Page last updated: 2024-08-05 15:22:23

EC 2.7.11.26 (tau-protein kinase) inhibitor

An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).

ChEBI ID: 91092

Members (16)

MemberDefinitionClass
1-azakenpaulloneAn organic heterotetracyclic compound that is 7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indole substituted at positions 6 and 9 by oxo and bromo groups respectively.1-azakenpaullone
2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1h-indole-5-carbonitrileA member of the class of hydroxyindoles that is 1H-indole substituted by hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups at positions 2, 3 and 5, respectively. It is a potent, brain permeable inhibitor of human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively. The drug was being developed by AstraZeneca for the treatment of Alzheimer's disease (clinical trial now discontinued).AZD1080
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dioneA member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease.TDZD-8
8-hydroxymanzamine aAn alkaloid that is manzamine A with a hydroxy substituent at position 8. Isolated from Pachypellina and Acanthostrongylophora, it exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).8-hydroxymanzamine A
alsterpaulloneAn organic heterotetracyclic compound that is 1,3-dihydro-2H-1-benzazepin-2-one which shares its 4-5 bond with the 3-2 bond of 5-nitro-1H-indole.alsterpaullone
azd2858A member of the class of pyrazines that is pyrazine substituted by (pyridin-3-yl)aminocarbonyl, amino, and 4-(4-methylpiperazine-1-sulfonyl)phenyl groups at positions 2, 3 and 6, respectively. It is a potent inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.9 and 4.9 nM, respectively) and increases bone mass (via Wnt activation) in rats.AZD2858
chir 98014A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively).CHIR-98014
chir 99021A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.CHIR 99021
GSK3-XIIIA member of the class of aromatic amines that is ammonia with two of the hydrogens replaced by 5-methylpyrazol-3-yl and 2-phenylquinazolin-4-yl groups.GSK3-XIII
ly2090314A member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer.LY-2090314
manzamine aAn alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).manzamine A
np 031112A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.tideglusib
nsc 664704An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).kenpaullone
paulloneAn indolobenzazepine that is 5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine carrying an oxo substituent at position 6.paullone
sb 415286A member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively.SB 415286
tak-632A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively.TAK-632

Research

Studies (772)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (1.04)18.2507
2000's170 (22.02)29.6817
2010's451 (58.42)24.3611
2020's143 (18.52)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials9 (0.96%)5.53%
Reviews53 (5.64%)6.00%
Case Studies1 (0.11%)4.05%
Observational1 (0.11%)0.25%
Other876 (93.19%)84.16%

Protein Targets (486)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.079511
67.9K proteinVaccinia virusPotency8.856124
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.183812
ATAD5 protein, partialHomo sapiens (human)Potency7.604734
Ataxin-2Homo sapiens (human)Potency39.810711
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.095311
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency37.933011
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency14.689211
Bloom syndrome protein isoform 1Homo sapiens (human)Potency34.411724
BRCA1Homo sapiens (human)Potency18.629812
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.118711
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency19.783022
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency25.118911
Chain A, CruzipainTrypanosoma cruziPotency39.810712
Chain A, Ferritin light chainEquus caballus (horse)Potency22.535822
Chain A, HADH2 proteinHomo sapiens (human)Potency13.940424
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency79.432811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency44.668411
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency29.572423
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency25.118911
Chain B, HADH2 proteinHomo sapiens (human)Potency13.940424
chromobox protein homolog 1Homo sapiens (human)Potency45.857712
cytochrome P450 2C19 precursorHomo sapiens (human)Potency39.810711
cytochrome P450 2C9 precursorHomo sapiens (human)Potency20.811412
cytochrome P450 2C9, partialHomo sapiens (human)Potency7.467217
cytochrome P450 2D6Homo sapiens (human)Potency8.040316
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency0.398111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency12.589326
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency2.630317
D(1A) dopamine receptorHomo sapiens (human)Potency4.218612
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency35.481311
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency23.715011
DNA polymerase betaHomo sapiens (human)Potency12.672812
DNA polymerase eta isoform 1Homo sapiens (human)Potency19.952611
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency28.183811
DNA polymerase kappa isoform 1Homo sapiens (human)Potency17.241513
dopamine D1 receptorHomo sapiens (human)Potency0.046111
endonuclease IVEscherichia coliPotency6.309611
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency3.913746
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency13.658015
EWS/FLI fusion proteinHomo sapiens (human)Potency17.3922411
flap endonuclease 1Homo sapiens (human)Potency14.001223
fructose-bisphosphate aldolase AOryctolagus cuniculus (rabbit)Potency125.892011
GVesicular stomatitis virusPotency7.467217
GABA theta subunitRattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency12.589314
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency12.589314
gemininHomo sapiens (human)Potency11.348747
glp-1 receptor, partialHomo sapiens (human)Potency2.578822
GLS proteinHomo sapiens (human)Potency14.129123
glucocerebrosidaseHomo sapiens (human)Potency17.782811
glucokinase regulatory proteinHomo sapiens (human)Potency17.782811
Glycoprotein hormones alpha chainHomo sapiens (human)Potency0.794311
Guanine nucleotide-binding protein GHomo sapiens (human)Potency2.511911
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency0.052111
hexokinase-4 isoform 1Homo sapiens (human)Potency17.782811
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency20.811416
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency29.315713
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency7.467217
huntingtin isoform 2Homo sapiens (human)Potency1.929323
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency7.875824
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency7.4672114
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency19.952611
Integrin alpha-IIbHomo sapiens (human)Potency31.622811
Integrin beta-3Homo sapiens (human)Potency31.622811
Interferon betaHomo sapiens (human)Potency19.3776222
lamin isoform A-delta10Homo sapiens (human)Potency2.989112
LuciferasePhotinus pyralis (common eastern firefly)Potency15.848911
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency22.387211
M-phase phosphoprotein 8Homo sapiens (human)Potency35.043713
Microtubule-associated protein tauHomo sapiens (human)Potency15.839624
mitogen-activated protein kinase 1Homo sapiens (human)Potency6.309611
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency12.431212
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency19.118012
NFKB1 protein, partialHomo sapiens (human)Potency4.152424
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency35.481311
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency0.517411
Nrf2Homo sapiens (human)Potency18.356411
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency1.847323
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency14.459825
Ornithine decarboxylaseRattus norvegicus (Norway rat)Potency3.162311
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency32.749813
ParkinHomo sapiens (human)Potency4.198822
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency55.008522
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency30.127212
phosphopantetheinyl transferaseBacillus subtilisPotency32.062013
PPM1D proteinHomo sapiens (human)Potency24.9358110
pyruvate kinaseLeishmania mexicana mexicanaPotency6.309622
pyruvate kinase PKM isoform bHomo sapiens (human)Potency3.162322
ras-related protein Rab-9AHomo sapiens (human)Potency0.366311
regulator of G-protein signaling 4Homo sapiens (human)Potency25.135813
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency16.511133
Smad3Homo sapiens (human)Potency3.028837
survival motor neuron protein isoform dHomo sapiens (human)Potency20.083314
TDP1 proteinHomo sapiens (human)Potency18.2860210
thioredoxin glutathione reductaseSchistosoma mansoniPotency7.079511
thioredoxin reductaseRattus norvegicus (Norway rat)Potency20.190237
ThrombopoietinHomo sapiens (human)Potency0.179024
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency79.432811
thyroid stimulating hormone receptorHomo sapiens (human)Potency26.553723
tyrosine-protein kinase YesHomo sapiens (human)Potency30.747511
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency25.954713

