Page last updated: 2024-12-05

4-bromotetramisole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-Bromotetramisole is a brominated derivative of the anthelmintic drug tetramisole. It has been studied as a potential anti-cancer agent, particularly for the treatment of leukemia. Research has shown that 4-bromotetramisole exhibits cytotoxic activity against various cancer cell lines. Its mechanism of action is believed to involve inhibition of tubulin polymerization, leading to disruption of microtubule formation and ultimately, cell death. The compound's importance lies in its potential to serve as a lead compound for the development of new anticancer drugs. The fact that 4-bromotetramisole is a halogenated derivative of a known drug makes it an attractive target for further investigation and optimization. Studies aim to understand its mechanism of action in detail, evaluate its efficacy in preclinical models, and ultimately explore its potential as a safe and effective therapeutic agent for treating cancer.'

4-bromotetramisole: available in levo & dextro form; L-form potent inhibitor of non specific alkaline phosphatase; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5121
CHEMBL ID3302525
SCHEMBL ID9281894
MeSH IDM0048547

Synonyms (29)

Synonym
AC-14900
l-4-bromotetramisole
1-(para-bromotetramisole)
6-bromolevamisole
4-bromotetramisole
imidazo(2,1-b)thiazole, 6-(4-bromophenyl)-2,3,5,6-tetrahydro-
d-4-bromotetramisole
p-bromotetramisole
6646-46-4
imidazo[2,1-b]thiazole, 6-(4-bromophenyl)-2,3,5,6-tetrahydro-
6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
A833695
(6s)-6-(4-bromophenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole, monoethanedioate
AKOS015961829
FT-0641349
unii-v3q75w2536
v3q75w2536 ,
CHEMBL3302525
SCHEMBL9281894
HTHGAIADRJRJOY-UHFFFAOYSA-N
6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
4-bromotetramisole, (+/-)-
(+/-)-p-bromotetramisole
6-(4-bromophenyl)-2h,3h,5h,6h-imidazo[2,1-b][1,3]thiazole
Z1509589658
DTXSID20985103
(+/-)-4-bromotetramisole
Q27291499
EN300-191712
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (38)

TimeframeStudies, This Drug (%)All Drugs %
pre-199021 (55.26)18.7374
1990's13 (34.21)18.2507
2000's4 (10.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.43 (24.57)
Research Supply Index3.66 (2.92)
Research Growth Index4.09 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other38 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]