Page last updated: 2024-08-05 15:24:20

Penicillium metabolite

Any fungal metabolite produced during a metabolic reaction in Penicillium.

ChEBI ID: 76964

Members (31)

MemberDefinitionClass
2-methyl-1,4-hydroquinoneA member of the class of hydroquinones that is hydroquinone in which one of the benzene hydrogens has been replaced by a methyl group.toluquinol
2,5-dihydroxybenzaldehydeA dihydroxybenzaldehyde carrying hydroxy groups at positions 2 and 5.2,5-dihydroxybenzaldehyde
3-methylfuranA member of the class of furans that is furan in which the hydrogen at position 3 is replaced by a methyl group. It is a chemical that is produced in foods during food processing and preservation techniques that involve heat treatment such as cooking and pasteurization.3-methylfuran
6-methylsalicylic acidA monohydroxybenzoic acid that is salicylic acid in which the hydrogen ortho to the carboxylic acid group is substituted by a methyl group.6-methylsalicylic acid
arisugacinAn organic heterotetracyclic compound that is 4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-4a,6,6a,12,12a,12b-hexahydro-4H,11H-benzo[f]pyrano[4,3-b]chromene-1,11(5H)-dione substituted by 3,4-dimethoxyphenyl group at position 9 (the 4aR,6aR,12aS,12bS steroisomer). Isolated from the culture broth of Penicillium, it acts as a selective inhibitor of acetylcholinesterase.arisugacin A
berkeleydioneA meroterpenoid found in Penicillium rubrum. It has been shown to exhibit inhibitory activity against caspase-1.berkeleydione
berkeleytrioneA meroterpenoid found in Penicillium rubrum and has been shown to exhibit inhibitory activity against caspase-1.berkeleytrione
brefeldin aA metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.brefeldin A
cathestatin bA carboxamide obtained by the formal condensation of the carboxylic group of oxirane-2,3-dicarboxylic acid with the amino group of N-(4-aminobutyl)-L-tyrosinamide (the 2S,3S stereoisomer). An antibiotic isolated from the fermentation broth of Penicillium citrinum, it acts as a potent inhibitor of cysteine protease.cathestatin B
coprogenAn iron(III) hydroxamate isolated from fungi and bacteria including Penicillium species and Neurospora crassa. It is a growth factor for coprophilous fungi.coprogen
emindole SBemindole SB
estinAn oxaspiro compound that is 3H,4'H-spiro[[1]benzofuran-2,1'-cyclohexa[2,5]diene]-3,4'-dione substituted by methoxycarbonyl, hydroxy, chloro, methyl, methoxy and chloro groups at positions 2', 4, 5, 6, 6' and 7, respectively. It is a fungal metabolite isolated from Aspergillus terreus and Penicillium glabrum.(+)-geodin
gluconic acidA gluconic acid having D-configuration.D-gluconic acid
griseofulvinAn oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.griseofulvin
hadacidinA monocarboxylic acid that is N-hydroxyglycine in which the hydrogen attached to the nitrogen is replaced by a formyl group. It was originally isolated from cultures of Penicillium frequentans.hadacidin
mevastatinA carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.mevastatin
mycophenolic acidA member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.mycophenolic acid
nidulalin aA member of the class xanthones which consists of a dihydroxanthone skeleton substituted by hydroxy groups at positions 4 and 8, a methyl group at position 6 and a methoxycarbonyl group at position 4a (the 4R,4aS stereoisomer). It is isolated from Emericella nidulans var lata and Penicillium and exhibits potent antitumour activity against both human and murine tumour cell lines.nidulalin A
ochratoxin aA phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.ochratoxin A
ochratoxin bA phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations.ochratoxin B
ochratoxin cA phenylalanine derivative that is the ethyl ester of ochratoxin A.ochratoxin C
patulinA furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.patulin
paxillineAn indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels.paxilline
pf 1163aA macrolide antibiotic that is 4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione substituted by a 4-(2-hydroxyethoxy)benzyl group at position 3 and a (2R)-2-hydroxypentyl group at position 13 (the 3S,10R,13S stereoisomer). It is isolated from Penicillium sp.PF1163 and exhibits antifungal activity against the pathogenic fungal strain Candida albicans TIMM1768.PF 1163A
pf 1163bA macrolide antibiotic that is 4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione substituted by a 4-(2-hydroxyethoxy)benzyl group at position 3 and a pentyl group at position 13 (the 3S,10R,13S stereoisomer). It is isolated from Penicillium sp.PF1163 and exhibits antifungal activity against the pathogenic fungal strain Candida albicans TIMM1768.PF 1163B
pyrrole-3-carboxylic acidA pyrrolecarboxylic acid that is 1H-pyrrole substituted by a carboxy group at position 3. It has been isolated from Penicillium chrysogenum.pyrrole-3-carboxylic acid
sch 642305A macrocyclic lactone isolated from the fermentation broth of the fungal culture Penicillium verrucosum and has been shown to exhibit inhibitory activity against bacterial DNA primase enzyme.sch 642305
topopyrone cA naphthochromene that is 4H-naphtho[2,3-h]chromene-4,7,12-trione substituted by hydroxy groups at positions 5, 9 and 11 and a methyl group at position 2. It is isolated from fungal strains Phoma and Penicillium and acts as an inhibitor of the enzyme topoisomerase I.topopyrone C
verruculogenAn organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species.verruculogen
viridicatinA hydroxyquinolone that is 3-hydroxyuinolin-2(1H)-one which is substituted at position 4 by a phenyl groups. Isolated from the mycelium of several Penicillium species, it exhibits strong antibiotic activity against M. tuberculosis and also against B. subtilis, S. aureus and S. cerevisiae.viridicatin
wortmanninwortmannin

