2100 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 75.5901 | 10 | 17 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 30.7500 | 4 | 8 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 10.0457 | 5 | 7 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | IC50 | 0.8081 | 3 | 3 |
| Atrial natriuretic peptide receptor 3 | Homo sapiens (human) | IC50 | 0.0018 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 2.0046 | 18 | 25 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.2819 | 8 | 16 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0038 | 1 | 2 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2157 | 7 | 12 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0347 | 1 | 1 |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | IC50 | 3.8042 | 3 | 4 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0288 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 1.9464 | 11 | 17 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 1.3297 | 8 | 17 |
| Beta-2 adrenergic receptor | Mus musculus (house mouse) | Ki | 13.5000 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 2.1918 | 5 | 9 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 2 | 3 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 0.9890 | 1 | 4 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 0.8500 | 1 | 1 |
| Beta-lactamase | Escherichia coli K-12 | IC50 | 300.0000 | 1 | 1 |
| Bile acid receptor | Homo sapiens (human) | IC50 | 4.9600 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 286.2665 | 9 | 48 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 405.4200 | 3 | 5 |
| Bile salt export pump | Homo sapiens (human) | Ki | 27.5000 | 1 | 1 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 6.1000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 111.6667 | 3 | 3 |
| Calcium dependent protein kinase | Zea mays | IC50 | 116.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 14 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 1.1000 | 1 | 1 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 1.0800 | 1 | 1 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 12.1000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 430.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 8.7000 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 39.1000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 1.6710 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Chain A, ADENOSINE RECEPTOR A2A | Homo sapiens (human) | Ki | 0.0309 | 1 | 2 |
| Chain H, Igg2b-kappa 40-50 Fab (heavy Chain) | Mus musculus (house mouse) | Ki | 0.0028 | 1 | 1 |
| Chain L, Igg2b-kappa 40-50 Fab (light Chain) | Mus musculus (house mouse) | Ki | 0.0028 | 1 | 1 |
| Cholecystokinin receptor type A | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Cholesteryl ester transfer protein | Oryctolagus cuniculus (rabbit) | IC50 | 238.6000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 7.3700 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 1.2300 | 1 | 1 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 | 360.0000 | 1 | 1 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | IC50 | 0.0015 | 4 | 4 |
| Cysteinyl leukotriene receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0034 | 1 | 2 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | Ki | 0.0011 | 1 | 1 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 5.7640 | 2 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 3.8000 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 28.0564 | 3 | 10 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 32.0000 | 1 | 1 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 19.9000 | 1 | 1 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 2.8000 | 1 | 1 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 26.9000 | 1 | 1 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 2.4620 | 48 | 50 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0357 | 4 | 4 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 43.5833 | 1 | 6 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 34.5000 | 3 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 7.7470 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 2.6310 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 4.9034 | 2 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 1.6900 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 3-like | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 3A | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Endoplasmin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 99.0985 | 2 | 2 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | IC50 | 40.0000 | 2 | 2 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| Equilibrative nucleoside transporter 2 | Homo sapiens (human) | IC50 | 106.0000 | 1 | 1 |
| Equilibrative nucleoside transporter 2 | Homo sapiens (human) | Ki | 106.0000 | 1 | 1 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 717.0000 | 1 | 1 |
| fructose-bisphosphate aldolase | Mycobacterium tuberculosis H37Rv | IC50 | 9.9910 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0288 | 1 | 2 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | IC50 | 74.5300 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 33,597.8571 | 7 | 7 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | Ki | 2,500.0000 | 1 | 1 |
| Heat shock 70 kDa protein 1A | Homo sapiens (human) | IC50 | 560.0000 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Ki | 3.0000 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 0.3851 | 2 | 2 |
| Histidine-rich protein PFHRP-II | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 325.0000 | 1 | 1 |
| Histone-lysine N-methyltransferase, H3 lysine-79 specific | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase 1 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Kruppel-like factor 5 | Homo sapiens (human) | IC50 | 0.0832 | 3 | 3 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 11.1800 | 1 | 1 |
| Lethal factor | Bacillus anthracis | IC50 | 4.8000 | 1 | 1 |
| Leukotriene C4 synthase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| Malate dehydrogenase, cytoplasmic | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 0.8560 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 206.8000 | 2 | 4 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 119.0200 | 1 | 15 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 6.5284 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.1646 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.9380 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 5.8189 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 1.4040 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 8.4200 | 2 | 2 |
