An organoiodine compound is a compound containing at least one carbon-iodine bond.
| Member | Definition | Role |
|---|
| 2-iodosobenzoic acid | A benzoic acid compound having an iodosyl substituent at the ortho-position. | ortho-iodosylbenzoic acid |
| 2,3,5-triiodobenzoic acid | A member of the class of benzoic acids that is benzoic acid in which the hydrogens at positions 2, 3 and 5 are replaced by iodine atoms. It is an auxin polar transport inhibitor. | 2,3,5-triiodobenzoic acid |
| 3-(2-iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl | | 3-(2-iodacetamido)-PROXYL |
| 3-iodo-2-propynylbutylcarbamate | A carbamate ester that is carbamic acid in which the nitrogen has been substituted by a butyl group and in which the hydrogen of the carboxy group is replaced by a 1-iodoprop-2-yn-3-yl group. A fungicide, it is used as a preservative and sapstain control chemical in wood products and as a preservative in adhesives, paints, latex paper coating, plastic, water-based inks, metal working fluids, textiles, and numerous consumer products. | 3-iodoprop-2-yn-1-yl butylcarbamate |
| 3-iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine | A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodo-4-aminobenzyl group. | 3-iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine |
| 3-iodobenzylguanidine | | 2-[(3-iodophenyl)methyl]guanidine |
| 3,5-diiodothyropropionic acid | A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)propanoic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxyphenyl group. An ionotropic analogue of L-thyroxine. | 3,5-diiodothyropropionic acid |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4. | 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine |
| 4-iodo-6-phenylpyrimidine | A member of the class of pyrimidines carrying iodo and phenyl substituents at positions 4 and 6 respectively. | 4-iodo-6-phenylpyrimidine |
| 4-iodopyrazole | | 4-iodopyrazole |
| 4'-deoxy-4'-iododoxorubicin | | 4'-deoxy-4'-iododoxorubicin |
| 5-iodo-2-(oxaloamino)benzoic acid | | 5-iodo-2-(oxaloamino)benzoic acid |
| 5-iodotubercidin | | 5-iodotubercidin |
| 5-iodouracil | An organoiodine compound consisting of uracil having an iodo substituent at the 5-position. | 5-iodouracil |
| 7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralin | A tertiary amino compound that consists of 2-amino-7-hydroxytetralin in which the two amino hydrogens are substituted by 2E)-3-iodoallyl and propyl groups. This ligand has uniquely high affinity and selectivity for the D3 receptor. | 2-{[(2E)-3-iodoprop-2-en-1-yl](propyl)amino}tetralin-7-ol |
| am 251 | A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor. | AM-251 |
| am 694 | A member of the class of indoles that is 1H-indole which is substituted at position 1 by a 5-fluoropentyl group and a position 3 by an o-fluorobenzoyl group. It is a selective agonist for the CB1 cannabinoid receptor; Ki values for the CB1 and CB2 receptors are 0.08 and 1.44 nM, respectively. | 1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole |
| amiodarone | A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. | amiodarone |
| calicheamicin gamma(1)i | A calcheamicin in which contains 3-O-methyl-alpha-L-rhamnosyl, 2,6-dideoxy-4-thio-beta-D-ribo-hexopyranosyl, and 4-amino-4,6-dideoxy-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-alpha-L-threo-pentopyranosyl]-alpha-L-idopyranose units and in which the aromatic ring contains an iodo substituent. | calicheamicin gamma1(I) |
| clioquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. | 5-chloro-7-iodoquinolin-8-ol |
| closantel | An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. | N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide |
| diatrizoic acid | A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography. | amidotrizoic acid |
| GDC-0623 | A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors. | GDC-0623 |
| gdc-0973 | A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma. | cobimetinib |
| idoxuridine | A pyrimidine 2'-deoxyribonucleoside compound having 5-iodouracil as the nucleobase; used as an antiviral agent. | 5-iodo-2'-deoxyuridine |
| iobitridol | A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a 3-hydroxy-2-(hydroxymethyl)propanimido at position 5. | iobitridol |
| iodamide | A benzoic acid compound having iodo substituents at the 2-, 4- and 6-positions, an acetamido substituent at the 3-position and an acetamidomethyl substituent at the 5-position. | iodamide |
| iodipamide | An organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. | adipiodone |
| iodixanol | A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography. | iodixanol |
| iodoacetic acid | A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom. | iodoacetic acid |
| iodohippuric acid | A member of the class of benzamides resulting from the formal condensation of the carboxy group of 2-iodobenzoic acid with the amino group of glycine. | 2-iodohippuric acid |
| iodoquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by iodine. It is considered the drug of choice for treating asymptomatic or moderate forms of amoebiasis. | iodoquinol |
| iohexol | A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position. | iohexol |
| iomeprol | A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a glycoloyl(methyl)amino group at the 5-position. | iomeprol |
| iopamidol | A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position. | iopamidol |
| iopromide | A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A water soluble x-ray contrast agent for intravascular administration. | iopromide |
| ioxaglate | A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an acetyl(methyl)amino group at the 5-position. | ioxaglic acid |
| ioxitalamic acid | An organoiodine compound that is 2,4,6-triiodobenzoic acid substituted by an acetylamino group at position 3 and a (2-hydroxyethyl)carbamoyl group at position 5. It is used as a contrast medium. | iooxitalamic acid |
| ml 7 | An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18). | ML-7 |
| n-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide | A piperidinecarboxamide that is TEMPO carrying an 2-iodoacetamido group at position 4. | 4-(2-iodacetamido)-TEMPO |
| n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine | A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodobenzyl group. | 3-iodobenzyl-5'-N-methylcarboxamidoadenosine |
| nitrohydroxyiodophenylacetate | A member of the class of phenylacetic acids that is phenylacetic acid in which the phenyl group is substituted by iodo, hydroxy and nitro groups at positions 3, 4 and 5 respectively. | (4-hydroxy-3-iodo-5-nitrophenyl)acetic acid |
| pd 0325901 | A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer). | PD 0325901 |
| pd 150606 | An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer). | (Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid |
| sodium diatrizoate | The sodium salt of a benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, often as a mixture with the meglumine salt, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography. | sodium amidotrizoate |
| trametinib | A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. | trametinib |
| triptorelin | | N'-[2-(4-iodophenyl)ethyl]carbamimidothioic acid 3-(1H-imidazol-5-yl)propyl ester |