Page last updated: 2024-12-11

rosavin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rosavin: isolated from Rhodiola rosea; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
RhodiolagenusA plant genus of the family CRASSULACEAE. Members contain rhodioloside. This roseroot is unrelated to the familiar rose (ROSA). Some species in this genus are called stonecrop which is also a common name for SEDUM.[MeSH]CrassulaceaeThe stonecrop plant family of the order ROSALES, subclass Rosidae, class Magnoliopsida that grow in warm, dry regions. The leaves are thick. The flower clusters are red, yellow, or white.[MeSH]

Cross-References

ID SourceID
PubMed CID9823887
CHEBI ID139523
SCHEMBL ID6441835
MeSH IDM0521787

Synonyms (44)

Synonym
MEGXP0_000476
ACON1_000096
NCGC00168798-01
beta-d-glucopyranoside, (2e)-3-phenyl-2-propenyl 6-o-alpha-l-arabinopyranosyl-
CHEBI:139523
rosavin
BRD-K76037119-001-01-2
A841023
(2e)-3-phenyl-2-propenyl 6-o-alpha-l-arabinopyranosyl-beta-d-glucopyranoside
84954-92-7
rosavidin
1r72c0rome ,
unii-1r72c0rome
rosavins
S3844
beta-d-glucopyranoside, (2e)-3-phenyl-2-propen-1-yl 6-o-alpha-l-arabinopyranosyl-
SCHEMBL6441835
Q-201679
rosavin (constituent of rhodiola rosea) [dsc]
rosavin, (-)-
.beta.-d-glucopyranoside, (2e)-3-phenyl-2-propenyl 6-o-.alpha.-l-arabinopyranosyl-
rosavin [usp-rs]
.beta.-d-glucopyranoside, (2e)-3-phenyl-2-propen-1-yl 6-o-.alpha.-l-arabinopyranosyl-
.beta.-d-glucopyranoside, 3-phenyl-2-propenyl 6-o-.alpha.-l-arabinopyranosyl-, (e)-
(-)-rosavin
rosavin, united states pharmacopeia (usp) reference standard
AS-72651
(2r,3r,4s,5s,6r)-2-{[(2e)-3-phenylprop-2-en-1-yl]oxy}-6-({[(2s,3r,4s,5s)-3,4,5-trihydroxyoxan-2-yl]oxy}methyl)oxane-3,4,5-triol
rosavin, >=98% (hplc)
AKOS030573529
HY-N0507
mfcd03427685
(2r,3r,4s,5s,6r)-2-(cinnamyloxy)-6-((((2s,3r,4s,5s)-3,4,5-trihydroxytetrahydro-2h-pyran-2-yl)oxy)methyl)tetrahydro-2h-pyran-3,4,5-triol
(2r,3r,4s,5s,6r)-2-[(e)-3-phenylprop-2-enoxy]-6-[[(2s,3r,4s,5s)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol
b-d-glucopyranoside, (2e)-3-phenyl-2-propenyl6-o-a-l-arabinopyranosyl-
HMS3885G08
CCG-268979
CS-0009047
EX-A5551
DTXSID101027577
NCGC00168798-02
beta-d-glucopyranoside, 3-phenyl-2-propenyl 6-o-alpha-l-arabinopyranosyl-, (e)-
rosavin (constituent of rhodiola rosea)
rosavin (usp-rs)

Research Excerpts

Overview

Rosavin is a bioactive antidepressant component isolated from Rhodiola rosea L.

ExcerptReferenceRelevance
"Rosavin is a bioactive antidepressant component isolated from Rhodiola rosea L. "( A Simple and Rapid UPLC Method for the Determination of Rosavin in Rat Plasma and Its Application to a Pharmacokinetic Study.
Chen, D; Hu, S; Igor, LP; Shen, J; Sun, H; Xiang, Z; Zheng, X, 2016
)
2.12

Treatment

Rosavin treatment significantly improved survival rate and intestinal damage in irradiated rats by modulating the inflammatory response and oxidative stress.

