Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased.
ChEBI ID: 65190
| Member | Definition | Class |
|---|---|---|
| clopenthixol | A thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry. | clopenthixol |
| droperidol | An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. | droperidol |
| haloperidol | A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. | haloperidol |
| mesoridazine | A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group. | mesoridazine |
| periciazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic. | periciazine |
| pimozide | A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group. | pimozide |
| pipamperone | A member of the class of bipiperidines that is 1,4'-bipiperidine which is substituted at the 1' and 4' positions by 4-(p-fluorophenyl)-4-oxobutyl and carboxamide groups, respectively. A first generation antipsychotic, its properties are generally similar to those of haloperidol. | pipamperone |
| pipamperone dihydrochloride | A hydrochloride resulting from the reaction of pipamperone with 2 mol eq. of hydrogen chloride. It is used as an antipsychotic. | pipamperone dihydrochloride |
| prochlorperazine | A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | prochlorperazine |
| reserpine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. | reserpine |
| serentil | The benzenesulfonate salt of mesoridazine prepared using equimolar amounts of mesoridazine and benzenesulfonic acid. | mesoridazine besylate |
| thioridazine | A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. | thioridazine |
| thioridazine hydrochloride | thioridazine hydrochloride | |
| triflupromazine | A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position. | triflupromazine |
| zuclopenthixol | The (Z)-isomer of clopenthixol. | zuclopenthixol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 23,829 (60.41) | 18.7374 |
| 1990's | 6,071 (15.39) | 18.2507 |
| 2000's | 4,796 (12.16) | 29.6817 |
| 2010's | 3,646 (9.24) | 24.3611 |
| 2020's | 1,105 (2.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,216 (7.22%) | 5.53% |
| Reviews | 1,705 (3.83%) | 6.00% |
| Case Studies | 2,671 (6.00%) | 4.05% |
| Observational | 47 (0.11%) | 0.25% |
| Other | 36,879 (82.84%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 20.3068 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 20.2375 | 2 | 7 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 45.7950 | 3 | 9 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 57.4836 | 2 | 5 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.8143 | 1 | 4 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 26.3648 | 1 | 3 |
| AR protein | Homo sapiens (human) | Potency | 29.9704 | 11 | 53 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 41.2800 | 2 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 13.2036 | 1 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 19.4544 | 3 | 10 |
| Ataxin-2 | Homo sapiens (human) | Potency | 25.8492 | 2 | 8 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 15.4889 | 1 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 34.5168 | 2 | 8 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 9.9304 | 1 | 2 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 22.6317 | 1 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 25.5366 | 1 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 46.9266 | 1 | 6 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 29.2184 | 1 | 4 |
| caspase-3 | Homo sapiens (human) | Potency | 46.9266 | 1 | 6 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 29.2184 | 1 | 4 |
| Caspase-7 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 44.3599 | 3 | 13 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 17.1828 | 2 | 9 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 30.6881 | 1 | 6 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 52.7739 | 2 | 5 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 3.1623 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 47.7080 | 1 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.1766 | 2 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 21.7088 | 1 | 12 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 43.6752 | 2 | 10 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 10.9233 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 20.8114 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 27.7231 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 3.7919 | 1 | 7 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 4.5880 | 1 | 10 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.4972 | 2 | 20 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.4293 | 2 | 10 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 31.8976 | 1 | 6 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.4998 | 3 | 10 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 19.7440 | 1 | 4 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 23.7781 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 36.5848 | 1 | 4 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 19.9594 | 1 | 3 |
| endonuclease IV | Escherichia coli | Potency | 17.2636 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 36.0367 | 12 | 69 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 25.1715 | 2 | 7 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 28.9733 | 10 | 63 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.2613 | 2 | 18 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.1592 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.2856 | 5 | 14 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 35.3799 | 1 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 29.0944 | 1 | 4 |
| G | Vesicular stomatitis virus | Potency | 27.7231 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| GALC protein | Homo sapiens (human) | Potency | 20.2593 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.4972 | 1 | 10 |
| geminin | Homo sapiens (human) | Potency | 17.4503 | 4 | 19 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 12.5621 | 2 | 18 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 18.4239 | 1 | 6 |
| GLS protein | Homo sapiens (human) | Potency | 15.0624 | 2 | 4 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 16.2086 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 29.4693 | 4 | 19 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 44.9252 | 1 | 8 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 11.5821 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 58.4789 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 44.0677 | 2 | 7 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 14.4045 | 2 | 22 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.3512 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 54.2714 | 2 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 58.6544 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 27.7231 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 23.7609 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 40.3755 | 2 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 7.5765 | 2 | 10 |
