ascorbic-acid has been researched along with 1-methylhistidine* in 1 studies
1 other study(ies) available for ascorbic-acid and 1-methylhistidine
| Article | Year |
|---|---|
Highly site-specific oxygenation of 1-methylhistidine and its analogue with a copper (II)/ascorbate-dependent redox system.
The reaction of histidine-related materials with copper(II) and ascorbate under physiological conditions has been studied chemically. We discovered that 1-methylimidazole and its analogues, including biological metabolites L-1-methylhistidine and anserine (beta-alanyl-L-1-methylhistidine), exhibited dramatic reactivity with copper(II)/ascorbate. Reaction of copper(II) and ascorbate occurs specifically at the C-2 position of the imidazole ring of L-1-methylhistidine and anserine derivatives with mono-oxygenation to give the 1-methyl-2-imidazolones in good to excellent yields (70-80%). The occurrence of an oxocopper(III) intermediate in the oxidation process of ascorbate is postulated. Topics: Acetylation; Anserine; Ascorbic Acid; Chromatography, High Pressure Liquid; Copper; Histidine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylhistidines; Molecular Structure; Oxidation-Reduction | 1990 |