Any methionyl aminopeptidase inhibitor that inhibits the action of methionyl aminopeptidase 2.
ChEBI ID: 73361
| Member | Definition | Class |
|---|---|---|
| fumagillin | A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. | fumagillin |
| o-(chloroacetylcarbamoyl)fumagillol | A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative. | O-(chloroacetylcarbamoyl)fumagillol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 58 (8.31) | 18.7374 |
| 1990's | 225 (32.23) | 18.2507 |
| 2000's | 298 (42.69) | 29.6817 |
| 2010's | 104 (14.90) | 24.3611 |
| 2020's | 13 (1.86) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 15 (1.87%) | 5.53% |
| Reviews | 74 (9.23%) | 6.00% |
| Case Studies | 23 (2.87%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 690 (86.03%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 34.0036 | 5 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 18.7824 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 18.7824 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 35.3848 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.6854 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 2.4489 | 3 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 21.5325 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 43.2771 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 6.1131 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 13.7369 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 34.6654 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 21.3930 | 4 | 6 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 12.2998 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.0960 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 11.4396 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 12.9587 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 0.1492 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.7824 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 55.2350 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.7974 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 6.8846 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 28.1820 | 2 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 24.0064 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 1.2314 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 6.1131 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Methionine aminopeptidase | Escherichia coli K-12 | IC50 | 100.0000 | 1 | 1 |
| Methionine aminopeptidase 1 | Saccharomyces cerevisiae S288C | IC50 | 100.0000 | 1 | 1 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | IC50 | 0.3006 | 7 | 8 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | Ki | 0.0010 | 2 | 2 |