Page last updated: 2024-09-27

Adjustment Sleep Disorder

A broad category of sleep disorders characterized by either hypersomnolence or insomnia. The three major subcategories include intrinsic (i.e., arising from within the body) (SLEEP DISORDERS, INTRINSIC), extrinsic (secondary to environmental conditions or various pathologic conditions), and disturbances of circadian rhythm. (From Thorpy, Sleep Disorders Medicine, 1994, p187)

Synonyms(9)

Synonym
Dyssomnias
Adjustment Sleep Disorder
Limit-Setting Sleep Disorder
Sleep Disorders, Extrinsic
Sleep Disorder, Adjustment
Environmental Sleep Disorder
Sleep Disorder, Limit-Setting
Sleep Disorder, Environmental
Nocturnal Eating-Drinking Syndrome

Research

Studies (69)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (1.45)23.3326
1990's0 (0.00)12.5806
2000's31 (44.93)18.1394
2010's34 (49.28)28.8240
2020's3 (4.35)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium21
carbamates0medium11
histamine0low10
melatonin0medium83
1-octanol0low10
taurine0low10
3,4-methylenedioxyamphetamine0low10
acetaminophen0low10
albuterol0low10
caffeine0low20
carbamazepine0low10
cetyltrimethylammonium ion0low10
chlorpromazine0low10
clobazam0low10
flunitrazepam0low10
gabapentin0medium21
midazolam0low10
prazosin0low20
propofol0low10
risperidone0low20
rofecoxib0medium11
trazodone0low10
ici 204,2190low10
zolpidem0low20
zonisamide0low10
prednisolone0low10
reserpine0low10
thyroxine0low10
serine0low10
isoxazoles0low10
betamethasone0low10
deoxycytidine0low10
durapatite0medium11
sodium hydroxide0low10
d-alpha tocopherol0low10
s,n,n'-tripropylthiocarbamate0low20
trolamine salicylate0low20
substance p0low10
salmeterol xinafoate0low10
efavirenz0low10
sertraline0low10
acamprosate0low10
n-desmethylclobazam0low10
homocysteine0low10
tamsulosin0low10
proline0low10
betamethasone-17,21-dipropionate0low10
trimethoprim, sulfamethoxazole drug combination0low10
retinol0low10
cocaine0low10
sesquiterpenes0medium11
D-fructopyranose0medium31
cystine0low10
calcitriol0low10
topiramate0medium31
morphine0medium22
clobetasol0low10
fluticasone0low10
naltrexone0medium11
pregabalin0low10
morphinans0medium11
glucagon0low10
sodium oxybate0low10
quetiapine fumarate0medium21
calcipotriene0low10
ascorbic acid0low10
ckd7320medium11
vitamin b 120low10
folic acid0low10
olanzapine0low10
leptin0low10

Protein Targets (865)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, HADH2 protein9009
Chain B, HADH2 protein9009
aldehyde dehydrogenase 1 family, member A1110011
glucocorticoid receptor [Homo sapiens]190019
retinoic acid nuclear receptor alpha variant 1170017
estrogen nuclear receptor alpha290029
peroxisome proliferator activated receptor gamma100010
chromobox protein homolog 1110011
thyroid hormone receptor beta isoform a8008
5-hydroxytryptamine receptor 2C010111
5-hydroxytryptamine receptor 2A010111
5-hydroxytryptamine receptor 1A09111
Sodium-dependent noradrenaline transporter 013114
Sodium-dependent dopamine transporter08210
5-hydroxytryptamine receptor 1B0819
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 2B09110
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter013215
Sodium-dependent serotonin transporter0517
5-hydroxytryptamine receptor 7 0314
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
Sodium-dependent dopamine transporter 0819
5-hydroxytryptamine receptor 4 0112
5-hydroxytryptamine receptor 3B0112
RAR-related orphan receptor gamma170017
ATAD5 protein, partial8008
GLS protein9009
Microtubule-associated protein tau8008
Smad35005
thyroid stimulating hormone receptor100010
nuclear receptor subfamily 1, group I, member 3120012
progesterone receptor8008
EWS/FLI fusion protein120012
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha230023
aryl hydrocarbon receptor140014
thyroid hormone receptor beta isoform 2150015
peripheral myelin protein 22150015
cytochrome P450 3A4 isoform 19009
Gamma-aminobutyric acid receptor subunit pi97117
ATP-binding cassette sub-family C member 3023023
Multidrug resistance-associated protein 4023024
Solute carrier family 22 member 60101
Carbonic anhydrase 120408
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump030030
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 107011
Carbonic anhydrase 207214
Myoglobin0101
Cytochrome P450 1A10113
Cytochrome P450 1A20114
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30406
Cytochrome P450 3A409111
Cytochrome P450 2D60719
Cytochrome P450 2C9 0809
Polyunsaturated fatty acid lipoxygenase ALOX150505
Gamma-aminobutyric acid receptor subunit beta-197117
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta97117
Gamma-aminobutyric acid receptor subunit gamma-297218
UDP-glucuronosyltransferase 1-60102
Glutamate receptor 28008
Gamma-aminobutyric acid receptor subunit alpha-597117
Gamma-aminobutyric acid receptor subunit alpha-397117
Arachidonate 5-lipoxygenase-activating protein0303
UDP-glucuronosyltransferase 1A1 0204
Carbonic anhydrase 40408
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60408
Gamma-aminobutyric acid receptor subunit gamma-197117
Gamma-aminobutyric acid receptor subunit alpha-297117
Gamma-aminobutyric acid receptor subunit alpha-497117
Gamma-aminobutyric acid receptor subunit gamma-397117
Gamma-aminobutyric acid receptor subunit alpha-697117
Carbonic anhydrase 5A, mitochondrial04210
Prostaglandin G/H synthase 20203
Carbonic anhydrase 70408
Nuclear receptor ROR-gamma4004
Cytochrome P450 2J20505
Gamma-aminobutyric acid receptor subunit alpha-198219
Gamma-aminobutyric acid receptor subunit beta-397117
Gamma-aminobutyric acid receptor subunit beta-297218
Carbonic anhydrase 90408
GABA theta subunit97117
Canalicular multispecific organic anion transporter 1022022
Carbonic anhydrase 150305
Carbonic anhydrase 130206
Gamma-aminobutyric acid receptor subunit epsilon97117
Carbonic anhydrase 140408
Carbonic anhydrase 5B, mitochondrial0408
toxin B0001
glp-1 receptor, partial5005
thioredoxin reductase130013
regulator of G-protein signaling 49009
NPYLR7B0011
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 2210021
thyroid stimulating hormone receptor100010
flap endonuclease 13003
Beta-2 adrenergic receptor0224
Beta-1 adrenergic receptor0022
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Beta-3 adrenergic receptor0011
Delta-type opioid receptor07311
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
Beta-2 adrenergic receptor 0013
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Beta-2 adrenergic receptor0224
ATP-dependent phosphofructokinase7007
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase8008
GLI family zinc finger 3180018
AR protein240024
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 4140014
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
IDH18008
nuclear factor erythroid 2-related factor 2 isoform 26006
nuclear factor erythroid 2-related factor 2 isoform 1130013
lethal(3)malignant brain tumor-like protein 1 isoform I2002
geminin160016
lethal factor (plasmid)7007
lamin isoform A-delta10190019
Polyphenol oxidase 20102
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Alpha-2B adrenergic receptor012114
Spike glycoprotein91111
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
pregnane X receptor3003
farnesoid X nuclear receptor8008
pregnane X nuclear receptor160016
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a160016
nuclear receptor subfamily 1, group I, member 24004
galanin receptor type 30202
Glucocorticoid receptor04110
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
ORF730011
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase8008
v-jun sarcoma virus 17 oncogene homolog (avian)100010
atrial natriuretic peptide receptor 1 precursor2002
DNA polymerase beta4004
nuclear receptor ROR-gamma isoform 16006
DNA polymerase kappa isoform 18008
muscarinic acetylcholine receptor M1110011
Potassium channel subfamily K member 20112
Glycogen phosphorylase, muscle form0101
Renin0101
Cholinesterase0303
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0213
Adenosine receptor A30303
Replicase polyprotein 1ab0213
Amine oxidase [flavin-containing] A0303
Acetylcholinesterase0303
Adenosine receptor A10306
Amine oxidase [flavin-containing] B0505
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0206
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0224
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20304
Guanine deaminase0101
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase6006
Chain A, Ferritin light chain6006
Vitamin D3 receptor0011
USP1 protein, partial170017
PPM1D protein3003
mitogen-activated protein kinase 1110011
Interferon beta120012
Vitamin D-binding protein0011
Androgen receptor0303
Vitamin D3 receptor0124
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0033
Cytochrome P450 2C190303
Kappa-type opioid receptor0517
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0303
