Degenerative Disc Disease
[description not available] | 0 | 2.41 | 1 | 0 |
Canine Diseases
[description not available] | 0 | 2.41 | 1 | 0 |
Cirrhosis
[description not available] | 0 | 4.49 | 5 | 1 |
Equine Diseases
[description not available] | 0 | 2.41 | 1 | 0 |
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. | 0 | 4.49 | 5 | 1 |
Intervertebral Disc Degeneration
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates. | 0 | 2.41 | 1 | 0 |
Cyst
[description not available] | 0 | 2.41 | 1 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 4.1 | 16 | 0 |
ACL Injuries
[description not available] | 0 | 2.6 | 1 | 0 |
Mucopolysaccharidosis
[description not available] | 0 | 2.25 | 1 | 0 |
Mucopolysaccharidoses
Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency. | 0 | 7.25 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 3.4 | 7 | 0 |
Diabetes Mellitus, Adult-Onset
[description not available] | 0 | 2.46 | 2 | 0 |
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. | 0 | 2.46 | 2 | 0 |
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). | 0 | 2.17 | 1 | 0 |
Tooth Discoloration
Any change in the hue, color, or translucency of a tooth due to any cause. Restorative filling materials, drugs (both topical and systemic), pulpal necrosis, or hemorrhage may be responsible. (Jablonski, Dictionary of Dentistry, 1992, p253) | 0 | 2.1 | 1 | 0 |
Genetic Diseases
[description not available] | 0 | 2.13 | 1 | 0 |
Genetic Diseases, Inborn
Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero. | 0 | 2.13 | 1 | 0 |
Cutis Elastica
[description not available] | 0 | 9.39 | 29 | 0 |
Brittle Bone Disease
[description not available] | 0 | 9.04 | 25 | 0 |
Amyoplasia Congenita
[description not available] | 0 | 3.06 | 1 | 0 |
Connective Tissue Diseases
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides. | 0 | 3.34 | 2 | 0 |
Ehlers-Danlos Syndrome
A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability. | 0 | 9.39 | 29 | 0 |
Osteogenesis Imperfecta
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I. | 0 | 14.04 | 25 | 0 |
Bone Loss, Osteoclastic
[description not available] | 0 | 7.8 | 23 | 2 |
Affective Psychosis, Bipolar
[description not available] | 0 | 2.07 | 1 | 0 |
Dementia Praecox
[description not available] | 0 | 2.07 | 1 | 0 |
Bipolar Disorder
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. | 0 | 2.07 | 1 | 0 |
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. | 0 | 2.07 | 1 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 7.1 | 39 | 0 |
Rheumatoid Arthritis
[description not available] | 0 | 3.59 | 3 | 0 |
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated. | 0 | 3.59 | 3 | 0 |
Malignant Melanoma
[description not available] | 0 | 2.01 | 1 | 0 |
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) | 0 | 2.01 | 1 | 0 |
Apoplexy
[description not available] | 0 | 2.01 | 1 | 0 |
Blood Pressure, High
[description not available] | 0 | 2.01 | 1 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 2.01 | 1 | 0 |
Hypertrophy
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA). | 0 | 2.67 | 3 | 0 |
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) | 0 | 2.01 | 1 | 0 |
Retinal Pigment Epithelial Detachment
[description not available] | 0 | 1.93 | 1 | 0 |
Retinal Degeneration
A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304) | 0 | 1.93 | 1 | 0 |
Retinal Detachment
Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12). | 0 | 1.93 | 1 | 0 |
Benign Neoplasms
[description not available] | 0 | 4.24 | 4 | 0 |
Ascites
Accumulation or retention of free fluid within the peritoneal cavity. | 0 | 2.34 | 2 | 0 |
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 4.24 | 4 | 0 |
