Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
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| "Chagas disease is endemic in Chile." | ( Apt, W; Rodríguez, J; Sánchez, G; Venegas, J; Zulantay, I, 1998) |
| "Chagas disease is caused by the protozoan parasite Trypanosoma cruzi." | ( Prata, A, 2001) |
| "Chagas disease is a transfusion-transmitted infection." | ( Bueno, JL; Carrión, J; Castro, E; Fresno, M; Gironés, N, 2006) |
| "Chagas disease is characterized by cardiac lesions and a high level of PGE2." | ( Abdalla, GK; Castro, EC; Faria, GE; Michelin, MA; Reis, MA; Silva, KT, 2008) |
| "Treatment of Chagas disease is a controversial issue because the available drugs are highly toxic." | ( Bazán, PC; Enders, J; Fernández, AR; Fretes, R; Lo Presti, MS; Paglini-Oliva, P; Rivarola, HW; Triquell, MF, 2008) |
| "Chagas disease is a significant public health problem in the Americas, despite efforts to decrease the number of new cases since 1990." | ( de Souza, JL; Ianni, BM; Mady, C, 2008) |
| "In summary, Chagas disease is a social disease, endemic in Latin America and shows different prevalence rates in Latin American countries." | ( Dubner, S; Riera, AR; Schapachnik, E; Valero, E, 2008) |
| "Chagas disease is a neglected parasitic disease endemic in the Americas." | ( Altcheh, J; Della Védova, CO; Garcia-Bournissen, F; Giglio, N; Koren, G; Mastrantonio, G, 2009) |
| "Chagas disease is one of the major neglected diseases of the world." | ( Buckner, FS; Gelb, MH; Karimi, M; Kraus, JM; Lepesheva, GI; Verlinde, CL, 2009) |
| "Chagas disease is caused by a parasite, Trypanosoma cruzi, transmitted primarily by a triatomine insect and affects approximately 8 million people in Latin American countries." | ( Alvarez, MG; Armenti, A; Bertocchi, G; Lococo, B; Petti, M; Vigliano, C; Viotti, R, 2009) |
| "Chagas disease is caused by Trypanosoma cruzi, which can be transmitted to the fetus via the transplacental route." | ( Díaz-Luján, C; Freilij, H; Fretes, RE; Paglini, P; Triquell, MF, 2009) |
| "Chagas disease is the most important vector-borne disease in Latin America." | ( Barbu, C; Dumonteil, E; Gourbière, S, 2009) |
| "Chagas disease is one of the leading causes of heart failure in Latin America and remains without an effective treatment other than cardiac transplantation." | ( Costa, CR; Guimarães, P; Klein, W; Lima, RS; Macambira, SG; Mendez, LC; Ribeiro-Dos-Santos, R; Soares, MB; Vasconcelos, JF; Vidal, DT, 2009) |
| "Chagas disease is the most important parasitic disease in the Americas, though treatments have not evolved towards a more efficient pharmacotherapy that (i) eradicates the scarce amastigotes present at the indeterminate/chronic form and (ii) employs less toxic drugs than benznidazole or nifurtimox." | ( Morilla, MJ; Romero, EL, 2010) |
| "Chagas disease is caused by the protozoan Trypanosoma cruzi and is an endemic zoonosis in the American continent." | ( Gascon, J; Muñoz, J; Oliveira, I; Torrico, F, 2010) |
| "The chemotherapy of Chagas disease is quite unsatisfactory mainly due to its poor efficacy especially during the later chronic phase and the considerable well-known side effects." | ( Arafa, RK; Boykin, DW; da Silva, PB; De Souza, EM; Ismail, MA; Nefertiti, AS; Nixon-Smith, CK; Soeiro, MN; Tao, B, 2011) |
| "Chagas disease is endemic in Latin America, affecting 16-18 million people with more than 100 million exposed to risk of infection." | ( Gascón, J; Guerrero, L; Pinazo, MJ; Posada, E; Ribas, J; Soy, D, 2011) |
| "Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi." | ( Faúndez, M; Maya, JD; Morello, A; Salas, CO; Tapia, RA, 2011) |
| "Chagas disease is caused by infection with Trypanosoma cruzi." | ( Altcheh, J; Freilij, H; Garcia-Bournissen, F; Moroni, S; Moscatelli, G, 2011) |
| "Chagas disease is a health threat for many people, mostly those living in Latin America." | ( Baquero, E; Echeverri, F; Genes, C; Maya, JD; Triana, O, 2011) |
| "Chagas disease is one of the most important public health problems and a leading cause of cardiac failure in Latin America." | ( Carlier, Y; Cencig, S; Coltel, N; Truyens, C, 2011) |
| "Chagas disease is a neglected illness, with limited treatments, caused by the parasite Trypanosoma cruzi." | ( Fernández, GJ; Mejía-Jaramillo, AM; Palacio, L; Triana-Chávez, O, 2011) |
| "Chagas disease is a disease endemic in Latin America, caused by the parasite Trypanosoma cruzi." | ( Carrilero, B; Martínez-Lage, L; Murcia, L; Segovia, M, 2011) |
| "Chagas disease is still an important health problem in Central and South America." | ( Albesa, I; Becerra, MC; Gea, S; Guiñazú, N; Hergert, LY; Mazzieri, MR; Pellegrini, A, 2012) |
| "Chagas disease is a zoonosis caused by the protozoan Trypanosoma cruzi." | ( Burgos, LG; Canese, A; Melo, M; Ojeda, A; Ortiz, BD, 2012) |
| "Chagas disease is a neglected tropical disease endemic in Latin America." | ( López-Vélez, R; Navarro, M; Norman, FF; Pérez-Molina, JA, 2012) |
| "Leishmaniasis and Chagas disease are parasitic protozoan infections that affect the poorest population in the world, causing high mortality and morbidity." | ( de Oliveira, A; Guimarães, EF; Kato, MJ; Lago, JH; Mesquita, JT; Tempone, AG, 2012) |