Vitamin D3 receptor A0022
TDP1 protein150015
Vpr1001
Albumin0044
Major prion protein0022
Cellular tumor antigen p53170017
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70102
Cytochrome P450 2B60012
Sodium channel protein type 4 subunit alpha0203
Potassium voltage-gated channel subfamily H member 2013013
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
interferon gamma precursor0002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Proteasome subunit beta type-110001
Fumarate hydratase4004
NFKB1 protein, partial2002
Thrombopoietin3003
caspase 7, apoptosis-related cysteine protease5005
estrogen receptor 2 (ER beta)7007
NADPH oxidase 10101
G7007
cytochrome P450 2D69009
polyprotein4004
67.9K protein4004
peroxisome proliferator-activated receptor delta8008
Snq2p0001
caspase-35005
Adenylate cyclase type 1 0202
Histone H2A.x4004
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a3003
D(1A) dopamine receptor6006
vitamin D3 receptor isoform VDRA7007
potassium voltage-gated channel subfamily H member 2 isoform d8008
caspase-31001
histone deacetylase 9 isoform 33003
heat shock protein beta-15005
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A5005
serine/threonine-protein kinase mTOR isoform 14004
survival motor neuron protein isoform d4004
M-phase phosphoprotein 84004
histone acetyltransferase KAT2A isoform 16006
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0506
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Transmembrane protease serine 20112
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 4012012
Epidermal growth factor receptor0303
HLA class I histocompatibility antigen, B alpha chain 7007
Albumin0022
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-33003
Tyrosine-protein kinase Fyn0202
Procathepsin L0112
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20606
Muscarinic acetylcholine receptor M40707
ATP-dependent translocase ABCB106010
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb3003
5-hydroxytryptamine receptor 1A06410
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50707
Alpha-2A adrenergic receptor013115
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10617
Angiotensin-converting enzyme0909
D(2) dopamine receptor09111
Alpha-1B adrenergic receptor09110
Sphingomyelin phosphodiesterase0101
Alpha-2C adrenergic receptor013014
D0707
D(3) dopamine receptor0505
Alpha-2B adrenergic receptor0729
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30606
Proteasome subunit beta type-10001
Substance-K receptor0404
D(1A) dopamine receptor0618
D(4) dopamine receptor0708
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0628
UDP-glucuronosyltransferase 1A40103
Alpha-2A adrenergic receptor0628
Alpha-1D adrenergic receptor0819
Histamine H2 receptor0527
Alpha-1D adrenergic receptor012216
D(1B) dopamine receptor0303
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A011011
5-hydroxytryptamine receptor 2C012012
Trypanothione reductase0202
D(4) dopamine receptor0404
Histamine H1 receptor0437
Melanocortin receptor 40202
Melanocortin receptor 50404
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70404
Histamine H1 receptor010313
Mu-type opioid receptor08314
Glutamate receptor ionotropic, NMDA 1 0305
D(3) dopamine receptor011012
Sodium channel protein type 1 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor06312
Kappa-type opioid receptor06212
5-hydroxytryptamine receptor 2B014014
Melanocortin receptor 30202
Alpha-1A adrenergic receptor011112
Histamine H2 receptor3014
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor4004
5-hydroxytryptamine receptor 60606
5-hydroxytryptamine receptor 70303
Gastrin/cholecystokinin type B receptor0101
Proteasome subunit alpha type-60012
D(2) dopamine receptor012114
Calmodulin 0112
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0204
Glutamate receptor ionotropic, NMDA 2B0305
Glutamate receptor ionotropic, NMDA 2C0204
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0204
Nuclear receptor subfamily 3 group C member 3 0909
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0204
Inositol hexakisphosphate kinase 17007
D0202
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Ataxin-27007
Sigma non-opioid intracellular receptor 10909
Angiotensin-converting enzyme 2 0112
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0204
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0426