Experimental Neoplasms
[description not available] | 0 | 1.93 | 1 | 0 |
Aminoaciduria, Renal
[description not available] | 0 | 2.34 | 2 | 0 |
Ectopic Ossification
[description not available] | 0 | 1.94 | 1 | 0 |
Osseous Paget's Disease
[description not available] | 0 | 7.16 | 12 | 2 |
Adult Rickets
[description not available] | 0 | 2.64 | 3 | 0 |
Age-Related Osteoporosis
[description not available] | 0 | 5.23 | 12 | 0 |
Bone Diseases
Diseases of BONES. | 0 | 5.16 | 8 | 0 |
Osteitis Deformans
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry. | 0 | 7.16 | 12 | 2 |
Osteomalacia
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis. | 0 | 2.64 | 3 | 0 |
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. | 0 | 5.23 | 12 | 0 |
Low Bone Density
[description not available] | 0 | 3.59 | 3 | 0 |
Bone Diseases, Metabolic
Diseases that affect the METABOLIC PROCESSES of BONE TISSUE. | 0 | 3.59 | 3 | 0 |
Arthritis, Degenerative
[description not available] | 0 | 3.79 | 4 | 0 |
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. | 0 | 3.79 | 4 | 0 |
Adjuvant Arthritis
[description not available] | 0 | 2.68 | 3 | 0 |
Decreased Muscle Tone
[description not available] | 0 | 2.03 | 1 | 0 |
Dermatoses
[description not available] | 0 | 4.48 | 9 | 0 |
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS. | 0 | 4.48 | 9 | 0 |
Dermatosclerosis
[description not available] | 0 | 5.65 | 7 | 1 |
Scleroderma, Localized
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules. | 0 | 5.65 | 7 | 1 |
Parodontosis
[description not available] | 0 | 2.87 | 1 | 0 |
Periodontal Diseases
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT. | 0 | 2.87 | 1 | 0 |
Congenital Hypocupremia
[description not available] | 0 | 6.95 | 5 | 0 |
Marfan Syndrome, Type I
[description not available] | 0 | 7.43 | 7 | 0 |
Collagen Diseases
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that collagen was equivalent to connective tissue, but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term collagen diseases now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494) | 0 | 8.69 | 20 | 0 |
Menkes Kinky Hair Syndrome
An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125) | 0 | 6.95 | 5 | 0 |
Marfan Syndrome
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue. Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2. | 0 | 7.43 | 7 | 0 |
Sclerosis, Systemic
[description not available] | 0 | 5.05 | 7 | 0 |
Scleroderma, Systemic
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA. | 0 | 5.05 | 7 | 0 |
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE. | 0 | 5.01 | 16 | 0 |
EHS Tumor
[description not available] | 0 | 1.96 | 1 | 0 |
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. | 0 | 2.36 | 2 | 0 |
Lathyrism
A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS. | 0 | 3.45 | 8 | 0 |
Cafe-au-Lait Spots with Pulmonic Stenosis
[description not available] | 0 | 1.96 | 1 | 0 |
Neurofibromatosis 1
An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS). | 0 | 1.96 | 1 | 0 |
Acantholysis Bullosa
[description not available] | 0 | 3.28 | 2 | 0 |
Epidermolysis Bullosa
Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties. | 0 | 3.28 | 2 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 2.87 | 4 | 0 |
Alloxan Diabetes
[description not available] | 0 | 3.46 | 8 | 0 |
Symptom Cluster
[description not available] | 0 | 2.65 | 3 | 0 |
Gigantism
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age. | 0 | 1.96 | 1 | 0 |
Syndrome
A characteristic symptom complex. | 0 | 2.65 | 3 | 0 |
Cirrhosis, Liver
[description not available] | 0 | 4.44 | 5 | 0 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 4.44 | 5 | 0 |
