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3beta-hydroxy steroid
A 3-hydroxy steroid in which the 3-hydroxy substituent is in the beta-position.
ChEBI ID: 36836
Members (29)
| Member | Definition | Role |
|---|---|---|
| 24-methylene cycloartanol | A pentacyclic triterpenoid that is (9beta)-24-methylene-9,19-cyclolanostane which carries a hydroxy group at position 3beta. It is isolated from several plant species including Euphorbia, Epidendrum, Psychotria and Sideritis. | 24-methylenecycloartanol |
| 5 alpha-androstane-3 beta,17 beta-diol | An androstane-3,17-diol that is 5alpha-androstane substituted by beta-hydroxy groups at positions 3 and 17. It is a metabolite of dihydrotestosterone. | 5alpha-androstane-3beta,17beta-diol |
| bufalin | A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo. | bufalin |
| cerevisterol | An ergostanoid that is (22E)-ergosta-7,22-diene substituted by hydroxy groups at positions 3, 5 and 6 (the 3beta,5alpha,6beta stereoisomer). It has been isolated from the fungus, Xylaria species. | cerevisterol |
| cholest-8(14)-en-3-ol-15-one | A 3beta-hydroxysteroid consisting of 3beta-hydroxy-5alpha-cholest-8(14)-ene having an additional oxo group at the 15-position. | 3beta-hydroxy-5alpha-cholest-8(14)-en-15-one |
| cholestane-3,5,6-triol, (3beta, 5alpha, 6beta)-isomer | 5alpha-cholestane-3beta,5,6beta-triol | |
| cholesterol alpha-oxide | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | |
| cyasterone | cyasterone | |
| cyclolaudenol | A pentacyclic triterpenoid that is (24S)-methyl-9beta,19-cyclolanost-25-ene which carries a hydroxy group at position 3beta. It is isolated from several plant species inclduing Turraeanthus and Tillandsia. | cyclolaudenol |
| digitoxigenin | A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22). | digitoxigenin |
| digoxigenin | A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis. | digoxigenin |
| epiandrosterone | A 3beta-hydroxy steroid that is (5alpha)-androstane substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. | epiandrosterone |
| epietiocholanolone | A 3beta-hydroxy steroid that is 5beta-androstane substituted by a hydroxy group at position 3beta and an oxo group at position 17. It is a metabolite of testosterone. | epietiocholanolone |
| ethynodiol | ethynodiol | |
| ginsenoside f1 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | ginsenoside F1 |
| ginsenoside m1 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | ginsenoside C-K |
| ginsenoside re | A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Re |
| ginsenoside rf | A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Rf |
| ginsenoside rg2 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Rg2 |
| ginsenoside rh1 | A tetracyclic triterpenoid that is (20S)-protopanaxadiol which is substituted by beta-D-glucoside at the 6alpha position. | (20S)-ginsenoside Rh1 |
| gitoxigenin | gitoxigenin | |
| gypenoside LXXV | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | gypenoside LXXV |
| notoginsenoside r1 | A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. | notoginsenoside R1 |
| oleandrigenin | A steroid ester that is the 16-acetyl derivative of gitoxigenin. | oleandrigenin |
| ouabagenin | A hexahydroxy steroidal lactone obtained by hydrolysis of ouabain. | ouabagenin |
| ponasterone a | ponasterone A | |
| protopanaxatriol | A tetracyclic triterpenoid sapogenin (isolated from ginseng and notoginseng) that is that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions and in which a double bond has been introduced at the 24-25 position. | protopanaxatriol |
| strophanthidin | strophanthidin | |
| tomatidine | A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group. | tomatidine |
Research
Studies (3,656)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 706 (19.31) | 18.7374 |
| 1990's | 1,053 (28.80) | 18.2507 |
| 2000's | 698 (19.09) | 29.6817 |
| 2010's | 876 (23.96) | 24.3611 |
| 2020's | 323 (8.83) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 19 (0.48%) | 5.53% |
| Reviews | 108 (2.73%) | 6.00% |
| Case Studies | 18 (0.46%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3,807 (96.33%) | 84.16% |