EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor

A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33).

ChEBI ID: 64996

Members (9)

Member	Definition	Class
2,5-dihydroxybenzoic acid	A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.	2,5-dihydroxybenzoic acid
baicalein	A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.	baicalein
benzoic acid	A compound comprising a benzene ring core carrying a carboxylic acid substituent.	benzoic acid
caffeic acid	A hydroxycinnamic acid that is cinnamic acid in which the phenyl ring is substituted by hydroxy groups at positions 3 and 4. It exists in cis and trans forms; the latter is the more common.	caffeic acid
dicranin	A trienoic fatty acid, that is octadecanoic acid containing double bonds at positions 9, 12 and 15 and a triple bond at position 6. Isolated from Dicranum scoparium, it exhibits antibacterial activity and inhibitory activity against arachidonate 15-lipoxygenase.	(9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoic acid
ebselen	A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.	ebselen
gallic acid	A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.	gallic acid
pd 146176	An organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits.	PD-146176
sodium benzoate	An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.	sodium benzoate

Research

Studies (9,865)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	1,312 (13.30)	18.7374
1990's	1,229 (12.46)	18.2507
2000's	2,119 (21.48)	29.6817
2010's	3,733 (37.84)	24.3611
2020's	1,472 (14.92)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	132 (1.27%)	5.53%
Reviews	299 (2.88%)	6.00%
Case Studies	146 (1.41%)	4.05%
Observational	2 (0.02%)	0.25%
Other	9,795 (94.42%)	84.16%

Protein Targets (364)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	6.8661	1	7
15-lipoxygenase, partial	Homo sapiens (human)	Potency	0.8188	1	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	Leishmania major strain Friedlin	Potency	7.5686	1	1
67.9K protein	Vaccinia virus	Potency	19.7020	2	2
acetylcholinesterase	Homo sapiens (human)	Potency	42.0796	2	2
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	4.7549	1	8
alpha-galactosidase	Homo sapiens (human)	Potency	32.4648	2	2
Alpha-synuclein	Homo sapiens (human)	Potency	4.4780	1	3
Amyloid-beta precursor protein	Homo sapiens (human)	Potency	16.3601	1	1
AR protein	Homo sapiens (human)	Potency	23.2909	4	4
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	21.9744	2	2
ATAD5 protein, partial	Homo sapiens (human)	Potency	7.9081	3	3
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	9.2487	5	7
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	6.7456	1	1
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	26.1216	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	11.0792	1	2
BRCA1	Homo sapiens (human)	Potency	10.8820	1	2
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	1.4125	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	9.2429	1	4
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	7.0289	2	5
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	4.1259	1	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	16.3482	1	3
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	57.1220	2	2
Chain A, Cruzipain	Trypanosoma cruzi	Potency	26.6514	2	2
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	12.5893	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	3.9257	2	10
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	32.5733	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	8.0651	2	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	15.3893	3	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	6.7103	2	10
Chain B, HADH2 protein	Homo sapiens (human)	Potency	3.9257	2	10
chromobox protein homolog 1	Homo sapiens (human)	Potency	42.5436	2	3
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	2.2409	1	3
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	2.0304	1	3
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	14.2076	1	3
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	20.2409	2	6
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	1.7377	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	49.5336	1	2
D(1A) dopamine receptor	Homo sapiens (human)	Potency	22.3872	1	1
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	0.6310	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	35.4813	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	3.1623	1	1
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	9.1318	2	2
DNA polymerase III, partial	Bacillus subtilis	Potency	4.7444	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	44.5452	2	5
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	7.0764	1	5
endonuclease IV	Escherichia coli	Potency	7.9433	1	1
Endothelin receptor type B	Rattus norvegicus (Norway rat)	Potency	22.3872	1	1
