| Assay ID | Title | Year | Journal | Article |
|---|
| AID712287 | Displacement of [3H]spiperone from rat cloned dopamine D3 receptor expressed in HEK-293 cells by competition binding assay | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID1298705 | Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. |
| AID690843 | Displacement of [3H]spiroperidol from rat cloned dopamine D3 receptor expressed in HEK293 cells | 2012 | Journal of medicinal chemistry, 06-28, Volume: 55, Issue:12
| Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agoni |
| AID750046 | Displacement of [3H]spiperone from rat cloned dopamine D3 receptor expressed in HEK293 cells after 1 hr | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors. |
| AID712282 | Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID750047 | Displacement of [3H]spiperone from rat cloned dopamine D2L receptor expressed in HEK293 cells after 1 hr | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors. |
| AID1298711 | Selectivity index, ratio of Ki for human beta2 receptor to Ki for human D2S receptor | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. |
| AID65118 | Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID1265372 | Displacement of [3H]Spiroperidol from cloned rat dopamine D2L receptor expressed in HEK293 cells by liquid scintillation counting analysis | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23
| Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treat |
| AID712285 | Selectivity ratio of Ki for rat cloned dopamine D2L receptor to Ki for rat cloned dopamine D3 receptor | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID712284 | Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTP gammaS binding assay | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID1265373 | Displacement of [3H]Spiroperidol from cloned rat dopamine D3 receptor expressed in HEK293 cells by liquid scintillation counting analysis | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23
| Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treat |
| AID750045 | Selectivity ratio of Ki for rat cloned dopamine D2L receptor to Ki for rat cloned dopamine D3 receptor | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors. |
| AID712288 | Displacement of [3H]spiperone from rat cloned dopamine D2L receptor expressed in HEK-293 cells by competition binding assay | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID1265374 | Selectivity ratio of Ki for cloned rat dopamine D2L receptor to Ki for cloned rat dopamine D3 receptor expressed in HEK293 cells | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23
| Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treat |
| AID690842 | Selectivity ratio of Ki for rat cloned dopamine D2L receptor to Ki for rat cloned dopamine D3 receptor | 2012 | Journal of medicinal chemistry, 06-28, Volume: 55, Issue:12
| Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agoni |
| AID64502 | Binding affinity was evaluated by calculating competition for [3H]N-0437 binding on Dopamine receptor D2L of CHO K-1 cells | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID186036 | In vivo locomotor activity (accumulated counts/30 min) in reserpine-pretreated rats, after subcutaneous administration of 0.31 umol/kg | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
| C3-methylated 5-hydroxy-2-(dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation. |
| AID177306 | Effect of in vivo DOPA accumulation in reserpine-pretreated rats at limbic region, at 5 mg/kg dosage administered subcutaneously | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
| C3-methylated 5-hydroxy-2-(dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation. |
| AID64635 | Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D2L of CHO K-1 cells. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID177308 | Effect of in vivo DOPA accumulation in reserpine-pretreated rats at striatum region, at 5 mg/kg dosage administered sc | 1987 | Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
| C3-methylated 5-hydroxy-2-(dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation. |
| AID64006 | Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID712281 | Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay relative to dopamine | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID712283 | Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTP gammaS binding assay relative to dopamine | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| AID1298708 | Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. |
| AID690844 | Displacement of [3H]spiroperidol from rat cloned dopamine D2L receptor expressed in HEK293 cells | 2012 | Journal of medicinal chemistry, 06-28, Volume: 55, Issue:12
| Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agoni |
| AID712280 | Selectivity ratio of EC50 for human cloned dopamine D2 receptor to EC50 for human cloned dopamine D3 receptor | 2012 | ACS medicinal chemistry letters, Oct-26, Volume: 3, Issue:12
| Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |