Marfan Syndrome

An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue. Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2.

Synonym
Marfan Syndrome

Excerpt	Reference
"The Marfan syndrome is an autosomal dominant heritable disorder of connective tissue with prominent involvement of the ocular, skeletal, and cardiovascular systems."	( Cutting, GR; Dietz, HC; Francomano, CA; Pyeritz, RE; Saraiva, JM, 1992)
"Marfan syndrome is known to have pulmonary manifestations such as pneumothorax."	( Boxer, R; König, P; Morrison, J; Pletcher, B, 1991)
"The Marfan syndrome is a serious heritable connective-tissue disorder characterized primarily by ocular, cardiovascular, and musculoskeletal abnormalities but also involving multiple other tissues and organs of the body."	( Bigley, RH; Godfrey, M; Hollister, DW; Koler, RD; Lovrien, E; Menashe, V; Weleber, RG; Zonana, J, 1990)
"Marfan syndrome is a hereditable disorder of connective tissue that causes several distinct cardiovascular abnormalities, including aortic regurgitation, dissection, and aneurysm."	( Baciewicz, FA; Grubb, B; Laden, N, 1990)
"Pregnancy in the Marfan syndrome is associated with two primary problems: potential catastrophic aortic dissection and the risk for having a child with the syndrome."	( Elkayam, U; Mehra, A; Ostrzega, E; Shotan, A, 1995)
"The Marfan syndrome is a heritable disease with an autosomal dominant inheritance."	( Capucho, R; Fernando, PM; Ferreira, A; Macedo, F, 1993)
"Marfan syndrome is a heritable disorder of connective tissue in which the most prominent abnormalities occur in the ocular, cardiovascular and skeletal systems."	( Yeh, SH; Yen, TC, 1993)
"Marfan syndrome is a heritable disorder of connective tissue which has been associated with mutations in a gene encoding fibrillin, a 350 kD glycoprotein found in microfibrils."	( Berg, JM; Bevilacqua, VL; Wu, YS, 1995)
"Marfan syndrome is an autosomal dominant connective tissue disorder characterized by skeletal, cardiovascular, and ocular anomalies."	( Arnold, PJ; Donohoe, MJ; Greenwald, MJ; Mets, MB, 1999)
"Marfan syndrome is an autosomal dominant disorder of connective tissue caused by mutations in fibrillin-1 (encoded by FBN1 in humans and Fbn1 in mice), a matrix component of extracellular microfibrils."	( Arking, DE; Bunton, TE; Dietz, HC; Frischmeyer, PA; Gayraud, B; Myers, L; Neptune, ER; Ramirez, F; Sakai, LY, 2003)
"Marfan syndrome is a connective tissue disorder with ocular, musculoskeletal and cardiovascular manifestations that are caused by mutations in fibrillin-1, the major constituent of extracellular microfibrils."	( Dietz, HC; Ramirez, F, 2007)
"The Marfan syndrome is an inherited multisystem disorder caused by mutations in fibrillin 1, with cardiovascular involvement being the most important feature of the phenoptype."	( Bendahan, D; Boehm, EA; Clarke, K; Crilley, JG; Rajagopalan, B; Styles, P; Wordsworth, P, 2007)
"Marfan syndrome is a common inherited disorder of connective tissue caused by deficiency of the matrix protein fibrillin-1."	( Dietz, HC; Judge, DP, 2008)
"Marfan syndrome is a systemic connective tissue disorder caused by mutations in the fibrillin-1 gene."	( Cameron, DE; Carrel, T; Dietz, HC; Habashi, J; Matt, P; Van Eyk, JE, 2008)
"Marfan syndrome is an inheritable connective tissue disorder with multisystem involvement and variable expression of signs and symptoms, caused by mutations within the fibrillin gene on chromosome 15q21."	( Elami, A; Ezra, Y; Gilon, D; Ginosar, Y; Pollak, A; Volach, V, 2006)
"Marfan syndrome is caused by mutations in fibrillin-1, which is one of the major constituents of connective tissue microfibrils."	( Cirulis, JT; Hubmacher, D; Keeley, FW; Miao, M; Reinhardt, DP, 2010)
"Marfan syndrome is a systemic connective tissue disorder that is inherited in an autosomal-dominant pattern with variable penetrance."	( Ikonomidis, JS; Jones, JA, 2010)
"Marfan syndrome is an inherited disease of the connective tissue."	( Centeno, J; Cortina, J; Evangelista, A; Forteza, A; García, D; García-Dorado, D; Gutiérrez, L; Rodríguez-Palomares, J; Sánchez, V; Sanz, P; Teixidó, G, 2011)
"Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent skeletal, ocular, and cardiovascular manifestations."	( Doelken, S; Gehle, P; Guo, G; Hetzer, R; Martin-Ventura, JL; Robinson, PN; von Kodolitsch, Y, 2011)
"Marfan syndrome is an inherited disorder of connective tissue based on abnormality of the FBN1 gene."	( Ishida, R; Kusaba, T; Nakanouchi, T; Takahashi, K, 2011)
"This review on Marfan syndrome is focused on the clinical heterogeneity and variability, the new diagnostic criteria as delineated by an expert group in 2010, the current knowledge on the molecular and pathogenetic etiology, and the options of the medical and surgical treament."	( Jokinen, E; Kaitila, I; Kokkonen, J, 2012)
"Marfan syndrome is an autosomal dominant disease characterized by aneurysm and dilatation of the aortic root, tall stature, and ectopia lentis."	( Ganburged, G; Moriyama, K; Suda, N, 2013)
"Marfan syndrome is associated with ventricular arrhythmia but risk factors including FBN1 mutation characteristics require elucidation."	( Adsay, BA; Aydin, A; Berger, J; Blankenberg, S; Detter, C; Hoffmann, BA; Keyser, B; Robinson, PN; Rybczynski, M; Schmidtke, J; Sheikhzadeh, S; Sondermann, C; Steven, D; von Kodolitsch, Y; Willems, S, 2013)
"Marfan syndrome is a connective tissue disorder with autosomal dominant inheritance caused by fibrillin gene mutation."	( Arranz-Marquez, E; Fatela-Cantillo, B; Figueroa, M; Teus, MÁ, 2015)
"Marfan syndrome is an autosomal dominant disease caused by mutations in the gene encoding for fibrillin-1 (FBN1)."	( Chan, AK; Chan, HH; Kozenko, M; Lostracco, R; Stevic, I, 2014)
"Marfan syndrome is a disorder of increased TGFβ signaling, and recent work in the mouse model suggests a role for TGFβ signaling in eye development and coloboma formation, suggesting a causal association between Marfan syndrome and coloboma."	( Barnett, CP; LeBlanc, SK; Morris, S; Taranath, D, 2014)
"Marfan syndrome is an autosomal dominant disorder, characterized by tall stature, long arms and legs, ectopia lentis, and aortic aneurysms and dissections."	( Fujita, D; Hirata, Y; Imai, Y; Takeda, N, 2014)
"Patients with Marfan syndrome are at risk for severe ventricular arrhythmias and SCD."	( Akbulak, RÖ; Daubmann, A; Hoffmann, BA; Jularic, M; Moser, J; Rybczynski, M; Schaeffer, BN; Schreiber, D; Sheikhzadeh, S; von Kodolitsch, Y; Willems, S, 2015)