| "Acute Chagas disease is rarely recognized, and the risk for acquiring the disease is undefined in travelers to Central America." | ( Carter, YL; Juliano, JJ; Montgomery, SP; Qvarnstrom, Y, 2012) |
| "The cardiac form of Chagas disease is evidenced by a progressive cardiac inflammation that leads to myocarditis, fibrosis and electrocardiographic (ECG) conduction abnormalities." | ( Azevedo, MA; Bahia, MT; Caldas, IS; da Matta Guedes, PM; da Silva do Nascimento, AF; de Figueiredo Diniz, L; de Lima, WG; dos Santos, FM; Martins, TA; Neto, RM; Talvani, A; Torres, RM, 2013) |
| "Chagas disease is a leading cause of heart disease affecting approximately 10 million people in Latin America and elsewhere worldwide." | ( Bacon, KM; Bottazzi, ME; Cravioto, MB; de Leon Rosales, SP; Dumonteil, E; Fleischer, B; Heffernan, MJ; Hotez, PJ; Jones, K; Kamhawi, S; Lee, BY; Ortega, J; Slingsby, BT; Tapia-Conyer, R; Valenzuela, JG; Zhan, B, 2012) |
| "Chagas disease is a zoonosis caused by T." | ( Avilés, CL; Benítez, R; Catalán, P; Noemí, I; Tassara, R, 2012) |
| "Chagas disease is a deadly infection caused by the protozoan parasite Trypanosoma cruzi." | ( Dobish, MC; Hargrove, TY; Johnson, CA; Johnston, JN; Kleshchenko, YY; Lepesheva, GI; Nde, PN; Villalta, F; Waterman, MR, 2013) |
| "Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and it affects as many as 10 million people in North and South America, where it represents a major public health problem." | ( Espinoza, B; Martínez, I; Martínez-Hernández, F; Nogueda, B, 2013) |
| "The treatment of Chagas disease is limited by the frequent cutaneous side effects of benznidazole." | ( Cabello, A; Fernández-Roblas, R; Górgolas, M; Peremarch, CP; Pérez-Tanoira, R; Rincón, JM; Robles, I; Williams, F, 2013) |
| "Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi." | ( Chica, JE; de Paula Rogerio, A; Lemos, JR; Miguel, CB; Miguel, RB; Oliveira, CJ; Parreira, RC; Rodrigues, WF, 2013) |
| "Chagas disease is still an important endemic disease in Brazil, and the cardiac involvement is its more severe manifestation." | ( Budni, P; Dalmarco, EM; Dalmarco, JB; Frode, TS; Pedrosa, RC; Wilhelm Filho, D, 2013) |
| "Chagas disease is caused by Trypanosoma cruzi (T." | ( Alba-Soto, CD; Briñón, MC; Gualdesi, MS; Novoa, MM; Raviolo, MA; Solana, ME, 2013) |
| "Chagas disease is caused by the parasite Trypanosoma cruzi, is endemic in Latin America and leads to an estimated 14,000 deaths per year and around 100 million people at risk of infection." | ( Andriani, G; Ashworth, R; Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rodriguez, A; Rosenzweig, HS; Wilkinson, SR, 2013) |
| "Chagas disease is responsible for a large number of human infections and many are also at risk of infection." | ( Aiub, CA; Bastos, MM; Boechat, N; Carvalho, AS; Felzenszwalb, I; Mello, FV, 2013) |
| "Chagas disease is a new imported paediatric disease that can affect children from endemic countries, but can also be acquired in our country by vertical transmission." | ( Fisa, R; Fumadó, V; Gállego, M; Gascón, J; Juncosa, T; Posada, E, 2014) |
| "Chagas disease is the highest impact parasitic disease in the Americas but often goes untreated due to the shortcomings of currently available therapeutics." | ( Bustamante, JM; Tarleton, RL, 2014) |
| "Chagas disease is a lifelong, systemic, parasitic infection caused by the protozoan Trypanosoma cruzi." | ( Bibolini, J; Cicora, F; Escurra, V; González, I; Petroni, J; Roberti, J, 2014) |
| "Chagas disease is caused by the parasite Trypanosoma cruzi." | ( Cervantes-Landín, AY; Espinoza, B; Martínez, I; Schabib, M, 2014) |
| "The prevention of Chagas disease is based primarily on the chemical control of Triatoma infestans (Klug) using pyrethroid insecticides." | ( Carvajal, G; Picollo, MI; Toloza, AC, 2014) |
| "Chagas disease is a neglected vector-borne disease with an estimated prevalence of 1." | ( Manne-Goehler, J; Ramsey, JM; Reich, MR; Salgado, MO; Wirtz, VJ, 2014) |
| "Chagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic." | ( Aldasoro, E; Gascon, J; Munoz, J; Oliveira, I; Pinazo, MJ; Posada, E; Requena-Méndez, A; Serret, N, 2015) |
| "Chagas disease is a chronic infection in humans caused by Trypanosoma cruzi and manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction." | ( Calvet, CM; Cameron, MD; Choi, JY; Gut, J; Johnston, JB; Kellar, D; McKerrow, JH; Podust, LM; Roush, WR; Siqueira-Neto, JL; Vieira, DF, 2014) |
| "Chagas disease is caused by Trypanosoma cruzi infection, being cardiomyopathy the more frequent manifestation." | ( Carbajosa, S; Chillón-Marinas, C; Fresno, M; Gironès, N; Guerrero, NA; Poveda, C, 2014) |
| "Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi." | ( Morilla, MJ; Romero, EL, 2015) |
| "Chagas disease is an anthropozoonosis caused by Trypanosoma cruzi." | ( Bianchi, F; Cucunubá, Z; Flórez, AC; Freilij, H; González, NL; Guhl, F; Montilla, M; Nicholls, RS; Ramírez, JD; Rosas, F; Saavedra, V; Silva, N, 2015) |