Chronic Primary Open Angle Glaucoma
[description not available] | 0 | 1.96 | 1 | 0 |
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed) | 0 | 2.65 | 3 | 0 |
Glaucoma, Open-Angle
Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris. | 0 | 1.96 | 1 | 0 |
Polyarthritis
[description not available] | 0 | 1.96 | 1 | 0 |
Arthritis
Acute or chronic inflammation of JOINTS. | 0 | 1.96 | 1 | 0 |
Alport Syndrome
[description not available] | 0 | 3.06 | 5 | 0 |
Nephritis, Hereditary
A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE. | 0 | 3.06 | 5 | 0 |
Scoliosis
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed) | 0 | 2.88 | 4 | 0 |
Dupuytren's Contracture
[description not available] | 0 | 3.56 | 3 | 0 |
Dupuytren Contracture
A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50. | 0 | 3.56 | 3 | 0 |
Injuries, Spinal Cord
[description not available] | 0 | 2.66 | 3 | 0 |
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.). | 0 | 2.66 | 3 | 0 |
Bone Cancer
[description not available] | 0 | 4.13 | 6 | 0 |
Breast Cancer
[description not available] | 0 | 8.58 | 3 | 0 |
Cancer of Lung
[description not available] | 0 | 3.29 | 2 | 0 |
Kahler Disease
[description not available] | 0 | 2.87 | 1 | 0 |
Cancer of Prostate
[description not available] | 0 | 2.87 | 1 | 0 |
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES. | 0 | 4.13 | 6 | 0 |
Breast Neoplasms
Tumors or cancer of the human BREAST. | 0 | 3.58 | 3 | 0 |
Lung Neoplasms
Tumors or cancer of the LUNG. | 0 | 3.29 | 2 | 0 |
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY. | 0 | 2.87 | 1 | 0 |
Prostatic Neoplasms
Tumors or cancer of the PROSTATE. | 0 | 2.87 | 1 | 0 |
Alcoholic Cirrhosis
[description not available] | 0 | 1.95 | 1 | 0 |
Liver Cirrhosis, Alcoholic
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING. | 0 | 1.95 | 1 | 0 |
Asthma, Bronchial
[description not available] | 0 | 1.95 | 1 | 0 |
Allergy, Food
[description not available] | 0 | 1.95 | 1 | 0 |
Inborn Errors of Metabolism
[description not available] | 0 | 3.97 | 5 | 0 |
Enteropathy, Exudative
[description not available] | 0 | 1.95 | 1 | 0 |
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). | 0 | 1.95 | 1 | 0 |
Food Hypersensitivity
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food. | 0 | 1.95 | 1 | 0 |
Metabolism, Inborn Errors
Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero. | 0 | 3.97 | 5 | 0 |
Protein-Losing Enteropathies
Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE. | 0 | 1.95 | 1 | 0 |
Muscular Dystrophy, Animal
MUSCULAR DYSTROPHY that occurs in VERTEBRATE animals. | 0 | 1.96 | 1 | 0 |
Osteoma
A benign tumor composed of bone tissue or a hard tumor of bonelike structure developing on a bone (homoplastic osteoma) or on other structures (heteroplastic osteoma). (From Dorland, 27th ed) | 0 | 1.96 | 1 | 0 |
Cancer of Skin
[description not available] | 0 | 3.28 | 2 | 0 |
Skin Neoplasms
Tumors or cancer of the SKIN. | 0 | 3.28 | 2 | 0 |
Aneurysm, Aortic
[description not available] | 0 | 2.37 | 2 | 0 |
Aortic Aneurysm
An abnormal balloon- or sac-like dilatation in the wall of AORTA. | 0 | 2.37 | 2 | 0 |
Osteogenic Sarcoma
[description not available] | 0 | 2.37 | 2 | 0 |
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed) | 0 | 2.37 | 2 | 0 |
Cardiovascular Stroke
[description not available] | 0 | 3.76 | 2 | 1 |
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). | 0 | 3.76 | 2 | 1 |
Bright Disease
A historical classification which is no longer used. It described acute glomerulonephritis, acute nephritic syndrome, or acute nephritis. Named for Richard Bright. | 0 | 3.05 | 5 | 0 |
Glomerulonephritis
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY. | 0 | 8.05 | 5 | 0 |
Nephrosis
Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA. | 0 | 1.96 | 1 | 0 |
Leg Ulcer
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes. | 0 | 1.96 | 1 | 0 |
Cataract, Membranous
[description not available] | 0 | 2.65 | 3 | 0 |
Cataract
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed) | 0 | 2.65 | 3 | 0 |
Adult Fanconi Syndrome
[description not available] | 0 | 1.95 | 1 | 0 |
Phosphorus Metabolism Disorders
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization. | 0 | 1.95 | 1 | 0 |
Humeral Fractures
Fractures of the HUMERUS. | 0 | 1.95 | 1 | 0 |
Deficiency, Protein
[description not available] | 0 | 1.95 | 1 | 0 |
Chronic Illness
[description not available] | 0 | 2.88 | 4 | 0 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 2.88 | 4 | 0 |
Arthropathies
[description not available] | 0 | 1.95 | 1 | 0 |
Joint Diseases
Diseases involving the JOINTS. | 0 | 1.95 | 1 | 0 |
Anasarca
[description not available] | 0 | 3.37 | 1 | 1 |
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. | 0 | 3.37 | 1 | 1 |
Avian Diseases
[description not available] | 0 | 1.98 | 1 | 0 |
Bone Fractures
[description not available] | 0 | 2.4 | 2 | 0 |
Fractures, Bone
Breaks in bones. | 0 | 2.4 | 2 | 0 |
Fibrocartilaginous Dysplasia of Bone
[description not available] | 0 | 1.98 | 1 | 0 |
Fibrous Dysplasia of Bone
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC). | 0 | 1.98 | 1 | 0 |
Skin Aging
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight. | 0 | 1.98 | 1 | 0 |
Stunted Growth
[description not available] | 0 | 1.98 | 1 | 0 |
Growth Disorders
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth. | 0 | 1.98 | 1 | 0 |
Eye Abnormalities
Congenital absence of or defects in structures of the eye; may also be hereditary. | 0 | 1.98 | 1 | 0 |
Hypermobility, Joint
[description not available] | 0 | 1.98 | 1 | 0 |
Bed Sores
[description not available] | 0 | 2.38 | 2 | 0 |
Pressure Ulcer
An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure. | 0 | 2.38 | 2 | 0 |
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES. | 0 | 8.06 | 5 | 0 |
Cicatrization
The formation of fibrous tissue in the place of normal tissue during the process of WOUND HEALING. It includes scar tissue formation occurring in healing internal organs as well as in the skin after surface injuries. | 0 | 4.66 | 11 | 0 |
Burns
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like. | 0 | 2.37 | 2 | 0 |
Cicatrix
The fibrous tissue that replaces normal tissue during the process of WOUND HEALING. | 0 | 4.66 | 11 | 0 |
Bone Loss, Perimenopausal
[description not available] | 0 | 2.9 | 4 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 2.91 | 4 | 0 |
Osteoporosis, Postmenopausal
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency. | 0 | 2.9 | 4 | 0 |
Alveolitis, Fibrosing
[description not available] | 0 | 2.38 | 2 | 0 |
Pulmonary Fibrosis
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. | 0 | 2.38 | 2 | 0 |
Hypermelanosis
[description not available] | 0 | 1.99 | 1 | 0 |
Facial Dermatoses
Skin diseases involving the FACE. | 0 | 1.99 | 1 | 0 |
Skin Diseases, Vascular
Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area. | 0 | 1.99 | 1 | 0 |
Contracture
Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint. | 0 | 1.99 | 1 | 0 |
Hyperpigmentation
Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. | 0 | 1.99 | 1 | 0 |
Cystic Fibrosis of Pancreas
[description not available] | 0 | 2.38 | 2 | 0 |
Congenital Hand Deformities
[description not available] | 0 | 1.99 | 1 | 0 |
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. | 0 | 2.38 | 2 | 0 |
