A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active fungicide for which it is a profungicide.
ChEBI ID: 136645
| Member | Definition | Class |
|---|---|---|
| pyrazophos | A member of the class of pyrazolopyrimidines that is the ethyl ester of 2-[(diethoxyphosphorothioyl)oxy]-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid. A profungicide (by hydrolysis of the thionophosphate group to afford the corresponding 2-hydroxypyrazolopyrimidine fungicide), it is used to control Erysiphe, Helminthosporium and Rhynchospium in cereals. | pyrazophos |
| s-methyl benzo(1,2,3)thiadiazole-7-carbothioate | A benzothiadiazole that is the S-methyl thioester derivative of acibenzolar. A profungicide (by hydrolysis of the thioester group to give the corresponding carboxylic acid), it is used as a fungicide and plant activator on a variety of crops, including cotton, chili peppers, lettuce, onions, spinach, tobacco, and tomatoes. | acibenzolar-S-methyl |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (2.88) | 18.7374 |
| 1990's | 3 (2.88) | 18.2507 |
| 2000's | 35 (33.65) | 29.6817 |
| 2010's | 40 (38.46) | 24.3611 |
| 2020's | 23 (22.12) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (0.93%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 106 (99.07%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 44.6086 | 4 | 7 |
| AR protein | Homo sapiens (human) | Potency | 48.8968 | 6 | 7 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 0.0757 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 39.8107 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.9028 | 2 | 2 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 40.7375 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 48.9662 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 27.0772 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 15.4845 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 17.3739 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 56.6142 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 30.8956 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 11.7144 | 3 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.6379 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 32.0856 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 38.4097 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.7517 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 24.1348 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 24.1348 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.2626 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.1000 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 36.6216 | 5 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |