A hormone antagonist that inhibits the action of the peptide hormone cholecystokinin.
| Member | Definition | Class |
|---|
| asperlicin c | A member of the class of asperlicins in which the core 6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione skeleton is substituted at the 7 pro-S position by an indol-3-ylmethyl group. It is a cholecystokinin antagonist. | asperlicin C |
| devazepide | An indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used for treatment of gastrointestinal disorders. | devazepide |
| proglumide | A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. | N(2)-benzoyl-N,N-dipropyl-alpha-glutamine; proglumide |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.1684 | 2 | 2 |
| AR protein | Homo sapiens (human) | Potency | 16.7303 | 5 | 5 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 10.4375 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 11.8832 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 12.1156 | 2 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 23.7101 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 23.7101 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 26.7797 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 7.9433 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 14.1254 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 10.5871 | 8 | 8 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 5.9557 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 4.6982 | 5 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 13.8640 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 2.7540 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 8.3039 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 8.9112 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 20.1548 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 6.6824 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.8470 | 2 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 0.0596 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.7540 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 16.5734 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 30.1065 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.3776 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 8.5825 | 3 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.4255 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 5.8436 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 6.6824 | 1 | 1 |