Roles > female contraceptive drug
Page last updated: 2024-08-05 15:29:24

female contraceptive drug

A chemical substance or agent with contraceptive activity in females.

ChEBI ID: 49324

Members (4)

MemberDefinitionClass
etonogestreletonogestrel
fluprostenolAn organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.fluprostenol
levonorgestrellevonorgestrel
medroxyprogesterone acetateAn acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.medroxyprogesterone acetate

Research

Studies (9,728)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,493 (15.35)18.7374
1990's2,190 (22.51)18.2507
2000's2,733 (28.09)29.6817
2010's2,507 (25.77)24.3611
2020's805 (8.28)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,255 (20.98%)5.53%
Reviews1,167 (10.86%)6.00%
Case Studies688 (6.40%)4.05%
Observational97 (0.90%)0.25%
Other6,539 (60.85%)84.16%

Protein Targets (109)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.622811
Alpha-synucleinHomo sapiens (human)Potency5.623411
AR proteinHomo sapiens (human)Potency2.59461262
ATAD5 protein, partialHomo sapiens (human)Potency17.441712
Ataxin-2Homo sapiens (human)Potency48.557711
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency48.557711
Cellular tumor antigen p53Homo sapiens (human)Potency34.306213
Chain A, Beta-lactamaseEscherichia coli K-12Potency36.499423
Chain A, CruzipainTrypanosoma cruziPotency39.810711
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency8.913812
chromobox protein homolog 1Homo sapiens (human)Potency79.432811
cytochrome P450 2C9, partialHomo sapiens (human)Potency7.696012
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.848922
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency15.715312
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.020713
DNA polymerase betaHomo sapiens (human)Potency100.000011
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency19.276413
estrogen nuclear receptor alphaHomo sapiens (human)Potency10.45751044
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency30.207234
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency33.2695629
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency7.504013
farnesoid X nuclear receptorHomo sapiens (human)Potency29.862246
GVesicular stomatitis virusPotency7.696012
GABA theta subunitRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency15.848911
gemininHomo sapiens (human)Potency12.928327
GLI family zinc finger 3Homo sapiens (human)Potency15.4633212
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency1.8999517
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency24.486414
Guanine nucleotide-binding protein GHomo sapiens (human)Potency19.702012
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency19.952611
Histone H2A.xCricetulus griseus (Chinese hamster)Potency120.053012
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency7.696012
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency43.641211
IDH1Homo sapiens (human)Potency29.092911
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency7.696014
Interferon betaHomo sapiens (human)Potency7.696012
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency19.149812
neuropeptide S receptor isoform AHomo sapiens (human)Potency2.511911
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency7.943311
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency28.8924313
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency5.601013
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency27.731714
Nuclear receptor ROR-gammaHomo sapiens (human)Potency16.785511
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency4.601112
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency56.502037
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency100.000011
ParkinHomo sapiens (human)Potency40.870812
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency20.314811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency26.422222
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency21.238658
PINK1Homo sapiens (human)Potency40.870812
pregnane X nuclear receptorHomo sapiens (human)Potency19.107339
pregnane X receptorRattus norvegicus (Norway rat)Potency2.436212
progesterone receptorHomo sapiens (human)Potency17.730739
RAR-related orphan receptor gammaMus musculus (house mouse)Potency25.976828
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency30.2765312
retinoid X nuclear receptor alphaHomo sapiens (human)Potency15.5946410
SMAD family member 2Homo sapiens (human)Potency11.279024
SMAD family member 3Homo sapiens (human)Potency11.279024
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency24.905412
TDP1 proteinHomo sapiens (human)Potency18.2886210
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency14.3741212
thyroid stimulating hormone receptorHomo sapiens (human)Potency35.749623
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency13.005112
USP1 protein, partialHomo sapiens (human)Potency89.125111
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency22.794125
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency19.124645
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency24.486414

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC501.197011
Aldo-keto reductase family 1 member C1Homo sapiens (human)IC501.800011
Aldo-keto reductase family 1 member C2 Homo sapiens (human)IC504.040522
Aldo-keto reductase family 1 member C3Homo sapiens (human)IC501.405922
Androgen receptorHomo sapiens (human)IC500.006122
Androgen receptorRattus norvegicus (Norway rat)IC500.279023
Androgen receptorHomo sapiens (human)Ki0.002955
Androgen receptorRattus norvegicus (Norway rat)Ki0.004811
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
Bile salt export pumpHomo sapiens (human)IC5074.350012
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Estrogen receptorHomo sapiens (human)IC500.924022
Estrogen receptor betaHomo sapiens (human)IC500.924022
Glucocorticoid receptorHomo sapiens (human)IC500.013033
Glucocorticoid receptorHomo sapiens (human)Ki0.012466
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki0.008611
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki0.008611
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.008611
Glycine receptor subunit betaRattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit betaRattus norvegicus (Norway rat)Ki0.008611
Histamine H2 receptorHomo sapiens (human)IC5027.920011
Histamine H2 receptorHomo sapiens (human)Ki27.453011
Mineralocorticoid receptor Homo sapiens (human)IC501.197033
Multidrug resistance-associated protein 4Homo sapiens (human)IC5077.750012
Progesterone receptorHomo sapiens (human)IC502.508144
Progesterone receptorHomo sapiens (human)Ki0.000588

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Androgen receptorHomo sapiens (human)EC500.006111
Androgen receptorMus musculus (house mouse)EC500.006122
Androgen receptorHomo sapiens (human)Kd0.001011
Estrogen receptorHomo sapiens (human)EC500.924011
Estrogen receptor betaHomo sapiens (human)EC500.924011
Glucocorticoid receptorHomo sapiens (human)EC500.010033
Progesterone receptorHomo sapiens (human)EC500.55591818
Prostacyclin receptorHomo sapiens (human)EC5010.000011
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)EC503.400011
Prostaglandin F2-alpha receptorHomo sapiens (human)EC500.003611
Sex hormone-binding globulinHomo sapiens (human)Kd0.318412