| "Chagas disease is a chronic parasitic infection restricted to America." | ( Mougabure-Cueto, G; Picollo, MI, 2015) |
| "Chagas disease is caused by the parasite Trypanosoma cruzi and is regularly found among particular people living in Central and South America." | ( Morel, CM; Thota, S, 2018) |
| "Chagas disease is a major unsolved health issue in Latin America and an emerging threat worldwide." | ( Alba Soto, CD; Curto, MLA; Lammel, EM; Miranda, CG; Schijman, AG; Solana, ME, 2015) |
| "Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi (T." | ( Ciapponi, A; Comandé, D; Cuesta, CB; Hicks, E; Roberts, KN; Sguassero, Y; Sosa-Estani, S, 2015) |
| "Chagas disease is a problem of global public health." | ( Ramos, C; Vela-Bahena, LE; Vergara, R; Vite, L, 2015) |
| "Chagas disease is a parasitosis endemic to South America." | ( Bellón, T; Cabañas, R; Cachafeiro, L; González-Ramos, J; Herranz-Pinto, P; Noguera-Morel, L; Ramírez, E; Ruiz-Bravo, E; Tong, HY, 2016) |
| "Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America." | ( Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A, 2016) |
| "Chagas disease is one of the most important endemic parasitic diseases in Latin America." | ( Costa, CA; Faccini, CC; Fragata, Cda S; Fragata-Filho, AA; França, FF; Lourenço, AM, 2016) |
| "Chagas disease is an important public health problem in Latin America, and its treatment by chemotherapy with benznidazole (BZ) or nifurtimox remains unsatisfactory." | ( Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM, 2016) |
| "Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy." | ( Brough, SJ; De Rycker, M; Gray, DW; Miles, TJ; Riley, J; Thomas, J, 2016) |
| "Chagas disease is one of the most important parasitic infections in Latin America." | ( Fronza, G; Mougabure-Cueto, GA; Picollo, MI; Spillmann, C; Toloza, AC, 2016) |
| "Chagas disease is the highest impact parasitic disease in Latin America." | ( Albareda, MC; Alvarez, MG; Bertocchi, GL; Castro Eiro, M; Cooley, G; Laucella, SA; Lococo, B; Perez-Mazliah, DE; Tarleton, RL; Viotti, R, 2016) |
| "Chagas disease is a vector-borne and potentially fatal parasitic disease that is transmitted by the triatomine bug, a nocturnal feeding, flying arthropod, often referred to by its colloquial name, the "kissing bug." | ( Antes, AW; Dolhun, EP, 2016) |
| "Chagas disease is characterised by an acute phase, which is partially resolved by the immune system, but then develops as a chronic life-long infection." | ( Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL, 2016) |
| "Chagas disease is a tropical parasitic disease caused by the protozoan Trypanosoma cruzi, which affects about ten million people in its endemic regions of Latin America." | ( Aiyyappan, JP; Almonte, V; Cui, MH; Law, C; Lizardo, K; Nagajyothi, JF, 2017) |
| "Chagas disease is a neglected tropical disease with 6-7 million people infected worldwide, and there is no effective treatment." | ( Azqueta, A; Cirauqui, N; Jimenez-Lopez, M; Jiménez-Montes, C; López de Ceráin, A; Marín, C; Martín-Escolano, R; Martin-Montes, A; Moreno-Viguri, E; Pérez-Silanes, S; Sánchez-Moreno, M; Santivañez-Veliz, M; Zamora Ledesma, S, 2016) |
| "BACKGROUND Chagas disease is a chronic parasitosis transmitted by the inoculation of infected triatomine feces into wounds or conjunctival sac, transfusion, congenitally, organ transplantation, and ingestion of contaminated food." | ( Navarrete-Sandoval, RH; Servín-Rojas, M, 2016) |
| "Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by heart failure and sudden death." | ( Fresno, M; Gironès, N; Marques, J; Mendoza, I; Mijares, A; Rodríguez-Angulo, H; Villegas, M, 2017) |
| "Chagas disease is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi." | ( Aimond, F; Branquinho, RT; de Lana, M; Farah, C; Garcia, GM; Grabe-Guimaraes, A; Le Guennec, JY; Mosqueira, VC; Richard, S; Roy, J; Saude-Guimarães, DA, 2017) |
| "The parasitic Chagas disease is caused by the protozoan Trypanosoma cruzi, which is mainly transmitted by insect vectors." | ( Alcover, MM; Cancino-Faure, B; Fisa, R; Girona-Llobera, E; Jimenez-Marco, T; Riera, C, 2017) |
| "In Latin America Chagas disease is an endemic illness caused by the parasite Trypanosoma cruzi (T." | ( Alho, I; Castiglioni, J; Correia, I; Costa Pessoa, J; Gambino, D; Marques, F; Mosquillo, MF; Pérez, L; Rostán, S; Scalese, G, 2017) |
| "Chagas disease is a neglected tropical disease; the only viable drugs are outdated and produce frequent side effects, and the overwhelming majority of cases are undiagnosed and untreated." | ( Forsyth, C, 2018) |
| "Chagas disease is an NTD caused by Trypanosoma cruzi; it is endemic to Latin America, infecting 8 million individuals." | ( Alpern, JD; Lopez-Velez, R; Stauffer, WM, 2017) |
| "Chagas disease is an endemic parasitic infection that occurs in 21 Latin American countries." | ( Almeida, PDO; Cardoso, MFDC; da Silva, FC; Dantas, ED; de Azevedo, EP; de Azevedo, PHA; de Souza, FJJ; Ferreira, VF; Guimarães Barbosa, E; Lima, ÁAN; Lima, ES; Nogueira, WNL; Silva, CC; Soares Aragão, CF, 2017) |