Research

Studies (25,664)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,004 (11.71)18.7374
1990's4,114 (16.03)18.2507
2000's9,117 (35.52)29.6817
2010's7,312 (28.49)24.3611
2020's2,117 (8.25)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,753 (6.45%)5.53%
Reviews1,959 (7.21%)6.00%
Case Studies1,765 (6.49%)4.05%
Observational103 (0.38%)0.25%
Other21,598 (79.47%)84.16%

Protein Targets (223)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency29.568016
67.9K proteinVaccinia virusPotency7.4553210
acetylcholinesteraseHomo sapiens (human)Potency59.112434
activating transcription factor 6Homo sapiens (human)Potency17.889523
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency35.830918
alpha-galactosidaseHomo sapiens (human)Potency27.717022
Alpha-synucleinHomo sapiens (human)Potency6.045712
AR proteinHomo sapiens (human)Potency20.50011026
aryl hydrocarbon receptorHomo sapiens (human)Potency34.948535
ATAD5 protein, partialHomo sapiens (human)Potency5.588036
Ataxin-2Homo sapiens (human)Potency28.817715
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency33.447429
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency35.481311
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency38.364613
caspase-3Homo sapiens (human)Potency38.364613
Cellular tumor antigen p53Homo sapiens (human)Potency30.0350311
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency10.266322
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency27.248515
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency35.481311
Chain A, Beta-lactamaseEscherichia coli K-12Potency21.507613
Chain A, CruzipainTrypanosoma cruziPotency31.622811
Chain A, Ferritin light chainEquus caballus (horse)Potency30.300112
Chain A, HADH2 proteinHomo sapiens (human)Potency25.818925
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency56.234111
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency31.622811
Chain B, HADH2 proteinHomo sapiens (human)Potency25.818925
chromobox protein homolog 1Homo sapiens (human)Potency67.833412
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.267226
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency34.671311
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency30.445516
D(1A) dopamine receptorHomo sapiens (human)Potency4.109211
D(1A) dopamine receptorSus scrofa (pig)Potency16.481611
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency31.622811
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency26.632012
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
DNA polymerase kappa isoform 1Homo sapiens (human)Potency35.481311
estrogen nuclear receptor alphaHomo sapiens (human)Potency18.3163928
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency31.806013
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency11.1958928
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency13.644514
farnesoid X nuclear receptorHomo sapiens (human)Potency31.123046
GABA theta subunitRattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency15.267213
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency15.267213
gemininHomo sapiens (human)Potency7.4536214
GLI family zinc finger 3Homo sapiens (human)Potency16.665739
glp-1 receptor, partialHomo sapiens (human)Potency7.508412
GLS proteinHomo sapiens (human)Potency3.548111
glucocerebrosidaseHomo sapiens (human)Potency31.622811
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency9.555747
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency25.376013
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency28.183811
Guanine nucleotide-binding protein GHomo sapiens (human)Potency11.220211
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency5.011911
Histone H2A.xCricetulus griseus (Chinese hamster)Potency19.912424
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency39.810711
huntingtin isoform 2Homo sapiens (human)Potency16.311412
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency62.324211
IDH1Homo sapiens (human)Potency10.504416
importin subunit beta-1 isoform 1Homo sapiens (human)Potency28.183811
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency22.983312
Integrin alpha-IIbHomo sapiens (human)Potency7.943311
Integrin beta-3Homo sapiens (human)Potency7.943311
lamin isoform A-delta10Homo sapiens (human)Potency0.386222
lethal factor (plasmid)Bacillus anthracis str. A2012Potency1.258911
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency35.481311
Microtubule-associated protein tauHomo sapiens (human)Potency12.252225
mitogen-activated protein kinase 1Homo sapiens (human)Potency34.352123
neuropeptide S receptor isoform AHomo sapiens (human)Potency12.924412
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency0.092713
Nrf2Homo sapiens (human)Potency22.387211
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency12.0182411
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency7.947816
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency44.668411
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency10.682211
Nuclear receptor ROR-gammaHomo sapiens (human)Potency1.188311
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency10.875025
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency22.983312
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency15.0825311
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency56.234111
ParkinHomo sapiens (human)Potency12.388933
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency51.468412
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency11.890923
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency26.6056511
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency23.103037
phosphopantetheinyl transferaseBacillus subtilisPotency35.481311
PINK1Homo sapiens (human)Potency12.589311
plasminogen precursorMus musculus (house mouse)Potency2.119215
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency70.794611
pregnane X nuclear receptorHomo sapiens (human)Potency35.156534
pregnane X receptorRattus norvegicus (Norway rat)Potency44.668411
progesterone receptorHomo sapiens (human)Potency31.904826
RAR-related orphan receptor gammaMus musculus (house mouse)Potency13.266229
ras-related protein Rab-9AHomo sapiens (human)Potency0.089112
regulator of G-protein signaling 4Homo sapiens (human)Potency17.782811
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency14.710139
retinoid X nuclear receptor alphaHomo sapiens (human)Potency13.9970410
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency12.875022
SMAD family member 2Homo sapiens (human)Potency20.759713
SMAD family member 3Homo sapiens (human)Potency20.759713
Smad3Homo sapiens (human)Potency7.8896411
snurportin-1Homo sapiens (human)Potency28.183811
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency8.912511
survival motor neuron protein isoform dHomo sapiens (human)Potency4.6704210
TAR DNA-binding protein 43Homo sapiens (human)Potency19.622813
TDP1 proteinHomo sapiens (human)Potency8.4458229
thioredoxin glutathione reductaseSchistosoma mansoniPotency50.118711
thioredoxin reductaseRattus norvegicus (Norway rat)Potency56.234111
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency16.9902212
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency23.150946
thyroid stimulating hormone receptorHomo sapiens (human)Potency21.6407611
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency22.387211
tumor susceptibility gene 101 proteinHomo sapiens (human)Potency25.118911
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency2.119215
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency2.119215
USP1 protein, partialHomo sapiens (human)Potency28.214122
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency35.047511
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency20.700534
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency44.500913
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency25.376013
VprHuman immunodeficiency virus 1Potency17.782811
WRNHomo sapiens (human)Potency14.125411

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHomo sapiens (human)IC500.048344
3-hydroxy-3-methylglutaryl-coenzyme A reductase Rattus norvegicus (Norway rat)IC500.134099
3-hydroxy-3-methylglutaryl-coenzyme A reductase Rattus norvegicus (Norway rat)Ki0.001011
AcetylcholinesteraseHomo sapiens (human)IC500.001044
Adenylosuccinate synthetase isozyme 2Homo sapiens (human)IC503.500011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
Bile salt export pumpHomo sapiens (human)IC5018.066723
BZLF2Human herpesvirus 4 type 2 (Epstein-Barr virus type 2)IC502.030011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC5079.033323
Cannabinoid receptor 1Homo sapiens (human)Ki7.050011
Cannabinoid receptor 2 Homo sapiens (human)Ki2.240011
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2Cricetulus griseus (Chinese hamster)Ki0.006011
CholinesteraseHomo sapiens (human)IC5018.000011
Dipeptidyl peptidase 4Homo sapiens (human)IC500.001011
DNA topoisomerase 1Mus musculus (house mouse)IC50172.000011
DNA topoisomerase 2Drosophila melanogaster (fruit fly)IC502.200011
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)Ki0.120022
G-protein coupled receptor 55Homo sapiens (human)IC5010.000011
Genome polyprotein IC503.800011
Glutamate receptor 1Rattus norvegicus (Norway rat)IC500.014011
Glutamate receptor 2Rattus norvegicus (Norway rat)IC500.014011
Glutamate receptor 3Rattus norvegicus (Norway rat)IC500.014011
Glutamate receptor 4Rattus norvegicus (Norway rat)IC500.014011
Heme oxygenase 1 Rattus norvegicus (Norway rat)IC50100.000012
Heme oxygenase 2Rattus norvegicus (Norway rat)IC50100.000012
Inosine-5'-monophosphate dehydrogenaseCryptococcus neoformans var. neoformans JEC21IC500.120011
Inosine-5'-monophosphate dehydrogenase 1 Homo sapiens (human)IC503.397766
Inosine-5'-monophosphate dehydrogenase 1 Homo sapiens (human)Ki0.036588
Inosine-5'-monophosphate dehydrogenase 2Homo sapiens (human)IC501.14212020
Inosine-5'-monophosphate dehydrogenase 2Homo sapiens (human)Ki0.008488
Insulin receptor Rattus norvegicus (Norway rat)IC500.119011
Interleukin-1 betaHomo sapiens (human)IC504.400011
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligaseMycobacterium tuberculosis H37RvIC502,500.000011
Lanosterol 14-alpha demethylaseHomo sapiens (human)IC5050.000011
major prion protein preproprotein Prp precursorHomo sapiens (human)IC503.505011
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)IC500.008522
Multidrug resistance-associated protein 4Homo sapiens (human)IC5098.100012
Myosin light chain kinase, smooth muscleGallus gallus (chicken)IC500.260011
Myosin light chain kinase, smooth muscleHomo sapiens (human)IC502.356733
N-arachidonyl glycine receptorHomo sapiens (human)IC5010.000011
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)IC500.134311
Palmitoleoyl-protein carboxylesterase NOTUMHomo sapiens (human)IC50100.000011
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)IC5016,333.543869
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)IC500.280011
Phosphatidylinositol 4-kinase betaHomo sapiens (human)IC500.440011
Phosphatidylinositol 4-kinase type 2-alphaHomo sapiens (human)IC5030.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)IC508,647.23311417
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)Ki0.120011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)IC5021,000.042347
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)IC5021,000.039947
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)IC5014,705.5394710
