A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.
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| "Whipple's disease is characterized morphologically by macrophages in the small intestine which store PAS-postive material, as well as coarsening and atrophy of the intestinal villi, with pseudocystic cavitations." | ( Boenigk, U; Falck, J; Franken, FH; Schmitt, H, 1975) |
| "Whipple's disease is characterized by typical endoscopic lesions in the duodenal wall." | ( Riemann, JF; Rösch, W, 1978) |
| "Whipple's disease is a rare multisystem disorder of infectious etiology." | ( McMenemy, A, 1992) |
| "A patient with Whipple's disease is described, and multiparameter flow cytometric examinations of several of the patient's phagocyte functions 3 and 9 mo after the start of oxytetracycline therapy are reported." | ( Bjerknes, R; Laerum, OD; Ødegaard, S, 1985) |
| "Whipple's disease is a systemic bacterial infection that once was uniformly fatal and now is treatable with several different antibiotics in most cases." | ( Feldman, M, 1986) |
| "Whipple's disease is a chronic systemic illness, the optimal treatment of which remains poorly defined." | ( Fleming, JL; Shorter, RG; Wiesner, RH, 1988) |
| "Two cases of Whipple's disease are reported in which a parallel course is confirmed between the clinical and ultrastructural findings." | ( González Campos, C; Mogena, HH; Navarro, V; Oliva, H, 1972) |
| "An unusual case of Whipple's disease is reported." | ( Bleibel, JM; Buge, A; Cabane, J; Kardouss, J; Poisson, M; Wechsler, B, 1983) |
| "Whipple's disease is frequently recognised only after numerous diagnostic sidetracks." | ( Gugler, R; Schäfer, PK; Schmidt, RE; Vogel, J, 1984) |
| "Whipple's disease is a multisystemic disorder in which almost all organ systems can be invaded by rod-shaped bacteria." | ( Feurle, GE; Marth, T, 1994) |
| "Whipple's disease is a chronic systemic syndrome which typically involves small intestinal mucosa." | ( Boni, R; Capasso, A; de Nucci, C; De Simone, R; Sessa, E, 1995) |
| "Whipple's disease is a rare systemic illness, with the main clinical feature being severe malabsorption syndrome." | ( Carnevale, V; Iannoni, C; Marcheggiano, A; Mazzuoli, G; Minisola, S; Romagnoli, E; Rosso, R, 1996) |
| "Whipple's disease is a rare infectious disease with systemic manifestation on different organs." | ( Bauer, S; Meier, R; Rowedder, A; Schlup, P; Wegmann, W, 1996) |
| "Whipple's disease is a systemic illness caused by a specific agent." | ( Altwegg, M; Dutly, F; Forrer, R; Goldenberger, D; Gunz, A; Höchli, M; Schaffner, A; Schoedon, G, 1997) |
| "Whipple's disease is a rare systemic infectious disease." | ( Singer, R, 1998) |
| "Although Whipple disease is typically evident with malabsorption, it can also present as uveitis without prominent gastrointestinal symptoms." | ( Cook, BE; Nishimura, JK; Pach, JM, 1998) |
| "Whipple's disease is a rare, generalized inflammatory disorder due to the recently described bacterium Tropheryma whippelii." | ( Ehninger, G; Mohm, J; Naumann, R; Schuler, U, 1998) |
| "Whipple's disease is characterized by malabsorption, weight loss, diarrhoea and abdominal pain, often preceded by a long period of migrating arthralgias." | ( Savelkoul, PH; Vandenbroucke-Grauls, CM; Zaaijer, HL, 1999) |
| "Whipple's disease is a multisystem disorder that was first reported just over 100 years ago." | ( Abrugiato, R; Cheng, WS; Forbes, GM; Garas, G, 2000) |
| "Whipple's disease is non-contagious, occurs mainly in middle-aged white males, and displays many, but not all, of the complications of hereditary haemochromatosis." | ( Weinberg, ED, 2001) |
| "Whipple disease is a rare infectious disorder with multiorgan manifestations and a widely varied clinical presentation." | ( Caples, SM; Petrovic, LM; Ryu, JH, 2001) |
| "Whipple disease is a multisystemic infectious disease due to Tropheryma whippelii that may present with prominent or isolated symptoms of either the central or the peripheral nervous system." | ( Besson, G; Cathebras, P; Durieu, I; Gerard, A; Liozon, E; Mosnier, JF; Robin, C; Rousset, H; Sarrot-Reynauld, F; Vighetto, A; Vital Durand, D, 2002) |
| "Whipple disease is a rare infection caused by the bacterium Tropheryma whippelii." | ( Deckert, M; Gross, WP; Klug, N; Löhr, M; Plum, G; Stenzel, W, 2004) |
| "Whipple's disease is a rare chronic disorder, which is caused by systemic infection with Tropheryma whipplei." | ( Kalt, A; Mahnel, R; Marth, T; Ring, S; Stallmach, A; Strober, W, 2005) |
| "Whipple's disease is a rare systemic infectious disease caused by the bacterium Tropheryma whippelii." | ( Alvarez Cuesta, CC; Arribas Castrillo, JM; Gallego Villalobos, M; García Bernárdez, AM; García Díez, AI; Vallina Alvarez, E, 2005) |
| "Whipple's disease is a rare chronic multi-systemic infectious disorder caused by the Gram-positive bacillus, Tropheryma whippelii." | ( Gounaris, T; Magira, EE; Sioula, E, 2005) |
| "Whipple disease is a relapsing systemic illness caused by Tropheryma whippelii." | ( Bonakis, A; Chatzipanagiotou, S; Ioannidis, A; Nicolaou, C; Papadopoulou, M; Potagas, C; Rentzos, M; Vagiakis, E; Vassilopoulos, D; Zouvelou, V, 2005) |
| "Whipple's disease is a rare infectious disorder affecting mostly middle aged men." | ( Marth, T, 2007) |
| "Whipple's disease is a systemic disorder caused by an infection with a gram-positive bacillus, Tropheryma whipplei." | ( Arnold, M; Clemetson, IA; Iizuka, T; Lieger, O; Otto, S, 2007) |
| "Whipple disease is a chronic infection caused by Tropheryma whipplei." | ( Bakkali, N; Biswas, S; Fenollar, F; Raoult, D; Rolain, JM, 2008) |
| "Whipple's disease is a very rare chronic multisystemic bacterial disease characterized by diarrhea, malabsorption, fever, and polyarthritis." | ( Dev, S; Deziel, PJ; Pulido, JS; Razonable, RR; Salomão, DR; Walker, RC, 2008) |
| "Whipple's disease is a chronic, multisystemic, curable, bacterial infection that usually affects middle-aged men." | ( Puéchal, X, 2009) |
| "Whipple's disease is a chronic multisystemic infection caused by Tropheryma whipplei." | ( Allers, K; Fenollar, F; Geelhaar, A; Ignatius, R; Kunkel, D; Loddenkemper, C; Moos, V; Moter, A; Raoult, D; Schinnerling, K; Schmidt, C; Schneider, T, 2010) |
| "Whipple's disease is a chronic infection caused by the actinomycete Tropheryma whipplei." | ( Feurle, GE; Junga, NS; Marth, T, 2010) |
| "Classic Whipple's disease is a chronic disease caused by Tropheryma whipplei." | ( Fenollar, F; Lagier, JC; Lepidi, H; Raoult, D, 2010) |
| "Whipple's disease is a rare, chronic infection caused by Tropheryma whipplei, an ubiquitary gram positive bacterium." | ( Battegay, M; Benz, D; Bloemberg, GV; Koligi, K; Mertz, D; Tyndall, A; Vogt, T; Walker, UA; Winter, L, 2011) |
| "Whipple's disease is a multisystemic infection caused by the ubiquitous bacterium Tropheryma whipplei." | ( Loddenkemper, C; Moos, V; Schneider, T, 2011) |
| "Whipple disease is a rare infection caused by Tropheryma whipplei." | ( Allanore, Y; Berthelot, JM; Caramaschi, P; Dieudé, P; Gossec, L; Gottenberg, JE; Hoppé, E; Kahan, A; Maury, E; Meunier, M; Morel, J; Puechal, X; Soubrier, M; Wipff, J, 2013) |
| "Whipple's disease is a rare multisystem infection caused by the actinomycete Tropheryma whipplei, first described by George Whipple in 1907." | ( Beale, L; Habboush, H; Lodge, F; Loughran, D; Stock, D, 2014) |
| "Whipple disease is a rare systemic illness characterized by arthralgias, chronic diarrhea, weight loss, fever, and abdominal pain." | ( Christidi, F; Kararizou, E; Potagas, C; Stamboulis, E; Triantafyllou, NI; Zalonis, I, 2014) |
| "Whipple's disease is a rare chronic multi-systemic infection, caused by Gram-positive bacillus Tropheryma whipplei." | ( Abbas, Z; Hassan, SM; Laeeq, SM; Luck, NH; Mubarak, M; Tasneem, AA, 2014) |
| "Whipple's disease is a systemic infection that sometimes is associated with cardiac manifestations." | ( Angelakis, E; Caus, T; Jos, SL; Raoult, D, 2015) |
| "Whipple's disease is a rare and chronic bacterial disease with multiorganic involvement." | ( Campelos, S; Couceiro, A; Dias, V; Luis, A; Oliveira, A; Ribeiro, I, 2014) |
| "Whipple disease is a rare and potentially fatal bacterial infection induced by a Gram-positive bacillus, Tropheryma whipplei." | ( André, R; Ehresmann, B; Seebach, JD; Stirnemann, J, 2016) |
| "Whipple disease is a rare, chronic multisystem infectious disease." | ( Coelho, F; Santana, I; Tábuas-Pereira, M; Vicente, M, 2016) |
| "Whipple's disease is a chronic systemic infection that is due to the bacterial agent Tropheryma whipplei and can be cured by appropriate antibiotic therapy." | ( Puéchal, X, 2016) |
| "Whipple's disease is considered an infection of middle-aged white men of European ancestry." | ( Langman, G; Moran, E; Papakonstantinou, D; Riste, MJ, 2017) |
| "Whipple's disease is a chronic, rare, multisystemic, infectious entity, described for the first time in 1907." | ( Alvarenga, MJ; Lopes, A; Mello E Silva, A; Santos, AF, 2018) |
| "Whipple disease is a rare chronic, systemic bacterial infection that predominantly affects the small intestine but also other organs of the body." | ( Anthony, SA; Eleff, ES; Kanikunnel, AM, 2020) |
| "Whipple disease is a rare cause of infectious optic nerve edema that may present with other rheumatoid and gastrointestinal symptoms." | ( Anthony, SA; Eleff, ES; Kanikunnel, AM, 2020) |
| "Whipple's disease is known to cause multiple varied systemic symptoms, and is a well-documented cause of culture-negative endocarditis." | ( Chen, Y; de Gijsel, D; Mahatanan, R; Martin, IW, 2023) |
| "Whipple's disease is a chronic multisystemic infectious disease that rarely presents as culture-negative endocarditis." | ( Delgado, DG; Ennis, DM; Kahn, MJ, 2023) |
| "Whipple's disease is a chronic infection due to Tropheryma whipplei, commonly reported in the Caucasian but not in the Chinese population." | ( Chan, JF; Chen, S; Chiu, KH; Hu, X; Li, T; Tong, TRS; Xing, F; Ye, H; Yuen, KY, 2023) |
| "Whipple disease is a rare disorder caused by infection with the gram-positive bacterium Tropheryma whipplei ." | ( Cheng, Y; Lu, KY; Shao, D, 2023) |