Keloid
A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues. | 0 | 1.99 | 1 | 0 |
Alkalosis
A pathological condition that removes acid or adds base to the body fluids. | 0 | 2 | 1 | 0 |
Hypocapnia
Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood. | 0 | 2 | 1 | 0 |
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures. | 0 | 2 | 1 | 0 |
Menopause
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age. | 0 | 4.06 | 3 | 1 |
Tendinitis
Inflammation of TENDONS. It is characterized by the degeneration of tendons accompanied by an inflammatory repair response, fibroblastic proliferation, and formation of granulation tissue. Tendinitis is not a clinical diagnosis and can be confirmed only by histopathological findings. | 0 | 2 | 1 | 0 |
Tendinopathy
Clinical syndrome describing overuse tendon injuries characterized by a combination of PAIN, diffuse or localized swelling, and impaired performance. | 0 | 2 | 1 | 0 |
Anterior Horn Cell Disease
[description not available] | 0 | 2 | 1 | 0 |
Motor Neuron Disease
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) | 0 | 2 | 1 | 0 |
Dwarfism, Growth Hormone Deficiency
[description not available] | 0 | 2.01 | 1 | 0 |
Dwarfism, Pituitary
A form of dwarfism caused by complete or partial GROWTH HORMONE deficiency, resulting from either the lack of GROWTH HORMONE-RELEASING FACTOR from the HYPOTHALAMUS or from the mutations in the growth hormone gene (GH1) in the PITUITARY GLAND. It is also known as Type I pituitary dwarfism. Human hypophysial dwarf is caused by a deficiency of HUMAN GROWTH HORMONE during development. | 0 | 2.01 | 1 | 0 |
Autoimmune Diabetes
[description not available] | 0 | 2 | 1 | 0 |
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. | 0 | 2 | 1 | 0 |
Osteoarthritis of Knee
[description not available] | 0 | 2.01 | 1 | 0 |
Osteoarthritis, Knee
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019) | 0 | 2.01 | 1 | 0 |
Abdominal Aortic Aneurysm
[description not available] | 0 | 2.01 | 1 | 0 |
Aortic Aneurysm, Abdominal
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm. | 0 | 2.01 | 1 | 0 |
Brain Disorders
[description not available] | 0 | 2.87 | 1 | 0 |
Cutis Laxa
A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed) | 0 | 2.87 | 1 | 0 |
CBS Deficiency
[description not available] | 0 | 3.56 | 3 | 0 |
Abnormalities, Skin
[description not available] | 0 | 2.87 | 1 | 0 |
Aortic Diseases
Pathological processes involving any part of the AORTA. | 0 | 3.27 | 2 | 0 |
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. | 0 | 2.87 | 1 | 0 |
Homocystinuria
Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979) | 0 | 3.56 | 3 | 0 |
Skin Abnormalities
Congenital structural abnormalities of the skin. | 0 | 2.87 | 1 | 0 |
Rachitis
[description not available] | 0 | 1.95 | 1 | 0 |
Deficiency, Vitamin D
[description not available] | 0 | 3.05 | 5 | 0 |
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406) | 0 | 3.05 | 5 | 0 |
Nutritional Disorders
[description not available] | 0 | 2.87 | 1 | 0 |
Nutrition Disorders
Disorders caused by nutritional imbalance, either overnutrition or undernutrition. | 0 | 2.87 | 1 | 0 |
Hypoascorbemia
[description not available] | 0 | 3.78 | 4 | 0 |
Scurvy
An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs. | 0 | 3.78 | 4 | 0 |
Vascular Diseases
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body. | 0 | 1.95 | 1 | 0 |
Palmoplantaris Pustulosis
[description not available] | 0 | 1.95 | 1 | 0 |
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. | 0 | 1.95 | 1 | 0 |
Granulomas
[description not available] | 0 | 4.44 | 5 | 0 |
Rheumatism
[description not available] | 0 | 3.74 | 2 | 0 |
Sclerosis
A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve. | 0 | 2.87 | 1 | 0 |
Plica Syndrome
[description not available] | 0 | 2.87 | 1 | 0 |
Granuloma
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents. | 0 | 4.44 | 5 | 0 |
Rheumatic Diseases
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement. | 0 | 3.74 | 2 | 0 |
Synovitis
Inflammation of the SYNOVIAL MEMBRANE. | 0 | 2.87 | 1 | 0 |
Liver Dysfunction
[description not available] | 0 | 3.27 | 2 | 0 |
Liver Diseases
Pathological processes of the LIVER. | 0 | 3.27 | 2 | 0 |
Diabetic Angiopathies
VASCULAR DISEASES that are associated with DIABETES MELLITUS. | 0 | 4.25 | 4 | 0 |
Spinal Diseases
Diseases involving the SPINE. | 0 | 2.87 | 1 | 0 |
Nephrotic Syndrome
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction. | 0 | 2.65 | 3 | 0 |
Metastase
[description not available] | 0 | 2.37 | 2 | 0 |
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. | 0 | 2.37 | 2 | 0 |
Hyperthyroid
[description not available] | 0 | 2.36 | 2 | 0 |
Central Hypothyroidism
[description not available] | 0 | 2.36 | 2 | 0 |
Hyperthyroidism
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. | 0 | 2.36 | 2 | 0 |
Hypothyroidism
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. | 0 | 2.36 | 2 | 0 |
Fong Disease
[description not available] | 0 | 1.95 | 1 | 0 |
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES. | 0 | 1.95 | 1 | 0 |
Anoxemia
[description not available] | 0 | 2.35 | 2 | 0 |
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms. | 0 | 2.35 | 2 | 0 |
Disc, Herniated
[description not available] | 0 | 1.95 | 1 | 0 |
Intervertebral Disc Displacement
An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region. | 0 | 1.95 | 1 | 0 |
Fibrodysplasia Ossificans Progressiva
[description not available] | 0 | 1.95 | 1 | 0 |
Myositis Ossificans
A disease characterized by bony deposits or the ossification of muscle tissue. | 0 | 1.95 | 1 | 0 |
Diabetic Glomerulosclerosis
[description not available] | 0 | 4.44 | 5 | 0 |
Nephrosclerosis
Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA. | 0 | 2.87 | 1 | 0 |
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE. | 0 | 4.44 | 5 | 0 |
Carbohydrate Metabolism, Inborn Error
[description not available] | 0 | 2.87 | 1 | 0 |
Lipid Metabolism, Inborn Error
[description not available] | 0 | 2.87 | 1 | 0 |
Arteriosclerosis
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries. | 0 | 1.95 | 1 | 0 |
Amino Acid Metabolism Disorders, Inborn
[description not available] | 0 | 4.47 | 9 | 0 |
Cerebral Palsy, Athetoid
[description not available] | 0 | 1.95 | 1 | 0 |
Cerebral Palsy
A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7) | 0 | 1.95 | 1 | 0 |
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. | 0 | 8.56 | 3 | 0 |
Innate Inflammatory Response
[description not available] | 0 | 1.95 | 1 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 1.95 | 1 | 0 |
Thyroid Diseases
Pathological processes involving the THYROID GLAND. | 0 | 1.95 | 1 | 0 |
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. | 0 | 1.95 | 1 | 0 |
Epulides
[description not available] | 0 | 1.95 | 1 | 0 |
Gingival Diseases
Diseases involving the GINGIVA. | 0 | 1.95 | 1 | 0 |
Chronic Kidney Failure
[description not available] | 0 | 2.86 | 1 | 0 |
CKD-MBD
[description not available] | 0 | 2.86 | 1 | 0 |
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. | 0 | 2.86 | 1 | 0 |
Chronic Kidney Disease-Mineral and Bone Disorder
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. | 0 | 2.86 | 1 | 0 |
Milk-Alkali Syndrome
[description not available] | 0 | 1.95 | 1 | 0 |
Hypercalcemia
Abnormally high level of calcium in the blood. | 0 | 1.95 | 1 | 0 |
Hyperglycemia, Postprandial
Abnormally high BLOOD GLUCOSE level after a meal. | 0 | 2.35 | 2 | 0 |
Hyperglycemia
Abnormally high BLOOD GLUCOSE level. | 0 | 2.35 | 2 | 0 |
Malignant Hypertension
[description not available] | 0 | 1.95 | 1 | 0 |
Hypertension, Malignant
A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction. | 0 | 1.95 | 1 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 1.95 | 1 | 0 |
Ataxia Telangiectasia Syndrome
[description not available] | 0 | 1.95 | 1 | 0 |
Antibody Deficiency Syndrome
[description not available] | 0 | 1.95 | 1 | 0 |
Ataxia Telangiectasia
An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23). | 0 | 1.95 | 1 | 0 |
Immunologic Deficiency Syndromes
Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. | 0 | 1.95 | 1 | 0 |
Alveolar Bone Atrophy
[description not available] | 0 | 1.98 | 1 | 0 |
Tooth Loss
The failure to retain teeth as a result of disease or injury. | 0 | 1.98 | 1 | 0 |
Mouth, Edentulous
Total lack of teeth through disease or extraction. | 0 | 1.98 | 1 | 0 |
Familial Turner Syndrome
[description not available] | 0 | 1.98 | 1 | 0 |
Noonan Syndrome
A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1. | 0 | 1.98 | 1 | 0 |
Disease, Pulmonary
[description not available] | 0 | 1.97 | 1 | 0 |
Lung Diseases
Pathological processes involving any part of the LUNG. | 0 | 1.97 | 1 | 0 |
Chronic Hepatitis
[description not available] | 0 | 1.97 | 1 | 0 |
Hepatitis
INFLAMMATION of the LIVER. | 0 | 1.97 | 1 | 0 |
Hepatitis, Chronic
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors. | 0 | 1.97 | 1 | 0 |
Glial Cell Tumors
[description not available] | 0 | 1.96 | 1 | 0 |
Arachnoidal Cerebellar Sarcoma, Circumscribed
[description not available] | 0 | 1.96 | 1 | 0 |
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 1.96 | 1 | 0 |
Medulloblastoma
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1) | 0 | 1.96 | 1 | 0 |
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma. | 0 | 1.97 | 1 | 0 |
Infections, Pseudomonas
[description not available] | 0 | 1.97 | 1 | 0 |
Bronchitis
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI. | 0 | 1.97 | 1 | 0 |
Pneumonia
Infection of the lung often accompanied by inflammation. | 0 | 1.97 | 1 | 0 |
Pseudomonas Infections
Infections with bacteria of the genus PSEUDOMONAS. | 0 | 1.97 | 1 | 0 |
Keratoconus
A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed) | 0 | 1.97 | 1 | 0 |
Acute Kidney Failure
[description not available] | 0 | 1.97 | 1 | 0 |
Acute Kidney Injury
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. | 0 | 1.97 | 1 | 0 |
Experimental Hepatoma
[description not available] | 0 | 1.97 | 1 | 0 |
Berger Disease
[description not available] | 0 | 1.96 | 1 | 0 |
Hematuria
Presence of blood in the urine. | 0 | 1.96 | 1 | 0 |
Glomerulonephritis, IGA
A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE. | 0 | 1.96 | 1 | 0 |
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues. | 0 | 2.36 | 2 | 0 |
Cystinuria
An inherited disorder due to defective reabsorption of CYSTINE and other BASIC AMINO ACIDS by the PROXIMAL RENAL TUBULES. This form of aminoaciduria is characterized by the abnormally high urinary levels of cystine; LYSINE; ARGININE; and ORNITHINE. Mutations involve the amino acid transport protein gene SLC3A1. | 0 | 1.96 | 1 | 0 |
Bonnevie-Ullrich Syndrome
This syndrome that was originally observed by Ullrich, and designated as identical to TURNER SYNDROME, related the webbing of the neck, loose skin and other anomalies of the syndrome to accumulation of fluid in the embryo starting at the head and dispersing to the extremities (as observed by Bonnevie in mice). Commonly observed at birth in Turner Syndrome and NOONAN SYNDROME; EDEMA of the extremities usually recedes by one year and is an early sign of Turner syndrome, especially in female neonates. | 0 | 1.96 | 1 | 0 |
