Pyometra

An accumulation of PUS in the uterine cavity (UTERUS). Pyometra generally indicates the presence of infections.

Synonym
Pyometra

Excerpt	Reference
"Canine pyometra is a life-threatening disease common in countries where spaying of dogs is not routinely performed."	( Bergström Ledin, H; Hagman, R; Karlstam, E; Reezigt, BJ, 2009)
"Pyometra is an inflammatory disease of the uterus that can be caused by chronic exposure to estrogens."	( Belcher, SM; Gear, RB; Kendig, EL; Kendziorski, JA, 2012)
"Pyometra is a pathological condition characterized by the accumulation of pus in the uterine lumen and bacterial infection."	( Dąbrowski, R; Dąbrowski, W; Kocki, T; Parada-Turska, J; Szczubiał, M, 2013)
"Canine pyometra is a dioestrus period disease in which systemic inflammatory response syndrome (SIRS) is a common outcome due to the response of the body to the bacterial infection."	( Ateş, A; Diren Sığırcı, B; Ekici, H; Enginler, SO; Evkuran Dal, G; Gürel, A; Karaçam, E; Sönmez, K; Sontaş, BH, 2014)
"Pyometra is a reproductive disorder very common in bitches over 8 years of age in which physiological effects of progesterone on the uterus play a major role."	( Fieni, F; Gogny, A; Topie, E, 2014)
"Pyometra is a common and life-threatening disease of intact bitches caused by hormonal influence of the uterus in combination with bacterial infection."	( Hagman, R; Holst, BS; Ros, L, 2014)
"Pyometra is one of the most common diseases in intact bitches."	( Carluccio, A; Contri, A; Gloria, A; Pantaleo, S; Robbe, D, 2015)
"Pyometra is the most common uterine disease in queens."	( Boos, A; Jursza, E; Kowalewski, MP; Siemieniuch, MJ; Skarzynski, DJ; Socha, P, 2015)
"Pyometra is a significant reproductive problem in cats."	( Jursza-Piotrowska, E; Siemieniuch, MJ, 2016)
"Pyometra is a common disease in countries where elective spaying is not routinely performed."	( Hagman, R, 2017)
"Pyometra is a common disease in intact bitches and queens and occurs, although less frequently,in most other female pets."	( Hagman, R, 2022)
"Pyometra is commonly seen in intact bitches and is usually treated by ovariohysterectomy."	( den Hertog, E; Sunesson, KW; Turkki, OM; Varjonen, K, 2023)
"Pyometra is a common infectious condition, especially in elderly bitches."	( Grönthal, T; Junnila, J; Laitinen-Vapaavuori, O; Mölsä, S; Rantala, M; Thomson, K; Ylhäinen, A, 2023)

Excerpt	Reference
"Our results show that cows treated for pyometra with prostaglandin f2 alpha (PGF2α) and oxytetracycline had significantly (P<0."	( el-Tahawy, Ael-G; Fahmy, MM, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (6.17)	23.3326
1990's	0 (0.00)	12.5806
2000's	6 (7.41)	18.1394
2010's	51 (62.96)	28.8240
2020's	19 (23.46)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
butyric acid	medium	1	1
lactic acid	low	2	0
formaldehyde	low	1	0
kynurenine	low	2	0
carprofen	low	1	0
fentanyl	medium	1	1
fluconazole	low	1	0
isoflurane	medium	1	1
kynurenic acid	low	3	0
metronidazole	medium	2	1
trimethoprim	medium	2	1
estrone	low	1	0
ethinyl estradiol	low	1	0
cephalothin	medium	1	1
edetic acid	low	1	0
ampicillin	low	2	0
medroxyprogesterone acetate	low	6	0
tryptophan	low	1	0
bisphenol a	low	1	0
thiazoles	low	1	0
eosine yellowish-(ys)	low	1	0
sulfadoxine	low	1	0
cephapirin	low	1	0
amoxicillin	low	2	0
cefoperazone	low	1	0
buserelin	low	1	0
itraconazole	low	1	0
marbofloxacin	low	1	0
cephalosporin c	low	1	0
sulbactam	low	2	0
casein hydrolysate	low	1	0
oleic acid	low	1	0
fosfomycin	low	1	0
diethylstilbestrol	low	2	0
diethylstilbestrol dipropionate	low	1	0
tamoxifen	medium	2	1
dinoprostone	low	1	0
dinoprost	medium	6	1
6-ketoprostaglandin f1 alpha	low	1	0
zearalenone	low	1	0
15-keto-13,14-dihydroprostaglandin f2alpha	low	1	0
cloprostenol	low	2	0
dexmedetomidine	medium	1	1
cefovecin	low	1	0
amoxicillin-potassium clavulanate combination	low	1	0
aglepristone	low	8	0
acyline	low	1	0
trelstar	low	1	0
deslorelin	low	1	0
interleukin-8	low	6	0
ascorbic acid	low	1	0
oxytetracycline, anhydrous	low	1	0
mobic	low	1	0
warfarin	low	1	0
epidermal growth factor	low	1	0
calca protein, human	low	1	0
kaolinite	low	1	0
kiss1 protein, human	low	1	0
caseins	low	1	0
transforming growth factor alpha	low	1	0
lactoferrin	low	1	0
alcian blue	low	1	0
lipoteichoic acid	low	1	0
eye	low	1	0

Protein Targets (717)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Solute carrier organic anion transporter family member 2A1	0	1	0	4
estrogen nuclear receptor alpha	28	0	0	28
Free fatty acid receptor 3	0	0	2	2
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	2	1	3
Fibrinogen C domain-containing protein 1	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	1	2
Gonadotropin-releasing hormone receptor	0	2	0	2
Mu-type opioid receptor	0	4	1	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
AR protein	20	0	0	20
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	12
Bile salt export pump	0	1	0	1
Bile salt export pump	0	15	0	15
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	1	0	3
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	1	0	3
Kappa-type opioid receptor	0	2	0	4
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	10	0	10
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	4	0	0	4
Beta-lactamase	0	0	0	3
acid sphingomyelinase	1	0	0	1
GLS protein	8	0	0	8
GLI family zinc finger 3	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
farnesoid X nuclear receptor	13	0	0	13
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
chromobox protein homolog 1	11	0	0	11
thyroid hormone receptor beta isoform 2	12	0	0	12
DNA polymerase beta	2	0	0	2
geminin	18	0	0	18
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	0	3
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	6	0	1	7
10 kDa heat shock protein, mitochondrial	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Thiosulfate sulfurtransferase	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	3
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	1	0	2
60 kDa chaperonin	0	1	0	1
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	1	0	1
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	1	0	3
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	1	0	3
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	7	0	0	7
RAR-related orphan receptor gamma	19	0	0	19
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
glucocorticoid receptor [Homo sapiens]	18	0	0	18
estrogen-related nuclear receptor alpha	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
IDH1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	6	0	0	6
lamin isoform A-delta10	11	0	0	11
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Luciferase	7	0	0	7
glp-1 receptor, partial	2	0	0	2
GALC protein	3	0	0	3
TDP1 protein	13	0	0	13
caspase 7, apoptosis-related cysteine protease	4	0	0	4
thyroid stimulating hormone receptor	9	0	0	9
estrogen receptor 2 (ER beta)	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	14	0	0	14
retinoid X nuclear receptor alpha	14	0	0	14
pregnane X nuclear receptor	17	0	0	17
G	8	0	0	8
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	14	0	0	14
caspase-3	4	0	0	4
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	10	0	0	10
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
Histone H2A.x	7	0	0	7
thyroid hormone receptor beta isoform a	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	0	0	11
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
GTPase KRas	0	0	1	1
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Estrogen receptor	0	11	6	19
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Cellular tumor antigen p53	19	0	0	19
Aldo-keto reductase family 1 member B1	0	8	0	8
Androgen receptor	0	3	2	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Androgen receptor	0	11	0	11
Gamma-aminobutyric acid receptor subunit beta-1	10	0	0	11
Gamma-aminobutyric acid receptor subunit delta	10	0	0	11
Gamma-aminobutyric acid receptor subunit gamma-2	10	0	0	11
Glutamate receptor 2	10	1	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	10	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-3	10	0	0	11
Gamma-aminobutyric acid receptor subunit gamma-1	10	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-2	10	0	0	11
Sodium-dependent noradrenaline transporter	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	10	0	0	11
Gamma-aminobutyric acid receptor subunit gamma-3	10	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-6	10	0	0	11
Sodium-dependent serotonin transporter	0	10	0	10
5-hydroxytryptamine receptor 6	0	6	0	6
Nuclear receptor ROR-gamma	6	0	0	6
Estrogen-related receptor gamma	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	10	0	0	11
Gamma-aminobutyric acid receptor subunit beta-3	10	0	0	11
Gamma-aminobutyric acid receptor subunit beta-2	10	0	0	11
Sodium-dependent dopamine transporter	0	8	0	8
GTP-binding protein Rheb	0	0	1	1
GABA theta subunit	10	0	0	11
Inositol hexakisphosphate kinase 1	8	0	0	8
Estrogen receptor beta	0	8	7	16
Gamma-aminobutyric acid receptor subunit epsilon	10	0	0	11
cytochrome P450 2C9, partial	8	0	0	8
Chain A, Nitrile Hydratase alpha subunit	0	1	0	1
Chain B, Nitrile Hydratase beta subunit	0	1	0	1
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
Lysine-specific demethylase 4E	0	1	0	1
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	3	0	3
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Microtubule-associated protein tau	9	0	0	9
nonstructural protein 1	4	0	0	4
67.9K protein	5	0	0	5
activating transcription factor 6	8	0	0	8
vitamin D3 receptor isoform VDRA	8	0	0	8
histone deacetylase 9 isoform 3	1	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Complement C5	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Prostaglandin G/H synthase 2	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
TAR DNA-binding protein 43	8	0	0	8
Solute carrier family 22 member 6	0	3	0	3
Glutathione reductase, mitochondrial	0	2	0	2
Glutathione peroxidase 1	0	1	0	1
Microsomal glutathione S-transferase 1	0	1	0	1
Solute carrier family 22 member 6	0	2	0	4
Solute carrier family 22 member 7	0	2	0	4
Solute carrier family 22 member 8	0	2	0	4
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 7	0	2	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
Beta-lactamase	0	1	0	2
endonuclease IV	3	0	0	3
thioredoxin reductase	5	0	0	5
WRN	2	0	0	2
phosphopantetheinyl transferase	7	0	0	7
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
heat shock protein beta-1	8	0	0	8
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase PLK1	4	0	0	4
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase OXA-1	0	1	0	2
Beta-lactamase TEM	0	2	0	3