| "Chagas disease is one of the most significant health problems in the American continent." | ( Anjos, PSD; Cardoso, MVO; Coelho, PL; de Oliveira Filho, GB; Espíndola, JWP; Ferreira, RS; Leite, ACL; Meira, CS; Moreira, DRM; Oliveira E Silva, DA; Santos, ES; Soares, MBP, 2017) |
| "Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 5-8 million people in Latin America." | ( Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC, 2017) |
| "Chagas disease is caused by the Trypanosoma cruzi affecting millions of people, and widespread throughout Latin America." | ( Amaral, RR; Faria, RX; Fernandes, CP; Lima, B; Rocha, L; Ruppelt, BM; Santos, MG; Souza, ALA; Tietbohl, LAC, 2017) |
| "Chagas disease is a potentially fatal disease caused by the parasite Trypanosoma cruzi, which can in some cases affect the central nervous system." | ( Acosta, N; Centurión-Wenninger, C; Figueredo-Thiel, S; Meza-Ojeda, A; Mongelós-Cardozo, M; Morínigo-Guayuán, S; Sanchez, DF; Silvero-Isidre, A, 2018) |
| "Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T." | ( Arrúa, EC; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Scalise, ML, 2017) |
| "Chagas disease is an endemic disease caused by Trypanosoma cruzi, which affects more than eight million people, mostly in the Americas." | ( Acevedo, CH; Scotti, L; Scotti, MT, 2018) |
| "Chagas disease is a major neglected vector-borne disease." | ( Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F, 2018) |
| "Chagas disease is a tropical disease caused by the hemoflagellate protozoan Trypanosoma cruzi." | ( Ceole, LF; Gandhi, H; O'Sullivan, TP; Soares, MJ; Villamizar, LH, 2018) |
| "Chagas disease is one of the most relevant endemic diseases in Latin America caused by the flagellate protozoan Trypanosoma cruzi." | ( da Silva, FC; Faria, RX; Ferreira, VF; Gonzaga, DTG; Pacheco, PAF; Souza, ALA, 2018) |
| "Leishmaniasis and Chagas disease are endemic pathologies in tropical countries." | ( Cardona-G, W; Herrera-R, A; Yepes, AF, 2018) |
| "Chagas disease is a vector-borne, systemic and chronic parasitic infection caused by Trypanosoma cruzi with approximately 8 million cases worldwide." | ( Chopra, S; Dasgupta, A; Thakare, R, 2018) |
| "Chagas disease is a parasitic disease that mostly affects Latin American countries, but it has currently become a worldwide epidemic due to migration." | ( Calbacho Robles, M; Crespillo-Andújar, C; Norman, FF; Pérez-Molina, JA, 2018) |
| "Chagas disease is a public health problem, affecting about 7 million people worldwide." | ( Albuquerque, EL; Barroso Neto, IL; Bezerra, EM; de Menezes, RRPPB; Dos Santos, RP; Freire, VN; Lima, DB; Magalhães, EP; Martins, AM; Mello, CP; Oliveira, MF; Sales, FAM; Tessarolo, LD, 2018) |
| "Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi." | ( Benaim, G; Hejchman, E; Hernández-Rodríguez, V; Pinto-Martinez, A; Rodríguez-Durán, J, 2018) |
| "Chagas disease is a neglected pathology responsible for about 12,000 deaths every year across Latin America." | ( Batista, MM; Corcoran, O; de Almeida Fiuza, LF; de Nazaré Correia Soeiro, M; Peres, RB; Reddy, TRK; Silva, PB; Ullah, AI, 2018) |
| "Chagas disease is caused by Trypanosoma cruzi." | ( Cuéllar, A; Egui, A; González, JM; López, MC; Pérez-Antón, E; Puerta, CJ; Segovia, M; Thomas, MC, 2018) |
| "Chagas disease is a neglected disease caused by the protozoan Trypanosoma cruzi and several research groups are focused on the illness treatment." | ( Abrahão, AAC; da Costa, CMB; de Freitas, MRB; do Prado, JC; Pereira, LM; Sala, MA, 2018) |
| "Chagas disease is caused by a parasite infection endemic of the Americas." | ( Morillo, CA; Velasco, A, 2020) |
| "Chagas disease is a neglected tropical disease." | ( Borges Migliavaca, C; Colpani, V; Falavigna, M; Nascimento Cruz, L; Oliveira Dantas, R; René Pinto de Sousa Miguel, S; Stein, C, 2018) |
| "Chagas disease is highly prevalent in Latin America, and vector control is the most effective control strategy to date." | ( Ballif, BA; Keller, JI; Schmidt, JO; Schmoker, AM; Stevens, L, 2018) |
| "Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of the most important neglected tropical diseases, especially in Latin American countries, where there is an association between low-income populations and mortality." | ( Bombaça, ACS; da Silva Júnior, EN; Goulart, MOF; Guimarães, ACR; Menna-Barreto, RFS; Rodrigues, ABM; Santos, ACC; Silva, TL; Viana, PG, 2019) |
| "Chagas disease is a parasite infection primarily transmitted to humans via the bite of triatomine insect vectors." | ( Borchardt, RA; Tzizik, DM, 2018) |
| "Chagas disease is a neglected chronical parasitosis caused by the parasite Trypanosoma cruzi (T." | ( Cirauqui, N; Gabano, E; Marín, C; Martín-Escolano, R; Moreno-Viguri, E; Paucar, R; Pérez-Silanes, S; Ravera, M; Rodrigues, CR; Sánchez-Moreno, M, 2019) |
| "Chagas disease is a neglected tropical disease (NTD) caused by the protozoan parasite Trypanosoma cruzi and is primarily transmitted to humans by the feces of infected Triatominae insects during their blood meal." | ( Andrade, CH; Braga, RC; Franco, CH; Freitas-Junior, LH; Melo-Filho, CC; Moraes, CB; Muratov, EN, 2019) |
| "Chagas Disease is caused by infection with the insect-transmitted protozoan Trypanosoma cruzi and affects more than 10 million people." | ( Costa, A; López, C; Marín, C; Martín-Escolano, R; Martin-Montes, Á; Medina-Carmona, E; Rotger, C; Sánchez-Moreno, M; Vega, M, 2019) |
| "Chagas disease is caused by Trypanosoma cruzi and remains one of the most neglected diseases in Latin America." | ( Brehmer, A; da Silveira, ABM; de Oliveira, EC; de Oliveira, JA; Freitas, MAR; Jabari, S, 2019) |
| "Chagas disease is still prevalent in rural areas of South America." | ( Dolgalev, I; Dominguez-Bello, MG; Frattaroli, P; Heguy, A; Hevia, A; Hoashi, M; Iraola, G; Maldonado, DP; Mojica, M; Montacutti, V; Robello, C, 2019) |
| "Chagas disease is the highest impact parasitic disease in Latin America." | ( Albareda, MC; Alvarez, MG; Castro Eiro, MD; Cesar, GL; Laucella, SA; Natale, MA, 2019) |
| "Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi." | ( Kratz, JM, 2019) |
| "Chagas disease is caused by Trypanosoma cruzi and affects about 7 million people worldwide." | ( de Azevedo, IEP; de Menezes, RRPPB; Dos Santos, RP; Lima, DB; Magalhães, EP; Marinho, MM; Martins, AMC; Sampaio, TL; Sousa, PL; Tessarolo, LD, 2019) |
| "Chagas disease is a lifelong pathology resulting from Trypanosoma cruzi infection." | ( Adami, PM; Aoki, MP; Bergero, G; Carrera Silva, EA; Eberhardt, N; Hernández-Vasquez, Y; Minguez, ÁR; Morelli, L; Postan, M; Quebrada Palacio, LP; Sanmarco, LM; Visconti, LM, 2019) |
| "Chagas disease is an infectious tropical disease included within the group of neglected tropical diseases." | ( Alberca, LN; Bellera, CL; Sbaraglini, ML; Talevi, A, 2020) |
| "Chagas disease is one of the main neglected diseases in the world, being endemic in 21 countries of Latin America." | ( Asís, SE; Buldain, GY; Frank, FM; Muscia, GC; Roldán Pacheco, FJ, 2020) |
| "Chagas disease is a vector-borne disease caused by the protozoan parasite Trypanosoma cruzi." | ( Campos-Estrada, C; Carillo, I; Castillo, C; González-Herrera, F; Greif, G; Guzmán-Rivera, D; Kemmerling, U; Liempi, A; Maya, JD; Robello, C, 2020) |
| "Chagas disease is caused by infection with the parasite Trypanosoma cruzi, which might lead to a chronic disease state and drive to irreversible damage to the heart and/or digestive tract tissues." | ( Alonso-Padilla, J; Cortes-Serra, N; Fernandez-Becerra, C; Gascon, J; Losada-Galvan, I; Pinazo, MJ, 2020) |
| "Chagas disease is a neglected tropical disease." | ( da Silva, RV; Felipe, I; Lovo-Martins, MI; Malvezi, AD; Martins-Pinge, MC; Panis, C; Pinge-Filho, P; Tatakihara, VLH; Wowk, PF; Zanluqui, NG, 2020) |
| "Chagas disease is a neglected disease that remains a public health threat, particularly in Latin America." | ( Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC, 2020) |
| "Chagas disease is one of the most prevalent tropical neglected diseases and causes high mortality and morbidity in endemic countries." | ( Alcolea, V; Pérez-Silanes, S, 2020) |
| "Chagas disease is endemic in Latin America, and medical care for the disease is the major expense for Brazil's Universal Healthcare System (Sistema Único de Saúde (SUS)." | ( Cunha-Neto, E; Kalil, J; Moore, CE; Nascimento, MS; Pandey, RP; Raj, VS, 2021) |
| "Chagas disease is a serious parasitic infection caused by Trypanosoma cruzi." | ( Búa, J; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Seremeta, KP, 2021) |
| "The complexity of Chagas disease is still a challenge in endemic regions and an emergent public health problem in non-endemic countries." | ( Canto, RFS; Cerecetto, H; Eifler-Lima, VL; Gonçalves, GA; Poser, GLV, 2021) |
| "Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi (T." | ( Fukami, T; Honma, T; Inaoka, DK; Kita, K; Koyama, H; Matsuo, Y; Nakagawa, Y; Nara, T; Ogawa, N; Sekimata, K; Shirouzu, M; Tanaka, A; Tsuganezawa, K; Yuki, H, 2021) |
| "Chagas disease is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi and is transmitted to humans through the excreta of infected blood-sucking triatomine bugs." | ( Dalhatou, S; Ferreira, EI; Katata-Seru, LM; Paumo, HK; Pone, KB, 2022) |
| "Chagas disease is a vector-borne neglected tropical disease caused by Trypanosoma cruzi." | ( Chopra, S; Dasgupta, A; Thakare, R, 2021) |
| "Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi (T." | ( Engman, DM; Falk, BA; Li, X; Martinez, SJ; Olson, CL; Romano, PS; Scariot, DB; Scott, EA; Yi, S, 2021) |
| "Chagas disease is a neglected tropical disease caused by the flagellate protozoan Trypanosoma cruzi (T." | ( da Silva Nascimento, DDS; de Moura Ferraz, LR; Ferreira, AS; Junior, SA; Rolim, LA; Rolim-Neto, PJ; Silva, JYR; Tabosa, AÉGA, 2021) |
| "Chagas disease is caused by Trypanosoma cruzi and affects thousands of people." | ( Amorim-Carmo, B; da Silva Barbosa, J; Damasceno, IZ; de Freitas Oliveira, JW; Moreno, CJG; Rocha, HAO; Silva, MS; Soares, AKMC; Torres, TM, 2021) |
