Page last updated: 2024-08-05 14:50:53
NMDA receptor agonist
An excitatory amino acid agonist which binds to NMDA receptors and triggers a response.
ChEBI ID: 64571
Members (6)
| Member | Definition | Class |
|---|---|---|
| acromelic acid a | A pyrrolidinecarboxylic acid that is siolated from the poisonous mushroom Clitocybe amoenolens. | acromelic acid A |
| cycloserine | A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). | D-cycloserine zwitterion; D-cycloserine |
| D-serine | The R-enantiomer of serine. | D-serine zwitterion; D-serine |
| glycine | The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. | glycine zwitterion; glycine |
| homocysteic acid | A homocysteic acid with L-configuration. | L-homocysteic acid |
| quinolinic acid | A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. | quinolinic acid |
Research
Studies (38,206)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 13,269 (34.73) | 18.7374 |
| 1990's | 6,527 (17.08) | 18.2507 |
| 2000's | 8,264 (21.63) | 29.6817 |
| 2010's | 7,506 (19.65) | 24.3611 |
| 2020's | 2,640 (6.91) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 969 (2.42%) | 5.53% |
| Reviews | 1,596 (3.98%) | 6.00% |
| Case Studies | 1,132 (2.83%) | 4.05% |
| Observational | 29 (0.07%) | 0.25% |
| Other | 36,344 (90.70%) | 84.16% |
Protein Targets (102)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.9889 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 19.2448 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.8492 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 25.7953 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.0404 | 2 | 6 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 1.5550 | 1 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 84.3679 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 8.2204 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 5.6276 | 1 | 2 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 24.8033 | 2 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.4840 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 18.8336 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 13.7234 | 1 | 10 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 46.9348 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.4840 | 1 | 5 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 39.8107 | 1 | 9 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.5849 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.4494 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5893 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 6.1278 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 23.4106 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 7.4978 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 3.6141 | 1 | 3 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 24.8033 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.5348 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.3681 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 23.7101 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 4.3247 | 2 | 6 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amino acid transporter | Rattus norvegicus (Norway rat) | IC50 | 2,086.5000 | 2 | 2 |
| Beta-lactamase | Aeromonas hydrophila | Ki | 200.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 2 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Chain A, N-methyl-D-aspartate Receptor Subunit 1 | Rattus norvegicus (Norway rat) | Ki | 124.0100 | 1 | 6 |
| Cystine/glutamate transporter | Homo sapiens (human) | IC50 | 35.0000 | 1 | 1 |
| D-alanine--D-alanine ligase | Enterococcus faecalis V583 | IC50 | 262.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 54.0000 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 11.8066 | 6 | 10 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 17.2627 | 4 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 17.2627 | 4 | 6 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 17.2627 | 4 | 6 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 17.2627 | 4 | 6 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 17.2627 | 4 | 6 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 17.2627 | 4 | 6 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 1.4350 | 2 | 2 |
| Large neutral amino acids transporter small subunit 1 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 1 |
| Metabotropic glutamate receptor 1 | Homo sapiens (human) | Ki | 87.0000 | 1 | 1 |
| Metabotropic glutamate receptor 2 | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| Metabotropic glutamate receptor 4 | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Homo sapiens (human) | Ki | 54.0000 | 1 | 1 |
| Neutral amino acid transporter A | Homo sapiens (human) | IC50 | 3,937.0000 | 1 | 1 |
| Neutral amino acid transporter B(0) | Homo sapiens (human) | IC50 | 4,913.0000 | 1 | 1 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 10,500.0000 | 1 | 3 |
| Serine racemase | Homo sapiens (human) | Ki | 366.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (house mouse) | IC50 | 2,238.7200 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (house mouse) | IC50 | 1,348.9600 | 1 | 1 |
| Sodium- and chloride-dependent glycine transporter 1 | Homo sapiens (human) | IC50 | 68.8000 | 2 | 2 |
| Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (human) | IC50 | 128.0000 | 1 | 1 |
| UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | Staphylococcus epidermidis RP62A | IC50 | 300.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Advanced glycosylation end product-specific receptor | Homo sapiens (human) | Kd | 0.0430 | 1 | 1 |
| Advanced glycosylation end product-specific receptor | Rattus norvegicus (Norway rat) | Kd | 0.0430 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 0.5438 | 6 | 13 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 0.7954 | 3 | 7 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 0.6340 | 3 | 7 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 2.7598 | 4 | 8 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 0.5456 | 3 | 7 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 0.7156 | 2 | 5 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 0.7156 | 2 | 5 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 94.7496 | 1 | 2 |
| Metabotropic glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| Olfactory receptor 51E2 | Homo sapiens (human) | EC50 | 0.0580 | 1 | 1 |