A drug used for its actions on skeletal muscle.
ChEBI ID: 51372
| Member | Definition | Class |
|---|---|---|
| domoic acid | An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP). | domoic acid |
| grayanotoxin i | A tetracyclic diterpenoid that is grayanotoxane in which the pro-R hydrogen at position 14 is substituted by an acetoxy group and in which the 3beta-, 5-, 6beta-, 10-, and 16- positions are substituted by hydroxy groups. | grayanotoxin I |
| paeoniflorigenone | A terpenoid with formula C17H18O6, isolated from several species of Paeoniae. | paeoniflorigenone |
| rocuronium | A 5alpha-androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium substituents. | rocuronium |
| rocuronium bromide | The organic bromide salt of a 5alpha androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium substituents. | rocuronium bromide |
| succinylcholine | A quaternary ammonium ion that is the bis-choline ester of succinic acid. | succinylcholine |
| vecuronium | A 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidino- and 16beta-N-methylpiperidinium substituents. | vecuronium |
| vecuronium bromide | The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium substituents. | vecuronium bromide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,552 (45.15) | 18.7374 |
| 1990's | 2,071 (20.54) | 18.2507 |
| 2000's | 1,492 (14.80) | 29.6817 |
| 2010's | 1,492 (14.80) | 24.3611 |
| 2020's | 474 (4.70) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,024 (17.34%) | 5.53% |
| Reviews | 613 (5.25%) | 6.00% |
| Case Studies | 1,586 (13.59%) | 4.05% |
| Observational | 83 (0.71%) | 0.25% |
| Other | 7,366 (63.11%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 19.6553 | 3 | 3 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 28.1838 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 6.5578 | 3 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 50.1187 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.7407 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 30.9008 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 30.0474 | 1 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 44.7164 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 19.7347 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.6011 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 4.5479 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 7.8552 | 1 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 21.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 25.2000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 176.0000 | 2 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Acetylcholinesterase | Mus musculus (house mouse) | Kd | 35.0000 | 1 | 14 |