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	2
phosphoglycerate kinase	2	0	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Thromboxane A2 receptor	0	2	2	4
Prostaglandin E2 receptor EP1 subtype	0	4	3	7
Prostaglandin E2 receptor EP4 subtype	0	4	1	5
Prostaglandin F2-alpha receptor	0	4	3	7
Prostaglandin E2 receptor EP3 subtype	0	4	3	7
Prostaglandin E2 receptor EP2 subtype	0	4	1	5
Prostacyclin receptor	0	4	1	5
Prostaglandin D2 receptor	0	2	0	2
USP1 protein, partial	6	0	0	6
huntingtin isoform 2	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
peripheral myelin protein 22	6	0	0	6
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
Alpha-2A adrenergic receptor	0	5	1	6
Alpha-1B adrenergic receptor	0	7	0	7
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	5	0	5
Alpha-1A adrenergic receptor	0	7	0	7
Histamine H2 receptor	4	0	0	4
Chain A, Ferritin light chain	2	0	0	2
interleukin 8	5	0	0	5
15-lipoxygenase, partial	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
ATAD5 protein, partial	6	0	0	6
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
regulator of G-protein signaling 4	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
mitogen-activated protein kinase 1	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
survival motor neuron protein isoform d	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
5-hydroxytryptamine receptor 4	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	1	1	2
Glucocorticoid receptor	0	6	1	7
Integrin beta-3	3	0	0	3
Glycine receptor subunit alpha-1	0	6	0	6
Integrin alpha-IIb	3	0	0	3
Beta-1 adrenergic receptor	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Adenosine receptor A3	0	6	0	6
Muscarinic acetylcholine receptor M1	0	4	0	4
D(2) dopamine receptor	0	5	0	5
Muscarinic acetylcholine receptor M3	0	4	0	4
Glycine receptor subunit beta	0	6	0	6
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	4	0	4
Acetylcholinesterase	0	1	0	1
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Thromboxane-A synthase	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Adenosine receptor A2a	0	6	0	6
Adenosine receptor A1	0	4	0	4
Mu-type opioid receptor	0	8	1	9
D(3) dopamine receptor	0	5	0	5
Vasopressin V1a receptor	0	2	0	2
Alpha-synuclein	3	1	0	4
Delta-type opioid receptor	0	6	0	6
Kappa-type opioid receptor	0	8	0	8
5-hydroxytryptamine receptor 2B	0	6	0	6
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Aldehyde oxidase	0	2	0	2
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Cysteinyl leukotriene receptor 1	0	2	0	2
Estrogen receptor 1	0	0	1	1
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	2	0	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Cytochrome P450 3A4	0	3	1	4
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
NFKB1 protein, partial	2	0	0	2
arylsulfatase A	3	0	0	3
Bloom syndrome protein isoform 1	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
glucokinase regulatory protein	1	0	0	1
Rap guanine nucleotide exchange factor 3	5	0	0	5
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	1	0	1
Steryl-sulfatase	0	1	0	1
Aromatase	0	3	0	3
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	2	2	4
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
pregnane X receptor	2	0	0	2
Fumarate hydratase	4	0	0	4
PPM1D protein	3	0	0	3
polyprotein	4	0	0	4
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Vpr	1	0	0	1
Cytochrome P450 2B1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
Cytochrome P450 2B6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	1	5
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
bcl-2-like protein 11 isoform 1	0	0	2	2
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	2	1	3
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
EWS/FLI fusion protein	3	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	0	6
Sodium channel protein type 4 subunit alpha	0	1	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	5
Glutamate receptor ionotropic, NMDA 2B	0	3	0	5
Glutamate receptor ionotropic, NMDA 2C	0	3	0	5
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	0	5
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	3	0	5
Glutamate receptor ionotropic, NMDA 3A	0	3	0	5
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
alpha-galactosidase	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
Mitogen-activated protein kinase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Glutamate receptor 1	0	1	0	2
Glutamate receptor 3	0	1	0	2
Glutamate receptor 4	0	1	0	2
Glutamate receptor ionotropic, kainate 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Aryl hydrocarbon receptor	0	0	1	1
Glutamate receptor ionotropic, kainate 2	0	1	0	2
Glutamate receptor ionotropic, kainate 3	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	1	0	2
Mitogen-activated protein kinase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
Glutamate receptor ionotropic, kainate 5	0	1	0	2
Vesicular glutamate transporter 3	0	1	0	1
G-protein coupled receptor 35	0	2	1	3
Histamine H3 receptor	0	0	1	1
PINK1	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Progesterone receptor	0	3	1	4
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	4	0	4
5-hydroxytryptamine receptor 1B	0	3	0	3
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Thioredoxin reductase	0	1	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Fatty acid-binding protein, liver	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Protein kinase C alpha type	0	1	0	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Beta-lactamase	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
5-hydroxytryptamine receptor 1A	0	3	0	3
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
dopamine D1 receptor	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	4	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Protein-arginine deiminase type-4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Substance-P receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
PTK2B protein tyrosine kinase 2 beta	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

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Overview

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Research

Studies (81)

Protein Targets (717)

Pyometra

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (81)

Drugs Studied (78)

Protein Targets (717)