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)IC500.019011
Potassium channel subfamily K member 9Homo sapiens (human)IC50159.000011
Prostaglandin G/H synthase 2Homo sapiens (human)IC500.119011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)IC505.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiens (human)IC505.000011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiens (human)IC505.000011
Serine/threonine-protein kinase mTORHomo sapiens (human)IC500.040011
Serine/threonine-protein kinase PLK1Homo sapiens (human)IC500.443333
Serine/threonine-protein kinase PLK1Homo sapiens (human)Ki6.825014
Serine/threonine-protein kinase PLK2Homo sapiens (human)Ki6.825014
Serine/threonine-protein kinase PLK3Homo sapiens (human)IC500.105733
Serine/threonine-protein kinase PLK3Homo sapiens (human)Ki6.825014
Serine/threonine-protein kinase PLK4Homo sapiens (human)Ki6.825014
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)IC500.011011
Solute carrier family 22 member 1 Homo sapiens (human)IC507.300011
Solute carrier family 22 member 20Mus musculus (house mouse)Ki48.989012
Solute carrier family 22 member 6Mus musculus (house mouse)Ki6.254812
steroidogenic factor 1Homo sapiens (human)IC5067.602011
Sterol O-acyltransferase 1Homo sapiens (human)IC5050.000011
TPA: protein transporter TIM10Saccharomyces cerevisiae S288CIC5033.550011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
endoribonuclease toxin MazFEscherichia coli str. K-12 substr. MG1655EC5099.000022
Mobilization protein AEscherichia coliEC5070.000011
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)Kd110.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)Kd0.005411
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)Kd0.007611
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)Kd0.005511
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)Kd0.015011
POsterior SegregationCaenorhabditis elegansEC5016.719011
Serine/threonine-protein kinase mTORHomo sapiens (human)Kd9.200011
Sodium-dependent noradrenaline transporter Homo sapiens (human)EC5012.272011
Wee1-like protein kinaseHomo sapiens (human)Kd0.001411
Zinc finger protein mex-5Caenorhabditis elegansEC5012.272011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
heat shock protein 90, putativePlasmodium falciparum 3D7AC500.215011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC500.363011
Inosine-5'-monophosphate dehydrogenaseCryptococcus neoformans var. neoformans JEC21Km87.166766
PAX8Homo sapiens (human)AC500.260011
Solute carrier family 22 member 11Homo sapiens (human)Km22.900011
Solute carrier family 22 member 19Mus musculus (house mouse)Km2.000011
Solute carrier family 22 member 6Homo sapiens (human)Km0.420011
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Km1.335022
Solute carrier family 22 member 8Homo sapiens (human)Km0.750011
Solute carrier family 22 member 8Rattus norvegicus (Norway rat)Km0.739011
Solute carrier organic anion transporter family member 1A1Rattus norvegicus (Norway rat)Km22.800022
Solute carrier organic anion transporter family member 1A3Rattus norvegicus (Norway rat)Km11.100022
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)Km185.000011
UDP-glucuronosyltransferase 1A10Homo sapiens (human)Km76.500012
UDP-glucuronosyltransferase 1A7Homo sapiens (human)Km30.000011
UDP-glucuronosyltransferase 1A8Homo sapiens (human)Km298.000011
UDP-glucuronosyltransferase 1A9Homo sapiens (human)Km225.500022