Syphilis, Congenital

Syphilis acquired in utero and manifested by any of several characteristic tooth (Hutchinson's teeth) or bone malformations and by active mucocutaneous syphilis at birth or shortly thereafter. Ocular and neurologic changes may also occur.

Synonym
Syphilis, Congenital

Excerpt	Reference
"The treatment of congenital syphilis is simple and effective although the patients may need to be linked with community-health facilities to assist in their compliance with follow-up appointments."	( Lane, GK; Oates, RK, 1988)
"Acquired and congenital syphilis are both known causes of potentially reversible sensorineural hearing loss."	( Dobbin, JM; Perkins, JH, 1983)
"Two infants with congenital syphilis are described."	( Heyman, S; Mandell, GA, 1983)
"Diagnosis of congenital syphilis is problematic: infants with congenital syphilis are often asymptomatic, and signs in symptomatic infants are frequently subtle and nonspecific."	( Crayne, EM; Finelli, L; Spitalny, KC, 1998)
"Cases of congenital syphilis are costly to health care systems but can be prevented through antenatal screening and treatment."	( Broutet, N; Simms, I, 2008)
"Congenital syphilis is a life threatening infection, but cannot always be diagnosed at birth."	( Arriagada, D; Cruces, P; Díaz, F; Donoso, A, 2012)
"Congenital syphilis is a prevalent infection in much of the world but rare in contexts where antenatal screening and treatment are available."	( Deall, H; Elliott, K; Fairhurst, J; Faust, SN; Patel, S; Pelosi, E, 2019)

Excerpt	Reference
"Concomitantly, congenital syphilis has increased causing spontaneous abortions, stillbirths, and neonatal morbidity and longterm neurologic sequela."	( Frecentese, DF; Schreiman, JS, 1991)
"Congenital syphilis has in large part disappeared in countries where antiveneral legislations and preventive measures are well developed."	( Belaïch, S; Crickx, B; Migeon, F; Sigal, M, 1985)
"Increasing rates of congenital syphilis have been reported in recent years despite the availability of adequate therapy."	( Ilagan, NB; Liang, KC; Shankaran, S; Weyhing, B; Womack, SJ, 1993)
"The incidence of congenital syphilis has experienced a fourfold to fivefold increase in 6 years."	( Balkowiec, KS; Bennett, ML; Klein, LE; Lynn, AW, 1997)
"Congenital syphilis has not been reported from the Kingdom of Lesotho."	( Agbahowe, SA; Mohaleroe, P; Oloruntoba, DO; Salami, BA; Shonubi, AM, 2003)
"The rate of congenital syphilis has started to rise as well, increasing the need for syphilis screening before pregnancy occurs."	( Duford, A; Duran, N; Harris, T; Sanchez, L, 2020)

Excerpt	Reference
"We emphasize that treatment for late congenital syphilis must be carried out early and completely."	( Horimoto, T; Karasawa, T; Sugiyama, K; Tsuchihara, K; Uchiyama, K, 2005)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	202 (67.11)	23.3326
1990's	37 (12.29)	12.5806
2000's	22 (7.31)	18.1394
2010's	29 (9.63)	28.8240
2020's	11 (3.65)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
salicylic acid	low	1	0
glycerol	low	1	0
iodine	low	2	0
urea	low	1	0
acetarsol	low	4	0
adiphenine	low	1	0
theophylline	low	1	0
chloroquine	low	1	0
erythrosine	low	2	0
gentamicin	low	2	0
guaifenesin	low	1	0
lidocaine	low	1	0
indomethacin	low	1	0
isoniazid	low	2	0
metronidazole	low	1	0
potassium iodide	low	3	0
probenecid	medium	2	1
procaine	low	5	0
thalidomide	low	3	0
thioridazine	low	1	0
tripelennamine	low	1	0
estriol	low	1	0
cephaloridine	low	5	0
prednisone	medium	14	1
dehydroepiandrosterone	low	1	0
penicillin g	medium	90	1
chloramphenicol	low	3	0
cyanides	low	1	0
kanamycin a	low	2	0
phenylalanine	low	1	0
ampicillin	low	9	0
histidine	low	1	0
penicillin v	low	2	0
dodecyl sulfate	low	1	0
benzathine	low	4	0
fluocortolone	low	1	0
aminophylline	low	1	0
methamphetamine	low	1	0
erythromycin	medium	24	1
dehydroepiandrosterone sulfate	low	1	0
thorium dioxide	low	1	0
spectinomycin	medium	1	1
streptomycin	low	1	0
mercury	low	13	0
technetium	low	1	0
gold	low	1	0
trolamine salicylate	low	6	0
cephalexin	low	1	0
cetylpyridinium chloride anhydrous	low	2	0
4-methoxyamphetamine	low	2	0
benethamine penicillin	low	1	0
cephalosporin c	medium	4	1
fluorodeoxyglucose f18	low	1	0
cobalt	low	1	0
cortisone	low	18	0
inositol 3-phosphate	low	2	0
erythromycin estolate	low	1	0
cocaine	low	8	0
clindamycin	low	1	0
zithromax	low	4	0
arsphenamine	low	4	0
bromochloroacetic acid	low	1	0
quinine	low	1	0
sodium dodecyl sulfate	low	1	0
bilirubin	low	3	0
dinoprostone	low	1	0
alprostadil	low	1	0
cholecalciferol	low	1	0
phenylephrine hydrochloride	low	4	0
morphine	low	1	0
aluminum	low	2	0
bismuth	medium	15	1
arsenic	low	16	0
cysteine	low	1	0
heroin	low	1	0
spirotrypan	low	2	0
nitrofurantoin	low	1	0
pituitrin	low	1	0
enerbol	low	2	0
acid phosphatase	low	1	0
phosphatidylcholines	medium	5	1
ro13-9904	low	4	0
sodium ethylxanthate	low	1	0
ascorbic acid	low	2	0
tetracycline	medium	21	1
chlortetracycline	low	2	0
oxytetracycline, anhydrous	low	2	0
minocycline	low	1	0
hyaluronoglucosaminidase	low	1	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	1	0
exudates	low	2	0
folic acid	low	1	0
eye	low	9	0
technetium tc 99m bicisate	low	1	0