| IDH1 | Homo sapiens (human) | Potency | 20.8635 | 1 | 7 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 28.1252 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 27.7231 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 2 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 24.1969 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 24.1969 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 27.8914 | 2 | 4 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 17.4548 | 2 | 12 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 18.9805 | 1 | 8 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 40.5334 | 1 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 22.8011 | 1 | 7 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.5806 | 2 | 12 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 20.2430 | 2 | 12 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 7.2138 | 2 | 10 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 13.1994 | 1 | 6 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 17.8615 | 2 | 6 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 6.3522 | 1 | 4 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 32.5000 | 4 | 15 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 22.1427 | 1 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 39.9868 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 45.5015 | 2 | 6 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 26.4538 | 2 | 10 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 41.5875 | 3 | 22 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 37.0264 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 23.1946 | 1 | 7 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 40.3959 | 1 | 4 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.5330 | 5 | 19 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.9758 | 5 | 20 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 58.7622 | 3 | 10 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 11.5997 | 1 | 4 |
| polyprotein | Zika virus | Potency | 29.0944 | 1 | 4 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.0019 | 1 | 8 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.0421 | 1 | 13 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 17.3049 | 3 | 18 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 41.8960 | 2 | 7 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 26.5529 | 2 | 17 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 77.3056 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 8.6647 | 1 | 6 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 37.2216 | 3 | 16 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 16.6441 | 4 | 17 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 19.8129 | 4 | 15 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 30.0162 | 3 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 23.4260 | 2 | 12 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 23.4260 | 2 | 12 |
| Smad3 | Homo sapiens (human) | Potency | 33.5520 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 28.1252 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 24.8651 | 2 | 8 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.5010 | 1 | 8 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 1.8623 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.5879 | 2 | 39 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 89.1251 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 18.4688 | 2 | 5 |
| Thrombopoietin | Homo sapiens (human) | Potency | 17.7800 | 2 | 10 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.6059 | 3 | 30 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 50.8454 | 1 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.2662 | 6 | 20 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 28.7652 | 2 | 2 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 11.5997 | 1 | 4 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 11.5997 | 1 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 38.8337 | 3 | 12 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 18.1692 | 2 | 10 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 22.9259 | 5 | 20 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 45.2396 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 44.9252 | 1 | 8 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | Ki | 0.1900 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 2.2744 | 6 | 9 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 2.3410 | 5 | 5 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 1.3139 | 8 | 10 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.4540 | 3 | 5 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.2383 | 1 | 3 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.5090 | 2 | 2 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.5090 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0754 | 2 | 5 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.1288 | 12 | 12 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.1480 | 18 | 21 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | Ki | 0.0265 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0483 | 20 | 21 |
| 5-hydroxytryptamine receptor 2A | Sus scrofa (pig) | Ki | 0.0300 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.9058 | 1 | 4 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.1451 | 9 | 9 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.4652 | 2 | 5 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | Ki | 0.0265 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0261 | 9 | 9 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 2.7846 | 2 | 5 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.2306 | 10 | 10 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 3.7433 | 11 | 14 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.4935 | 10 | 10 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | Ki | 0.0265 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.7858 | 2 | 5 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.9134 | 2 | 5 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.1690 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 1.5689 | 6 | 8 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 95.7500 | 1 | 4 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.5329 | 5 | 6 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0885 | 2 | 3 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 7.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.3180 | 1 | 1 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | IC50 | 1.4250 | 2 | 2 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Albumin | Homo sapiens (human) | IC50 | 3.5000 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.2623 | 1 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.2513 | 1 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0794 | 5 | 7 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0124 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0142 | 10 | 12 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0794 | 5 | 7 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0124 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0142 | 10 | 12 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0517 | 1 | 4 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0794 | 5 | 7 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0209 | 3 | 6 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0142 | 10 | 12 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 2.0600 | 1 | 4 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0355 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.6180 | 2 | 5 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 9.6000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.4910 | 1 | 4 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0355 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.1795 | 2 | 5 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 9.6000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.9652 | 1 | 4 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0355 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 1.1122 | 2 | 5 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 9.6000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 2.8408 | 2 | 4 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 1.1916 | 1 | 3 |
| AP-2 complex subunit sigma | Rattus norvegicus (Norway rat) | Ki | 0.0242 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 3.1423 | 14 | 14 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 27.4500 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 6.1400 | 6 | 7 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 10.9650 | 2 | 2 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 46.4967 | 5 | 15 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 14.3257 | 4 | 4 |
| C-8 sterol isomerase | Saccharomyces cerevisiae S288C | Ki | 0.0005 | 1 | 1 |
| Calcitonin gene-related peptide type 1 receptor | Homo sapiens (human) | Ki | 0.0004 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 111.4667 | 1 | 3 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Ki | 295.0000 | 1 | 1 |
| Cathepsin D | Bos taurus (cattle) | IC50 | 0.0600 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | Ki | 0.0500 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 3.8150 | 1 | 2 |
| Chromaffin granule amine transporter | Homo sapiens (human) | IC50 | 0.0500 | 2 | 2 |
| Cocaine esterase | Homo sapiens (human) | Ki | 0.0063 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 5.6662 | 1 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 6.3778 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 4.6900 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 1.0363 | 1 | 2 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 4.6900 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 4.8775 | 2 | 2 |
| D | Bos taurus (cattle) | IC50 | 0.2509 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.1398 | 11 | 18 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.1550 | 17 | 23 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.3112 | 2 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.1296 | 9 | 12 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Ki | 0.0095 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | IC50 | 0.0050 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0187 | 5 | 11 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.1010 | 4 | 4 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0017 | 2 | 2 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 0.1332 | 4 | 4 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0739 | 10 | 14 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0205 | 23 | 36 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.0070 | 3 | 3 |
| D(2) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.0049 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0654 | 99 | 106 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0029 | 36 | 60 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0072 | 6 | 9 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0187 | 5 | 11 |
| D(3) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.0030 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0095 | 48 | 53 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0151 | 10 | 10 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.5457 | 6 | 8 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0187 | 5 | 11 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.0430 | 41 | 44 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0060 | 2 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 3.7600 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 7.0700 | 2 | 3 |
| DNA damage-inducible transcript 3 protein | Mus musculus (house mouse) | IC50 | 6.3400 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 160.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 2.9470 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Gastrin/cholecystokinin type B receptor | Mus musculus (house mouse) | Ki | 0.0234 | 1 | 2 |
| Genome polyprotein | Human rhinovirus sp. | IC50 | 140.0000 | 1 | 1 |
| Genome polyprotein | Human rhinovirus sp. | Ki | 0.1000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 5.0006 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 1.8490 | 1 | 4 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6997 | 2 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.3637 | 5 | 8 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.0580 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 1.0405 | 1 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| Integrin alpha-4 | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Integrin beta-1 | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 1.7400 | 2 | 2 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0026 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 0.9960 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 7.0700 | 2 | 3 |
| Mcl-1 | Homo sapiens (human) | IC50 | 3.7733 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.3223 | 2 | 3 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 3.7870 | 3 | 4 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 7.0700 | 2 | 3 |
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Homo sapiens (human) | IC50 | 3.7650 | 2 | 2 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 3.0050 | 3 | 4 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 1.3163 | 3 | 6 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.6231 | 4 | 5 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 4.6306 | 4 | 5 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.6090 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 1.9475 | 3 | 4 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.9383 | 2 | 3 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 5.2542 | 5 | 5 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.8020 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 1.9475 | 3 | 4 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 1.6700 | 2 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 8.7066 | 2 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.7640 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 1.9475 | 3 | 4 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 1.3520 | 2 | 4 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 8.7066 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 1.6043 | 1 | 4 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 1.9475 | 3 | 4 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 1.8561 | 2 | 5 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 8.7066 | 2 | 2 |
| N-acetyltransferase Eis | Mycobacterium tuberculosis H37Rv | IC50 | 6.2950 | 1 | 2 |
| N-acetyltransferase Eis | Mycobacterium tuberculosis H37Rv | Ki | 0.3900 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 1.4544 | 1 | 3 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 1.1916 | 1 | 3 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 2.6333 | 1 | 3 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | IC50 | 3.6500 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 0.2505 | 21 | 58 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 0.7311 | 3 | 7 |
| Protease | Human immunodeficiency virus 1 | IC50 | 125.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | Ki | 50.0500 | 2 | 2 |
| Quinolone resistance protein NorA | Staphylococcus aureus | IC50 | 8.5429 | 7 | 7 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.6900 | 1 | 1 |
| Sigma intracellular receptor 2 | Homo sapiens (human) | Ki | 0.0616 | 6 | 6 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | Ki | 0.0721 | 11 | 11 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.1007 | 6 | 9 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1261 | 5 | 6 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0048 | 36 | 36 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0095 | 37 | 43 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0148 | 7 | 7 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.3400 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 2.9613 | 3 | 3 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 3.5270 | 2 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0355 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 2.0237 | 2 | 3 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 2.0555 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.6335 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.2623 | 1 | 3 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.3135 | 2 | 4 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.7687 | 1 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.2838 | 3 | 5 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0342 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 20.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 95.7500 | 1 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 34.2000 | 1 | 1 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | IC50 | 0.0147 | 3 | 3 |
| Synaptic vesicular amine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0177 | 1 | 10 |
| Synaptic vesicular amine transporter | Bos taurus (cattle) | Ki | 0.0010 | 1 | 1 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | Ki | 0.3484 | 3 | 3 |
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 5.5000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | IC50 | 110.0000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 30.2000 | 1 | 1 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 5.3670 | 1 | 2 |
| Ubiquitin carboxyl-terminal hydrolase 1 | Homo sapiens (human) | IC50 | 2.0000 | 2 | 2 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Ki | 344.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Ki | 590.0000 | 1 | 1 |
| Vesicular acetylcholine transporter | Rattus norvegicus (Norway rat) | Ki | 0.3910 | 1 | 1 |
| Vitamin D-binding protein | Rattus norvegicus (Norway rat) | Ki | 0.0037 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 1.4150 | 2 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 2.2603 | 7 | 7 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 2.4170 | 6 | 6 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 2.4170 | 6 | 6 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 2.4170 | 6 | 6 |
| WD repeat-containing protein 48 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| XBP1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Zinc finger protein 664 | Cavia porcellus (domestic guinea pig) | Ki | 0.0066 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Rattus norvegicus (Norway rat) | Kd | 51.7950 | 1 | 2 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 6.0700 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Kd | 0.0147 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Kd | 0.3162 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | EC50 | 5.0085 | 2 | 2 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 1.7000 | 1 | 1 |
| HLA class I histocompatibility antigen, A alpha chain | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| Major prion protein | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | EC50 | 0.3540 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 6.0700 | 1 | 2 |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | EC50 | 9.9000 | 1 | 2 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 6.0700 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 6.0700 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 6.0700 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 6.0700 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 6.0700 | 1 | 2 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 6.0700 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 6.0700 | 1 | 2 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | Kd | 0.0080 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 6.0700 | 1 | 2 |
| Voltage-dependent T-type calcium channel subunit alpha-1G | Homo sapiens (human) | Kd | 0.0400 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldehyde oxidase | Homo sapiens (human) | Kii | 1.3000 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | Kis | 1.3000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 33.0000 | 1 | 1 |
| Carbonyl reductase [NADPH] 1 | Homo sapiens (human) | Km | 1,200.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | INH | 26.2000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kb | 0.0014 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | Kb | 0.0014 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Kb | 0.0014 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | pKi | 0.0091 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Kb | 0.0014 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | pKi | 0.0083 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Kb | 0.0014 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | pKi | 0.0080 | 1 | 1 |
| DNA repair protein RAD52 homolog isoform a | Homo sapiens (human) | AC50 | 13.6600 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | K0.5 | 0.2150 | 1 | 2 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | INH | 23.7333 | 1 | 3 |
| protein AF-9 isoform a | Homo sapiens (human) | AC50 | 6.3100 | 1 | 1 |
| Quinolone resistance protein NorA | Staphylococcus aureus | MMC | 6.5700 | 1 | 1 |
| Snq2p | Saccharomyces cerevisiae EC1118 | INH | 24.3333 | 1 | 3 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 64.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Km | 174.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Km | 45.0000 | 1 | 1 |