An agonist at the A2A receptor.
ChEBI ID: 73310
| Member | Definition | Class |
|---|---|---|
| 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine | A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and the hydrogen at position 2 on the adenine is replaced by a 4-(2-carboxyethyl)phenethylamino group. | CGS-21680 |
| adenosine-5'-(n-ethylcarboxamide) | A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group. | N-ethyl-5'-carboxamidoadenosine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 272 (13.36) | 18.7374 |
| 1990's | 861 (42.29) | 18.2507 |
| 2000's | 563 (27.65) | 29.6817 |
| 2010's | 287 (14.10) | 24.3611 |
| 2020's | 53 (2.60) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (0.26%) | 5.53% |
| Reviews | 19 (0.83%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,260 (98.91%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-synuclein | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 7.5686 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.0116 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 5.9728 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.1581 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 33.5875 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 9.5970 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 1.0954 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.0616 | 1 | 2 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 5.1095 | 3 | 3 |
| relaxin receptor 2 isoform 1 | Homo sapiens (human) | Potency | 0.9742 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 2.1076 | 2 | 2 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| vasopressin V1b receptor | Homo sapiens (human) | Potency | 1.9438 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-oxoglutarate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Adenosine receptor A1 | Gallus gallus (chicken) | IC50 | 0.0170 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 0.0007 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 21.8554 | 8 | 9 |
| Adenosine receptor A1 | Bos taurus (cattle) | Ki | 0.0140 | 3 | 3 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 0.3931 | 37 | 47 |
| Adenosine receptor A1 | Mus musculus (house mouse) | Ki | 0.0004 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.8380 | 24 | 38 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 0.0320 | 8 | 9 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 0.0513 | 5 | 10 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 0.1840 | 60 | 74 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 0.0217 | 18 | 29 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | IC50 | 0.0175 | 3 | 8 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 2.1079 | 10 | 14 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 0.1735 | 8 | 16 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 4.3824 | 15 | 15 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.4290 | 52 | 59 |
| Adenosine receptor A3 | Mus musculus (house mouse) | Ki | 0.0141 | 1 | 1 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 0.2506 | 8 | 9 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | Ki | 0.0350 | 1 | 2 |
| Aflatoxin B1 aldehyde reductase member 3 | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0122 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| Chain A, ADENOSINE RECEPTOR A2A | Homo sapiens (human) | Ki | 0.0138 | 1 | 2 |
| Cytochrome P450 2C8 | Homo sapiens (human) | Ki | 0.0068 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0068 | 1 | 1 |
| Endoplasmin | Homo sapiens (human) | Ki | 0.1100 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Ki | 2.7000 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.1140 | 1 | 1 |
| Thyroid hormone receptor beta | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 2 |
| Transmembrane domain-containing protein TMIGD3 | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | EC50 | 12.3051 | 1 | 2 |
| Adenosine receptor A1 | Homo sapiens (human) | EC50 | 32.4326 | 17 | 20 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | EC50 | 12.4941 | 4 | 6 |
| Adenosine receptor A1 | Homo sapiens (human) | Kd | 0.8143 | 7 | 7 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Kd | 0.2951 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | EC50 | 1.0103 | 18 | 21 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 0.1642 | 3 | 4 |
| Adenosine receptor A2a | Homo sapiens (human) | Kd | 0.0802 | 12 | 12 |
| Adenosine receptor A2b | Homo sapiens (human) | EC50 | 216.9340 | 25 | 32 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | EC50 | 0.1300 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | EC50 | 16.6013 | 18 | 19 |
| Adenosine receptor A3 | Mus musculus (house mouse) | EC50 | 0.1880 | 1 | 1 |
| Chain A, Endoplasmin | Canis lupus familiaris (dog) | Kd | 0.2000 | 1 | 1 |
| Endoplasmin | Canis lupus familiaris (dog) | Kd | 2.8000 | 1 | 1 |
| Endoplasmin | Homo sapiens (human) | Kd | 0.5300 | 1 | 1 |
| Endoplasmin | Sus scrofa (pig) | Kd | 0.2000 | 2 | 2 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Kd | 30.0000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A1 | Homo sapiens (human) | Affinity constant | 0.1000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | KD hydro | 250.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Affinity constant | 2.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ratio | 0.0126 | 1 | 4 |
| Adenosine receptor A2b | Homo sapiens (human) | Affinity constant | 2.0000 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ratio | 0.0126 | 1 | 4 |