"Marfan syndrome is an autosomal dominant inherited disorder of connective tissue."	( Arif, R; Ensminger, S; Kallenbach, K; Karck, M; Richter, K; Robinson, PN; Schwill, S; Seppelt, PC; Wagner, AH; Weber, A; Weymann, A; Zaradzki, M, 2016)
"Marfan syndrome is an autosomal dominant connective tissue disorder, predominantly affecting the ocular, skeletal and cardiovascular systems."	( Fedorenko, V; Loeys, BL; Meester, JA; Proost, D; VAN Laer, L; Zerbino, D; Zhurayev, R, 2016)
"Marfan syndrome is a hereditary disorder affecting the connective tissue and is caused by a mutation of the fibrillin-1 (FBN1) gene."	( Koo, HK; Lawrence, KA; Musini, VM, 2017)
"Marfan syndrome is a rare cause of heart failure due to primary or secondary cardiomyopathy."	( Angeletti, S; Anguissola, GB; Bono, MC; Ciccozzi, M; Costantino, S; Locorriere, L; Pantano, AL; Spoto, S; Terracciani, F; Valeriani, E, 2019)
"Marfan syndrome is an autosomal dominant connective tissue disease with an estimated incidence of 1 in 5000 individuals."	( Almeida, AG; Coelho, SG, 2020)
"Marfan syndrome is one of the most common inherited disorders of connective tissue caused by fibrillin-1 mutations, characterized by enhanced transcription factor AP-1 DNA binding activity and subsequently abnormally increased expression and activity of matrix-metalloproteinases (MMPs)."	( Arif, R; Franz, M; Frey, N; Hecker, M; Heckmann, MB; Jungmann, A; Kallenbach, K; Karck, M; Müller, OJ; Puehler, T; Remes, A; Wagner, AH; Zaradzki, M, 2021)
"Marfan syndrome is caused by mutations of the fibrillin-1 gene, which weakens the connective tissue integrity."	( Heno, J; Michel-Behnke, I; Pees, C, 2022)
"Marfan syndrome is a pleiotropic genetic connective tissue disorder most commonly involving the cardiovascular, skeletal, and ocular systems, which have abundant connective tissue."	( Mares Beltran, CF; Nesheiwat, N, 2023)
"Marfan syndrome is a genetic connective tissue disorder affecting skeletal, ocular, and cardiovascular organ systems."	( Burnyte, B; Gegieckiene, R; Kemezyte, A, 2023)

Excerpt	Reference
"The Marfan syndrome has been linked to the FBN1 gene encoding the microfibrillar glycoprotein fibrillin."	( Child, AH; Kielty, CM; Phillips, JE; Pope, FM; Shuttleworth, CA, 1994)
"Mouse models of Marfan syndrome have revealed that fibrillin-1 mutations perturb local TGFbeta signaling, in addition to impairing tissue integrity."	( Dietz, HC; Ramirez, F, 2007)
"Marfan syndrome has changed over the last few years: new diagnostic criteria have been proposed, new clinical entities recognised and life expectancy increased."	( Boileau, C; Jondeau, G; Michel, JB, 2011)
"Patients with Marfan syndrome have an increased risk of life-threatening aortic complications, mostly preceded by aortic dilatation."	( de Waard, V; den Hartog, AW; Franken, R; Groenink, M; Marquering, HA; Mulder, BJ; Radonic, T; Scholte, AJ; Spijkerboer, AM; Timmermans, J; van den Berg, MP; Zwinderman, AH, 2013)
"Patients with Marfan syndrome have an increased risk of life-threatening aortic complications, mostly preceded by aortic dilatation."	( de Vries, CJ; de Waard, V; den Hartog, AW; Franken, R; Groenink, M; Hibender, S; Mulder, BJ; Radonic, T; Zwinderman, AH, 2014)

Excerpt	Reference
"Estrogen treatment in Marfan syndrome is discussed with regard to beneficial effects, possible side-effects and optimal age for starting treatment."	( Aarskog, D; Knudtzon, J, 1988)
"The primary cause of early death in untreated Marfan syndrome (MFS) patients is aortic dilatation and dissection."	( Booms, P; Dietz, HC; Guo, G; Halushka, M; Hecht, J; Mundlos, S; Ney, A; Robinson, PN; Stricker, S, 2006)
"Beta-blockers are the standard treatment in Marfan syndrome (MFS)."	( Evangelista, A; Forteza, A; García-Dorado, D; González Mirelis, J; Gutiérrez, L; Ibáñez, B; Rodríguez-Palomares, J; Sánchez, V; Teixido-Tura, G, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	237 (27.85)	23.3326
1990's	107 (12.57)	12.5806
2000's	171 (20.09)	18.1394
2010's	257 (30.20)	28.8240
2020's	79 (9.28)	9.53

Drug	Relationship Strength	Studies	Trials
allantoin	low	1	0
quinacrine	low	1	0
betaine	low	1	0
carnitine	low	1	0
salicylic acid	low	3	0
bupropion	low	1	0
methylmalonic acid	low	1	0
cytosine	low	1	0
dimethyl sulfoxide	low	1	0
formaldehyde	medium	3	1
glycine	low	4	0
glycerol	low	1	0
histamine	low	2	0
nitrates	low	1	0
nitrites	low	1	0
nitrous oxide	low	1	0
pyridoxine	low	3	0
thiosulfates	low	1	0
urea	low	3	0
aminopropionitrile	low	5	0
homovanillic acid	low	1	0
hydroxyindoleacetic acid	low	1	0
acetaminophen	low	1	0
acetazolamide	low	1	0
albuterol	low	1	0
alendronate	low	1	0
diatrizoic acid	low	2	0
amiodarone	low	3	0
aspirin	low	1	0
aztreonam	low	1	0
bisoprolol	low	1	0
bupivacaine	low	1	0
verapamil	medium	2	1
carbamazepine	low	1	0
cetylpyridinium	low	1	0
deferoxamine	low	1	0
erythrosine	low	1	0
fentanyl	low	1	0
flumazenil	low	1	0
furosemide	low	2	0
gentamicin	low	2	0
guaifenesin	low	2	0
guanethidine	low	1	0
halothane	low	1	0
hydralazine	low	4	0
ibuprofen	low	1	0
iothalamic acid	low	1	0
2-propanol	medium	58	2
khellin	low	3	0
labetalol	low	2	0
metoprolol	low	4	0
metyrapone	low	1	0
nicardipine	low	2	0
nifedipine	low	2	0
nitroglycerin	low	3	0
phenazopyridine	low	1	0
phenobarbital	low	1	0
phenylbutazone	low	1	0
procainamide	low	1	0
procarbazine	low	1	0
resorcinol	low	1	0
sevoflurane	low	1	0
sotalol	low	1	0
sulfisoxazole	low	1	0
thalidomide	low	1	0
tranexamic acid	low	1	0
trihexyphenidyl	low	2	0
prednisolone	low	3	0
reserpine	low	2	0
hydroxyproline	low	43	0
aldosterone	low	1	0
penicillamine	low	3	0
prednisone	low	3	0
androsterone	low	1	0
penicillin g	low	2	0
pilocarpine	low	4	0
triiodothyronine	low	2	0
alanine	low	2	0
serine	low	2	0
4-nitroquinoline-1-oxide	low	2	0
aspartic acid	low	2	0
glutamine	low	2	0
lysine	low	4	0
cyanides	low	1	0
ethinyl estradiol	low	4	0
adenosine diphosphate	medium	2	1
cephalothin	low	1	0
phenylephrine	low	3	0
edetic acid	low	3	0
tyrosine	low	3	0
methacholine chloride	low	1	0
methionine	low	9	0
phenylalanine	low	1	0
colchicine	low	2	0
cycloheximide	low	2	0
egtazic acid	low	4	0
norethindrone	low	1	0
17-alpha-hydroxyprogesterone	low	1	0
ampicillin	low	1	0
cytarabine	low	1	0
histidine	low	5	0
valine	low	1	0
threonine	low	1	0
methandrostenolone	low	2	0
arginine	low	6	0
trichloroacetic acid	low	1	0
perflutren	low	1	0
penicillin v	low	1	0
thiophenes	low	1	0
pyrazolanthrone	low	1	0
diatrizoate meglumine	low	1	0
meglumine	low	2	0
indazoles	low	1	0
cyclopentane	low	1	0
thiazoles	low	1	0
ephedrine	low	1	0
perfluorooctane	low	1	0
methysergide	low	1	0
citrulline	low	1	0
homocystine	low	10	0
n-pentyl nitrite	low	2	0
cyanogen bromide	low	2	0
medroxyprogesterone	low	2	0
methoxyhydroxyphenylglycol	low	1	0
diphenylamine	low	1	0
acetylcysteine	low	2	0
erythromycin	low	1	0
isodesmosine	low	1	0
fucose	low	1	0
mannose	low	2	0
norleucine	low	1	0
trimethaphan	low	1	0
ruthenium	low	1	0
gadolinium	low	1	0
gold	low	1	0
barium sulfate	low	2	0
galactose	low	1	0
trolamine salicylate	low	7	0
daunorubicin	low	1	0
phenyl acetate	low	2	0
4-methoxyamphetamine	low	2	0
timolol	low	1	0
etoposide	low	1	0
ng-nitroarginine methyl ester	low	2	0
sufentanil	low	1	0
idarubicin	low	1	0
pravastatin	low	1	0
technetium tc 99m mertiatide	low	1	0
remifentanil	low	3	0
valsartan	low	3	0
nitrogen trioxide	low	1	0
iopamidol	low	2	0
telmisartan	low	3	0
fluorodeoxyglucose f18	low	2	0
perindoprilat	medium	1	1
rosiglitazone	low	1	0
fibrinogen	low	5	0
homocysteine	low	16	0
arginyl-glycyl-aspartic acid	low	1	0
vitamin b 6	low	3	0
pyridinoline	low	2	0
deoxypyridinoline	low	1	0
kt 5823	low	1	0
landiolol	low	2	0
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid	low	1	0
delta-hydroxylysylnorleucine	low	2	0
imatinib mesylate	low	1	0
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone	low	1	0
5,5'-dihydroxylysylnorleucine	low	1	0
methotrexate	low	1	0
1,3,4,6-tetra-o-acetyl-2-azido-2-deoxyglucopyranose	low	2	0
proline	low	14	0
naproxen	low	1	0
ukrain	low	1	0
technetium tc 99m pentetate	low	1	0
angiotensin ii	medium	7	2
cystinylglycine	low	1	0
atropine	low	2	0
ropivacaine	low	1	0
enzastaurin	low	1	0
benzofurans	low	1	0
leupeptins	low	1	0
glycogen	low	2	0
fibrin	low	4	0
bradykinin	low	1	0
glucosamine	low	1	0
elastin	low	63	0
oxytocin	low	1	0
inositol 3-phosphate	low	3	0
quinidine	low	1	0
pancuronium	low	1	0
temocaprilat	medium	1	1
arachidonic acid	low	1	0
resveratrol	low	3	0
oleic acid	low	1	0
keratan sulfate	low	1	0
eptifibatide	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
glycosides	low	1	0
isomethyleugenol	low	1	0
stilbenes	low	1	0
picibanil	low	1	0
mercaptopurine	low	1	0
D-fructopyranose	low	1	0
digoxin	low	4	0
nitrogen dioxide	low	1	0
hydroxylysine	low	4	0
cystine	low	2	0
alpha-chymotrypsin	low	1	0
17-ketosteroids	low	2	0
sodium borohydride	low	1	0
vitamin k semiquinone radical	low	1	0
thromboxane a2	low	2	0
amphotericin b	low	1	0
phenylephrine hydrochloride	low	3	0
sirolimus	low	3	0
brefeldin a	low	1	0
morphine	low	1	0
deamino arginine vasopressin	low	2	0
pd 123319	medium	1	1
iridal	low	1	0
arsenic	low	1	0
ramipril	low	1	0
enalapril	medium	2	1
fumarates	medium	2	1
cysteine	medium	23	1
phosphorus	low	1	0
selenium	low	1	0
gadolinium dtpa	low	1	0
phosphocreatine	low	1	0
oxadiazoles	low	1	0
ptc 124	low	1	0
technetium tc 99m exametazime	low	1	0
acid phosphatase	low	1	0
felypressin	low	1	0
nad	low	1	0
desmosine	low	7	0
n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide	low	1	0
atrial natriuretic factor	low	1	0
angiotensinogen	low	2	0
oligonucleotides	low	2	0
c-peptide	low	1	0
calpain	low	1	0
ro13-9904	low	1	0
10-nitro-oleic acid	low	1	0
cardiovascular agents	low	10	0
glycolipids	low	2	0
piperidines	low	3	0
natriuretic peptide, brain	low	5	0
chondroitin	low	8	0
ascorbic acid	low	4	0
tetracycline	low	1	0
minocycline	low	1	0
piroxicam	low	1	0
warfarin	low	4	0
epidermal growth factor	medium	39	1
transforming growth factor beta	medium	154	3
gsk343	low	1	0
kiss1 protein, human	low	1	0
rome	low	1	0
hirudin	low	1	0
cyclin d1	low	1	0
calpastatin	low	1	0
cobinamide	low	1	0
hyaluronoglucosaminidase	low	2	0
vitamin b 12	low	4	0
refludan	low	1	0
thromboplastin	low	2	0
muramidase	low	1	0
cyclic gmp	low	2	0
guanine	low	1	0
folic acid	low	6	0
dacarbazine	low	1	0
ganciclovir	low	1	0
allopurinol	low	1	0
sildenafil citrate	low	1	0
defibrotide	low	1	0
eye	low	32	0
leptin	low	1	0

Protein Targets (2,075)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
ATAD5 protein, partial	24	0	0	24
apical membrane antigen 1, AMA1	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	62	0	0	62
chromobox protein homolog 1	39	0	0	39
DNA polymerase iota isoform a (long)	25	0	0	25
geminin	56	0	0	56
lethal factor (plasmid)	17	0	1	18
botulinum neurotoxin type A	0	0	1	1
botulinum neurotoxin type F, BoNT/F	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	4	7	12
Peroxisome proliferator-activated receptor alpha	1	4	3	8
acetylcholinesterase	16	0	0	16
pregnane X receptor	9	0	0	9
SMAD family member 2	19	0	0	19
SMAD family member 3	19	0	0	19
TDP1 protein	59	0	0	59
GLI family zinc finger 3	59	0	0	59
Microtubule-associated protein tau	22	0	0	22
AR protein	75	0	0	75
progesterone receptor	30	0	0	30
glucocorticoid receptor [Homo sapiens]	56	0	0	56
retinoic acid nuclear receptor alpha variant 1	54	0	0	54
retinoid X nuclear receptor alpha	41	0	0	41
estrogen-related nuclear receptor alpha	61	0	0	61
farnesoid X nuclear receptor	31	0	0	31
pregnane X nuclear receptor	42	0	0	42
estrogen nuclear receptor alpha	81	0	0	81
G	27	0	0	27
vitamin D (1,25- dihydroxyvitamin D3) receptor	35	0	0	35
arylsulfatase A	28	0	0	28
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	33	0	0	33
activating transcription factor 6	20	0	0	20
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	49	0	0	49
survival motor neuron protein isoform d	22	0	0	22
histone acetyltransferase KAT2A isoform 1	24	0	0	24
lamin isoform A-delta10	57	0	0	57
Voltage-dependent calcium channel gamma-2 subunit	28	0	0	28
Interferon beta	37	0	0	37
HLA class I histocompatibility antigen, B alpha chain	27	0	0	27
Glucocorticoid receptor	0	12	2	19
Sex hormone-binding globulin	0	0	5	5
Glycine receptor subunit alpha-1	0	12	0	12
Corticosteroid-binding globulin	0	4	0	4
Adenosine receptor A3	0	10	1	11
Replicase polyprotein 1ab	0	7	1	8
Androgen receptor	0	14	0	14
Alpha-1B adrenergic receptor	0	12	1	13
Glutamate receptor 2	29	0	0	29
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Mitogen-activated protein kinase 3	0	1	2	3
Alpha-1A adrenergic receptor	0	12	1	13
Sodium-dependent dopamine transporter	0	10	0	10
TAR DNA-binding protein 43	14	0	0	14
Inositol hexakisphosphate kinase 1	27	0	0	27
cytochrome P450 2C9, partial	27	0	0	27
ATP-dependent phosphofructokinase	28	0	0	28
hypoxia-inducible factor 1 alpha subunit	13	0	0	13
RAR-related orphan receptor gamma	51	0	0	51
aldehyde dehydrogenase 1 family, member A1	45	0	0	45
peroxisome proliferator-activated receptor delta	25	0	0	25
v-jun sarcoma virus 17 oncogene homolog (avian)	21	0	0	21
Histone H2A.x	16	0	0	16
thyroid hormone receptor beta isoform a	25	0	0	25
heat shock protein beta-1	11	0	0	11
5-hydroxytryptamine receptor 2C	0	4	1	6
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 1A	0	17	5	24
5-hydroxytryptamine receptor 1B	0	12	1	13
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	12	1	13
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	2	1	3
5-hydroxytryptamine receptor 4	0	1	1	3
5-hydroxytryptamine receptor 3B	0	2	1	3
GLS protein	31	0	0	31
Smad3	10	0	0	10
thyroid stimulating hormone receptor	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	44	0	0	44
EWS/FLI fusion protein	31	0	0	31
peroxisome proliferator activated receptor gamma	33	0	0	33
aryl hydrocarbon receptor	23	0	0	23
thyroid hormone receptor beta isoform 2	46	0	0	46
peripheral myelin protein 22	30	0	0	30
cytochrome P450 3A4 isoform 1	29	0	0	29
Gamma-aminobutyric acid receptor subunit pi	29	5	5	40
ATP-binding cassette sub-family C member 3	0	44	0	44
Multidrug resistance-associated protein 4	0	44	0	47
Solute carrier family 22 member 6	0	12	0	12
Carbonic anhydrase 12	0	8	1	17
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	14	0	14
Bile salt export pump	0	72	0	72
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	15	1	31
Carbonic anhydrase 2	0	16	2	33
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	3	1	5
Cytochrome P450 1A2	0	9	0	10
Prostaglandin G/H synthase 1	0	9	2	11
Carbonic anhydrase 3	0	8	1	16
Cytochrome P450 3A4	0	22	2	26
Cytochrome P450 2D6	0	14	0	14
Cytochrome P450 2C9	0	28	1	29
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	29	5	5	40
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	29	5	5	40
Gamma-aminobutyric acid receptor subunit gamma-2	29	5	5	40
UDP-glucuronosyltransferase 1-6	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	29	5	5	40
Gamma-aminobutyric acid receptor subunit alpha-3	29	5	5	40
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	4	0	7
Carbonic anhydrase 4	0	11	1	19
Prostaglandin G/H synthase 1	0	9	0	9
Carbonic anhydrase 6	0	8	1	16
Gamma-aminobutyric acid receptor subunit gamma-1	29	5	5	40
Gamma-aminobutyric acid receptor subunit alpha-2	29	5	5	40
Gamma-aminobutyric acid receptor subunit alpha-4	29	5	5	40
Gamma-aminobutyric acid receptor subunit gamma-3	29	5	5	40
Gamma-aminobutyric acid receptor subunit alpha-6	29	5	5	40
Carbonic anhydrase 5A, mitochondrial	0	8	1	17
Prostaglandin G/H synthase 2	0	10	2	14
Carbonic anhydrase 7	0	8	1	16
Nuclear receptor ROR-gamma	15	1	1	17
Cytochrome P450 2J2	0	16	0	16
Gamma-aminobutyric acid receptor subunit alpha-1	29	6	5	41
Gamma-aminobutyric acid receptor subunit beta-3	29	5	5	40
Gamma-aminobutyric acid receptor subunit beta-2	29	5	5	40
Carbonic anhydrase 9	0	8	1	17
GABA theta subunit	29	5	5	40
Canalicular multispecific organic anion transporter 1	0	45	0	46
Carbonic anhydrase 15	0	9	0	14
Carbonic anhydrase 13	0	7	0	13
Gamma-aminobutyric acid receptor subunit epsilon	29	5	5	40
Carbonic anhydrase 14	0	8	1	17
Carbonic anhydrase 5B, mitochondrial	0	8	1	17
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	26	0	0	26
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	20	0	0	20
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	45	0	0	45
GALC protein	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	41	0	0	41
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	23	0	0	23
muscleblind-like protein 1 isoform 1	13	0	0	13
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	4	0	4
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Cytochrome P450 2C8	0	5	0	6
Cytochrome P450 2A6	0	3	2	5
Translocator protein	0	1	1	2
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 2B6	0	2	1	5
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	8
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	2
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	7	0	11
Delta-type opioid receptor	0	5	0	6
Cytochrome P450 2C19	0	9	0	9
Delta-type opioid receptor	0	7	2	10
Mu-type opioid receptor	0	10	2	15
Carbonic anhydrase	0	4	0	8
Kappa-type opioid receptor	0	6	0	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	6	1	0	7
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	6
D(2) dopamine receptor	0	4	0	4
Cholinesterase	0	5	0	5
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	7	0	7
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	4	1	10
Squalene synthase	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	7
Carbonic anhydrase	0	1	0	7
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	1	6
Renin	0	2	0	2
Carbonic anhydrase	0	1	0	6
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	8
Carbonic anhydrase 4	0	2	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	24	0	0	24
Chain A, ATP-DEPENDENT DNA HELICASE Q1	8	0	0	8
dopamine D1 receptor	5	0	0	5
15-lipoxygenase, partial	9	0	0	9
phosphopantetheinyl transferase	21	0	0	21
USP1 protein, partial	38	0	0	38
NFKB1 protein, partial	11	0	0	11
Thrombopoietin	7	0	0	7
regulator of G-protein signaling 4	22	0	0	22
D(1A) dopamine receptor	15	0	0	15
flap endonuclease 1	20	0	0	20
muscarinic acetylcholine receptor M1	15	0	0	15
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Guanine nucleotide-binding protein G	8	0	0	8
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	24	0	0	24
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	2	4
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	11	5	17
Delta-type opioid receptor	0	7	3	11
Kappa-type opioid receptor	0	9	3	13
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	7	0	0	7
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	1	3
P2X purinoceptor 2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	40	0	0	40
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	4
Glutamate receptor ionotropic, NMDA 1	0	5	2	12
Proton-coupled amino acid transporter 1	0	7	0	8
Adenosine deaminase	0	0	0	1
glp-1 receptor, partial	17	0	0	17
NPYLR7B	0	0	3	3
thyroid stimulating hormone receptor	20	0	0	20
Beta-2 adrenergic receptor	0	15	9	24
Beta-1 adrenergic receptor	0	14	9	23
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-3 adrenergic receptor	0	7	8	15
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
Beta-2 adrenergic receptor	0	0	2	4
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Beta-2 adrenergic receptor	0	3	7	12
nuclear factor erythroid 2-related factor 2 isoform 2	21	0	0	21
Mineralocorticoid receptor	0	3	3	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	3	0	7
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	9	0	9
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Fumarate hydratase	14	0	0	14
polyprotein	14	0	0	14
Pepsin A	0	1	0	1
Renin-1	0	1	0	1
Renin	0	1	0	1
Cathepsin D	0	1	0	1
Renin	0	1	0	1
Protease	0	1	0	1
RGS12	2	0	0	2
estrogen receptor 2 (ER beta)	26	0	0	26
vitamin D3 receptor isoform VDRA	21	0	0	21
Alpha-synuclein	6	2	0	8
interleukin 8	12	0	0	12
IDH1	25	0	0	25
transcriptional regulator ERG isoform 3	5	0	0	5
ras-related protein Rab-9A	12	0	0	12
Polyphenol oxidase 2	0	5	1	10
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	3
Cellular tumor antigen p53	41	0	0	41
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	4	2	6
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	3	3
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	2	0	4
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
PPM1D protein	11	0	0	11
caspase 7, apoptosis-related cysteine protease	8	0	0	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
cytochrome P450 2D6	23	0	0	23
caspase-3	8	0	0	8
cytochrome P450 2D6 isoform 1	11	0	0	11
cellular tumor antigen p53 isoform a	12	0	0	12
cytochrome P450 2C9 precursor	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	14	0	0	14
huntingtin isoform 2	5	0	0	5
mitogen-activated protein kinase 1	15	0	0	15
serine/threonine-protein kinase mTOR isoform 1	10	0	0	10
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	13	0	0	13
urokinase-type plasminogen activator precursor	12	0	0	12
plasminogen precursor	12	0	0	12
urokinase plasminogen activator surface receptor precursor	12	0	0	12
nuclear receptor ROR-gamma isoform 1	18	0	0	18
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Solute carrier organic anion transporter family member 1A4	0	5	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	7	0	7
5-hydroxytryptamine receptor 4	0	14	0	14
Lysine-specific demethylase PHF2	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
Integrin beta-3	9	3	1	13
Tyrosine-protein kinase Fyn	0	1	2	3
ATP-dependent translocase ABCB1	0	11	0	11
Aldo-keto reductase family 1 member B1	0	10	0	10
Muscarinic acetylcholine receptor M2	0	11	3	18
Muscarinic acetylcholine receptor M4	0	8	1	12
ATP-dependent translocase ABCB1	0	26	3	45
Integrin alpha-IIb	9	3	0	12
Muscarinic acetylcholine receptor M5	0	9	1	13
Alpha-2A adrenergic receptor	0	12	4	17
Thyroid hormone receptor alpha	0	3	3	6
Thyroid hormone receptor beta	0	3	3	6
Muscarinic acetylcholine receptor M1	0	10	4	18
D(2) dopamine receptor	0	8	1	9
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	7	2	10
Thyroid hormone receptor beta	0	2	0	2
Muscarinic acetylcholine receptor M3	0	9	2	14
ATP-dependent translocase ABCB1	0	11	0	12
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	5	1	6
D(4) dopamine receptor	0	3	0	3
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
Sodium-dependent noradrenaline transporter	0	12	1	13
Histamine H2 receptor	0	7	2	9
Endothelin-1 receptor	0	6	1	7
5-hydroxytryptamine receptor 2A	0	13	1	14
5-hydroxytryptamine receptor 2C	0	14	1	15
Lysine-specific demethylase 5A	0	1	0	1
B2 bradykinin receptor	0	4	1	7
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	11	0	11
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	4
Squalene synthase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	12	1	13
C-C chemokine receptor type 2	0	5	0	5
Melanocortin receptor 3	0	2	0	2
Histamine H2 receptor	14	0	1	16
5-hydroxytryptamine receptor 6	0	6	1	7
Carnitine O-palmitoyltransferase 1, liver isoform	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	21	0	1	22
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	7	0	7
Potassium voltage-gated channel subfamily H member 2	0	15	0	15
Voltage-dependent L-type calcium channel subunit alpha-1S	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	11
Sodium channel protein type 5 subunit alpha	0	5	0	5
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	4	0	4
Lysine-specific demethylase 7A	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	11	1	12
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	2	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	2	0	2
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
Chain A, HADH2 protein	21	0	0	21
Chain B, HADH2 protein	21	0	0	21
Chain A, Cruzipain	9	0	0	9
tumor necrosis factor	3	0	0	3
Aurora kinase B	0	1	2	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	9	1	12
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	0	0	3
acid sphingomyelinase	5	0	0	5
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	0	3
Metallo-beta-lactamase VIM-11	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	15	0	0	15
DNA polymerase beta	8	0	0	8
DNA polymerase eta isoform 1	7	0	0	7
DNA polymerase kappa isoform 1	20	0	0	20
Beta-lactamase OXA-7	0	0	0	2
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	2	0	2
Angiopoietin-1 receptor	0	0	2	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Metallo-beta-lactamase VIM-13	0	1	0	4
Efflux transporter	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	0	0	3
Class D beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	1	0	4
Chain A, retinol dehydratase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
G-protein coupled bile acid receptor 1	0	0	1	1
glucocerebrosidase	7	0	0	7
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	6	3	9
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	7	0	7
Type-1 angiotensin II receptor	0	11	5	21
Type-2 angiotensin II receptor	0	6	0	6
Type-2 angiotensin II receptor	0	7	0	7
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
thioredoxin glutathione reductase	8	0	0	8
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
caspase-1 isoform alpha precursor	5	0	0	5
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 1	0	5	0	6
Trypsin	0	2	0	2
Coagulation factor VII	0	2	0	2
Aromatase	0	6	0	6
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	3	1	4
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Prostaglandin G/H synthase 2	0	7	0	8
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Fatty acid-binding protein 5	0	2	0	2
Fatty acid-binding protein 5	0	0	1	1
Lanosterol 14-alpha demethylase	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	11	0	13
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	12	0	15
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	6	0	0	6
cytochrome P450 2C19 precursor	13	0	0	13
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	3	0	4
Nitric oxide synthase, brain	0	1	0	3
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	1	1	5
Cationic amino acid transporter 3	0	2	0	2
Integrin beta-1	0	1	0	1
Integrin alpha-V	0	1	1	2
Integrin alpha-5	0	2	0	2
Integrin beta-5	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	3	0	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Neutral amino acid transporter A	0	5	0	5
Neutral amino acid transporter B(0)	0	5	0	5
Carbonic anhydrase-like protein, putative	0	0	0	7
Amino acid transporter	0	5	0	5
Chain A, Ferritin light chain	9	0	0	9
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	9
Glutamate receptor ionotropic, NMDA 2C	0	3	1	9
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	9
Glutamate receptor ionotropic, NMDA 3B	0	3	1	9
Glutamate receptor ionotropic, NMDA 3A	0	3	1	9
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	4	0	0	4
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Epidermal growth factor receptor	0	2	2	4
Fatty acid-binding protein, liver	0	5	0	5
Myeloperoxidase	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	1	2
Beta-1 adrenergic receptor	0	1	5	7
Alpha-1D adrenergic receptor	0	7	2	10
Alpha-1A adrenergic receptor	0	3	4	8
Alpha-1B adrenergic receptor	0	2	3	6
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	2	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	11	0	15
Muscarinic acetylcholine receptor M1	0	6	2	11
Muscarinic acetylcholine receptor M3	0	6	2	11
Muscarinic acetylcholine receptor M4	0	6	2	11
Muscarinic acetylcholine receptor M5	0	6	2	11
Muscarinic acetylcholine receptor M2	0	6	2	12
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	6	0	6
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	1	1	2
Luciferase	23	0	0	23
lysosomal alpha-glucosidase preproprotein	7	0	0	7
Neuronal acetylcholine receptor subunit alpha-4	3	2	0	5
Neuronal acetylcholine receptor subunit beta-2	3	2	0	5
Thromboxane A2 receptor	0	1	0	5
Sodium/bile acid cotransporter	0	5	0	5
Multidrug and toxin extrusion protein 1	0	8	0	8
Leukotriene B4 receptor 2	0	0	2	3
Proteasome subunit beta type-11	0	1	0	1
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Indoleamine 2,3-dioxygenase 1	0	1	1	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Beta-1 adrenergic receptor	0	3	0	3
Angiotensin-converting enzyme	0	7	0	8
B2 bradykinin receptor	0	1	0	1
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	3	3
PAX8	0	0	0	3
67.9K protein	20	0	0	20
NPC intracellular cholesterol transporter 1 precursor	10	0	0	10
major prion protein preproprotein Prp precursor	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	2	2
Potassium channel subfamily K member 9	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	3
Sodium-dependent dopamine transporter	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
Vpr	3	0	0	3
Albumin	0	0	4	4
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
endonuclease IV	12	0	0	12
WRN	1	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
importin subunit beta-1 isoform 1	7	0	0	7
serine/threonine-protein kinase PLK1	5	0	0	5
snurportin-1	7	0	0	7
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 8	0	3	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase OXA-1	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	1	0	3
B2 metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 6	0	7	0	9
Solute carrier family 22 member 7	0	2	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 8	0	7	0	9
Solute carrier family 22 member 11	0	3	0	5
Solute carrier family 22 member 8	0	3	0	6
Solute carrier family 22 member 7	0	2	0	3
phosphoglycerate kinase	1	0	0	1
interferon gamma precursor	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
General amino-acid permease GAP1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
neuropeptide S receptor isoform A	6	0	0	6
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	5
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	2	3
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	4	0	4
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	3	0	3
Similar to alpha-tubulin isoform 1	0	3	0	3
CREB-binding protein	1	0	0	1
ATPase family AAA domain-containing protein 5	14	0	0	14
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
P53	2	0	0	2
RPL19A	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	1	3
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	4	0	4
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	1	5
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	3	0	5
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	2	3
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Caspase-7	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
caspase-3	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	8	0	0	8
Transthyretin	0	2	1	5
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
DNA topoisomerase 2-alpha	0	1	2	9
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Platelet-activating factor receptor	1	0	0	2
Multidrug resistance-associated protein 1	0	4	1	8
Vasopressin V2 receptor	0	2	2	4
Oxytocin receptor	0	2	3	5
Vasopressin V1a receptor	0	4	3	7
Vasopressin V1b receptor	0	2	2	4
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	2	1	3
Lysine-specific demethylase 4A	0	1	0	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Hsf1 protein	0	0	1	1
STAT3, partial	0	2	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	2	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	9	0	0	9
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Cereblon isoform 4	0	4	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	4	1	6
ClpP	5	0	0	5
Glycoprotein hormones alpha chain	1	0	0	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	1	3	1	5
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
peripheral myelin protein 22 isoform 1	8	0	0	8
Angiotensin-converting enzyme	0	3	0	3
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Bone morphogenetic protein receptor type-1B	0	0	2	2
Cell division cycle 7-related protein kinase	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	3	3
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Pyridoxal kinase	0	0	2	3
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	2
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	3	3
Cyclin-G-associated kinase	0	0	3	3
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	2	2
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	1	2	3
Ribosomal protein S6 kinase alpha-5	0	0	3	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	2	2
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Cyclin-dependent kinase 14	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	2	4	7
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
High affinity nerve growth factor receptor	0	0	2	2
Protein kinase C gamma type	0	1	0	1
ADP/ATP translocase 2	0	0	2	2
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	2	3
Insulin receptor	0	0	2	2
Tyrosine-protein kinase Lck	0	1	2	3
Cyclin-dependent kinase 1	0	1	2	3
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	0	2	2
Tyrosine-protein kinase HCK	0	0	2	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Platelet-derived growth factor receptor beta	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	2	2
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	1	2	3
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	1	3	5
Fibroblast growth factor receptor 1	0	0	2	2
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	0	2	2
Proto-oncogene tyrosine-protein kinase Src	0	1	2	3
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	3	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	3	5
Platelet-derived growth factor receptor alpha	0	1	2	3
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	1	3	5
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Interferon-induced, double-stranded RNA-activated protein kinase	0	1	1	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	2	2
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Multifunctional protein ADE2	0	0	2	2
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Protein kinase C eta type	0	1	1	2
Cyclin-dependent kinase 2	0	1	4	5
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Activin receptor type-2A	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Mitogen-activated protein kinase 1	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	1	2	3
RAC-beta serine/threonine-protein kinase	0	0	2	2
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	1	3	4
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	2	2
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
Serine/threonine-protein kinase receptor R3	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	2	3
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	1	3	4
Mitogen-activated protein kinase 9	0	1	3	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	2	2
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	3	3
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	3	3
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	2	2
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 12	0	0	2	2
Mitogen-activated protein kinase 10	0	1	3	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	2	2
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	2	2
Protein kinase C gamma type	0	1	0	1
Casein kinase II subunit alpha	0	0	1	1
Protein kinase C beta type	0	1	0	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	3	3
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Protein kinase C epsilon type	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
DNA topoisomerase 2-beta	0	1	3	10
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	2	3
Tyrosine-protein kinase BTK	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	2	2
Serine/threonine-protein kinase 4	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	3
Serine/threonine-protein kinase PAK 1	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	1	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	1	2	3
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	1	2	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	1	2	3
Mitogen-activated protein kinase 11	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Mitogen-activated protein kinase 14	0	1	2	3
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	0	3	3
Myosin light chain kinase 3	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Rab-like protein 3	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Protein kinase C eta type	0	1	0	1
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	3	3
Serine/threonine-protein kinase Nek1	0	0	2	2
Cyclin-dependent kinase 15	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	3	3
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO3	0	0	2	2
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	3	3
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	3	3
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
BMP-2-inducible protein kinase	0	0	3	3
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
Serine/threonine-protein kinase PLK2	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	3
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	3	3
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	2	2
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	2	2
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	1	2
Protein kinase C theta type	0	1	0	1
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	2	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	2	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	6	0	0	6
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
Albumin	0	5	6	11
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	4	0	4
50S ribosomal protein L36 2	0	2	1	3
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
thyrotropin-releasing hormone receptor	4	0	0	4
eyes absent homolog 2 isoform a	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	2	2
large T antigen	0	2	0	2
Solute carrier family 22 member 2	0	2	0	3
Estrogen receptor	0	7	1	8
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	2	0	2
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Estrogen receptor beta	0	3	1	4
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	3	0	4
DNA topoisomerase 2	0	0	0	1
Caspase-3	0	3	0	3
DNA topoisomerase 2-alpha	0	0	0	1
Integrase	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Amine oxidase [flavin-containing] A	0	4	0	4
Amine oxidase [flavin-containing] B	0	4	0	4
Kappa-type opioid receptor	0	5	1	7
Histamine H1 receptor	0	3	2	5
Mu-type opioid receptor	0	3	1	6
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	3	0	3
Holo-[acyl-carrier-protein] synthase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Thymidine kinase	0	2	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Asc-type amino acid transporter 1	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	7	0	8
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Histone-lysine N-methyltransferase 2D	0	1	0	1
Protein arginine N-methyltransferase 5	0	1	0	1
Histone-lysine N-methyltransferase SUV39H1	0	1	0	1
Protein arginine N-methyltransferase 3	0	1	0	1
Polycomb protein EED	0	2	0	2
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Histone-lysine N-methyltransferase 2A	0	1	0	1
Histone-binding protein RBBP4	0	2	0	2
Polycomb protein SUZ12	0	2	0	2
Histone-lysine N-methyltransferase EZH2	0	2	0	3
Histone-binding protein RBBP7	0	2	0	2
Histone-lysine N-methyltransferase SETMAR	0	1	0	1
Zinc finger protein AEBP2	0	1	0	1
Histone-arginine methyltransferase CARM1	0	1	0	1
Histone-lysine N-methyltransferase 2C	0	1	0	1
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Histone-lysine N-methyltransferase EZH1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Histone-lysine N-methyltransferase SUV39H2	0	1	0	1
Histone-lysine N-methyltransferase 2B	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	2	0	2
Purine nucleoside phosphorylase	0	2	0	2
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Guanine deaminase	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Solute carrier family 22 member 1	0	6	0	8
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	5	0	6
Histamine H3 receptor	0	1	2	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
M-phase phosphoprotein 8	10	0	0	10
Parkin	9	0	0	9
pyruvate kinase	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	2	0	2
Single-stranded DNA cytosine deaminase	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Glutamine synthetase	0	1	0	1
nonstructural protein 1	6	0	0	6
Acid-sensing ion channel 3	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Cholinesterase	0	3	0	3
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	6
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	6
UDP-glucuronosyltransferase 1A3	0	0	0	2
Aldo-keto reductase family 1 member C3	0	2	0	2
Caspase-4	0	2	0	2
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	6
Dehydrogenase/reductase SDR family member 9	0	1	0	1
DNA polymerase III, partial	2	0	0	2
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
tumor susceptibility gene 101 protein	3	0	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 3A5	0	0	1	2
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Cyclin-A2	0	1	0	1
Cyclin-A1	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
Alpha-2B adrenergic receptor	0	2	2	4
Alpha-2C adrenergic receptor	0	2	2	4
Alpha-2A adrenergic receptor	0	2	2	4
Heparanase	0	0	1	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Neprilysin	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Platelet glycoprotein VI	0	1	2	4
Type-1 angiotensin II receptor	0	1	1	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	5	0	5
Alpha-mannosidase 2C1	0	1	0	1
PINK1	1	0	0	1
hemoglobin subunit beta	3	0	0	3
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
galanin receptor type 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Caspase-7	3	0	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	6
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
Beta-secretase 1	0	1	0	1
Cytochrome P450 2A13	0	2	2	4
Serine racemase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
D	0	1	0	1
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Beta-1 adrenergic receptor	0	5	2	8
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	3	0	3
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	2	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Adenosine receptor A3	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
beta-2 adrenergic receptor	2	0	0	2
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	2
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A1	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Estrogen receptor	0	0	1	1
Progesterone receptor	0	4	2	7
Estrogen receptor beta	0	0	1	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Sterol O-acyltransferase 1	0	2	0	2
Fatty acid-binding protein, liver	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	4	0	6
Sterol O-acyltransferase 1	0	2	0	2
Peroxisome proliferator-activated receptor delta	0	3	2	6
Rap guanine nucleotide exchange factor 4	2	0	0	2
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Cystathionine gamma-lyase	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	2
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	4	3	8
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain A, NUCLEOSIDE DIPHOSPHATE KINASE	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	3	0	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Glutamate 5-kinase	0	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
histone deacetylase 9 isoform 3	3	0	0	3
Chain A, Mitogen-activated protein kinase 10	0	1	0	1
Chain A, Mitogen-activated protein kinase 10	0	1	0	1
Chain A, Mitogen-activated protein kinase 10	0	1	0	1
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
N	0	1	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Trypanothione reductase	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, Bacterial regulatory proteins, tetR family	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	2
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Myc proto-oncogene protein	0	1	0	2
Cathepsin D	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Tyrosinase	0	3	0	3
Ornithine decarboxylase	0	1	0	1
Estrogen receptor	0	0	1	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Endothelin receptor type B	1	0	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Endothelin-1 receptor	1	1	0	2
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Alpha-glucosidase MAL12	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	3
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Prenyltransferase homolog	0	0	0	1
Zinc finger protein mex-5	0	0	1	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	1	2
Catechol O-methyltransferase	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	1	2	3
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Cannabinoid receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Thrombin	0	0	1	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
UMP-CMP kinase	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Neutrophil collagenase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Diamine acetyltransferase 1	0	0	0	1
Thialysine N-epsilon-acetyltransferase	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (851)

Protein Targets (2,075)

Marfan Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (851)

Drugs Studied (324)

Protein Targets (2,075)