An antagonist that binds to and deactivates the dopamine receptor D2, the main receptor for all antipsychotic drugs.
ChEBI ID: 131787
| Member | Definition | Class |
|---|---|---|
| prochlorperazine | A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. | prochlorperazine |
| yohimbine | An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina. | yohimbine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,346 (50.16) | 18.7374 |
| 1990's | 1,715 (25.71) | 18.2507 |
| 2000's | 907 (13.60) | 29.6817 |
| 2010's | 582 (8.73) | 24.3611 |
| 2020's | 120 (1.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 459 (6.54%) | 5.53% |
| Reviews | 180 (2.56%) | 6.00% |
| Case Studies | 166 (2.37%) | 4.05% |
| Observational | 7 (0.10%) | 0.25% |
| Other | 6,206 (88.43%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 11.2202 | 2 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 15.8489 | 1 | 1 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 17.0505 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 2.3934 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.5878 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.1180 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.7569 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 18.4927 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.7624 | 2 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 35.4813 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 27.0050 | 2 | 2 |
| ClpP | Bacillus subtilis | Potency | 14.1254 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 8.9221 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.5962 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 10.4304 | 2 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.5251 | 2 | 4 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 13.0918 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 25.6388 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.7775 | 1 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 16.0892 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 19.5147 | 2 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 15.8489 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 21.9741 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3392 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 24.9054 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 5.6234 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.2202 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 44.6684 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| polyprotein | Zika virus | Potency | 5.6234 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 8.4127 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 14.3984 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.7330 | 4 | 5 |
| Smad3 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 11.5494 | 2 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.9449 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.5380 | 1 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.2079 | 2 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.5380 | 1 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.3075 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0071 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0880 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0560 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0780 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0410 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0780 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0410 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.9780 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.4540 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 49.6000 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.3960 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0036 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 1.0570 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3886 | 3 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.3248 | 3 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3886 | 3 | 4 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.5235 | 1 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.2012 | 3 | 4 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2203 | 4 | 8 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0544 | 6 | 7 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0682 | 4 | 6 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0152 | 19 | 22 |
| Alpha-2A adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0281 | 3 | 4 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0593 | 14 | 17 |
| Alpha-2A adrenergic receptor | Sus scrofa (pig) | Ki | 0.0044 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0373 | 5 | 6 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0682 | 4 | 6 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0141 | 18 | 22 |
| Alpha-2B adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0281 | 3 | 4 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0561 | 15 | 18 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.0525 | 5 | 6 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0682 | 4 | 6 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0130 | 18 | 21 |
| Alpha-2C adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0281 | 3 | 4 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0593 | 14 | 17 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 1.8481 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 1.5141 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 3 | 4 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.7800 | 2 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.3500 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.1550 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.0780 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 1.0355 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.3453 | 1 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0130 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0045 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 2.1433 | 2 | 3 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 2.3110 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 2 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Estrogen receptor | Mus musculus (house mouse) | Ki | 0.0840 | 1 | 2 |
| Estrogen receptor beta | Mus musculus (house mouse) | Ki | 0.0840 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0240 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0028 | 1 | 1 |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | Ki | 0.0087 | 1 | 1 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | Ki | 0.0087 | 1 | 1 |
| M-phase inducer phosphatase 1 | Homo sapiens (human) | IC50 | 22.3000 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 3.7733 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 1.0130 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.2440 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 3.1120 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.1070 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 1.5140 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.3210 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.3630 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1900 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.2200 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.1580 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 1.8481 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 1.5141 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 1.7000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 1.8481 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 1.5141 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0230 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 1.7350 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.3790 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.3960 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.1690 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.6210 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 49.6000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 5.6840 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5543 | 5 | 8 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5543 | 5 | 8 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5543 | 5 | 8 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 0.0085 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0634 | 3 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0634 | 3 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0634 | 3 | 3 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 300.0000 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 103.4860 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 103.4860 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | INH | 7.2000 | 1 | 1 |
| Snq2p | Saccharomyces cerevisiae EC1118 | INH | 6.6000 | 1 | 1 |