Page last updated: 2024-11-05

diphenylcarbazone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Diphenylcarbazone is a chemical compound with the formula (C6H5NH)2C=O. It is a yellow solid that is soluble in ethanol and ether. Diphenylcarbazone is used as a reagent in analytical chemistry, particularly in the detection of metals such as mercury, chromium, and iron. It is also used as a dye in the textile industry. Diphenylcarbazone is synthesized by reacting phenylhydrazine with benzil in the presence of an acid catalyst. The compound forms a colored complex with mercury ions, making it useful in the detection and quantification of mercury in environmental samples. The study of diphenylcarbazone is important because of its applications in analytical chemistry and its potential use in the development of new analytical methods for the detection of heavy metals.'

diphenylcarbazone: sensitive reagent for Hg, for which it gives blue color; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10860
CHEMBL ID79409
SCHEMBL ID1057265
SCHEMBL ID1551533
MeSH IDM0046051

Synonyms (57)

Synonym
(e)-n',2-diphenyldiazenecarbohydrazide
CHEMBL79409 ,
diazenecarboxylic acid, 2-phenyl-, 2-phenylhydrazide
4-16-00-00017 (beilstein handbook reference)
diphenylcarbazone
diazenecarboxylic acid, phenyl-, 2-phenylhydrazide
einecs 208-698-0
1,5-diphenylcarbazone
phenyldiazenecarboxylic acid 2-phenylhydrazide
brn 0959475
(phenylazo)formic acid 2-phenylhydrazide
formic acid, (phenylazo)-, 2-phenylhydrazide
538-62-5
sym-diphenylcarbazone
D0881
1-anilino-3-phenyliminourea
bdbm50071644
(e)-n'',2-diphenyldiazenecarbohydrazide
AKOS003273042
AKOS024348870
STL280245
FT-0606976
diphenylcarbazone, (e)-
diphenylcarbazone (e)-form
diphenylcarbazone [mi]
96YS88318X ,
diazenecarboxylic acid, phenyl-, 2-phenylhydrazide, (1e)-
SCHEMBL1057265
diazenecarboxylic acid, phenyl-, 2-phenylhydrazide, (z)-
diphenylcarbazone z-form [mi]
119295-40-8
diphenylcarbazone, (z)-
5UYJ4R0D5T ,
unii-5uyj4r0d5t
1,5-diphenylcarbazone (for colorimetry tests)
SCHEMBL1551533
DTXSID5060225
diazenecarbohydrazonic acid, n,2-diphenyl-
3-hydroxy-1,5-diphenylformazan
n',2-diphenyldiazenecarbohydrazide #
phenylazoformic acid 2-phenylhydrazide
hydrazinecarboxamide, 2-phenyl-n-(phenylimino)-
ZFWAHZCOKGWUIT-BMRADRMJSA-N
119295-41-9
unii-96ys88318x
mfcd00003024
CS-0132463
diphenylcarbazone, p.a.
diphenylcarbazon
(e)-1,5-diphenylcarbazone
Q1227136
H11948
Q27262902
Q27271938
(z)-diphenylcarbazone
diphenylcarbazone (contains diphenylcarbazide)
(e)-1-(phenylamino)-3-(phenylimino)urea
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
ProthrombinHomo sapiens (human)Ki1.70000.00000.78469.0000AID219611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (33)

Processvia Protein(s)Taxonomy
positive regulation of protein phosphorylationProthrombinHomo sapiens (human)
proteolysisProthrombinHomo sapiens (human)
acute-phase responseProthrombinHomo sapiens (human)
cell surface receptor signaling pathwayProthrombinHomo sapiens (human)
G protein-coupled receptor signaling pathwayProthrombinHomo sapiens (human)
blood coagulationProthrombinHomo sapiens (human)
positive regulation of cell population proliferationProthrombinHomo sapiens (human)
regulation of cell shapeProthrombinHomo sapiens (human)
response to woundingProthrombinHomo sapiens (human)
negative regulation of platelet activationProthrombinHomo sapiens (human)
platelet activationProthrombinHomo sapiens (human)
regulation of blood coagulationProthrombinHomo sapiens (human)
positive regulation of blood coagulationProthrombinHomo sapiens (human)
positive regulation of cell growthProthrombinHomo sapiens (human)
positive regulation of insulin secretionProthrombinHomo sapiens (human)
positive regulation of collagen biosynthetic processProthrombinHomo sapiens (human)
fibrinolysisProthrombinHomo sapiens (human)
negative regulation of proteolysisProthrombinHomo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STATProthrombinHomo sapiens (human)
negative regulation of astrocyte differentiationProthrombinHomo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosolProthrombinHomo sapiens (human)
regulation of cytosolic calcium ion concentrationProthrombinHomo sapiens (human)
cytolysis by host of symbiont cellsProthrombinHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionProthrombinHomo sapiens (human)
negative regulation of fibrinolysisProthrombinHomo sapiens (human)
antimicrobial humoral immune response mediated by antimicrobial peptideProthrombinHomo sapiens (human)
neutrophil-mediated killing of gram-negative bacteriumProthrombinHomo sapiens (human)
positive regulation of lipid kinase activityProthrombinHomo sapiens (human)
negative regulation of cytokine production involved in inflammatory responseProthrombinHomo sapiens (human)
positive regulation of protein localization to nucleusProthrombinHomo sapiens (human)
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathwayProthrombinHomo sapiens (human)
ligand-gated ion channel signaling pathwayProthrombinHomo sapiens (human)
positive regulation of reactive oxygen species metabolic processProthrombinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
lipopolysaccharide bindingProthrombinHomo sapiens (human)
serine-type endopeptidase activityProthrombinHomo sapiens (human)
signaling receptor bindingProthrombinHomo sapiens (human)
calcium ion bindingProthrombinHomo sapiens (human)
protein bindingProthrombinHomo sapiens (human)
growth factor activityProthrombinHomo sapiens (human)
heparin bindingProthrombinHomo sapiens (human)
thrombospondin receptor activityProthrombinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (9)

Processvia Protein(s)Taxonomy
external side of plasma membraneProthrombinHomo sapiens (human)
collagen-containing extracellular matrixProthrombinHomo sapiens (human)
extracellular regionProthrombinHomo sapiens (human)
extracellular spaceProthrombinHomo sapiens (human)
endoplasmic reticulum lumenProthrombinHomo sapiens (human)
Golgi lumenProthrombinHomo sapiens (human)
plasma membraneProthrombinHomo sapiens (human)
extracellular exosomeProthrombinHomo sapiens (human)
blood microparticleProthrombinHomo sapiens (human)
collagen-containing extracellular matrixProthrombinHomo sapiens (human)
extracellular spaceProthrombinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID219611Dissociation constant was evaluated by competitive inhibition of alpha-thrombin using the method of Dixon enzyme assay.1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (27.27)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.21 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.87 (4.65)
Search Engine Demand Index52.19 (26.88)
Search Engine Supply Index2.02 (0.95)

This Compound (39.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]