A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
ChEBI ID: 35488
| Member | Definition | Class |
|---|---|---|
| alfentanil | A member of the class of piperidines that is piperidine having a 2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl group at the 1-position as well as N-phenylpropanamido- and methoxymethyl groups at the 4-position. | alfentanil |
| baclofen | A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant. | baclofen zwitterion; baclofen |
| buclizine | An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups. | buclizine |
| chloroprocaine | Procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. | chloroprocaine |
| cyclizine | An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. | cyclizine |
| cyclizine hydrochloride | A hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. | cyclizine hydrochloride |
| ecgonine methyl ester | The O-debenzoyl analogue of cocaine. | ecgonine methyl ester |
| eszopiclone | The (5S)- (active) enantiomer of zopiclone. Unlike almost all other hypnotic sedatives, which are approved only for the relief of short-term (6-8 weeks) insomnia, eszopiclone is approved by the U.S. Food and Drug Administration for long-term use. | eszopiclone |
| melatonin | A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans. | melatonin |
| midazolam | An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively. | midazolam |
| midazolam hydrochloride | The hydrochloride salt of midazolam. | midazolam hydrochloride |
| naloxone | A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose. | naloxone |
| naloxone hydrochloride | A hydrochloride resulting from the formal reaction of equimolar amounts of naloxone and hydrogen chloride. A specific opioid antagonist, it is used to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose. | naloxone hydrochloride |
| naltrexone | An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence. | naltrexone |
| naltrexone hydrochloride | A hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. | naltrexone hydrochloride |
| phenoxyethanol | An aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group. | 2-phenoxyethanol |
| procaine | A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. | procaine |
| sevoflurane | An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups. | sevoflurane |
| solasodine | An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills. | solasodine |
| suvorexant | An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia. | suvorexant |
| zaleplon | A pyrazolo[1,5-a]pyrimidine having a nitrile group at position 3 and a 3-(N-ethylacetamido)phenyl substituent at the 7-position. | zaleplon |
| zolpidem | An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position. | zolpidem |
| zopiclone | A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position. | zopiclone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 21,608 (26.34) | 18.7374 |
| 1990's | 16,127 (19.66) | 18.2507 |
| 2000's | 17,498 (21.33) | 29.6817 |
| 2010's | 18,762 (22.87) | 24.3611 |
| 2020's | 8,050 (9.81) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 11,585 (12.72%) | 5.53% |
| Reviews | 7,121 (7.82%) | 6.00% |
| Case Studies | 4,421 (4.85%) | 4.05% |
| Observational | 405 (0.44%) | 0.25% |
| Other | 67,563 (74.17%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 29.9033 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 9.6578 | 2 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.0002 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 260.2775 | 8 | 10 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 41.1349 | 2 | 7 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.7664 | 3 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.9682 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.6245 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 22.1799 | 2 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.1006 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 69.6372 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 69.6372 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 471.4271 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 27.3979 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 7.0009 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 50.1187 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 55.8092 | 2 | 3 |
| ClpP | Bacillus subtilis | Potency | 28.1838 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 26.0429 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 22.8581 | 1 | 5 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 16.9385 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.0344 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 17.5597 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 32.9607 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.5804 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.0227 | 8 | 10 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 16.7256 | 6 | 10 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 36.8953 | 1 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 5.8862 | 4 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 11.8823 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 26.0429 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.0344 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 9.6999 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.9660 | 2 | 8 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 11.8486 | 4 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 10.5909 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 37.0814 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 26.0429 | 1 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 11.5821 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 26.0429 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 26.0429 | 1 | 2 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.9779 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.5404 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.1778 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.6571 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 5.6234 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 25.1547 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 2.1314 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 58.5706 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 6.3096 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 30.0076 | 3 | 6 |