Turner Syndrome
A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant. | 0 | 1.96 | 1 | 0 |
Colonic Polyps
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base. | 0 | 1.96 | 1 | 0 |
Aneuploid
[description not available] | 0 | 1.95 | 1 | 0 |
Abnormalities, Autosome
[description not available] | 0 | 2.35 | 2 | 0 |
47,XX,+21
[description not available] | 0 | 1.95 | 1 | 0 |
Deficiency, Mental
[description not available] | 0 | 1.95 | 1 | 0 |
Autosomal Chromosome Disorders
[description not available] | 0 | 2.35 | 2 | 0 |
Down Syndrome
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213) | 0 | 1.95 | 1 | 0 |
Intellectual Disability
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28) | 0 | 1.95 | 1 | 0 |
Libman-Sacks Disease
[description not available] | 0 | 2.35 | 2 | 0 |
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. | 0 | 2.35 | 2 | 0 |
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES. | 0 | 2.64 | 3 | 0 |
Groenblad-Strandberg Syndrome
[description not available] | 0 | 1.95 | 1 | 0 |
Pseudoxanthoma Elasticum
An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE. | 0 | 1.95 | 1 | 0 |
Autoimmune Disease
[description not available] | 0 | 1.95 | 1 | 0 |
Autoimmune Diseases
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. | 0 | 1.95 | 1 | 0 |
Deficiency, Pyridoxine
[description not available] | 0 | 1.94 | 1 | 0 |
Diseases of Endocrine System
[description not available] | 0 | 2.86 | 1 | 0 |
Endocrine System Diseases
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES. | 0 | 2.86 | 1 | 0 |
Teeth, Unerupted
[description not available] | 0 | 1.95 | 1 | 0 |
Extravascular Hemolysis
[description not available] | 0 | 2.35 | 2 | 0 |
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity. | 0 | 2.35 | 2 | 0 |
Starvation
Lengthy and continuous deprivation of food. (Stedman, 25th ed) | 0 | 1.94 | 1 | 0 |
Leucocythaemia
[description not available] | 0 | 2.86 | 1 | 0 |
Leukemia L 1210
[description not available] | 0 | 2.86 | 1 | 0 |
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) | 0 | 2.86 | 1 | 0 |
Metabolic Acidosis
[description not available] | 0 | 1.94 | 1 | 0 |
Acidosis
A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up. | 0 | 1.94 | 1 | 0 |
Coagulation Disorders, Blood
[description not available] | 0 | 1.94 | 1 | 0 |
Thrombocytopathy
[description not available] | 0 | 1.94 | 1 | 0 |
Blood Coagulation Disorders
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions. | 0 | 1.94 | 1 | 0 |
Blood Platelet Disorders
Disorders caused by abnormalities in platelet count or function. | 0 | 1.94 | 1 | 0 |
Capdepont Teeth
[description not available] | 0 | 1.95 | 1 | 0 |
Carbon Tetrachloride Poisoning
Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE. | 0 | 1.95 | 1 | 0 |
Glycosuria
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA). | 0 | 2.35 | 2 | 0 |
Cadaver
A dead body, usually a human body. | 0 | 1.95 | 1 | 0 |
Deficiency Diseases
A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed) | 0 | 1.95 | 1 | 0 |
Autolysis
The spontaneous disintegration of tissues or cells by the action of their own autogenous enzymes. | 0 | 1.94 | 1 | 0 |
Alcaptonuria
[description not available] | 0 | 1.94 | 1 | 0 |
Alkaptonuria
An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS. | 0 | 1.94 | 1 | 0 |
Infective Endocarditis
[description not available] | 0 | 1.94 | 1 | 0 |
Endocarditis
Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening. | 0 | 1.94 | 1 | 0 |