| "Chagas disease is a life-threatening disorder caused by the protozoan parasite Trypanosoma cruzi." | ( Alvarez, JM; Amarante-Mendes, GP; Bortoluci, KR; Cassado, A; D'Império-Lima, MR; Hernández-Torres, M; Matteucci, KC; Rebouças, MC; Silva do Nascimento, R; Vasconcelos, JRC, 2021) |
| "Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and in Central America, it is considered one of the four most infectious diseases." | ( Castillo, UG; Kiuchi, F; Komatsu, A; Martínez, ML; Menjívar, J; Nakajima-Shimada, J; Narukawa, Y; Núñez, MJ; Uekusa, Y, 2022) |
| "Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole." | ( Côrte-Real, S; Decote-Ricardo, D; Freire de Lima, ME; Freire-de-Lima, CG; Trindade, JDS, 2021) |
| "Chagas disease is a neglected parasitosis caused by the protozoan parasite Trypanosoma cruzi." | ( Bosch-Nicolau, P; Crespillo-Andújar, C; Molina, I; Pérez-Molina, JA, 2021) |
| "Chagas disease is mainly transmitted by triatomine insect vectors that feed on vertebrate blood." | ( Ballif, BA; Galván, MF; Laparra-Ruiz, E; Monroy, MC; Penados, D; Pineda, JP; Schmoker, AM; Stevens, L, 2022) |
| "Chagas disease is endemic in rural areas of Latin America, but T." | ( Abbott, A; Chancey, RJ; Montgomery, SP, 2022) |
| "Chagas disease is a disease that is emerging in North America and Europe countries." | ( Ameida-Neto, FWQ; Freitas, TA; Gomes, NDB; Lima-Neto, P; Magalhães, EP; Marinho, ES; Marinho, MM; Martins, AMC; Menezes, RRPPB; Ribeiro, LR; Sampaio, TL; Santos, HSD; Silva, BP; Teixeira, AMR, 2022) |
| "Chagas disease is endemic in ~70% of Ecuador." | ( Baus, EG; Grijalva, MJ; Moncayo, AL; Ocaña-Mayorga, S; Villacís, AG; Yumiseva, CA, 2022) |
| "Chagas disease is a neglected tropical disease affecting the American continent and also some regions of Europe." | ( Arrua, EC; Goicoechea, H; Hartwig, O; Lehr, CM; Loretz, B; Murgia, X; Salomon, CJ, 2022) |
| "Chagas disease is a neglected parasitic infection and a major public health problem in the Americas." | ( Cárdenas, WB; Erickson, D; Medina-Rivera, M; Mehta, S, 2022) |
| "Chagas disease is caused by the parasite Trypanosoma cruzi and affects millions of people worldwide, having no effective cure." | ( De Oliveira, CS; Freire, KA; García-Jareño, AB; Lima, DB; Magalhães, EP; Marinho, MM; Martins, AMC; Menezes, RRPPB; Monteiro, ML; Nicolaski Pedron, C; Nunes, JVS; Oliveira Junior, VX; Orzaéz, M; Silva, BP, 2022) |
| "Chagas disease is caused by infection with the parasite Trypansoma cruzi ." | ( La Hoz, RM, 2022) |
| "Chagas Disease is caused by the protozoan Trypanosoma cruzi and is considered a tropical neglected disease by the World Health Organization (WHO)." | ( Andricopulo, AD; Brasil, BFAB; Brondani, D; Cenci, AR; Chipoline, IC; de Oliveira, AS; Ferreira, LLG; Krogh, R; Nascimento, V; Neto, JSS; Teixeira, KF; Valli, M; Zapp, E, 2022) |
| "Chagas disease is a parasitic disease from South America, affecting around 7 million people worldwide." | ( Almeida, RR; Brochet, P; Buck, P; Cândido, DDS; Chevillard, C; Cunha-Neto, E; Dias, F; Donadi, E; Ferreira, LRP; Frade, AF; Fragata, A; Hirata, MH; Ianni, B; Kalil, J; Kuramoto, A; Lin-Wang, HT; Mady, C; Marin-Neto, JA; Martinelli, M; Nunes, JPS; Peixoto, GDL; Pereira, AC; Pissetti, CW; Rigaud, VOC; Rodrigues Junior, V; Saba, B; Sampaio, M; Schmidt, A; Siqueira, S; Spinelli, L; Teixeira, PC; Zaniratto, RCF, 2022) |
| "Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi." | ( Andricopulo, AD; Caljon, G; Campbell, S; Chelucci, RC; de Oliveira Rezende Júnior, C; Dias, LC; Ferreira, LLG; Ferreira, RAA; Koovits, PJ; Kratz, JM; Maes, L; Martinez, PDG; Matheeussen, A; Michelan-Duarte, S; Miranda Soares, B; Mowbray, CE; Van Pelt, N, 2023) |
| "Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi." | ( Andricopulo, AD; Caljon, G; Campbell, S; Chelucci, RC; de Oliveira Rezende Júnior, C; Dias, LC; Ferreira, LLG; Ferreira, RAA; Koovits, PJ; Kratz, JM; Maes, L; Martinez, PDG; Matheeussen, A; Michelan-Duarte, S; Miranda Soares, B; Mowbray, CE; Van Pelt, N, 2023) |
| "Chagas disease is caused by the parasite Trypanosoma cruzi (T." | ( Alvim, JM; Krieger, JE; Oliveira, TGM; Pereira, AC; Seidman, CE; Seidman, JG; Venturini, G, 2023) |
| "Chagas disease is a neglected tropical disease (NTD) caused by Trypanosoma cruzi, whilst leishmaniasis, which is caused by over 20 species of Leishmania, represents a group of NTDs endemic to most countries in the tropical and subtropical belt of the planet." | ( Freitag-Pohl, S; Murillo, AM; Pohl, E; Silber, AM; Sowerby, K, 2023) |
| "Chagas disease is a deadly and centenary neglected disease that is recently surging as a potential global threat." | ( Accioly Brelaz de Castro, MC; Bezerra de Oliveira Filho, G; Cox Holanda de Barros Dias, M; Cristovão Silva, AC; da Silva Santos, AC; de Freitas E Silva, R; Gomes Rebello Ferreira, LF; Lima Leite, AC; Maria Nascimento Moura, D; Rêgo Alves Pereira, V; Souza Barbalho, M; Veríssimo de Oliveira Cardoso, M; Zaldini Hernandes, M, 2023) |
| "Chagas disease is a health concern for humans and animals across the Americas, and control options targeting the triatomine vectors of Trypanosoma cruzi, the causative agent of Chagas disease, are limited." | ( Busselman, RE; Hamer, GL; Hamer, SA; Zecca, IB, 2023) |