| P53 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 25.3574 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 21.3138 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 42.2395 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 27.9597 | 2 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 17.4006 | 2 | 8 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.1127 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 24.4121 | 3 | 10 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 25.4055 | 2 | 8 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 32.9227 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 18.4763 | 2 | 7 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.3502 | 2 | 4 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0040 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.5655 | 3 | 3 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 14.7263 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 80.6866 | 1 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 21.1300 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 10.5909 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.2250 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0640 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.3730 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.2380 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 1.0210 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.5350 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.0600 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.0600 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.0600 | 1 | 1 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.0600 | 1 | 1 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.0600 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.0210 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.5350 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.1000 | 1 | 2 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 0.1000 | 2 | 3 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 1.2150 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.5970 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.5510 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.5820 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 6 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 65.5000 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 41.5000 | 4 | 4 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0055 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 316.1427 | 4 | 15 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 6 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 0.1000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 0.1000 | 1 | 2 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 59.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Cytochrome P450 2C11 | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 3.0725 | 1 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 2.7427 | 3 | 3 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 2.9920 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.0160 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 20.0000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 0.0953 | 23 | 33 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 50.0160 | 4 | 10 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0148 | 4 | 11 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 0.0647 | 56 | 69 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0456 | 9 | 10 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0402 | 9 | 12 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 1.3614 | 11 | 39 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.8019 | 13 | 13 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 1.4693 | 9 | 37 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.3830 | 9 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 1.5089 | 11 | 39 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.2986 | 8 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 2.2599 | 2 | 30 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 3.9175 | 8 | 36 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 3.3517 | 6 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 3.4150 | 5 | 33 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 4.0569 | 8 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 0.0530 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 2.4630 | 5 | 35 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 1.8864 | 25 | 25 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 3.0819 | 30 | 30 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 2.0220 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 2.7078 | 36 | 66 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 2.1183 | 27 | 27 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0385 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 3 | 3 |
| Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Gamma-aminobutyric acid type B receptor subunit 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2762 | 4 | 6 |
| Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Rattus norvegicus (Norway rat) | IC50 | 0.2762 | 4 | 6 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Rattus norvegicus (Norway rat) | Ki | 0.2200 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0380 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0044 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 2.5104 | 7 | 12 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 0.0465 | 15 | 22 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 250.0030 | 2 | 2 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 3 | 7 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0101 | 23 | 33 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 0.0127 | 39 | 46 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0027 | 3 | 4 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 4 | 5 |
| kappa-type opioid receptor isoform 1 | Homo sapiens (human) | IC50 | 0.3680 | 2 | 4 |
| Melatonin receptor type 1A | Homo sapiens (human) | IC50 | 0.0025 | 18 | 18 |
| Melatonin receptor type 1A | Gallus gallus (chicken) | Ki | 0.0007 | 7 | 8 |
| Melatonin receptor type 1A | Homo sapiens (human) | Ki | 0.0003 | 67 | 69 |
| Melatonin receptor type 1B | Homo sapiens (human) | IC50 | 0.0035 | 12 | 12 |
| Melatonin receptor type 1B | Gallus gallus (chicken) | Ki | 0.0007 | 8 | 9 |
| Melatonin receptor type 1B | Homo sapiens (human) | Ki | 0.0004 | 62 | 64 |
| Melatonin receptor type 1C | Gallus gallus (chicken) | Ki | 0.0007 | 7 | 8 |
| Metabotropic glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 2 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0067 | 4 | 6 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 0.0197 | 26 | 36 |
| Mu-type opioid receptor | Mus musculus (house mouse) | IC50 | 100.0077 | 5 | 5 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0060 | 4 | 8 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0012 | 18 | 23 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.0099 | 53 | 65 |
| Mu-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0013 | 12 | 13 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0026 | 16 | 23 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 6 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.6750 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.1630 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.1580 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.4120 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.7480 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.1590 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.8520 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1190 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.6330 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.4550 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 5 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Nociceptin receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Nociceptin receptor | Mus musculus (house mouse) | Ki | 0.0003 | 1 | 1 |
| Orexin receptor type 1 | Homo sapiens (human) | IC50 | 0.0873 | 4 | 4 |
| Orexin receptor type 1 | Homo sapiens (human) | Ki | 0.0010 | 6 | 6 |
| Orexin receptor type 1 | Mus musculus (house mouse) | Ki | 0.0017 | 1 | 1 |
| Orexin receptor type 2 | Homo sapiens (human) | IC50 | 0.0613 | 5 | 5 |
| Orexin receptor type 2 | Homo sapiens (human) | Ki | 0.0027 | 5 | 5 |
| Orexin receptor type 2 | Mus musculus (house mouse) | Ki | 0.0087 | 1 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | IC50 | 75.4000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 416.8690 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 | 7.3161 | 8 | 8 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | Ki | 0.0422 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.1030 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0017 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.7630 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.6060 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 157.5100 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 3.7000 | 1 | 1 |
| Sphingosine-1-phosphate lyase 1 | Mus musculus (house mouse) | Ki | 0.7650 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | IC50 | 4.7000 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 75.5000 | 1 | 4 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 75.5000 | 1 | 4 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 75.5000 | 1 | 4 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 75.5000 | 1 | 4 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 75.5000 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Homo sapiens (human) | Kd | 63.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 31.5000 | 1 | 2 |
| Beta-galactosidase | Escherichia coli | EC50 | 31.5000 | 1 | 2 |
| calcineurin A1, putative | Candida dubliniensis CD36 | EC50 | 180.0000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | EC50 | 0.0091 | 4 | 4 |
| Delta-type opioid receptor | Mus musculus (house mouse) | EC50 | 0.0044 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0010 | 1 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | Kd | 0.0013 | 2 | 2 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Kd | 0.0002 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Kd | 0.1200 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 0.2298 | 4 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | EC50 | 0.8490 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | EC50 | 2.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | EC50 | 2.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | EC50 | 0.2367 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | EC50 | 1.2100 | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | EC50 | 0.6680 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens (human) | EC50 | 1.7000 | 1 | 1 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens (human) | EC50 | 1.7000 | 1 | 1 |
| heat shock protein 90 | Candida albicans | EC50 | 120.0330 | 3 | 4 |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | EC50 | 0.0010 | 1 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | EC50 | 0.0045 | 5 | 5 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | EC50 | 0.0008 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0010 | 1 | 2 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0180 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Kd | 0.0010 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Kd | 0.0935 | 3 | 5 |
| kappa-type opioid receptor isoform 1 | Homo sapiens (human) | EC50 | 5.0000 | 1 | 1 |
| Melatonin receptor type 1A | Gallus gallus (chicken) | EC50 | 0.0226 | 1 | 1 |
| Melatonin receptor type 1A | Homo sapiens (human) | EC50 | 0.0008 | 11 | 11 |
| Melatonin receptor type 1B | Gallus gallus (chicken) | EC50 | 0.0226 | 1 | 1 |
| Melatonin receptor type 1B | Homo sapiens (human) | EC50 | 0.0025 | 12 | 12 |
| Melatonin receptor type 1C | Gallus gallus (chicken) | EC50 | 0.0226 | 1 | 1 |
| Melatonin receptor type 1C | Xenopus laevis (African clawed frog) | EC50 | 0.0001 | 3 | 3 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0019 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 0.0057 | 3 | 3 |
| Mu-type opioid receptor | Mus musculus (house mouse) | EC50 | 0.0002 | 2 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0010 | 1 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0002 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Kd | 0.0004 | 4 | 4 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Kd | 0.0784 | 4 | 6 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | EC50 | 0.1910 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | Kb | 0.0006 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Kb | 0.0111 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ke | 0.0283 | 9 | 9 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ke | 0.0382 | 10 | 14 |
| Kappa-type opioid receptor | Homo sapiens (human) | Kb | 0.0030 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ke | 0.0090 | 5 | 7 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ke | 0.0040 | 11 | 11 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | Ke | 0.0159 | 1 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | pA2 | 0.0097 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Kb | 0.0006 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ke | 0.0010 | 5 | 6 |
| Mu-type opioid receptor | Homo sapiens (human) | Ke | 0.0020 | 19 | 20 |
| Mu-type opioid receptor | Mus musculus (house mouse) | Ke | 0.0008 | 2 | 2 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | CD | 60.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Km | 1,310.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A8 | Homo sapiens (human) | Km | 1,000.0000 | 1 | 2 |