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NMDA receptor agonist

An excitatory amino acid agonist which binds to NMDA receptors and triggers a response.

ChEBI ID: 64571

Members (6)

MemberDefinitionClass
acromelic acid aA pyrrolidinecarboxylic acid that is siolated from the poisonous mushroom Clitocybe amoenolens.acromelic acid A
cycloserineA 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).D-cycloserine zwitterion; D-cycloserine
D-serineThe R-enantiomer of serine.D-serine zwitterion; D-serine
glycineThe simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.glycine zwitterion; glycine
homocysteic acidA homocysteic acid with L-configuration.L-homocysteic acid
quinolinic acidA pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.quinolinic acid

Research

Studies (38,206)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199013,269 (34.73)18.7374
1990's6,527 (17.08)18.2507
2000's8,264 (21.63)29.6817
2010's7,506 (19.65)24.3611
2020's2,640 (6.91)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials969 (2.42%)5.53%
Reviews1,596 (3.98%)6.00%
Case Studies1,132 (2.83%)4.05%
Observational29 (0.07%)0.25%
Other36,344 (90.70%)84.16%

Protein Targets (102)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency39.810711
acetylcholinesteraseHomo sapiens (human)Potency0.870911
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency14.988911
AR proteinHomo sapiens (human)Potency19.244822
arylsulfatase AHomo sapiens (human)Potency0.849211
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency25.795322
Bloom syndrome protein isoform 1Homo sapiens (human)Potency50.040426
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency6.309611
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency1.555013
Chain A, HADH2 proteinHomo sapiens (human)Potency39.810711
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency0.891311
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency84.367911
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency8.220412
Chain B, HADH2 proteinHomo sapiens (human)Potency39.810711
chromobox protein homolog 1Homo sapiens (human)Potency5.627612
core-binding factor subunit beta isoform 2Homo sapiens (human)Potency24.803322
cytochrome P450 2C9 precursorHomo sapiens (human)Potency39.810713
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency17.4840210
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency38.901811
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency18.833611
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency39.810711
estrogen nuclear receptor alphaHomo sapiens (human)Potency26.832511
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency13.7234110
flap endonuclease 1Homo sapiens (human)Potency46.934812
GABA theta subunitRattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency17.484015
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency17.484015
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency39.810719
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency1.584922
lamin isoform A-delta10Homo sapiens (human)Potency9.449412
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.589311
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency22.387211
M-phase phosphoprotein 8Homo sapiens (human)Potency44.668411
Microtubule-associated protein tauHomo sapiens (human)Potency6.127813
mitogen-activated protein kinase 1Homo sapiens (human)Potency5.011911
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency28.183811
neuropeptide S receptor isoform AHomo sapiens (human)Potency1.000011
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency23.410622
phosphopantetheinyl transferaseBacillus subtilisPotency89.125111
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency35.481311
RAR-related orphan receptor gammaMus musculus (house mouse)Potency7.497811
regulator of G-protein signaling 4Homo sapiens (human)Potency3.614113
runt-related transcription factor 1 isoform AML1bHomo sapiens (human)Potency24.803322
survival motor neuron protein isoform dHomo sapiens (human)Potency14.125412
TDP1 proteinHomo sapiens (human)Potency1.534822
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.368124
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency23.710111
thyroid stimulating hormone receptorHomo sapiens (human)Potency4.324726

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Amino acid transporterRattus norvegicus (Norway rat)IC502,086.500022
Beta-lactamase Aeromonas hydrophilaKi200.000011
Bile salt export pumpHomo sapiens (human)IC501,000.000022
Bile salt export pumpRattus norvegicus (Norway rat)IC501,000.000011
Chain A, N-methyl-D-aspartate Receptor Subunit 1Rattus norvegicus (Norway rat)Ki124.010016
Cystine/glutamate transporterHomo sapiens (human)IC5035.000011
D-alanine--D-alanine ligaseEnterococcus faecalis V583IC50262.000011
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)Ki54.000011
Glutamate receptor 1Rattus norvegicus (Norway rat)IC50100.000011
Glutamate receptor 2Rattus norvegicus (Norway rat)IC50100.000011
Glutamate receptor 3Rattus norvegicus (Norway rat)IC50100.000011
Glutamate receptor 4Rattus norvegicus (Norway rat)IC50100.000011
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)IC5011.8066610
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)Ki1.435022
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)IC5017.262746
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)Ki1.435022
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)IC5017.262746
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)Ki1.435022
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)IC5017.262746
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)Ki1.435022
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)IC5017.262746
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)Ki1.435022
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)IC5017.262746
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)Ki1.435022
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)IC5017.262746
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)Ki1.435022
Large neutral amino acids transporter small subunit 1Homo sapiens (human)IC50200.000011
Lysine-specific demethylase 4EHomo sapiens (human)IC505,000.000011
Metabotropic glutamate receptor 1Homo sapiens (human)Ki87.000011
Metabotropic glutamate receptor 2Homo sapiens (human)Ki300.000011
Metabotropic glutamate receptor 4Homo sapiens (human)Ki53.000011
Metabotropic glutamate receptor 5Homo sapiens (human)Ki54.000011
Neutral amino acid transporter AHomo sapiens (human)IC503,937.000011
Neutral amino acid transporter B(0)Homo sapiens (human)IC504,913.000011
Proton-coupled amino acid transporter 1Homo sapiens (human)Ki10,500.000013
Serine racemaseHomo sapiens (human)Ki366.000011
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)IC502,238.720011
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)IC501,348.960011
Sodium- and chloride-dependent glycine transporter 1Homo sapiens (human)IC5068.800022
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)IC50128.000011
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Staphylococcus epidermidis RP62AIC50300.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Advanced glycosylation end product-specific receptorHomo sapiens (human)Kd0.043011
Advanced glycosylation end product-specific receptorRattus norvegicus (Norway rat)Kd0.043011
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)EC500.5438613
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)EC500.795437
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)EC500.634037
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)EC502.759848
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)EC500.545637
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)EC500.715625
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)EC500.715625
Glycine receptor subunit alpha-1Homo sapiens (human)EC5094.749612
Metabotropic glutamate receptor 4Rattus norvegicus (Norway rat)EC50100.000011
Olfactory receptor 51E2Homo sapiens (human)EC500.058011