Roles > renal agent
Page last updated: 2024-08-05 15:26:12

renal agent

A drug used for its effect on the kidneys' regulation of body fluid composition and volume.

ChEBI ID: 35846

Members (3)

MemberDefinitionClass
deamino arginine vasopressinA synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.desmopressin
nitroxolineA monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.nitroxoline
sulfameterA sulfonamide consisting of pyrimidine having a methoxy substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 2-position.sulfamethoxydiazine

Research

Studies (4,381)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,002 (22.87)18.7374
1990's1,122 (25.61)18.2507
2000's1,031 (23.53)29.6817
2010's929 (21.21)24.3611
2020's297 (6.78)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials524 (11.32%)5.53%
Reviews698 (15.08%)6.00%
Case Studies854 (18.45%)4.05%
Observational17 (0.37%)0.25%
Other2,536 (54.79%)84.16%

Protein Targets (111)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency9.456222
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.810711
Alpha-synucleinHomo sapiens (human)Potency15.848911
AR proteinHomo sapiens (human)Potency10.204066
aryl hydrocarbon receptorHomo sapiens (human)Potency4.180122
ATAD5 protein, partialHomo sapiens (human)Potency19.223822
Ataxin-2Homo sapiens (human)Potency4.216312
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency4.216312
beta-2 adrenergic receptorHomo sapiens (human)Potency2.818411
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency3.548111
caspase-3Cricetulus griseus (Chinese hamster)Potency5.955711
Caspase-7Cricetulus griseus (Chinese hamster)Potency5.955711
Cellular tumor antigen p53Homo sapiens (human)Potency6.682411
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency2.818411
Chain A, Beta-lactamaseEscherichia coli K-12Potency20.082722
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency22.387211
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency19.905411
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency0.398111
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency38.901811
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency7.497811
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency22.387211
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
estrogen nuclear receptor alphaHomo sapiens (human)Potency17.627388
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency5.955711
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency5.594566
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency20.405412
farnesoid X nuclear receptorHomo sapiens (human)Potency6.314022
flap endonuclease 1Homo sapiens (human)Potency2.818411
Fumarate hydrataseHomo sapiens (human)Potency6.309611
gemininHomo sapiens (human)Potency6.966624
GLI family zinc finger 3Homo sapiens (human)Potency0.356022
glp-1 receptor, partialHomo sapiens (human)Potency7.943311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency23.914511
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency18.833611
heat shock protein beta-1Homo sapiens (human)Potency0.150822
Histone H2A.xCricetulus griseus (Chinese hamster)Potency28.971022
huntingtin isoform 2Homo sapiens (human)Potency9.827833
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency0.477211
IDH1Homo sapiens (human)Potency6.513111
importin subunit beta-1 isoform 1Homo sapiens (human)Potency125.892011
Interferon betaHomo sapiens (human)Potency29.410713
lamin isoform A-delta10Homo sapiens (human)Potency6.740312
Microtubule-associated protein tauHomo sapiens (human)Potency8.912522
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency28.183811
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency1.122011
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency6.309611
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency1.333211
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency3.662611
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.239111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.499724
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency26.268334
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency10.000011
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency17.769311
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency15.089011
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency10.590111
plasminogen precursorMus musculus (house mouse)Potency3.981111
polyproteinZika virusPotency6.309611
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency31.622811
PPM1D proteinHomo sapiens (human)Potency29.410712
pregnane X nuclear receptorHomo sapiens (human)Potency21.987422
progesterone receptorHomo sapiens (human)Potency0.530811
RAR-related orphan receptor gammaMus musculus (house mouse)Potency18.673622
ras-related protein Rab-9AHomo sapiens (human)Potency6.309611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency20.689533
retinoid X nuclear receptor alphaHomo sapiens (human)Potency2.394022
Smad3Homo sapiens (human)Potency2.867812
snurportin-1Homo sapiens (human)Potency125.892011
survival motor neuron protein isoform dHomo sapiens (human)Potency11.220211
TAR DNA-binding protein 43Homo sapiens (human)Potency7.943311
TDP1 proteinHomo sapiens (human)Potency3.717124
thioredoxin glutathione reductaseSchistosoma mansoniPotency3.981111
thioredoxin reductaseRattus norvegicus (Norway rat)Potency75.113722
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency4.244322
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.981111
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.981111
USP1 protein, partialHomo sapiens (human)Potency53.808322
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency7.008822
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency8.358333
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.810711
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency18.833611

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bromodomain-containing protein 4Homo sapiens (human)IC500.980022
Catechol O-methyltransferaseRattus norvegicus (Norway rat)IC5019.952611
Cathepsin BHomo sapiens (human)Ki155.233366
Chain B, Cathepsin BHomo sapiens (human)Ki154.400011
Cystathionine gamma-lyaseHomo sapiens (human)IC508.233333
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)IC5046.530011
Methionine aminopeptidase 1Homo sapiens (human)IC5015.000011
Methionine aminopeptidase 2Homo sapiens (human)IC500.055022
Mu-type opioid receptorRattus norvegicus (Norway rat)IC506.000011
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))IC504.723011
photoreceptor-specific nuclear receptorHomo sapiens (human)IC508.962011
Prostaglandin G/H synthase 2Homo sapiens (human)Ki1.000011
transactivating tegument protein VP16 [Human herpesvirus 1]Human alphaherpesvirus 1 (Herpes simplex virus type 1)IC506.357011
Translocator proteinMus musculus (house mouse)Ki0.000312
Vasopressin V1a receptorHomo sapiens (human)Ki0.062411
Vasopressin V1b receptorHomo sapiens (human)Ki0.005811
Vasopressin V2 receptorHomo sapiens (human)Ki0.023311
Vasopressin V2 receptor Rattus norvegicus (Norway rat)Ki0.000311
VifHuman immunodeficiency virus 1IC5046.530011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
amino acid transporter AGP1Saccharomyces cerevisiae S288CEC505.980011
citrate synthase 2, partialSaccharomyces cerevisiae (brewer's yeast)EC5014,600.000012
heat shock protein 90Candida albicansEC500.681011
LAP4Saccharomyces cerevisiae (brewer's yeast)EC502.643023
Oxytocin receptorHomo sapiens (human)EC500.091022
recombinase AMycobacterium tuberculosis H37RvEC5019.715022
RPL19ASaccharomyces cerevisiae (brewer's yeast)EC5025.360011
Vasopressin V1a receptorHomo sapiens (human)EC501.000011
Vasopressin V1b receptorHomo sapiens (human)EC500.011022
Vasopressin V2 receptorHomo sapiens (human)EC500.000222
Vasopressin V2 receptor Rattus norvegicus (Norway rat)EC500.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Caspase 6, apoptosis-related cysteine peptidaseHomo sapiens (human)AC5014.860011
heat shock protein 90, putativePlasmodium falciparum 3D7AC501.657011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC500.996011
MSHDrosophila melanogaster (fruit fly)AC5048.690011
replicative DNA helicaseMycobacterium tuberculosis H37RvAC508.277522