Protein Targets (861)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	4	1	5
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	4	1	5
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	6	2	8
Sodium-dependent serotonin transporter	0	4	0	5
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
RAR-related orphan receptor gamma	21	0	0	21
ATAD5 protein, partial	4	0	0	4
thioredoxin glutathione reductase	6	0	0	6
heat shock protein beta-1	10	0	0	10
importin subunit beta-1 isoform 1	2	0	0	2
DNA polymerase beta	4	0	0	4
eyes absent homolog 2 isoform a	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase iota isoform a (long)	9	0	0	9
geminin	23	0	0	23
survival motor neuron protein isoform d	7	0	0	7
muscleblind-like protein 1 isoform 1	4	0	0	4
lamin isoform A-delta10	15	0	0	15
Bile salt export pump	0	33	0	33
14 kDa phosphohistidine phosphatase	0	1	0	1
ATP-dependent phosphofructokinase	6	0	0	6
USP1 protein, partial	12	0	0	12
cytochrome P450 2D6 isoform 1	4	0	0	4
Histamine H1 receptor	0	5	0	5
TDP1 protein	22	0	0	22
AR protein	28	0	0	28
glucocorticoid receptor [Homo sapiens]	19	0	0	19
estrogen nuclear receptor alpha	34	0	0	34
peroxisome proliferator activated receptor gamma	16	0	0	16
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	19	0	23
Cellular tumor antigen p53	18	0	0	18
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin E2 receptor EP1 subtype	0	3	0	3
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	18	0	18
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
peripheral myelin protein 22	7	0	0	7
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Aminoglycoside 3'-phosphotransferase	0	0	0	1
thioredoxin reductase	10	0	0	10
Microtubule-associated protein tau	10	0	0	10
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, Beta-lactamase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	4
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	9	0	0	9
Bile salt export pump	0	7	0	7
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase SHV-1	0	0	0	4
Cytochrome P450 2C9	0	3	0	3
Beta-lactamase	0	0	0	4
Kappa-type opioid receptor	0	2	0	5
Solute carrier family 15 member 1	0	9	0	9
Solute carrier family 15 member 1	0	3	0	3
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	6	0	7
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Cruzipain	6	0	0	6
Beta-lactamase	0	0	0	3
acid sphingomyelinase	3	0	0	3
GLS protein	9	0	0	9
GLI family zinc finger 3	25	0	0	25
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
farnesoid X nuclear receptor	15	0	0	15
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	0	3
Metallo-beta-lactamase VIM-11	0	0	0	3
euchromatic histone-lysine N-methyltransferase 2	18	0	0	18
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
chromobox protein homolog 1	12	0	0	12
thyroid hormone receptor beta isoform 2	21	0	0	21
Carbonic anhydrase 1	0	7	0	10
Carbonic anhydrase 2	0	7	0	10
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	2
Spike glycoprotein	7	1	1	9
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	3
Efflux transporter	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	4
Beta-lactamase	0	0	0	3
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	4
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	4
Beta-lactamase VIM-1	0	0	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
estrogen-related nuclear receptor alpha	20	0	0	20
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
IDH1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	27	0	0	27
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	6	0	0	6
Polyphenol oxidase 2	0	3	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	3	1	4
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
phosphopantetheinyl transferase	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
vitamin D3 receptor isoform VDRA	12	0	0	12
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	2	0	0	2
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	8	0	10
Solute carrier organic anion transporter family member 1B1	0	8	0	10
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
thyroid stimulating hormone receptor	11	0	0	11
Nuclear receptor ROR-gamma	7	0	0	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 6	0	8	0	8
Albumin	0	3	5	8
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	2
Solute carrier family 22 member 6	0	7	0	8
Solute carrier family 22 member 7	0	3	0	6
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 8	0	7	0	9
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 11	0	4	0	7
Solute carrier family 22 member 8	0	6	0	7
Solute carrier family 22 member 7	0	4	0	6
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
mitogen-activated protein kinase 1	6	0	0	6
Interferon beta	7	0	0	7
Beta-lactamase	0	0	0	2
aryl hydrocarbon receptor	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, Ferritin light chain	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	4	0	0	4
estrogen receptor 2 (ER beta)	8	0	0	8
progesterone receptor	11	0	0	11
retinoid X nuclear receptor alpha	20	0	0	20
67.9K protein	3	0	0	3
peroxisome proliferator-activated receptor delta	12	0	0	12
caspase-3	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	7	0	0	7
thyrotropin-releasing hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glutamate receptor 2	7	0	0	7
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	4	0	0	4
interleukin 8	5	0	0	5
EWS/FLI fusion protein	8	0	0	8
pregnane X nuclear receptor	15	0	0	15
G	3	0	0	3
cytochrome P450 2D6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
streptokinase A precursor	0	0	6	6
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
Cytochrome P450 3A4	0	6	2	8
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Inositol hexakisphosphate kinase 1	3	0	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
Carbonic anhydrase 4	0	4	0	6
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 15	0	3	0	5
PPM1D protein	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	6	0	0	6
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	2	1	3
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	1	4
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	4	1	5
Muscarinic acetylcholine receptor M1	0	3	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2C adrenergic receptor	0	3	0	3
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	3	0	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	7	0	7
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	5	0	5
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	9	0	9
Luciferase	10	0	0	10
15-lipoxygenase, partial	1	0	0	1
thyroid hormone receptor beta isoform a	9	0	0	9
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	1	0	8
60 kDa chaperonin	0	2	0	2
Vitamin D3 receptor	0	1	1	4
Gamma-aminobutyric acid receptor subunit beta-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit delta	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	7	1	0	8
Glycine receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	7	1	0	8
Vitamin D3 receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-2	7	1	0	8
GABA theta subunit	7	1	0	8
Gamma-aminobutyric acid receptor subunit epsilon	7	1	0	8
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	2
Sodium-dependent noradrenaline transporter	0	4	1	5
Sodium-dependent dopamine transporter	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
pregnane X receptor	2	0	0	2
regulator of G-protein signaling 4	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
Glucocorticoid receptor	0	6	1	7
Sex hormone-binding globulin	0	0	3	3
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Multidrug and toxin extrusion protein 1	0	4	0	4
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Alpha-synuclein	2	2	0	4
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	3	0	4
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	2
thyroid stimulating hormone receptor	7	0	0	7
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	3	0	4
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	6	0	7
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Histone H2A.x	8	0	0	8
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Fumarate hydratase	2	0	0	2
hypothetical protein, conserved	1	0	0	1
polyprotein	2	0	0	2
Bloom syndrome protein isoform 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Estrogen receptor	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Androgen receptor	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	2	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
glp-1 receptor, partial	3	0	0	3
glucocerebrosidase	3	0	0	3
alpha-galactosidase	3	0	0	3
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	2	0	4
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	1	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	1	0	3
Adenosine receptor A1	0	3	0	6
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	2	0	6
Carbonic anhydrase 5A, mitochondrial	0	2	0	4
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	0	5
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	1	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
Parkin	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	4
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Substance-P receptor	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Histamine H2 receptor	1	0	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Prostaglandin D2 receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
histone deacetylase 9 isoform 3	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	1	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	6
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	2	0	2
GALC protein	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Canalicular multispecific organic anion transporter 1	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
Cereblon isoform 4	0	2	0	2
arylsulfatase A	3	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Renin	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	2	5
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A1	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Snq2p	0	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
huntingtin isoform 2	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Albumin	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	3	0	3
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Proteasome subunit alpha type-6	0	0	1	1
Cathepsin D	0	1	0	1
Aldehyde oxidase	0	0	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (301)

Protein Targets (861)

Syphilis, Congenital

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (301)

Drugs Studied (115)

Protein Targets (861)