Page last updated: 2024-09-28

Hyperthyroxinemia

Abnormally elevated THYROXINE level in the BLOOD.

Synonyms(1)

Synonym
Hyperthyroxinemia

Research

Studies (122)

TimeframeStudies, This Condition (%)All Conditions %
pre-199029 (23.77)23.3326
1990's54 (44.26)12.5806
2000's18 (14.75)18.1394
2010's17 (13.93)28.8240
2020's4 (3.28)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
cytosine0low10
iodine0low50
urea0low10
vanilmandelic acid0low10
amiodarone0low40
aspirin0low10
deferoxamine0low10
propranolol0low20
corticosterone0low10
thyroxine0medium922
aldosterone0low10
triiodothyronine0medium452
methionine0low10
asparagine0low10
histidine0low50
valine0low10
arginine0low60
lithium carbonate0low10
metanephrine0low10
danazol0low10
iodine0low10
tetraiodothyroacetic acid0low10
proline0low10
propylthiouracil0low20
methimazole0low20
unithiol0low10
lithium0low10
bilirubin0low10
calcitriol0low10
thyronines0low10
gastrins0low10
sodium pertechnetate tc 99m0low10
triiodothyronine, reverse0low60
ascorbic acid0low10
warfarin0low20
guanine0low10
allopurinol0low10

