An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
| Member | Definition | Class |
|---|
| 11-hydroxysugiol | An abietane diterpenoid that is sugiol in which the hydrogen ortho to the phenolic hydroxy group has been replaced by a hydroxy group. | 11-hydroxysugiol |
| acephate | A phosphoramide that is methamidophos in which one of the hydrogens is replaced by an acetyl group. | acephate |
| aminocarb | A carbamate ester that is phenyl methylcarbamate substituted by a dimethylamino group at position 4 and a methyl group at position 3. | aminocarb |
| ar-turmerone | A sesquiterpenoid that is 2-methylhept-2-en-4-one substituted by a 4-methylphenyl group at position 6. It has been isolated from Peltophorum dasyrachis. | (+)-(S)-ar-turmerone |
| arisugacin | An organic heterotetracyclic compound that is 4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-4a,6,6a,12,12a,12b-hexahydro-4H,11H-benzo[f]pyrano[4,3-b]chromene-1,11(5H)-dione substituted by 3,4-dimethoxyphenyl group at position 9 (the 4aR,6aR,12aS,12bS steroisomer). Isolated from the culture broth of Penicillium, it acts as a selective inhibitor of acetylcholinesterase. | arisugacin A |
| azamethiphos | | azamethiphos |
| azinphos ethyl | | azinphos-ethyl |
| azinphosmethyl | A member of the class of benzotriazines that is 1,2,3-benzotriazine substituted by an oxo group at position 4 and a [(dimethoxyphosphorothioyl)sulfanyl]methyl group at position 3. | azinphos-methyl |
| bambuterol | A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol |
| bambuterol hydrochloride | The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol hydrochloride |
| bay 93820 | | isocarbophos |
| bellidifolin | A member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris. | bellidifolin |
| bendiocarb | | bendiocarb |
| benfuracarb | | benfuracarb |
| berberine | | berberine |
| bis(7)-tacrine | A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. | bis(7)-tacrine |
| bpmc | A carbamate ester obtained by the formal condensation of 2-sec-butylphenol with methylcarbamic acid. | fenobucarb |
| cadusafos | | cadusafos |
| carbaryl | A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid. | carbaryl |
| carbofuran | | carbofuran |
| chlorfenvinphos | | chlorfenvinfos |
| chlorpyrifos | An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group. | chlorpyrifos |
| chlorpyrifos-methyl | An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group. | chlorpyrifos-methyl |
| corynoline | A benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotective activity. | corynoline |
| croneton | | ethiofencarb |
| cyanophos | | cyanophos |
| cyclanoline | A charged berberine alkaloid obtained by N-methylation of (S)-scoulerine. | cyclanoline |
| decursinol | An organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8. It is isolated from the roots of Angelica gigas and has been found to possess significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). | decursinol |
| deltanit | | furathiocarb |
| demethylbellidifolin | A member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris. | bellidin |
| demeton-s-methyl | | demeton-S-methyl |
| diazinon | A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4. | diazinon |
| dibutylaminosulfenylcarbofuran | | carbosulfan |
| dichlorvos | An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate. | dichlorvos |
| dicrotophos | | dicrotophos |
| dimethoate | A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group. | dimethoate |
| dimethoxon | | omethoate |
| disulfoton | An organic thiophosphate that is the diethyl ester of S-[2-(ethylsulfanyl)ethyl] dihydrogen phosphorodithioate. | disulfoton |
| donepezil | A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one; donepezil |
| edifenphos | An organic thiophosphate that is the O-ethyl-S,S-diphenyl ester of phosphorodithioic acid. Used to control a variety of fungal diseases on rice including blast, ear blight and stem rot. Edifenphos is moderately toxic to mammals and fish but poses more of a risk to aquatic invertebrates. | edifenphos |
| erucyl amide | A primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia. It is commonly used as a slip additive in the plastic manufacturing industry. | erucamide |
| ethion | An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7). | ethion |
| ethoprophos | | ethoprophos |
| famophos | | famphur |
| fenamiphos | | fenamiphos |
| fenitrothion | An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4. | fenitrothion |
| fensulfothion | | fensulfothion |
| fenthion | An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen atom of the hydroxy group is replaced by a 3-methyl-4-(methylsulfanyl)phenyl group. It exhibits acaricidal and insecticidal activities. | fenthion |
| fonofos | | fonofos |
| formetanate | | formetanate |
| fosthiazate | | fosthiazate |
| galantamine | A benzazepine alkaloid isolated from certain species of daffodils. | galanthamine |
| geissospermine | A indole alkaloid comprising two indole-derived polycyclic moieties joined by a cyclic ether linkage. | geissospermine |
| heptenophos | | heptenophos |
| huperzine a | A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease. | huperzine A |
| hypochlorous acid | A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water. | hypochlorous acid |
| imperatorin | A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. | imperatorin |
| isofenphos | | isofenphos |
| isoimperatorin | A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. | isoimperatorin |
| isoprocarb | | isoprocarb |
| liriodenine | An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities. | liriodenine |
| loganin | An iridoid monoterpenoid with formula C17H26O10 that is isolated from several plant species and exhibits neuroprotective and anti-inflammatory properties. | loganin |
| lycojapodine a | An alkaloid isolated from the club moss Lycopodium japonicum and has been shown to exhibit acetylcholinesterase inhibitory and anti-HIV-1 activity. | lycojapodine A |
| mecarbam | An organic thiophosphate that is O,O-diethyl hydrogen phosphorodithioate in which the hydrogen attached to a sulfur is replaced by a 2-[(ethoxycarbonyl)(methyl)amino]-2-oxoethyl group. | mecarbam |
| methidathion | | methidathion |
| methiocarb | A carbamate ester obtained by the formal condensation of the phenolic group of 3,5-dimethyl-4-(methylsulfanyl)phenol with the carboxy group of methylcarbamic acid. | methiocarb |
| methomyl | A carbamate ester obtained by the formal condensation of methylcarbamic acid with the hydroxy group of 1-(methylsulfanyl)acetaldoxime. | methomyl |
| methyl parathion | A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4. | parathion-methyl |
| metolcarb | | metolcarb |
| monocrotophos | An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate. | monocrotophos |
| naled | An dialkyl phosphate resulting from the formal condensation of the acidic hydroxy group of dimethyl hydrogen phosphate with the alcoholic hydroxy group of 1,2-dibromo-2,2-dichloroethanol. An organophosphate insecticide, it is no longer approved for use within the European Union. | naled |
| neostigmine | A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor. | neostigmine |
| norswertianolin | A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and Gentiana germanica. | norswertianolin |
| paraoxon | An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl. | paraoxon |
| parathion | | parathion |
| phenthoate, (+-)-isomer | An organic thiophosphate that is ethyl mandelate in which the hydroxy group has been replaced by a (dimethoxyphosphorothioyl)sulfanediyl group. | phenthoate |
| phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester | | EPN |
| phorate | | phorate |
| phosalone | A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide. | phosalone |
| phosmet | | phosmet |
| pirimicarb | An aminopyrimidine that is N,N,4,5-tetramethylpyrimidin-2-amine substituted by a (dimethylcarbamoyl)oxy group at position 4. | pirimicarb |
| pirimiphos methyl | An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2. | pirimiphos-methyl |
| profenofos | | profenofos |
| propetamphos | | propetamphos |
| propoxur | A carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group. | propoxur |
| prothiophos | An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid. | prothiofos |
| pyraclofos | | pyraclofos |
| pyridafenthion | | pyridaphenthion |
| quinalphos | | quinalphos |
| sulfotepp | | sulfotep |
| sulprofos | | sulprofos |
| tacrine | A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. | tacrine |
| temefos | An organic sulfide that is diphenyl sulfide in which the hydrogen at the para position of each of the phenyl groups has been replaced by a (dimethoxyphosphorothioyl)oxy group. | temephos |
| terbufos | | terbufos |
| terbutaline | A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group. | terbutaline |
| tetrachlorvinphos | | tetrachlorvinphos |
| thiometon | | thiometon |
| triazophos | | triazophos |
| trichlorfon | A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group. | trichlorfon |
| vx | A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare. | VX nerve agent |
| xyloketal a | A xyloketal with formula C27H36O6. It was initially isolated from the mangrove fungus Xylaria sp. from the South China sea coast. | xyloketal A |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.8482 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 27.2846 | 1 | 5 |
| 67.9K protein | Vaccinia virus | Potency | 0.4496 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 29.1027 | 4 | 230 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 21.4212 | 1 | 19 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 29.0548 | 1 | 25 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 22.3872 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 34.4508 | 12 | 234 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.2654 | 3 | 92 |
| arylsulfatase A | Homo sapiens (human) | Potency | 13.8717 | 1 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.1686 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 26.8860 | 2 | 8 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 12.1800 | 5 | 7 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 34.9562 | 2 | 9 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 54.8842 | 1 | 3 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 54.8842 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 42.3487 | 3 | 39 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 18.9156 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.6651 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 23.4742 | 2 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 29.6667 | 1 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 28.1234 | 2 | 13 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 55.5354 | 1 | 8 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 2.5810 | 1 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 14.4975 | 1 | 7 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 46.1446 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 28.1234 | 2 | 13 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 87.4351 | 2 | 11 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.9804 | 1 | 9 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 14.0660 | 1 | 7 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 17.0674 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.1692 | 2 | 30 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.5215 | 2 | 11 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 45.2793 | 1 | 28 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 58.1630 | 1 | 4 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 24.7452 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 38.3612 | 11 | 203 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 42.4187 | 2 | 30 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 39.1631 | 9 | 161 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 21.6152 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 12.3214 | 4 | 8 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 30.7762 | 5 | 41 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 44.7038 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 6.9804 | 1 | 9 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.1692 | 1 | 15 |
| geminin | Homo sapiens (human) | Potency | 9.5001 | 2 | 14 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 29.2461 | 3 | 74 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 6.0837 | 3 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 21.9256 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 31.6143 | 4 | 34 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 51.2755 | 1 | 17 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 3.0783 | 1 | 3 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 20.7834 | 2 | 4 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 34.1929 | 2 | 27 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 8.7591 | 1 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 34.0759 | 1 | 7 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 51.0726 | 2 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 82.2143 | 2 | 30 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.9804 | 1 | 9 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 24.9618 | 3 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 33.5929 | 2 | 15 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 18.3808 | 3 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 24.5900 | 2 | 4 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.9804 | 1 | 18 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 16.3482 | 2 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 15.8139 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 15.8139 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 9.8018 | 3 | 13 |
| interleukin 8 | Homo sapiens (human) | Potency | 51.5934 | 1 | 3 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 32.9838 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 18.5079 | 1 | 10 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 16.8090 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 51.2193 | 2 | 27 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 30.6163 | 3 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.4194 | 2 | 9 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.5415 | 1 | 6 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.3374 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 19.9526 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 34.8759 | 4 | 105 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 21.8370 | 1 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 7.7650 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 25.5059 | 1 | 17 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 39.3618 | 1 | 5 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.6431 | 2 | 11 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 27.9617 | 3 | 174 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 54.9379 | 1 | 3 |
| Parkin | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 59.8585 | 2 | 4 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 10.4668 | 2 | 9 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 33.2443 | 5 | 48 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 30.7260 | 4 | 24 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 35.3977 | 1 | 14 |
| PINK1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 11.2202 | 1 | 1 |
| polyprotein | Zika virus | Potency | 44.7038 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 8.7591 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 30.4346 | 1 | 7 |
| PPM1D protein | Homo sapiens (human) | Potency | 10.4353 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 42.1192 | 2 | 86 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 42.0490 | 1 | 11 |
| progesterone receptor | Homo sapiens (human) | Potency | 26.7975 | 2 | 41 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 23.4667 | 1 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 31.9612 | 2 | 48 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 36.9075 | 1 | 6 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 43.8645 | 3 | 82 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 26.9036 | 4 | 83 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 24.3269 | 1 | 7 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 39.5848 | 2 | 8 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 39.5848 | 2 | 8 |
| Smad3 | Homo sapiens (human) | Potency | 20.5523 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 24.5900 | 2 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 21.2804 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 19.0817 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.5829 | 2 | 33 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.5270 | 3 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 53.8329 | 3 | 65 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 16.8580 | 7 | 19 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.9904 | 6 | 88 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 11.2202 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 11.2202 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 45.2901 | 2 | 8 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 36.5991 | 2 | 45 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 31.0651 | 5 | 27 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 42.9286 | 1 | 27 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 51.2755 | 1 | 17 |
| Vpr | Human immunodeficiency virus 1 | Potency | 33.5520 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| [Tau protein] kinase | Sus scrofa (pig) | IC50 | 10.0000 | 1 | 1 |
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 16.1870 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 7.4200 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0780 | 1 | 1 |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | IC50 | 0.0382 | 2 | 2 |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | Ki | 0.1523 | 1 | 1 |
| Acetylcholinesterase | Anopheles gambiae (African malaria mosquito) | IC50 | 0.1524 | 2 | 4 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 3.6249 | 324 | 445 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 6.1796 | 319 | 440 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 2.2670 | 15 | 18 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 0.4957 | 63 | 86 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 0.2453 | 18 | 26 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 0.4707 | 13 | 15 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 1.8666 | 29 | 43 |
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 0.0180 | 1 | 1 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 6.4970 | 2 | 5 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 0.4023 | 26 | 39 |
| Acetylcholinesterase | Drosophila melanogaster (fruit fly) | IC50 | 1.8300 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | Ki | 0.0146 | 4 | 9 |
| Acyl-CoA desaturase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0470 | 1 | 1 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 0.1375 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.5170 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.5130 | 1 | 1 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 6.7100 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 317.2767 | 5 | 6 |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | IC50 | 414.0235 | 1 | 2 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 214.7334 | 3 | 8 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 26.6400 | 5 | 5 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 108.8859 | 5 | 8 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 2.1283 | 3 | 4 |
| Aromatase | Homo sapiens (human) | IC50 | 2.9000 | 1 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 34.8500 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 87.5025 | 10 | 13 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 321.5214 | 4 | 14 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 759.6500 | 1 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | IC50 | 1.0210 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 0.0590 | 1 | 1 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 5.5676 | 16 | 21 |
| Carboxylic ester hydrolase | Musca domestica (house fly) | IC50 | 9.5100 | 1 | 1 |
| Carboxylic ester hydrolase | Plutella xylostella (diamondback moth) | IC50 | 1,355.5000 | 2 | 2 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 12.2101 | 24 | 30 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 1.0341 | 4 | 9 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Chain A, Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 0.3401 | 1 | 3 |
| Chain A, Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 0.2500 | 1 | 1 |
| Chain A, Histamine N-methyltransferase | Homo sapiens (human) | Ki | 0.0382 | 1 | 8 |
| Chain A, liver Carboxylesterase I | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | IC50 | 0.0053 | 1 | 1 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| Cholinesterase | Canis lupus familiaris (dog) | IC50 | 10,000.0000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 4.9084 | 238 | 300 |
| Cholinesterase | Homo sapiens (human) | IC50 | 140.9477 | 198 | 279 |
| Cholinesterase | Mus musculus (house mouse) | IC50 | 0.6879 | 2 | 3 |
| Cholinesterase | Equus caballus (horse) | Ki | 1.9752 | 4 | 5 |
| Cholinesterase | Homo sapiens (human) | Ki | 6.6064 | 12 | 18 |
| Coagulation factor XII | Homo sapiens (human) | Ki | 100.0000 | 1 | 2 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 5.1000 | 2 | 2 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 3.6333 | 3 | 3 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | Ki | 0.1700 | 1 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.7875 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 1.9400 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 4.5410 | 4 | 4 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 2.8088 | 2 | 5 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0598 | 1 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 1.1500 | 1 | 2 |
| Cytochrome P450 2E1 | Homo sapiens (human) | IC50 | 0.0750 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 16.4874 | 6 | 10 |
| D | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 59.0000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 8.3973 | 1 | 2 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 0.0010 | 1 | 1 |
| Dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 30.0000 | 2 | 2 |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | IC50 | 5.9000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 31.9167 | 6 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 25.8750 | 4 | 4 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | IC50 | 44.0000 | 2 | 2 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 35.5000 | 4 | 6 |
| Glycogen synthase kinase-3 beta | Sus scrofa (pig) | IC50 | 10.0000 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | IC50 | 0.3500 | 1 | 1 |
| Histamine N-methyltransferase | Rattus norvegicus (Norway rat) | IC50 | 0.1100 | 1 | 1 |
| Hormone-sensitive lipase | Rattus norvegicus (Norway rat) | IC50 | 0.3700 | 1 | 1 |
| kallikrein-5 preproprotein | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 3.2000 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 2 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 100.0000 | 1 | 2 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 6.9700 | 1 | 1 |
| Microtubule-associated protein tau | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 99.1200 | 1 | 5 |
| Muscarinic acetylcholine receptor DM1 | Drosophila melanogaster (fruit fly) | Ki | 100.0000 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 5.8000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 6.6000 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 35.3500 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Ki | 14.3000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 119.1000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0457 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 119.1000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0457 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 119.1000 | 3 | 3 |
| Nitric oxide synthase, endothelial | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 20.4630 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 11.9110 | 1 | 1 |
| polyadenylate-binding protein 1 | Homo sapiens (human) | IC50 | 66.0000 | 2 | 4 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 23.6422 | 3 | 6 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 162.3333 | 2 | 3 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0146 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0146 | 2 | 2 |
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | IC50 | 14.1050 | 2 | 2 |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | IC50 | 6.3710 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 26.5000 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.5170 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.5130 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 19.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 52.3600 | 2 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 0.6800 | 1 | 1 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 3.8850 | 2 | 2 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 16.5000 | 2 | 2 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 140.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 7 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Vascular endothelial growth factor receptor 1 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Voltage-dependent calcium channel gamma-1 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-3 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-4 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-5 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-6 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-7 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-8 subunit | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-2 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-3 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-4 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 25.6500 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 25.6500 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 25.6500 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 25.6500 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit beta-1 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit beta-2 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit beta-3 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit beta-4 | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent R-type calcium channel subunit alpha-1E | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent T-type calcium channel subunit alpha-1G | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent T-type calcium channel subunit alpha-1H | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Voltage-dependent T-type calcium channel subunit alpha-1I | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |