A role borne by a molecule that acts to counteract or neutralise the deleterious effects of organophosphates or acetylcholinesterase inhibitors (nerve agents).
ChEBI ID: 90753
| Member | Definition | Class |
|---|---|---|
| duodote | A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. | pralidoxime |
| pralidoxime | A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. | pralidoxime |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 163 (26.12) | 18.7374 |
| 1990's | 111 (17.79) | 18.2507 |
| 2000's | 162 (25.96) | 29.6817 |
| 2010's | 152 (24.36) | 24.3611 |
| 2020's | 36 (5.77) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 28 (4.15%) | 5.53% |
| Reviews | 35 (5.19%) | 6.00% |
| Case Studies | 85 (12.61%) | 4.05% |
| Observational | 1 (0.15%) | 0.25% |
| Other | 525 (77.89%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 706.8000 | 5 | 5 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 878.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | Kd | 140.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | K | 400.0000 | 4 | 4 |