| "Chagas Disease is a pathology caused by the parasite Trypanosoma cruzi." | ( Escalante Rivas, MJ; Inojosa Mackenzie, R; Pimentel González, J; Vergara Zuñiga, C, 2022) |
| "Chagas disease is caused by the protozoan parasite, Trypanosoma cruzi." | ( Costa Dos Santos Junior, G; de Almeida Nogueira, NP; Paes, MC; Pinheiro Aguiar, R; Silva Dias Vieira, C, 2023) |
| Excerpt | Reference |
|---|
| "Indications for treatment of Chagas disease in immunocompetent patients and immunocompromised hosts are detailed." | ( A, IZ; B, WA; G, IH; H, IN; H, MT; L, MI; M, LJ; P, JS; V, AM; V, PM, 2008) |
| "Only two drugs are available for the treatment of Chagas disease, benznidazole and nifurtimox." | ( Altcheh, J; Della Védova, CO; Garcia-Bournissen, F; Giglio, N; Koren, G; Mastrantonio, G, 2009) |
| "Four years after treatment for acute Chagas disease, all patients presented with negative parasitological tests and persistent IgG anti-T." | ( Ferreira, AG; Harada, GS; Pinto, AY; Valente, SA; Valente, Vda C, 2009) |
| "The only approved therapeutics for the treatment of Chagas disease are two nitroheterocyclic compounds as a nitrofuran (nifurtimox; Lampit) and a nitroimidazole (benznidazole; Rochagan)." | ( Campillo, NE; Páez, JA; Sánchez-Sancho, F, 2010) |
| "Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce." | ( Alirol, E; Chappuis, F; Combescure, C; Getaz, L; Jackson, Y; Wolff, H, 2010) |
| "The latter may be the drug to treat Chagas disease in the future when all the investigations related to it are finished." | ( Apt, W, 2010) |
| "To date, benznidazole is the only treatment of Chagas disease available in Europe." | ( Gascón, J; Guerrero, L; Pinazo, MJ; Posada, E; Ribas, J; Soy, D, 2011) |
| "Though current treatment for Chagas disease is still controversial, if it were considered as a thromboembolic risk factor the antiparasitic treatment strategy could be reinforced." | ( Ayala, E; Fisa, R; Gállego, M; Gascon, J; Monteagudo, J; Muñoz, J; Pinazo, MJ; Posada, Ede J; Reverter, JC; Tàssies, D, 2011) |
| "New safe and effective treatments for Chagas disease (CD) are urgently needed." | ( Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; do Nascimento, ÁF; Martins, TA; Ribeiro, I; Talvani, A; Torreele, E; Trunz, BB, 2012) |
| "In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin which has shown significant activity on trypomastigote forms of Trypanosoma cruzi." | ( Assis, Md; Callejon, DR; Cramer, B; da Silva, DB; de Albuquerque, S; de Barros, VP; De Santis Ferreira, L; Engemann, A; Humpf, HU; Kato, MJ; Lopes, NP; Okano, LT, 2012) |
| "The two major drugs available for the treatment of Chagas disease have limited efficacy in Trypanosoma cruzi-infected adults with indeterminate (patients who have seroconverted but do not yet show signs or symptoms) and determinate (patients who have both seroconverted and have clinical disease) status; they require prolonged treatment courses and are poorly tolerated and expensive." | ( Bacon, KM; Bottazzi, ME; Cravioto, MB; de Leon Rosales, SP; Dumonteil, E; Fleischer, B; Heffernan, MJ; Hotez, PJ; Jones, K; Kamhawi, S; Lee, BY; Ortega, J; Slingsby, BT; Tapia-Conyer, R; Valenzuela, JG; Zhan, B, 2012) |
| "Specific treatment for Chagas disease does not appear to be related to a higher incidence of neoplasms, and a direct role of T." | ( Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J, 2013) |
| "The etiological treatment of Chagas disease is recommended for all patients with acute or recent chronic infection, but controversies remain regarding the benefit of chemotherapy and interpretations of the parasitological cure after etiological treatment." | ( Albajar-Viñas, P; Coura, JR; Dias, JC; Diniz, GA; Lana, Md; Machado-Coelho, GL; Machado-de-Assis, GF; Montoya, RA; Torres, RM, 2013) |
| "The currently available treatments for Chagas disease show limited therapeutic potential and are associated with serious side effects." | ( Cerecetto, H; Chiriboga, X; de Bilbao, NI; González, M; Miño, P; Serna, E; Torres, S; Varela, J; Yaluff, G, 2014) |
| "Recent research showed that access to treatment of Chagas disease is limited in Mexico, with < 0." | ( Manne-Goehler, J; Ramsey, JM; Reich, MR; Salgado, MO; Wirtz, VJ, 2014) |
| "This study demonstrates that access to treatment of Chagas disease in the United States is limited." | ( Manne-Goehler, J; Reich, MR; Wirtz, VJ, 2015) |
| "It is currently unknown whether treatment of Chagas disease decreases the risk of congenital transmission from previously treated mothers to their infants." | ( Altcheh, J; Ballering, G; Bisio, M; Freilij, H; García-Bournissen, F; Moroni, S; Moscatelli, G, 2015) |
| "In order to identify new compounds to treat Chagas disease during the acute phase with higher activity and lower toxicity than the reference drug benznidazole (Bz), two hydroxyphthalazine derivative compounds were prepared and their trypanocidal effects against Trypanosoma cruzi were evaluated by light microscopy through the determination of IC50 values." | ( Marín, C; Martín-Escolano, R; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Urbanová, K, 2015) |
