Roles > astringent
Page last updated: 2024-08-05 14:40:51

astringent

A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.

ChEBI ID: 74783

Members (10)

MemberDefinitionClass
boric acidboric acid
dichloroacetic acidAn organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.dichloroacetic acid
ferric chlorideiron trichloride
ferric sulfateA compound of iron and sulfate in which the ratio of iron(3+) to sulfate ions is 3:2.iron(3+) sulfate
formic acidThe simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.formic acid
formic acid, sodium saltAn organic sodium salt which is the monosodium salt of formic acid.sodium formate
gallic acidA trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.gallic acid
iodic acidiodic acid
silver nitratesilver(1+) nitrate
zinc chlorideA compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.zinc dichloride

Research

Studies (16,545)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,502 (21.17)18.7374
1990's2,120 (12.81)18.2507
2000's3,575 (21.61)29.6817
2010's5,638 (34.08)24.3611
2020's1,710 (10.34)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials354 (2.03%)5.53%
Reviews473 (2.72%)6.00%
Case Studies434 (2.49%)4.05%
Observational10 (0.06%)0.25%
Other16,137 (92.70%)84.16%

Protein Targets (104)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.079511
67.9K proteinVaccinia virusPotency19.702022
acetylcholinesteraseHomo sapiens (human)Potency80.421011
activating transcription factor 6Homo sapiens (human)Potency56.571711
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency5.453912
AR proteinHomo sapiens (human)Potency14.505933
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency31.622811
Cellular tumor antigen p53Homo sapiens (human)Potency5.805612
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency11.294722
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency0.354811
Chain A, HADH2 proteinHomo sapiens (human)Potency10.001422
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency16.126912
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency8.832622
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency9.900424
Chain B, HADH2 proteinHomo sapiens (human)Potency10.001422
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency1.737711
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency69.217911
DNA polymerase kappa isoform 1Homo sapiens (human)Potency10.000011
estrogen nuclear receptor alphaHomo sapiens (human)Potency43.976657
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency44.583057
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.995311
farnesoid X nuclear receptorHomo sapiens (human)Potency62.233611
fructose-bisphosphate aldolase AOryctolagus cuniculus (rabbit)Potency19.952611
GLI family zinc finger 3Homo sapiens (human)Potency24.411822
GLS proteinHomo sapiens (human)Potency10.000011
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency9.179647
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency49.002511
glyceraldehyde-3-phosphate dehydrogenase isoform 1Homo sapiens (human)Potency25.118911
heat shock protein beta-1Homo sapiens (human)Potency55.465711
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
Histone H2A.xCricetulus griseus (Chinese hamster)Potency31.875923
hypothetical protein, conservedTrypanosoma bruceiPotency12.589311
Integrin alpha-IIbHomo sapiens (human)Potency12.589311
Integrin beta-3Homo sapiens (human)Potency12.589311
interleukin 8Homo sapiens (human)Potency47.307911
lamin isoform A-delta10Homo sapiens (human)Potency0.132413
lethal factor (plasmid)Bacillus anthracis str. A2012Potency10.430412
LuciferasePhotinus pyralis (common eastern firefly)Potency51.288012
Microtubule-associated protein tauHomo sapiens (human)Potency1.627122
mitogen-activated protein kinase 1Homo sapiens (human)Potency23.753122
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency5.563035
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency13.891422
phosphopantetheinyl transferaseBacillus subtilisPotency8.912511
RAR-related orphan receptor gammaMus musculus (house mouse)Potency26.603211
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency59.025435
retinoid X nuclear receptor alphaHomo sapiens (human)Potency9.317824
survival motor neuron protein isoform dHomo sapiens (human)Potency15.848911
TDP1 proteinHomo sapiens (human)Potency14.491124
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency42.791236
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.158511
thyroid stimulating hormone receptorHomo sapiens (human)Potency1.584922
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency58.849622
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.001011
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.118711
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency49.002511

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialHomo sapiens (human)IC501,677.600045
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrialHomo sapiens (human)IC502,353.400045
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrialHomo sapiens (human)IC501,955.750034
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialHomo sapiens (human)IC50747.500034
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6Homo sapiens (human)IC5065.008617
72 kDa type IV collagenaseHomo sapiens (human)IC5065.008617
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki8.260033
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki6.550022
Alpha-(1,3)-fucosyltransferase 7Homo sapiens (human)IC5065.008617
Alpha-synucleinHomo sapiens (human)IC504.430011
Angiotensin-converting enzyme Homo sapiens (human)IC507,700.000011
Anthrax toxin receptor 2Homo sapiens (human)IC50300.000011
Autoinducer 2-binding periplasmic protein LuxPVibrio harveyiIC5050.000011
Beta-lactamaseEscherichia coli K-12Ki2,150.000012
Beta-lactamaseStaphylococcus aureusKi2,150.000012
Carbonic anhydraseCandida albicans SC5314Ki35.100011
Carbonic anhydraseDicentrarchus labrax (European seabass)Ki4.130011
Carbonic anhydrase 1Homo sapiens (human)Ki19,570.640045
Carbonic anhydrase 12Homo sapiens (human)Ki7.780011
Carbonic anhydrase 13Mus musculus (house mouse)Ki9.860011
Carbonic anhydrase 14Homo sapiens (human)Ki7.030011
Carbonic anhydrase 2Homo sapiens (human)Ki17,530.321467
Carbonic anhydrase 3Homo sapiens (human)Ki7.490011
Carbonic anhydrase 4Homo sapiens (human)Ki27,802.450044
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki8,236.020044
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki4,989.985022
Carbonic anhydrase 6Homo sapiens (human)Ki6.130011
Carbonic anhydrase 7Homo sapiens (human)Ki6.070011
Carbonic anhydrase 9Homo sapiens (human)Ki13,036.747544
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Homo sapiens (human)IC5065.008617
Dipeptidyl peptidase 4Homo sapiens (human)IC504.650011
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)IC50200.000011
E-selectinHomo sapiens (human)IC50500.000011
L-selectinHomo sapiens (human)IC5027.600011
MatrilysinHomo sapiens (human)IC5065.008617
Nitric oxide synthase, inducibleMus musculus (house mouse)IC5050.000011
P-selectinHomo sapiens (human)IC5019.100011
Pancreatic triacylglycerol lipaseSus scrofa (pig)IC501,000.000011
Plasminogen activator inhibitor 1Homo sapiens (human)IC506.600011
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)IC501.370011
Prolyl 4-hydroxylase subunit alpha-1Gallus gallus (chicken)Ki30.000012
Proteasome subunit beta type-5Homo sapiens (human)IC507,100.000011
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC50100.000011
Squalene monooxygenase Rattus norvegicus (Norway rat)IC5073.000011
Tissue-type plasminogen activatorHomo sapiens (human)IC506.600011
Toll-like receptor 2 Mus musculus (house mouse)IC5069.250011
Urokinase-type plasminogen activatorHomo sapiens (human)IC506.600011
Urokinase-type plasminogen activatorMus musculus (house mouse)IC506.600011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Polypeptide N-acetylgalactosaminyltransferase 2Homo sapiens (human)Kd0.924011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
LactoperoxidaseBos taurus (cattle)Km176.780011