Page last updated: 2024-12-06

dicetylphosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dicetylphosphate is an organophosphate compound with the formula (CH3(CH2)15O)2PO2H. It is a colorless, waxy solid that is insoluble in water but soluble in organic solvents. Dicetylphosphate is used as a surfactant and emulsifier in a variety of applications, including cosmetics, pharmaceuticals, and food processing. It is also used as a plasticizer in some polymers. Dicetylphosphate is synthesized by reacting cetyl alcohol with phosphorus oxychloride. The reaction is typically carried out in the presence of a base, such as pyridine. Dicetylphosphate is a relatively non-toxic compound. However, it can cause skin irritation and eye irritation. Dicetylphosphate is studied for its potential applications in a variety of fields, including drug delivery, gene therapy, and nanotechnology. It is also being investigated for its potential use as a biocompatible material for tissue engineering and regenerative medicine.'

dicetylphosphate: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dicetyl hydrogen phosphate : The dihexadecyl ester of phosphoric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID75143
CHEBI ID60424
SCHEMBL ID64861
MeSH IDM0042833

Synonyms (50)

Synonym
unii-2v6e5wn99n
2v6e5wn99n ,
1-hexadecanol, 1,1'-(hydrogen phosphate)
nsc 12429
einecs 218-594-7
phosphoric acid, dihexadecyl ester
brn 1717117
dicetylphosphate
bis(hexadecyl) phosphate
di-n-hexadecyl phosphate
dicetyl phosphate
dihexadecyl hydrogen phosphate
1-hexadecanol, hydrogen phosphate
nsc-12429
dicetylphosphoric acid
2197-63-9
dihexadecyl phosphate
dicetyl hydrogen phosphate
nsc12429
dipalmityl phosphate
dipalmityl hydrogen phosphate
1-hexadecanol hydrogen phosphate
CHEBI:60424 ,
phosphoric acid dihexadecyl ester
rnpxcfinmksqpq-uhfffaoysa-
inchi=1/c32h67o4p/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-37(33,34)36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-32h2,1-2h3,(h,33,34)
FT-0634112
dicetyl phosphate [inci]
EPITOPE ID:156812
AKOS015903310
SCHEMBL64861
DTXSID7062243
RNPXCFINMKSQPQ-UHFFFAOYSA-N
1-hexadecanol,1,1'-(hydrogen phosphate)
mfcd00008999
bis(hexadecyloxy)phosphinic acid
AS-60121
J-014386
dicetyl phosphate, dihexadecyl phosphate, powder
A878841
Q27127272
BCP32676
dicetyl phosphate;dihexadecyl phosphate
AMY7721
dhp, dicetyl phosphate
CS-0152189
CAA19763
c32h67o4p
BP-29565
HY-W099547

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The mucoadhesiveness of polymer-coated liposomes was evaluated to develop a novel drug carrier system for oral administration of poorly absorbed drugs such as peptide drugs."( Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes.
Hino, T; Kawashima, Y; Niwa, T; Takeuchi, H; Yamamoto, H, 1996
)
0.29
" The in vivo study revealed that the niosomal dispersion significantly improved the oral bioavailability of acyclovir in rabbits after a single oral dose of 40 mg kg(-1)."( Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits.
Attia, IA; Donia, AM; El-Gizawy, SA; Fouda, MA, 2007
)
0.34
"The objectives of this research were to prepare celecoxib proniosomes and evaluate the influence of proniosomal formulation on the oral bioavailability of the drug in human volunteers."( In vitro and in vivo evaluation of proniosomes containing celecoxib for oral administration.
Nasr, M, 2010
)
0.36
"Nitrendipine, a dihydropyridine calcium channel blocker, has very poor oral bioavailability (10-20%) due to first pass effect."( Preparation and characterization of nitrendipine solid lipid nanoparticles.
Hussain, A; Manjunath, K; Venkateswarlu, V, 2011
)
0.37

Dosage Studied

ExcerptRelevanceReference
"3% (w/w) stearylamine could only be obtained when lecithins dosing up to 80% (w/w) phosphatidylcholine (PC) were employed, but they did not resist to long term storage up to 90 days."( Influence of stearylamine and dicetylphosphate on the physical properties of submicron O/W emulsions.
Ludwig, A; Mbela, N; Verschueren, E,
)
0.42
" This electrode system was applied to the determination of lovastatin in dosage drug forms and the results were in accordance with the ultraviolet-visible spectroscopy method."( Development of an acetylene black-dihexadecyl hydrogen phosphate composite-modified glassy-carbon electrode, and its application in the determination of lovastatin in dosage drug forms.
Hu, C; Hu, S; Lan, W; Zhang, H, 2004
)
0.32
" These results indicate that niosomes could be developed as sustained release oral dosage forms for delivery of peptides and proteins such as insulin."( In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin.
Pardakhty, A; Rouholamini, A; Varshosaz, J, 2007
)
0.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
dialkyl phosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (133)

TimeframeStudies, This Drug (%)All Drugs %
pre-199028 (21.05)18.7374
1990's26 (19.55)18.2507
2000's48 (36.09)29.6817
2010's30 (22.56)24.3611
2020's1 (0.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.35 (24.57)
Research Supply Index4.95 (2.92)
Research Growth Index4.52 (4.65)
Search Engine Demand Index50.33 (26.88)
Search Engine Supply Index1.96 (0.95)

This Compound (36.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (0.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other139 (99.29%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]