| "This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice." | ( Araújo, EJ; Massocatto, CL; Moreira, NM; Muniz, E; Pinge-Filho, P; Rossi, RM; Sant'Ana, DM, 2017) |
| "Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults." | ( Altcheh, J; Bournissen, FG; Fernández, ML; Marson, ME; Mastrantonio, G; Ramirez, JC; Riarte, AR; Schijman, AG, 2016) |
| "The etiological treatment of Chagas disease remains neglected." | ( Branquinho, RT; de Mello, CG; Lana, Md; Milagre, MM; Mosqueira, VC; Oliveira, MT; Saúde-Guimarães, DA, 2016) |
| "Current drugs available for the treatment of Chagas disease are fraught with several challenges including severe toxicity and limited efficacy." | ( Adeyemi, OS; Eseola, AO; Fonseca-Berzal, C; Gómez-Barrio, A; Molina, MT, 2017) |
| "Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist." | ( Cardoso, JM; Carneiro, CM; Correa-Oliveira, R; Fonseca, KD; Mathias, FA; Molina, I; Moreira da Silva, R; Perin, L; Reis, LE; Vieira, PM, 2017) |
| "Etiological treatment of Chagas disease in chronic asymptomatic patients is still in debate and the adverse effects of traditional drugs are one of the main concerns in clinical practice." | ( Agreda-Rudenko, D; Cucunubá, ZM; Duque, S; Flórez, C; Herazo, R; Nicholls, RS; Olivera, MJ; Valencia-Hernández, CA, 2017) |
| "In fact, treatment of Chagas disease with benznidazole has to be discontinued in as much as 20% of cases due to side effects." | ( Acarregui, A; Elizondo, E; Esquisabel, A; Herráez, R; Oliver, L; Pedraz, JL; Veciana, J; Ventosa, N; Viñas, M; Vinuesa, T, 2017) |
| "The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variable efficacy against different strains of the parasite and may lead to severe side effects." | ( Calvet, CM; Choi, JY; de Mesquita, LB; de Souza Pereira, MC; Hirata, K; Lostracco-Johnson, S; McKerrow, JH; Meuser-Batista, M; Nogueira, A; Podust, LM; Roush, WR; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D, 2017) |
| "In the search for new treatments against Chagas disease and leishmaniasis, several studies have shown that hybrid molecules display high antiprotozoal activity and this emerging strategy is quite promising in the field of new drug discovery and development." | ( Cardona-G, W; Herrera-R, A; Yepes, AF, 2018) |
| "Benznidazole is the preferred drug for treatment of Chagas disease." | ( Crespillo-Andújar, C; López-Polín, A; López-Vélez, R; Monge-Maillo, B; Norman, F; Pérez-Molina, JA; Venanzi-Rullo, E, 2018) |
| "The two drugs used for treating Chagas disease are benznidazole and nifurtimox (1,2), which have been used in Latin America since the 1970s and 1960s, respectively." | ( Allen, CK; Brown, MN; Dougherty, CP; Herwaldt, BL; Jolly, JP; Yu, P; Yu, Y, 2018) |
| "The drugs currently used to treat Chagas disease and HAT present efficacy, toxicity, and/or resistance issues; thus, there is a clear need for the discovery of novel targets and drug candidates to combat these diseases." | ( Andrade, SF; Ferreira, RS; Fortes, IS; Lopes, MS; Rocha, DA; Silva, EB, 2018) |
| "Benznidazole is used for treating Chagas disease (CD)." | ( Arruda, HMBDS; Gontijo, MKCL; Noronha, EF; Toledo, MI, 2020) |
| "Nifurtimox is a recommended treatment for Chagas disease, but data from treated children are limited." | ( Altcheh, J; Castro, L; Dib, JC; Grossmann, U; Huang, E; Moscatelli, G; Pinto Rocha, JJ; Ramírez, TE, 2021) |
| "Current treatment for Chagas disease with the only available drugs, benznidazole or nifurtimox, has substantial limitations, including long treatment duration and safety and tolerability concerns." | ( Almeida, IC; Alonso-Vega, C; Barboza, T; Barreira, F; Bilbe, G; Blum, B; Correia, E; Garcia, W; Gascón, J; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F; Vaillant, M, 2021) |
| "The current treatment for Chagas disease consists of benznidazole and nifurtimox under the World Health Organization (WHO) authorization protocol." | ( Chopra, S; Dasgupta, A; Thakare, R, 2021) |
| "Benznidazole is the first-line treatment for Chagas disease." | ( Arrese-Muñoz, I; Aznar, ML; Bosch-Nicolau, P; Espinosa-Pereiro, J; Franco-Jarava, C; Molina, I; Oliveira-Souto, I; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre-Delcor, N; Sulleiro, E; Treviño, B; Valerio, L, 2022) |
| "Current treatment for Chagas disease is based on only two drugs: benznidazole and nifurtimox." | ( Alcolea, V; Pérez-Silanes, S; Rubio-Hernández, M, 2022) |
| "Nifurtimox is recommended for the treatment of Chagas disease; however, long-term follow-up data are scarce." | ( Altcheh, J; Ding, O; Grossmann, U; Huang, E; Moscatelli, G; Pinto Rocha, JJ; Ramirez, T; Sierra, V, 2023) |
| "Current treatment of Chagas disease (CD) is based on two substances, nifurtimox (NT) and benzonidazole (BZ), both considered unsatisfactory mainly due to their low activities and high toxicity profile." | ( Bello, ML; Boechat, N; Calabrese, K; de Jesus, DH; de Souza Ferreira Pereira, C; Dos Santos Galvão, RM; Faria, AFM; Faria, RX; Gonzaga, DTG; Pacheco, PAF; Teixeira, GP, 2023) |