Roles > antiatherosclerotic agent

Page last updated: 2024-08-05 15:24:59

antiatherosclerotic agent

A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.

ChEBI ID: 145947

Members (4)

Member	Definition	Class
baicalin	The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.	baicalin
manumycin	A polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.	manumycin A
ml 236a	A carbobicyclic compound that is ML-236C substituted by a hydroxy group at position 8S. It is a fungal metabolite isolated from Penicillium citrinum and exhibits anticholesteremic activity.	compactin diol lactone
pj-34	A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.	PJ34

Research

Studies (1,582)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	13 (0.82)	18.7374
1990's	84 (5.31)	18.2507
2000's	372 (23.51)	29.6817
2010's	787 (49.75)	24.3611
2020's	326 (20.61)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	15 (0.93%)	5.53%
Reviews	60 (3.71%)	6.00%
Case Studies	1 (0.06%)	4.05%
Observational	1 (0.06%)	0.25%
Other	1,539 (95.24%)	84.16%

Protein Targets (60)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	25.1189	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	35.4813	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	31.6228	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	22.3872	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	13.4504	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	26.6795	1	1
G	Vesicular stomatitis virus	Potency	13.4504	1	1
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	13.4504	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	13.4504	1	2
Interferon beta	Homo sapiens (human)	Potency	13.4504	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	0.8528	2	2
phosphopantetheinyl transferase	Bacillus subtilis	Potency	8.9125	1	1
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	2.2387	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 7	Homo sapiens (human)	IC50	200.0000	1	1
Aurora kinase B	Homo sapiens (human)	IC50	12.1900	1	1
Canalicular multispecific organic anion transporter 1	Rattus norvegicus (Norway rat)	Ki	7.9500	1	1
Chain A, Exotoxin A	Pseudomonas aeruginosa	Ki	0.1400	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	14.3600	1	1
Dipeptidyl peptidase 4	Homo sapiens (human)	IC50	225.0000	1	1
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	14.3600	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit delta	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit pi	Homo sapiens (human)	Ki	77.6247	1	1
Gamma-aminobutyric acid receptor subunit theta	Homo sapiens (human)	Ki	77.6247	1	1
GTPase KRas	Homo sapiens (human)	IC50	3.5800	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	3.1900	3	3
Poly [ADP-ribose] polymerase 1	Homo sapiens (human)	IC50	0.1096	13	17
Poly [ADP-ribose] polymerase 2	Homo sapiens (human)	IC50	0.1687	3	5
Poly [ADP-ribose] polymerase 2	Mus musculus (house mouse)	IC50	0.0405	1	2
Poly [ADP-ribose] polymerase tankyrase-1	Homo sapiens (human)	IC50	1.1077	4	6
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens (human)	IC50	1.2683	3	5
Prolyl endopeptidase	Homo sapiens (human)	IC50	12.1500	2	2
Protein farnesyltransferase subunit beta	Homo sapiens (human)	IC50	11.9000	1	1
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Homo sapiens (human)	IC50	11.9000	1	1
Protein mono-ADP-ribosyltransferase PARP10	Homo sapiens (human)	IC50	6.3123	2	4
Protein mono-ADP-ribosyltransferase PARP12	Homo sapiens (human)	IC50	0.2269	1	2
Protein mono-ADP-ribosyltransferase PARP14	Homo sapiens (human)	IC50	4.1843	1	2
Protein mono-ADP-ribosyltransferase PARP15	Homo sapiens (human)	IC50	8.9563	1	2
Protein mono-ADP-ribosyltransferase PARP3	Homo sapiens (human)	IC50	1.4377	1	2
Protein mono-ADP-ribosyltransferase PARP4	Homo sapiens (human)	IC50	0.7586	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	6.4104	4	5
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	6.4100	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	3.6100	1	1
Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus (Norway rat)	IC50	0.8100	3	3
Trypsin-1	Homo sapiens (human)	IC50	1,000.0000	1	1
Trypsin-2	Homo sapiens (human)	IC50	1,000.0000	1	1
Trypsin-3	Homo sapiens (human)	IC50	1,000.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Poly [ADP-ribose] polymerase 1	Homo sapiens (human)	EC50	0.0200	1	1
Poly [ADP-ribose] polymerase 1	Homo sapiens (human)	Kd	0.1100	1	1
Protein mono-ADP-ribosyltransferase PARP3	Homo sapiens (human)	Kd	0.7000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	10.2700	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Kd	11.9500	2	2

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