Compounds > cv 3611
Page last updated: 2024-11-13

cv 3611

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID71458136
SCHEMBL ID21113803
MeSH IDM0169719

Synonyms (2)

Synonym
cv-3611
SCHEMBL21113803
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (62)

Assay IDTitleYearJournalArticle
AID174766Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 1 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID195554The IC50 value was measured for inhibition of lipid autoxidation in rat brain homogenate.1995Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15
Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals.
AID187612Reducing activity determined by the use of stable radical alpha,alpha-di-phenyl-beta-picrylhydrazyl (DPPH)1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID182007In vivo percent inhibition of lipid peroxidation in rat brain homogenates at 10e-6 M1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID180669Reduction of lipid peroxide formed in rat brain homogenates.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID179361Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID179370Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 1 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID193258Antiarrhythmic activity against anesthetized rats after peroral administration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID193904Change in arterial blood pressure was measured at 0.1 mg/kg dose(iv) in anesthetized rats1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID170001Effect of AOS scavenger on premeture ventricular complexes PVCs, arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 3 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID170000Effect of AOS scavenger on premeture ventricular complexes PVCs, arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 1 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID195222The compound was tested for the inhibition of lipid peroxidation in rat liver microsomes induced by [Fe3+] at a concentration of 10E-5 M.1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation.
AID173159Antilipid peroxidation was determined1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID179362Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 1 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID212776Inhibitory activity of compound against thromboxane A2 synthase evaluated as percent inhibition of thromboxane B2 formation after 24 hr of administration of 10 mg/kg of compound in rat; not tested1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID170817Effect (100 mg/kg, po) on coronary reperfusion-induced arrhythmias was assessed in anesthetized rats.(Intervals of ventricular tachycardia (VT)+ventricular fibrillation (VF) within 600 s1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID183780Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 10 mg/kg; 5/51988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID183785Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 10 mg/kg; 13/131988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID174777Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat duration at 1 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID190982Protective effect was evaluated by measuring the urinary total protein by peroral administering 100 mg/kg per day for four weeks in adriamycin induced proteinuria in 7 rats for four weeks.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID179373Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, timesat 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID80298Inhibitory activity on atrial rate in isolated Guinea pig right atrea at 0.1 mg/mL concentration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID166530The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells; not tested1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID169999Effect of AOS scavenger on premeture ventricular complexes PVCs, arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID193140inhibitory activity was tested against anesthetized rats at 100 mg/kg1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID25509Partition ratio obtained from HPLC analysis.1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation.
AID183789Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat incidence at 10 mg/kg; 4/51988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID179970Inhibition of lipid peroxidation was determined with rat brain tissue homogenates.1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID183775Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 10 mg/kg; 4/131988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID80196Inhibitory activity on atrial contractility in isolated Guinea pig right atrea at 0.3 mg/mL concentration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID170811Effect (0.1 mg/kg, iv) on coronary reperfusion-induced arrhythmias was assessed in anesthetized rats.(Intervals of ventricular tachycardia (VT)+ventricular fibrillation (VF) within 600 s1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID195076The compound was tested for the inhibition of lipid peroxidation in rat liver microsomes induced by [Fe2+] at a concentration of 10E-5 M.1991Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
3-O-alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation.
AID16877The reaction rate constant(K) by measuring competition with nitroblue tetrazolium of the superoxide radicals formed by xanthine oxidase/xanthine1995Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15
Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals.
AID80297Inhibitory activity on atrial rate in isolated Guinea pig right atrea at 0.03 mg/mL concentration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID183778Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 3 mg/kg; 3/101988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID174775Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 3 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID193905Change in arterial blood pressure was measured at 0.3 mg/kg dose(iv) in anesthetized rats1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID183788Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 3 mg/kg; 10/101988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID183790Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat incidence at 1 mg/kg; 12/141988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID184873Minimum effective dose of the compound1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID179969Inhibition of lipid peroxidation was determined with rat brain tissue homogenates1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID193139inhibitory activity was tested against anesthetized rats at 10 mg/kg1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID183777Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 1 mg/kg; 5/141988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID193257Antiarrhythmic activity against anesthetized rats after intravenous administration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID80299Inhibitory activity on atrial rate in isolated Guinea pig right atrea at 0.3 mg/mL concentration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID80194Inhibitory activity on atrial contractility in isolated Guinea pig right atrea at 0.1 mg/mL concentration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID80192Inhibitory activity on atrial contractility in isolated Guinea pig right atrea at 0.03 mg/mL concentration1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID174767Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 3 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID194567Change in heart rate was measured at 0.3 mg/kg dose(iv) in anesthetized rats1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID174774Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID194634Inhibitory effect on production of active oxygen species by rat peritoneal exudate macrophages1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID179372Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID212455Inhibitory activity of compound against thromboxane A2 synthase evaluated as molar concentration required to reduce thromboxane B2 formed by 50% after incubating PGH-2 with horse platelet microsomes; not tested1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID194566Change in heart rate was measured at 0.1 mg/kg dose(iv) in anesthetized rats1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID172458Protective effect was evaluated by measuring the urinary albumin by peroral administering 100 mg/kg per day for four weeks in adriamycin induced proteinuria 7 rats for four weeks.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID170816Effect (10 mg/kg, po) on coronary reperfusion-induced arrhythmias was assessed in anesthetized rats.(Intervals of ventricular tachycardia (VT)+ventricular fibrillation (VF) within 600 s.1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID174771Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID174768Effect of AOS scavenger on ventricular fibrillation (VF),arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 10 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID179371Effect of AOS scavenger on ventricular tachycardia (VT),arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 3 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
AID212602Inhibitory activity of compound against thromboxane A2 synthase evaluated as percent inhibition of thromboxane B2 formed by incubating PGH-2 with horse platelet microsomes at 10e-6 M; not tested1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
AID227994Inhibition of lipid peroxidation in rat liver microsomes.1992Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats.
AID179365Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, timesat 3 mg/kg1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aa 861
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone: structure given in first source. docebenone : A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group.		1.97101,4-benzoquinones;
acetylenic compound;
primary alcohol		EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor
tocopheroxy radical
tocopheroxy radical: RN given refers to radical ion (1+), (2R-(2R*(4R*,8R*)))-isomer; RN for cpd without isomeric designation not available 12/90		1.9810tocopherol
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9810aromatic ether;
nitrile;
polyether;
tertiary amino compound
mannitol
[no description available]		1.9710mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		1.9710alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		1.9810chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
cv 6504
CV 6504: structure given in first source		1.9710
mdl 73404
MDL 73404: structure given in first source; a hydrophilic cardioselective free radical scavenger; analog of alpha-tocopherol		1.9810
isbogrel
[no description available]		1.9710
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.6730ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		1.9710nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Arrhythmia
[description not available]		02.3820
Injury, Myocardial Reperfusion
[description not available]		01.9810
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.		01.9810
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.		02.3820
Basophilic Leukemia, Acute
[description not available]		01.9710
Leukemia, Basophilic, Acute
A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.		01.9710