| Neprilysin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | IC50 | 16.6419 | 10 | 10 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Ki | 0.6600 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphoglycerate kinase 1 | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| Phosphoglycerate kinase 2 | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| Platelet glycoprotein VI | Homo sapiens (human) | IC50 | 4.0000 | 2 | 2 |
| Potassium channel subfamily K member 18 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | IC50 | 141.9000 | 3 | 4 |
| Potassium channel subfamily K member 3 | Homo sapiens (human) | IC50 | 108.1333 | 2 | 3 |
| Potassium voltage-gated channel subfamily A member 1 | Homo sapiens (human) | IC50 | 209.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily A member 5 | Homo sapiens (human) | IC50 | 748.7667 | 1 | 3 |
| Potassium voltage-gated channel subfamily D member 2 | Rattus norvegicus (Norway rat) | IC50 | 407.4333 | 1 | 3 |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | IC50 | 204.8390 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 27.3556 | 33 | 63 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 0.1866 | 3 | 5 |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | IC50 | 204.8390 | 2 | 2 |
| procathepsin L isoform 1 preproprotein | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Purine nucleoside phosphorylase | Homo sapiens (human) | Ki | 2,000.0000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 128.0000 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 1,600.0000 | 1 | 1 |
| Renin | Rattus norvegicus (Norway rat) | Ki | 13.5000 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 2.7218 | 2 | 4 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 2.7400 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 1.1515 | 1 | 2 |
| signal transducer and activator of transcription 1-alpha/beta isoform alpha | Homo sapiens (human) | IC50 | 55.7000 | 1 | 2 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 118.0000 | 3 | 3 |
| Sodium channel protein type 1 subunit alpha | Mus musculus (house mouse) | IC50 | 21.0000 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 53.0000 | 2 | 3 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 133.0000 | 3 | 3 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 171.5000 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 115.3000 | 3 | 3 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 53.0000 | 2 | 3 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 117.8333 | 3 | 3 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 53.0000 | 2 | 3 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 115.0000 | 3 | 3 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 118.1724 | 17 | 19 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 171.5000 | 2 | 2 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 171.5000 | 2 | 2 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 7,099.1250 | 8 | 8 |
| Sodium channel protein type 9 subunit alpha | Mus musculus (house mouse) | IC50 | 11.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | Ki | 13.0000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 2.2345 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.7755 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.8525 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.8290 | 1 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.2020 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Sodium/hydrogen exchanger | Amphiuma tridactylum (three-toed salamander) | IC50 | 8.7000 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0200 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Oryctolagus cuniculus (rabbit) | Ki | 0.0200 | 2 | 2 |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 2 | 2 |
| Sodium/hydrogen exchanger 2 | Oryctolagus cuniculus (rabbit) | IC50 | 0.5000 | 1 | 1 |
| Sodium/hydrogen exchanger 2 | Oryctolagus cuniculus (rabbit) | Ki | 0.5000 | 2 | 2 |
| Sodium/hydrogen exchanger 2 | Rattus norvegicus (Norway rat) | Ki | 0.0800 | 2 | 2 |
| Sodium/hydrogen exchanger 3 | Rattus norvegicus (Norway rat) | IC50 | 2.4000 | 1 | 1 |
| Sodium/hydrogen exchanger 3 | Rattus norvegicus (Norway rat) | Ki | 2.4000 | 2 | 2 |
| Sodium/hydrogen exchanger 5 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Sodium/hydrogen exchanger 5 | Homo sapiens (human) | Ki | 0.4200 | 2 | 2 |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | Ki | 1.8000 | 1 | 1 |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | Ki | 5.3000 | 1 | 1 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Canis lupus familiaris (dog) | IC50 | 0.5000 | 2 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (human) | IC50 | 1.7400 | 4 | 4 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 4.3000 | 1 | 1 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (human) | Ki | 0.1078 | 1 | 4 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.1950 | 2 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens (human) | Ki | 0.1077 | 1 | 4 |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.1255 | 2 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0039 | 2 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens (human) | Ki | 0.1077 | 1 | 4 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.9022 | 4 | 5 |
| Sodium/potassium-transporting ATPase subunit beta-2 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-3 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0018 | 1 | 1 |
| Sodium/potassium-transporting ATPase subunit gamma | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Solute carrier family 15 member 1 | Rattus norvegicus (Norway rat) | Ki | 25.0000 | 1 | 1 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 7.8000 | 1 | 1 |
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | IC50 | 3.9000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 9.6400 | 5 | 5 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 28.5200 | 4 | 5 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 58.3914 | 4 | 7 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 62.4000 | 1 | 3 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 2.9000 | 1 | 1 |
| Solute carrier family 22 member 2 | Mus musculus (house mouse) | IC50 | 312.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 156.1000 | 5 | 6 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 28.3667 | 2 | 3 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | Ki | 738.0000 | 1 | 1 |
| Solute carrier family 22 member 4 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Solute carrier family 22 member 7 | Rattus norvegicus (Norway rat) | Ki | 12.3000 | 1 | 1 |
| Solute carrier family 28 member 3 | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Solute carrier family 28 member 3 | Homo sapiens (human) | Ki | 2.1000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 9.2700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 40.2057 | 3 | 3 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 5.6249 | 4 | 5 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 0.1600 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 7.1654 | 1 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 0.8900 | 1 | 1 |
| Squalene synthase | Rattus norvegicus (Norway rat) | IC50 | 4.2000 | 1 | 1 |
| Squalene synthase | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| STAT3, partial | Homo sapiens (human) | IC50 | 1.5080 | 1 | 2 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 3.8220 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 1.2740 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| Thromboxane A2 receptor | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 1.5250 | 1 | 1 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 14.9000 | 1 | 1 |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0180 | 1 | 1 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | IC50 | 0.4289 | 12 | 13 |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | IC50 | 0.0250 | 2 | 2 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | Ki | 0.0113 | 3 | 3 |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0247 | 14 | 16 |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | Ki | 0.0132 | 5 | 8 |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 1.7366 | 19 | 21 |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | Ki | 0.0212 | 6 | 9 |
| Type-2 angiotensin II receptor | Homo sapiens (human) | IC50 | 8.0038 | 5 | 5 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 28.0030 | 8 | 8 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | Ki | 0.0316 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 4.7020 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 273.2000 | 1 | 5 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | Ki | 6.5400 | 1 | 1 |
| Urease | Canavalia ensiformis (jack bean) | IC50 | 64.3600 | 1 | 1 |
| Vasopressin V1a receptor | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 160.7143 | 4 | 7 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 272.4939 | 15 | 15 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 522.0000 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 204.5222 | 9 | 9 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 204.5222 | 9 | 9 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 204.5222 | 9 | 9 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Kd | 1.2548 | 2 | 9 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | EC50 | 85.8470 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | EC50 | 3.3884 | 2 | 2 |
| Adenosine receptor A1 | Homo sapiens (human) | EC50 | 0.6588 | 8 | 8 |
| Adenosine receptor A1 | Homo sapiens (human) | Kd | 0.2951 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Kd | 1.9498 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | EC50 | 5.5385 | 11 | 11 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 40.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Kd | 0.0173 | 1 | 1 |
| Adenosine receptor A2b | Homo sapiens (human) | EC50 | 18.9935 | 9 | 9 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | EC50 | 40.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | EC50 | 1.0322 | 7 | 7 |
| Adenosine receptor A3 | Homo sapiens (human) | Kd | 0.7400 | 1 | 1 |
| Albumin | Homo sapiens (human) | Kd | 520.3425 | 6 | 6 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Kd | 100.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0148 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | EC50 | 0.3267 | 3 | 3 |
| Aurora kinase B | Homo sapiens (human) | Kd | 1.1400 | 1 | 1 |
| Avidin | Gallus gallus (chicken) | Kd | 117.0000 | 1 | 1 |
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Kd | 7.0242 | 8 | 35 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.1159 | 3 | 3 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.5957 | 15 | 23 |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | Kd | 0.1862 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.8327 | 6 | 15 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Kd | 6.5166 | 12 | 43 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Kd | 10.4985 | 1 | 2 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Kd | 7.4556 | 7 | 33 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 | 350.0000 | 1 | 1 |
| Chain A, Membrane lipoprotein tmpC | Treponema pallidum | Kd | 0.2700 | 1 | 3 |
| Chain A, Na, K-ATPase alpha subunit | Squalus acanthias (spiny dogfish) | Kd | 0.0007 | 1 | 1 |
| Chain A, Structure of PAE2307 in complex with adenosine | Pyrobaculum aerophilum str. IM2 | Kd | 15.0000 | 1 | 1 |
| Chain A, tRNA (guanine-N(1)-)-methyltransferase | Haemophilus influenzae Rd KW20 | Kd | 641.0000 | 1 | 2 |
| Chain A, Uncharacterized protein MJ0883 | Methanocaldococcus jannaschii | Kd | 641.0000 | 1 | 2 |
| Chain B, Structure of PAE2307 in complex with adenosine | Pyrobaculum aerophilum str. IM2 | Kd | 15.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | EC50 | 0.0720 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| delta-type opioid receptor | Homo sapiens (human) | EC50 | 26.2176 | 3 | 3 |
| Endoplasmin | Homo sapiens (human) | Kd | 50.0000 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Envelope glycoprotein | Ebola virus - Mayinga, Zaire, 1976 | Kd | 290.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Kd | 1.4112 | 1 | 4 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 2 |
| Heat shock cognate 71 kDa protein | Homo sapiens (human) | Kd | 111.1010 | 1 | 2 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Kd | 50.0000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (human) | Kd | 19.2000 | 2 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 51.0195 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Neuromedin-K receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0024 | 1 | 1 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 0.0390 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Kd | 0.1090 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 4.3000 | 3 | 3 |
| Nuclear receptor subfamily 1 group I member 2 | Rattus norvegicus (Norway rat) | EC50 | 23.4000 | 1 | 1 |
| Nuclear receptor subfamily 2 group E member 1 | Homo sapiens (human) | EC50 | 37.0000 | 3 | 4 |
| Nuclear receptor subfamily 2 group E member 1 | Homo sapiens (human) | Kd | 0.5000 | 1 | 1 |
| Platelet glycoprotein VI | Homo sapiens (human) | Kd | 170.0000 | 2 | 2 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | EC50 | 64.0000 | 1 | 1 |
| Streptavidin | Streptomyces avidinii | Kd | 168.0000 | 1 | 1 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0126 | 1 | 1 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | Kd | 0.0033 | 1 | 1 |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | Kd | 0.0426 | 5 | 6 |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | Kd | 0.0100 | 1 | 1 |
| Vasopressin V1a receptor | Homo sapiens (human) | EC50 | 5.0119 | 1 | 1 |