ExcerptReferenceRelevance
"Rosavin-treated mice showed reduced infarct volume, neuronal loss and neuronal cytotoxicity in I/R-injured brains."( Rosavin protects the blood-brain barrier against ischemia/reperfusion-induced cerebral injury by regulating MAPK-mediated MMPs pathway.
Li, L; Tang, L; Wang, C; Yang, Z; Zou, H, 2023
)
3.07
"The rosavin treatment significantly improved survival rate and intestinal damage in irradiated rats by modulating the inflammatory response and oxidative stress."( The Protective Effect of Rosavin from Rhodiola rosea on Radiation-Induced Intestinal Injury.
Chen, H; Chen, K; Guo, K; Lu, Q; Luo, Y; Sha, W; Wang, J; Zhang, C; Zheng, Y; Zhou, W; Zhuo, Z, 2020
)
1.34

Pharmacokinetics

ExcerptReferenceRelevance
" The pharmacokinetic parameters were analyzed using the drug and statistics software."( A Simple and Rapid UPLC Method for the Determination of Rosavin in Rat Plasma and Its Application to a Pharmacokinetic Study.
Chen, D; Hu, S; Igor, LP; Shen, J; Sun, H; Xiang, Z; Zheng, X, 2016
)
0.68

Bioavailability

ExcerptReferenceRelevance
" The simple and rapid UPLC method was successfully applied to the pharmacokinetic and bioavailability study of rosavin in rats."( A Simple and Rapid UPLC Method for the Determination of Rosavin in Rat Plasma and Its Application to a Pharmacokinetic Study.
Chen, D; Hu, S; Igor, LP; Shen, J; Sun, H; Xiang, Z; Zheng, X, 2016
)
0.89
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (8 Product(s))

Product Categories

Product CategoryProducts
Herbs, Botanicals & Homeopathy5
Active Lifestyle & Fitness3

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Gaia Herbs Adrenal Health Daily Support -- 180 Vegan Liquid Phyto-CapsGaia HerbsHerbs, Botanicals & Homeopathy Rosavins2024-11-29 10:47:42
Gaia Herbs Adrenal Health Daily Support -- 60 CapsulesGaia HerbsHerbs, Botanicals & Homeopathy Rosavins2024-11-29 10:47:42
Gaia Herbs Adrenal Health® Daily Support -- 120 Vegan Liquid Phyto-CapsGaia HerbsHerbs, Botanicals & Homeopathy Rosavins2024-11-29 10:47:42
Gaia Herbs Single Herbs Rhodiola Rosea -- 120 Vegan Liquid Phyto-Caps®Gaia HerbsHerbs, Botanicals & Homeopathy Rosavins2024-11-29 10:47:42
Natural Factors Stress-Relax® Adrenal Serenity -- 60 Vegetarian CapsulesNatural FactorsHerbs, Botanicals & HomeopathyRosavins, Withanolides2024-11-29 10:47:42
Vega Sport® Energizer Sugar-Free Strawberry Lemonade -- 35 ServingsVegaActive Lifestyle & Fitnesscitric acid, Vitamin C, Caffeine, citric acid, malic acid, Rosavins2024-11-29 10:47:42
Vega Sport® Premium Energizer Acai Berry -- 25 ServingsVegaActive Lifestyle & Fitnesscitric acid, Caffeine, citric acid, malic acid, Rosavins, Vitamin B122024-11-29 10:47:42
Vega Sport® Premium Energizer Strawberry Lemonade -- 25 ServingsVegaActive Lifestyle & Fitnesscitric acid, Caffeine, citric acid, malic acid, Rosavins, Vitamin B122024-11-29 10:47:42

Drug Classes (1)

ClassDescription
O-acyl carbohydrateA carbohydrate derivative in which the hydrogen atom of at least one alcoholic hydroxy group of a carbohydrate has been replaced by an acyl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (8.33)29.6817
2010's15 (62.50)24.3611
2020's7 (29.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.54 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index5.27 (4.65)
Search Engine Demand Index74.68 (26.88)
Search Engine Supply Index3.98 (0.95)

This Compound (31.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (8.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (92.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]