Page last updated: 2024-08-05 11:26:46
3-hydroxy steroid
Any hydroxy steroid carrying a hydroxy group at position 3.
ChEBI ID: 36834
Members (47)
| Member | Definition | Role |
|---|---|---|
| 1,3,5,(10),16-estratetraen-3-ol | A 3-hydroxy steroid that is obtained by formal dehydration at the 17-position of estradiol. | 16-estratetraen-3-ol |
| 11 beta-hydroxyandrosterone | 3alpha,11beta-Dihydroxy-5alpha-androstane-17-one | |
| 11-beta-chloromethyl-estradiol | 11beta-Chloromethylestradiol | |
| 11-hydroxyandrostenedione | 11-Hydroxyandrostenedione | |
| 11-ketoetiocholanolone | 11-Ketoetiocholanolone | |
| 16-ketoestrone | 16-Ketoestrone | |
| 17-desoxyestradiol | A 3-hydroxy steroid resulting from deoxygenation at position 17 of estradiol or estrone. | estra-1,3,5(10)-trien-3-ol |
| 17-methylestradiol | 17alpha-Methylestradiol | |
| 2-methoxyestradiol | A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2. | 2-methoxy-17beta-estradiol |
| 2-methoxyestrone | A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group. | 2-methoxyestrone |
| 3beta-hydroxy-17-(1h-benzimidazole-1-yl)androsta-5,16-diene | Galeterone | |
| 4-androstene-3,17-diol | 4-Androstenediol | |
| 4-hydroxyestrone | A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4. | 4-hydroxyestrone |
| 4-methoxyestradiol | A 17beta-hydroxy steroid that is 17beta-estradiol in which the hydrogen at position 4 has been replaced by a methoxy group. | 4-methoxy-17beta-estradiol |
| 5-androstene-3,16,17-triol | 5-Androstenetriol | |
| alfatradiol | An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer). | 17alpha-estradiol |
| altrenogest | Altrenogest | |
| androstan-3-ol | 5alpha-Androstan-3beta-ol | |
| androstane-3,17-diol | androstane-3,17-diol | |
| bolasterone | Bolasterone | |
| calusterone | calusterone | |
| clostebol | clostebol | |
| d-4-chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene | 4-Chloromethandienone | |
| dimethisterone | Dimethisterone | |
| equilenin | A 3-hydroxy steroid that is estrone which carries two double bonds at positions 6 and 8. It is found in the urine of pregnant mare's and extensively used for estrogen replacement therapy in postmenopausal women. | equilenin |
| equilin | equilin | |
| estetrol | A 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. | estetrol |
| estradiol 17-sulfate | A steroid sulfate obtained by the formal condensation of sulfuric acid with the 17-hydroxy group of 17beta-estradiol. | 17beta-estradiol 17-sulfate |
| estradiol-17 beta-glucuronide | A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 17 via a glycosidic linkage. | 17beta-estradiol 17-glucosiduronic acid |
| estriol | A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer). | estriol |
| estriol-16 alpha-glucuronide | A steroid glucosiduronic acid that is estriol in which the phenolic hydrogen has been replaced by a beta-D-glucuronyl residue. | estriol 16-O-(beta-D-glucuronide) |
| estrone | A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17. | estrone |
| ethinyl estradiol | A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. | 17alpha-ethynylestradiol |
| fulvestrant | A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer. | fulvestrant |
| ici 164384 | A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines. | ICI-164384 |
| methandriol | Methandriol | |
| methenolone | methenolone | |
| moxestrol | Moxestrol | |
| pregna-4,17-diene-3,16-dione | E-Guggulsterone | |
| quinbolone | quinbolone | |
| ru 58668 | A 17beta-hydroxy steroid that is 17beta-estradiol in the the hydrogen at the 11beta position has been replaced by a p-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl group. RU 58668 is a pure anti-estrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). | RU 58668 |
| stenbolone | Stenbolone | |
| stigmastanol | A 3-hydroxy steroid that is 5alpha-stigmastane which is substituted at the 3beta position by a hydroxy group. | stigmastanol |
| testosterone | 17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| tetrahydrogestrinone | Tetrahydrogestrinone | |
| tipredane | Tipredane | |
| trilostane | An epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions. | trilostane |
Research
Studies (28,381)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 13,935 (49.10) | 18.7374 |
| 1990's | 3,623 (12.77) | 18.2507 |
| 2000's | 5,034 (17.74) | 29.6817 |
| 2010's | 4,521 (15.93) | 24.3611 |
| 2020's | 1,268 (4.47) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,739 (8.33%) | 5.53% |
| Reviews | 1,453 (4.42%) | 6.00% |
| Case Studies | 920 (2.80%) | 4.05% |
| Observational | 59 (0.18%) | 0.25% |
| Other | 27,698 (84.27%) | 84.16% |