Protein Targets (486)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein110011
glucocorticoid receptor [Homo sapiens]100010
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 24004
geminin120012
Sex hormone-binding globulin0033
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0134
Androgen receptor0606
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10102
Guanine nucleotide-binding protein G2002
interleukin 83003
TDP1 protein100010
thyroid stimulating hormone receptor5005
estrogen receptor 2 (ER beta)5005
progesterone receptor9009
estrogen-related nuclear receptor alpha140014
estrogen nuclear receptor alpha140014
IDH16006
euchromatic histone-lysine N-methyltransferase 2130013
Bloom syndrome protein isoform 13003
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 29009
ras-related protein Rab-9A1001
nuclear factor erythroid 2-related factor 2 isoform 1120012
survival motor neuron protein isoform d4004
lamin isoform A-delta10100010
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Polyphenol oxidase 20405
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump010010
Hypoxanthine-guanine phosphoribosyltransferase0002
Cellular tumor antigen p537007
Glutamate receptor 23003
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0123
Xanthine dehydrogenase/oxidase0202
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 431001
Canalicular multispecific organic anion transporter 10808
Shiga toxin subunit A0202
Histamine H3 receptor0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
acetylcholinesterase3003
phosphopantetheinyl transferase5005
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma9009
SMAD family member 22002
ATAD5 protein, partial2002
Fumarate hydratase1001
USP1 protein, partial5005
NFKB1 protein, partial3003
PPM1D protein3003
SMAD family member 32002
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nuclear receptor subfamily 1, group I, member 35005
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha7007
farnesoid X nuclear receptor6006
pregnane X nuclear receptor110011
G4004
cytochrome P450 2D63003
polyprotein1001
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma8008
caspase-32002
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x5005
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor2002
chromobox protein homolog 17007
potassium voltage-gated channel subfamily H member 2 isoform d1001
heat shock protein beta-15005
huntingtin isoform 21001
mitogen-activated protein kinase 13003
flap endonuclease 14004
serine/threonine-protein kinase mTOR isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
nuclear receptor ROR-gamma isoform 13003
peripheral myelin protein 224004
cytochrome P450 3A4 isoform 13003
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)6006
Gamma-aminobutyric acid receptor subunit pi3126
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Solute carrier organic anion transporter family member 1A40204
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40404
Lysine-specific demethylase PHF20101
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 4004
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-31203
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10415
Integrin alpha-IIb1102
Beta-1 adrenergic receptor0415
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0528
Adenosine receptor A30516
Cytochrome P450 2C80202
Thyroid hormone receptor alpha0347
Thyroid hormone receptor beta0347
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0617
D(2) dopamine receptor0314
Gamma-aminobutyric acid receptor subunit beta-13126
Alpha-1B adrenergic receptor0516
Lethal factor0101
Alpha-2B adrenergic receptor0427
Thyroid hormone receptor beta0202
Gamma-aminobutyric acid receptor subunit delta3126
Gamma-aminobutyric acid receptor subunit gamma-23126
Gamma-aminobutyric acid receptor subunit alpha-53126
Gamma-aminobutyric acid receptor subunit alpha-33126
Muscarinic acetylcholine receptor M30516
ATP-dependent translocase ABCB10101
Substance-K receptor0404
D(1A) dopamine receptor0516
D(4) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit gamma-13126
Gamma-aminobutyric acid receptor subunit alpha-23126
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0202
Endothelin-1 receptor0314
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 2C0415
Gamma-aminobutyric acid receptor subunit alpha-43126
Gamma-aminobutyric acid receptor subunit gamma-33126
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-63126
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0606
Melanocortin receptor 40202
C-8 sterol isomerase0202
Melanocortin receptor 50202
Mu-type opioid receptor0516
D(3) dopamine receptor0404
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor0314
Kappa-type opioid receptor0516
5-hydroxytryptamine receptor 2B0415
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0516
Histamine H2 receptor1001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60415
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein3003
Gamma-aminobutyric acid receptor subunit alpha-13227
Gamma-aminobutyric acid receptor subunit beta-33126
Gamma-aminobutyric acid receptor subunit beta-23126
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0202
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit3126
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 14004
Sodium channel protein type 2 subunit alpha0101
Ataxin-23003
Sigma non-opioid intracellular receptor 10516
Gamma-aminobutyric acid receptor subunit epsilon3126
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial4004
ATP-dependent phosphofructokinase3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase5005
GLS protein3003
alpha-galactosidase1001
cytochrome P450 2C19 precursor2002
DNA polymerase iota isoform a (long)4004
Cytochrome P450 3A40305
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, Hyaluronidase, phage associated0101
GLI family zinc finger 38008
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 45005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Carbonic anhydrase 10407
Carbonic anhydrase 20407
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Carbonic anhydrase-like protein, putative0002
Amino acid transporter0202
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
hypothetical protein, conserved1001
glucocerebrosidase2002
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase kappa isoform 13003
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0101
Myeloperoxidase0202
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10102
Adenosine receptor A2a0102
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma2002
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10011
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, Cruzipain2002
Microtubule-associated protein tau2002
vitamin D3 receptor isoform VDRA1001
caspase-1 isoform alpha precursor1001
Caspase-71001
Inositol monophosphatase 11001
Solute carrier organic anion transporter family member 1B30204
Solute carrier organic anion transporter family member 1B10205
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase3003
Chain A, Ferritin light chain1001
Vitamin D3 receptor0011
Vitamin D-binding protein0011
Cytochrome P450 1A20203
Androgen receptor0202
Cytochrome P450 2D60202
Vitamin D3 receptor0124
Cytochrome P450 2C9 0405
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0055
Cytochrome P450 2C190202
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Carbonic anhydrase 40203
Carbonic anhydrase0203
Carbonic anhydrase 150203
pregnane X receptor2002
GALC protein1001
nonstructural protein 11001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0303
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Solute carrier family 22 member 10202
Solute carrier family 22 member 20202
Deoxycytidine kinase0001
glp-1 receptor, partial2002
nuclear receptor subfamily 1, group I, member 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Rap guanine nucleotide exchange factor 33003
Estrogen receptor0202
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Alpha-2C adrenergic receptor0326
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Cytochrome P450 2J20303
ATPase family AAA domain-containing protein 51001
apical membrane antigen 1, AMA13003
67.9K protein1001
Lysine-specific demethylase 4A0101
Hypoxia-inducible factor 1-alpha0011
Methylcytosine dioxygenase TET20101
Deoxyhypusine hydroxylase0101
Purine nucleoside phosphorylase0202
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Guanine deaminase0001
Chain A, HISTIDINE-BINDING PROTEIN0011
histone acetyltransferase KAT2A isoform 11001
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Carbonic anhydrase 60001
5-hydroxytryptamine receptor 1D0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0102
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10303
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Carbonic anhydrase 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Luciferase3003
aryl hydrocarbon receptor3003
activating transcription factor 61001
histone deacetylase 9 isoform 31001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Bile salt export pump0202
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Proton-coupled amino acid transporter 10101
Beta-1 adrenergic receptor 0113
arylsulfatase A1001
Albumin0022
Beta-2 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0203
Beta-1 adrenergic receptor0214
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0214
Alpha-2B adrenergic receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Alpha-1D adrenergic receptor0012
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 1B0202
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 70101
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
NADH-cytochrome b5 reductase 3 0101
Thyroid peroxidase0101
Taste receptor type 2 member 380012
thyrotropin-releasing hormone receptor1001
Integrin alpha-V 0101
Peroxisome proliferator-activated receptor gamma0066
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Transthyretin0103
Proliferating cell nuclear antigen0202
UDP-glucuronosyltransferase 1A1 0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
muscleblind-like protein 1 isoform 11001
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Prothrombin0011
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30101
Adenosine receptor A10202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1C10101
Gamma-aminobutyric acid receptor subunit theta0101
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Chain A, Arginase 10101
atrial natriuretic peptide receptor 1 precursor1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]