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial7007
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Amyloid-beta precursor protein0202
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10202
Gamma-aminobutyric acid receptor subunit alpha-106511
Gamma-aminobutyric acid receptor subunit beta-10426
Gamma-aminobutyric acid receptor subunit gamma-206410
Liver carboxylesterase 10001
Gamma-aminobutyric acid receptor subunit beta-30628
Gamma-aminobutyric acid receptor subunit alpha-50549
Gamma-aminobutyric acid receptor subunit alpha-30538
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20538
Gamma-aminobutyric acid receptor subunit beta-20549
Gamma-aminobutyric acid receptor subunit alpha-40426
Gamma-aminobutyric acid receptor subunit epsilon0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60527
Sodium-dependent dopamine transporter0202
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit gamma-30303
Leukotriene B4 receptor 20101
Gamma-aminobutyric acid receptor subunit theta0303
Transporter0505
activating transcription factor 66006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Thymidine kinase 2 0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0001
AAA family ATPase 0001
Reverse transcriptase/RNaseH 0229
Chain A, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, Pol Polyprotein0101
Chain B, Pol Polyprotein0101
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 23003
SMAD family member 33003
neuropeptide S receptor isoform A4004
Prothrombin 0101
Gag-Pol polyprotein0202
Gag-Pol polyprotein0101
Acetylcholinesterase0001
Cannabinoid receptor 10101
Microsomal triglyceride transfer protein large subunit0101
Disintegrin and metalloproteinase domain-containing protein 172103
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 0101
Protease 0001
ATPase family AAA domain-containing protein 54004
Fructose-1,6-bisphosphatase 1 0001
Reverse transcriptase 0112
Cholesterol 24-hydroxylase0011
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase9009
acid sphingomyelinase1001
glucocerebrosidase3003
alpha-galactosidase2002
lysosomal alpha-glucosidase preproprotein3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 17007
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1102
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Bloom syndrome protein isoform 18008
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B4004
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10404
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
GALC protein3003
apical membrane antigen 1, AMA13003
transforming acidic coiled-coil-containing protein 30001
DNA polymerase iota isoform a (long)5005
Solute carrier family 22 member 20304
Solute carrier family 22 member 30203
Plasma kallikrein0002
Macrophage migration inhibitory factor0202
5-hydroxytryptamine receptor 1D0102
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase0103
Carbonic anhydrase0205
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0205
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0104
Carbonic anhydrase0205
Solute carrier family 22 member 10203
Carbonic anhydrase 0205
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130304
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40203
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Luciferase5005
streptokinase A precursor0011
Nuclear receptor subfamily 1 group I member 20022
Estrogen receptor0011
Thromboxane-A synthase 0101
Mitogen-activated protein kinase 3 0101
Mitogen-activated protein kinase 10101
Bifunctional epoxide hydrolase 20202
Peroxisome proliferator-activated receptor gamma0033
Cytosolic phospholipase A20101
Sodium/bile acid cotransporter0101
Mitogen-activated protein kinase 140101
Cysteinyl leukotriene receptor 10202
Estrogen receptor beta0011
Multidrug and toxin extrusion protein 20303
Multidrug and toxin extrusion protein 10303
Cysteinyl leukotriene receptor 20202
Nuclear receptor subfamily 1 group I member 20011
Cysteinyl leukotriene receptor 10213
Chain A, JmjC domain-containing histone demethylation protein 3A3003
dopamine D1 receptor1001
15-lipoxygenase, partial3003
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
pyruvate kinase1001
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 13003
Tyrosine-protein kinase Lck0101
Solute carrier family 15 member 10101
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Monocarboxylate transporter 100001
phosphoglycerate kinase1001
interleukin 83003
ClpP1001
peripheral myelin protein 22 isoform 14004
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 2C11 0101
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0303
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor07212
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Carboxylic ester hydrolase 0101
ATP-dependent translocase ABCB10303
Translocator protein0314
ATP-dependent translocase ABCB10303
UDP-glucuronosyltransferase 2B10 0101
Opioid receptor, delta 1b 0101
Acetylcholinesterase0202
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Histidine decarboxylase0022
Proteinase-activated receptor 10112
Delta-type opioid receptor0518
Kappa-type opioid receptor0427
Kappa-type opioid receptor0427
UDP-glucuronosyltransferase 1A30001
Mu-type opioid receptor0429
Nociceptin receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0719
Mas-related G-protein coupled receptor member X20022
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 3E0202
5-hydroxytryptamine receptor 3B0202
Nociceptin receptor0101
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 3D0202
5-hydroxytryptamine receptor 3C0202
UDP-glucuronosyltransferase 1A80002
FAD-linked sulfhydryl oxidase ALR0001
Glucose-6-phosphate 1-dehydrogenase0101
Alpha-1A adrenergic receptor07314
Alpha-1B adrenergic receptor06311
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Inositol monophosphatase 12002
Sigma non-opioid intracellular receptor 10101
NPC intracellular cholesterol transporter 1 precursor2002
cytochrome P450 2C9 precursor1001
Alpha-1A adrenergic receptor0224
Beta-casein0101
Interstitial collagenase0101
Matrix metalloproteinase-90101
Alpha-1A adrenergic receptor0202
Alpha-1B adrenergic receptor0202
Alpha-2A adrenergic receptor0101
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
5-hydroxytryptamine receptor 1B0101
Alpha-2B adrenergic receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20202
Type-1 angiotensin II receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-2A adrenergic receptor0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Androgen receptor0101
Nociceptin receptor0011
Estrogen receptor beta0202
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Fatty-acid amide hydrolase 10101
Amine oxidase [flavin-containing] B0303
Amine oxidase [flavin-containing] A 0202
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
endonuclease IV1001
nonstructural protein 13003
hemoglobin subunit beta1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Quinolone resistance protein NorA0102
DNA topoisomerase 10101
Chromaffin granule amine transporter0101
Caspase-71001
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Retinol-binding protein 40011
Beta-lactoglobulin0011
cytochrome P450 2C19 precursor2002
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 1A0101
inositol monophosphatase 11001
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Seed linoleate 13S-lipoxygenase-10101
Polyunsaturated fatty acid 5-lipoxygenase0303
Calpain-2 catalytic subunit0101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 2 0101
C-X-C chemokine receptor type 30101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 1 0101
Transporter0101
Sodium-dependent serotonin transporter0101
LMP1 [Human herpesvirus 4]0001
beta-2 adrenergic receptor1012
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transient receptor potential cation channel subfamily V member 11001
Pyruvate kinase PKM0011
Cholinesterase0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Transcriptional activator protein LuxR0101
Envelope glycoprotein0011
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Free fatty acid receptor 30011
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0101
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Alpha-1D adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0202
Prolyl endopeptidase0202
Carbonic anhydrase-related protein 110001
Cytochrome P450 2C80101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Carbonic anhydrase 0202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Neuronal acetylcholine receptor subunit alpha-70202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0202
Delta carbonic anhydrase0202
Sphingosine-1-phosphate lyase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 30101
Amine oxidase [flavin-containing]0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]