Endothelin-1 receptor	Rattus norvegicus (Norway rat)	Potency	22.3872	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	34.4339	9	11
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	37.4444	2	2
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	38.9850	6	9
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	0.9960	1	5
EWS/FLI fusion protein	Homo sapiens (human)	Potency	21.5597	4	8
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	62.2336	1	1
flap endonuclease 1	Homo sapiens (human)	Potency	53.0324	1	4
fructose-bisphosphate aldolase A	Oryctolagus cuniculus (rabbit)	Potency	21.1699	1	2
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	20.2409	1	3
geminin	Homo sapiens (human)	Potency	17.3379	4	9
GLI family zinc finger 3	Homo sapiens (human)	Potency	16.4885	2	3
glp-1 receptor, partial	Homo sapiens (human)	Potency	14.1254	1	1
GLS protein	Homo sapiens (human)	Potency	6.5519	2	4
glucocerebrosidase	Homo sapiens (human)	Potency	35.5869	1	4
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	9.8875	3	3
glucokinase regulatory protein	Homo sapiens (human)	Potency	14.1254	1	1
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	24.8168	2	2
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	Homo sapiens (human)	Potency	25.1189	1	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	Homo sapiens (human)	Potency	12.5893	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	55.4657	1	1
hemoglobin subunit beta	Homo sapiens (human)	Potency	31.6228	1	1
hexokinase-4 isoform 1	Homo sapiens (human)	Potency	14.1254	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	2.4283	2	15
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	10.6660	1	6
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	31.8759	2	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	44.6684	1	1
huntingtin isoform 2	Homo sapiens (human)	Potency	35.4813	1	1
hypothetical protein, conserved	Trypanosoma brucei	Potency	14.8294	4	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	17.5594	2	4
IDH1	Homo sapiens (human)	Potency	23.1093	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	8.2852	1	2
Integrin beta-3	Homo sapiens (human)	Potency	8.2852	1	2
Interferon beta	Homo sapiens (human)	Potency	18.5569	1	3
interleukin 8	Homo sapiens (human)	Potency	47.3079	1	1
isocitrate dehydrogenase 1, partial	Homo sapiens (human)	Potency	50.1187	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	0.1419	1	2
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	5.2154	1	6
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	15.8489	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	35.2601	4	8
luciferase	Photuris pensylvanica (Pennsylania firefly)	Potency	18.0789	3	5
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	4.0027	1	2
Microtubule-associated protein tau	Homo sapiens (human)	Potency	9.7118	2	14
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	23.7531	2	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	10.0000	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	12.5893	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	2.1154	1	2
Nrf2	Homo sapiens (human)	Potency	29.2953	2	2
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	5.5630	3	5
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	19.1040	2	14
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	39.9920	2	2
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	10.0000	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	125.8920	1	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	14.1254	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	28.6954	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	33.8078	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	13.6236	1	8
plasminogen precursor	Mus musculus (house mouse)	Potency	11.2947	1	2
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	3.0741	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	3.0252	1	3
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	35.4813	1	1
PPM1D protein	Homo sapiens (human)	Potency	18.5569	1	2
pyruvate kinase	Leishmania mexicana mexicana	Potency	15.5513	5	5
pyruvate kinase PKM isoform a	Homo sapiens (human)	Potency	5.1189	4	4
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	10.0000	2	2
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	31.6228	1	1
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	26.6032	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	14.4270	1	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	59.9623	3	3
RGS12	Homo sapiens (human)	Potency	12.5893	1	1
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	20.4054	2	2
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	2.9935	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Potency	5.7988	1	1
Smad3	Homo sapiens (human)	Potency	23.7531	1	2
Sodium channel protein type 1 subunit alpha	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	Potency	5.7988	1	1
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	14.2191	1	2
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	6.3096	1	1
TDP1 protein	Homo sapiens (human)	Potency	14.1651	2	19
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	44.6684	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	28.9104	2	5
Thrombopoietin	Homo sapiens (human)	Potency	3.1623	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	35.5787	2	4
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	44.6684	2	2
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	10.0000	2	2
transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	Potency	31.6228	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	0.6310	1	1
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	11.2947	1	2
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	11.2947	1	2
USP1 protein, partial	Homo sapiens (human)	Potency	31.6228	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	58.8496	2	2
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	15.9571	1	6
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	49.0025	1	1
WRN	Homo sapiens (human)	Potency	5.3233	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	IC50	2.2555	2	2
1-deoxy-D-xylulose 5-phosphate reductoisomerase	Escherichia coli K-12	IC50	2.2000	1	1
4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens (human)	IC50	12,800.0000	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	Homo sapiens (human)	IC50	71.2575	1	8
5-hydroxytryptamine receptor 7	Homo sapiens (human)	IC50	350.0000	1	1
72 kDa type IV collagenase	Homo sapiens (human)	IC50	71.2575	1	8
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	28.0050	2	2
Acetylcholinesterase	Homo sapiens (human)	IC50	15.0000	1	1
Adenosine receptor A1	Rattus norvegicus (Norway rat)	Ki	8.2600	3	3
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Ki	6.5500	2	2
Alpha-(1,3)-fucosyltransferase 7	Homo sapiens (human)	IC50	71.2575	1	8
Alpha-glucosidase MAL12	Saccharomyces cerevisiae S288C	IC50	300.0000	1	1
Alpha-synuclein	Homo sapiens (human)	IC50	6.3150	2	2
Aminopeptidase N	Sus scrofa (pig)	IC50	100.0000	1	1
Angiotensin-converting enzyme	Homo sapiens (human)	IC50	7,700.0000	1	1
Angiotensin-converting enzyme 2	Homo sapiens (human)	IC50	0.6700	1	1
Anthrax toxin receptor 2	Homo sapiens (human)	IC50	300.0000	1	1
Arrestin, beta 1	Homo sapiens (human)	IC50	1.5240	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	41.0000	1	1
Aurora kinase B	Homo sapiens (human)	IC50	4.0600	1	1
Autoinducer 2-binding periplasmic protein LuxP	Vibrio harveyi	IC50	50.0000	1	1
Beta-lactamase	Klebsiella pneumoniae	IC50	2,000.0000	1	1
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	IC50	0.7575	4	4
Bile salt export pump	Homo sapiens (human)	IC50	10.0000	1	1
Carbonic anhydrase	Candida albicans SC5314	Ki	24.4000	1	1
Carbonic anhydrase	Dicentrarchus labrax (European seabass)	Ki	4.1300	1	1
Carbonic anhydrase 1	Homo sapiens (human)	Ki	509.4800	4	5
Carbonic anhydrase 12	Homo sapiens (human)	Ki	7.5400	2	2
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	9.8600	1	1
Carbonic anhydrase 14	Homo sapiens (human)	Ki	37.0150	2	2
Carbonic anhydrase 2	Homo sapiens (human)	IC50	5,000.0000	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	312.7250	5	6
Carbonic anhydrase 3	Homo sapiens (human)	Ki	7.4900	1	1
Carbonic anhydrase 4	Homo sapiens (human)	Ki	42.2500	2	2
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	3,507.0400	2	2
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	9.9700	1	1
Carbonic anhydrase 6	Homo sapiens (human)	Ki	6.1300	1	1
Carbonic anhydrase 7	Homo sapiens (human)	Ki	37.0350	2	2
Carbonic anhydrase 9	Homo sapiens (human)	Ki	50,004.5300	3	3
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit alpha 3	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit beta	Homo sapiens (human)	IC50	10.0000	1	1
Caspase-1	Homo sapiens (human)	IC50	4.0400	1	1
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	Enterobacter cloacae	Ki	100.0000	1	1
Chain A, RNA-directed RNA polymerase NS5	Dengue virus 2 16681-PDK53	IC50	35.0600	1	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	Enterobacter cloacae	Ki	100.0000	1	1
Cholinesterase	Equus caballus (horse)	IC50	10.4740	2	2
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	Homo sapiens (human)	IC50	71.2575	1	8
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	6.5300	1	1
Cytochrome P450 11B1, mitochondrial	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Ki	1.2200	1	1
Cytochrome P450 1B1	Homo sapiens (human)	Ki	0.2600	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	29.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	9.2000	1	1
D-amino-acid oxidase	Homo sapiens (human)	IC50	62.1723	4	4
D-amino-acid oxidase	Homo sapiens (human)	Ki	22.2800	5	5
D-aspartate oxidase	Homo sapiens (human)	IC50	10,000.0000	2	2
Death-associated protein kinase 1	Homo sapiens (human)	IC50	120.0000	1	1
Dipeptidyl peptidase 4	Homo sapiens (human)	IC50	102.3250	2	2
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	IC50	200.0000	1	1
E-selectin	Homo sapiens (human)	IC50	500.0000	1	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	Homo sapiens (human)	IC50	1.1500	1	1
eukaryotic translation initiation factor 4E isoform 1	Mus musculus (house mouse)	IC50	1.1500	1	1
Fructose-1,6-bisphosphatase 1	Homo sapiens (human)	IC50	29.0000	1	1
G protein-coupled receptor kinase 6	Homo sapiens (human)	IC50	8.7000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	IC50	28.2000	1	1
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	6.5300	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	Ki	5.6234	1	1
Gamma-butyrobetaine dioxygenase	Homo sapiens (human)	IC50	0.7420	5	5
Glucocorticoid receptor	Homo sapiens (human)	IC50	19.0000	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	Homo sapiens (human)	IC50	13.2000	1	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	IC50	15.0867	3	3
hexokinase	Trypanosoma brucei brucei TREU927	IC50	0.9009	1	1
Histone deacetylase 5	Homo sapiens (human)	IC50	3.4000	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	6.5333	3	3
Histone deacetylase 9	Homo sapiens (human)	IC50	3.7000	1	1
Histone-lysine N-methyltransferase EHMT1	Homo sapiens (human)	IC50	0.7300	1	1
Histone-lysine N-methyltransferase EHMT2	Homo sapiens (human)	IC50	0.4000	1	1
Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)	Ki	0.0940	3	3
Insulin-degrading enzyme	Homo sapiens (human)	IC50	33.3520	3	3
Integrase	Human immunodeficiency virus 1	IC50	3.2960	5	5
L-selectin	Homo sapiens (human)	IC50	27.6000	1	1
Lactoylglutathione lyase	Homo sapiens (human)	IC50	11.0000	1	1
large T antigen	Betapolyomavirus macacae	IC50	13.9100	1	1
Linoleate 9S-lipoxygenase-4	Glycine max (soybean)	IC50	22.0000	1	1
Lysine-specific demethylase 4E	Homo sapiens (human)	IC50	3.0000	1	1
Lysine-specific demethylase 4E	Homo sapiens (human)	Ki	4.3300	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	12.5000	1	1
Lysosomal alpha-glucosidase	Homo sapiens (human)	IC50	500.0000	1	1
Macrophage migration inhibitory factor	Homo sapiens (human)	IC50	2.4000	1	1
Macrophage migration inhibitory factor	Homo sapiens (human)	Ki	0.5700	2	2
Matrilysin	Homo sapiens (human)	IC50	71.2575	1	8
Methionine aminopeptidase 2	Homo sapiens (human)	IC50	2.4300	1	1
MPI protein	Homo sapiens (human)	IC50	0.2905	2	2
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	54.0000	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	54.0000	1	1
neutrophil cytosol factor 1	Homo sapiens (human)	IC50	0.3900	1	1
Neutrophil cytosol factor 1	Homo sapiens (human)	Ki	125.0000	3	3
Nicotinate phosphoribosyltransferase	Homo sapiens (human)	Ki	0.0019	1	1
Nitric oxide synthase, inducible	Mus musculus (house mouse)	IC50	50.0000	1	1
P-selectin	Homo sapiens (human)	IC50	19.1000	1	1
Pancreatic triacylglycerol lipase	Sus scrofa (pig)	IC50	1,000.0000	1	1
perilipin-1	Homo sapiens (human)	IC50	3.4100	1	1
perilipin-5	Homo sapiens (human)	IC50	1.1010	1	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	Homo sapiens (human)	IC50	0.1110	1	1
phosphomannomutase 2	Homo sapiens (human)	IC50	0.6720	1	1
Plasminogen activator inhibitor 1	Homo sapiens (human)	IC50	6.6000	1	1
Polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens (human)	IC50	1.3700	1	1
Polyphenol oxidase 2	Agaricus bisporus	IC50	425.3220	5	5
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	58.6167	2	3
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus (Norway rat)	IC50	10.0000	2	2
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	IC50	31.5320	2	5
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Ki	1.6000	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	IC50	27.7850	3	6
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	2.9133	3	3
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	Ki	2.7400	3	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	IC50	51.0929	3	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	Rattus norvegicus (Norway rat)	IC50	0.2600	1	1
Procathepsin L	Homo sapiens (human)	IC50	0.6700	1	1
Progesterone receptor	Homo sapiens (human)	IC50	15.0000	1	1
Prolyl 4-hydroxylase subunit alpha-1	Gallus gallus (chicken)	Ki	486.6667	1	3
Prolyl endopeptidase	Homo sapiens (human)	IC50	36.0000	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	150.0000	1	1
Prostaglandin G/H synthase 1	Bos taurus (cattle)	IC50	2.1000	1	1
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	150.0000	1	1
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	7,100.0000	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	10.0000	1	1
Receptor-type tyrosine-protein phosphatase S	Homo sapiens (human)	IC50	10.3000	1	1
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	IC50	0.6700	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	6.8900	2	3
Replicase polyprotein 1ab	Human coronavirus 229E	IC50	0.6700	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	0.9708	19	24
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	0.7000	2	4
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1	IC50	100.0000	1	1
RNA polymerase beta subunit (EC 2.7.7.6), partial	Escherichia coli	IC50	11.6872	1	1
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	IC50	22.6000	1	1
Serine racemase	Homo sapiens (human)	IC50	10,000.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	9.0000	1	1
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	IC50	314.0000	1	1
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	IC50	40.0000	1	1
Sialidase-2	Homo sapiens (human)	IC50	130.0000	1	1
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Solute carrier family 22 member 20	Mus musculus (house mouse)	Ki	13.8019	1	2
Solute carrier family 22 member 6	Mus musculus (house mouse)	Ki	252.0945	1	2
Spike glycoprotein	Betacoronavirus England 1	IC50	0.6700	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	IC50	0.6700	1	1
Squalene monooxygenase	Rattus norvegicus (Norway rat)	IC50	73.0000	1	1
Structural capsid protein	Human immunodeficiency virus 1	IC50	0.0467	1	1
Sucrase-isomaltase, intestinal	Homo sapiens (human)	IC50	43.5000	2	2
Sucrase-isomaltase, intestinal	Rattus norvegicus (Norway rat)	IC50	156.0000	2	2
Sulfhydryl oxidase 1	Homo sapiens (human)	IC50	5.4000	1	1
Testosterone 17-beta-dehydrogenase 3	Homo sapiens (human)	IC50	97.6100	2	2
Tissue-type plasminogen activator	Homo sapiens (human)	IC50	6.6000	1	1
Toll-like receptor 2	Mus musculus (house mouse)	IC50	69.2500	1	1
Toxin B	Clostridioides difficile	IC50	0.0172	1	1
TPA: protein transporter TIM10	Saccharomyces cerevisiae S288C	IC50	5.2900	2	2
TPA: protein transporter TIM23	Saccharomyces cerevisiae S288C	IC50	0.8800	1	1
Transmembrane protease serine 2	Homo sapiens (human)	IC50	0.6700	1	1
Trypsin-1	Homo sapiens (human)	IC50	3.7000	1	1
Trypsin-2	Homo sapiens (human)	IC50	3.7000	1	1
Trypsin-3	Homo sapiens (human)	IC50	3.7000	1	1
Tyrosinase	Homo sapiens (human)	Ki	520.0000	1	1
Tyrosine-protein kinase Yes	Homo sapiens (human)	IC50	3.3000	1	1
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50	100.0000	1	1
UDP-glucose 4-epimerase	Homo sapiens (human)	IC50	0.0140	1	1
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)	IC50	5.7000	2	2
Urease subunit alpha	Helicobacter pylori 26695	IC50	82.5780	5	5
Urease subunit alpha	Helicobacter pylori 26695	Ki	0.2260	1	1
Urease subunit beta	Helicobacter pylori 26695	IC50	82.5780	5	5
Urease subunit beta	Helicobacter pylori 26695	Ki	0.2260	1	1
Urokinase-type plasminogen activator	Homo sapiens (human)	IC50	6.6000	1	1
Urokinase-type plasminogen activator	Mus musculus (house mouse)	IC50	6.6000	1	1
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	IC50	37.4000	2	2
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	IC50	2.7900	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Angiotensin-converting enzyme 2	Homo sapiens (human)	EC50	4.6700	1	1
Beta-lactamase	Klebsiella pneumoniae	Kd	1,000.0000	1	1
D-amino-acid oxidase	Homo sapiens (human)	Kd	4.5000	3	3
D-amino-acid oxidase	Sus scrofa (pig)	Kd	2.3000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	16.5000	2	2
Gamma-butyrobetaine dioxygenase	Homo sapiens (human)	Kd	4.1000	2	2
hexokinase HKDC1	Homo sapiens (human)	EC50	38.8000	1	1
hexokinase-1 isoform HKI	Homo sapiens (human)	EC50	41.9000	1	1
Metabotropic glutamate receptor 5	Homo sapiens (human)	EC50	10.0000	1	1
Polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens (human)	Kd	0.9240	1	1
Procathepsin L	Homo sapiens (human)	EC50	4.6700	1	1
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	EC50	4.6700	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	EC50	4.6700	1	1
Replicase polyprotein 1ab	Human coronavirus 229E	EC50	4.6700	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	3.4925	3	4
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	4.0933	2	3
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Kd	18.4000	3	3
Spike glycoprotein	Betacoronavirus England 1	EC50	4.6700	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	EC50	4.6700	1	1
streptokinase A precursor	Streptococcus pyogenes M1 GAS	EC50	1.5190	1	1
Transmembrane protease serine 2	Homo sapiens (human)	EC50	4.6700	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Androgen receptor	Homo sapiens (human)	EC150	18.9000	1	1
Cyclic AMP-responsive element-binding protein 1	Homo sapiens (human)	AC50	13.5000	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	AC50	14.5280	1	1
Glucocorticoid receptor	Homo sapiens (human)	EC150	18.9000	1	1
H3 histone acetyltransferase	Candida albicans SC5314	AC50	1.5500	1	1
hypothetical protein CAALFM_CR05890CA	Candida albicans SC5314	AC50	1.5500	1	1
Lactoperoxidase	Bos taurus (cattle)	Km	176.7800	1	1
Monocarboxylate transporter 1	Rattus norvegicus (Norway rat)	Km	3.0500	1	1