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialHomo sapiens (human)IC506.200011
[tau protein] kinase Oryctolagus cuniculus (rabbit)IC502.000011
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)IC5010.000011
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)IC5033.000012
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC500.437012
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC500.437012
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)IC500.437012
Angiopoietin-1 receptorHomo sapiens (human)IC503.580023
Angiotensin-converting enzyme 2 Homo sapiens (human)IC501.550011
Aurora kinase AHomo sapiens (human)IC500.028011
Aurora kinase AHomo sapiens (human)Ki0.058022
Aurora kinase BHomo sapiens (human)IC500.462022
Beta-caseinBos taurus (cattle)IC50100.000013
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)IC5020.000011
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)IC5020.000011
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)IC5020.000011
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)IC5020.000011
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)IC50100.000013
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)IC5020.000011
Casein kinase I isoform alphaSus scrofa (pig)IC5010.000012
Casein kinase I isoform deltaHomo sapiens (human)IC5010.000011
Casein kinase I isoform epsilonHomo sapiens (human)IC505.000012
Casein kinase II subunit alphaHomo sapiens (human)IC5060.000022
Casein kinase II subunit alpha'Homo sapiens (human)IC50100.000011
Casein kinase II subunit betaHomo sapiens (human)IC50100.000011
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)IC500.004012
Chain B, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)IC500.004011
Class A sortase SrtA Staphylococcus aureusIC5052.166733
Cyclin-A1Homo sapiens (human)IC501.135034
Cyclin-A2Homo sapiens (human)IC500.855856
Cyclin-dependent kinase 1Homo sapiens (human)IC5013.09941736
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)IC501.7709215
Cyclin-dependent kinase 2Homo sapiens (human)IC500.993878
Cyclin-dependent kinase 2Homo sapiens (human)Ki0.540011
Cyclin-dependent kinase 4Homo sapiens (human)IC505.900022
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)IC501.98451028
Cyclin-dependent kinase 9Homo sapiens (human)IC500.437012
Cyclin-dependent-like kinase 5 Homo sapiens (human)IC501.74011232
Cyclin-T1Homo sapiens (human)IC500.437012
D(2) dopamine receptorRattus norvegicus (Norway rat)IC5010.000012
Dipeptidyl peptidase 4Homo sapiens (human)IC5010.200011
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)IC503.700011
Dual specificity protein kinase CLK1Homo sapiens (human)IC5010.000012
Dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)IC5010.000012
Epidermal growth factor receptorHomo sapiens (human)IC5010.000011
Fibroblast growth factor receptor 1Homo sapiens (human)IC503.000012
Fibroblast growth factor receptor 3Homo sapiens (human)IC500.280011
G1/S-specific cyclin-E1Homo sapiens (human)Ki0.540011
G1/S-specific cyclin-E2Homo sapiens (human)Ki0.540011
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)IC501.7709215
G2/mitotic-specific cyclin-B1Homo sapiens (human)IC5017.35361226
G2/mitotic-specific cyclin-B2Homo sapiens (human)IC508.2473717
G2/mitotic-specific cyclin-B3Homo sapiens (human)IC508.2473717
Glycogen synthase kinase 3 Plasmodium falciparum 3D7IC5010.000012
Glycogen synthase kinase-3 alphaHomo sapiens (human)IC502.02321117
Glycogen synthase kinase-3 alphaHomo sapiens (human)Ki0.027422
Glycogen synthase kinase-3 betaHomo sapiens (human)IC502.35506088
Glycogen synthase kinase-3 betaMus musculus (house mouse)IC500.076011
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)IC501.6613316
Glycogen synthase kinase-3 betaHomo sapiens (human)Ki0.021366
Heat shock factor protein 1Homo sapiens (human)IC5010.000011
Hepatocyte growth factor receptorHomo sapiens (human)IC5010.000011
Inhibitor of nuclear factor kappa-B kinase subunit betaHomo sapiens (human)IC503.700011
Insulin receptorHomo sapiens (human)IC5030.500034
Insulin-like growth factor 1 receptorHomo sapiens (human)IC506.000012
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)IC5015.000011
large T antigenBetapolyomavirus macacaeIC5055.430011
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)IC500.800012
LIM domain kinase 1Homo sapiens (human)IC5010.000044
LIM domain kinase 2Homo sapiens (human)IC5010.000044
Mast/stem cell growth factor receptor KitHomo sapiens (human)IC5010.000011
Mitogen-activated protein kinase 1Homo sapiens (human)IC509.666723
Mitogen-activated protein kinase 11Homo sapiens (human)IC5020.000011
Mitogen-activated protein kinase 12Homo sapiens (human)IC5020.000011
Mitogen-activated protein kinase 13Homo sapiens (human)IC5020.000011
Mitogen-activated protein kinase 14Homo sapiens (human)IC5010.300022
Mitogen-activated protein kinase 3 Homo sapiens (human)IC5015.000022
Mitogen-activated protein kinase 8Homo sapiens (human)IC5010.000011
Mitogen-activated protein kinase kinase kinase 1Homo sapiens (human)IC5010.000011
Mitogen-activated protein kinase kinase kinase 20Homo sapiens (human)IC5020.000011
MO15-related protein kinase Pfmrk Plasmodium falciparum (malaria parasite P. falciparum)IC5033.000024
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)IC5029.000022
NAD-dependent protein deacetylase sirtuin-2Homo sapiens (human)IC5048.900034
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)IC500.833511
PirinHomo sapiens (human)IC5010.000011
Platelet-derived growth factor receptor betaHomo sapiens (human)IC500.120011
Platelet-derived growth factor subunit AHomo sapiens (human)IC500.610011
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)IC504.800011
Procathepsin LHomo sapiens (human)IC501.550011
Protein kinase C alpha typeRattus norvegicus (Norway rat)IC50100.000011
Protein kinase C beta typeHomo sapiens (human)IC500.420011
Protein kinase C beta typeRattus norvegicus (Norway rat)IC50100.000022
Protein kinase C delta typeRattus norvegicus (Norway rat)IC50100.000011
Protein kinase C epsilon typeRattus norvegicus (Norway rat)IC50100.000011
Protein kinase C eta typeRattus norvegicus (Norway rat)IC50100.000011
Protein kinase C gamma typeRattus norvegicus (Norway rat)IC50100.000011
Protein kinase C theta typeHomo sapiens (human)IC5010.000011
Protein kinase C theta typeRattus norvegicus (Norway rat)IC50100.000011
Protein kinase C zeta typeHomo sapiens (human)IC5010.000011
Protein kinase C zeta typeRattus norvegicus (Norway rat)IC50100.000011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC5012.500022
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)Ki0.081022
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)IC5011.666723
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)IC500.015655
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)IC5010.000011
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusIC501.550011
Replicase polyprotein 1abBetacoronavirus England 1IC507.183323
Replicase polyprotein 1abHuman coronavirus 229EIC501.550011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC501.1591813
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC501.750023
Serine/threonine-protein kinase B-rafHomo sapiens (human)IC500.02011515
Serine/threonine-protein kinase Chk1Homo sapiens (human)IC507.133323
Serine/threonine-protein kinase PLK1Homo sapiens (human)IC50100.000011
Serine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens (human)IC501.300011
Spike glycoproteinBetacoronavirus England 1IC501.550011
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusIC501.550011
steroidogenic factor 1Homo sapiens (human)IC5067.518011
Sterol O-acyltransferase 1Homo sapiens (human)IC506.300022
Sterol O-acyltransferase 2Homo sapiens (human)IC504.800011
TGF-beta receptor type-2Homo sapiens (human)IC501.200011
Transmembrane protease serine 2Homo sapiens (human)IC501.550011
Tyrosine-protein kinase LckHomo sapiens (human)IC500.470011
Vascular endothelial growth factor receptor 1 Homo sapiens (human)IC505.000012
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC5025.432045

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
26S proteasome regulatory subunit 6BHomo sapiens (human)Kd30.000011
5'-AMP-activated protein kinase catalytic subunit alpha-1Homo sapiens (human)Kd30.000011
5'-AMP-activated protein kinase subunit gamma-1Homo sapiens (human)Kd30.000011
5'-AMP-activated protein kinase subunit gamma-2Homo sapiens (human)Kd30.000011
AarF domain-containing protein kinase 1Homo sapiens (human)Kd30.000011
Actin-related protein 2Homo sapiens (human)Kd30.000011
Actin-related protein 3Homo sapiens (human)Kd30.000011
Activated CDC42 kinase 1Homo sapiens (human)Kd30.000011
Activin receptor type-1Homo sapiens (human)Kd30.000011
Activin receptor type-1BHomo sapiens (human)Kd30.000011
Activin receptor type-2BHomo sapiens (human)Kd30.000011
Acyl-CoA dehydrogenase family member 10Homo sapiens (human)Kd30.000011
Adenine phosphoribosyltransferaseHomo sapiens (human)Kd30.000011
Adenosine kinaseHomo sapiens (human)Kd30.000011
Adenylate kinase 2, mitochondrialHomo sapiens (human)Kd30.000011
ADP/ATP translocase 2Homo sapiens (human)Kd30.000011
ADP/ATP translocase 3Homo sapiens (human)Kd30.000011
AP2-associated protein kinase 1Homo sapiens (human)Kd30.000011
ATP-dependent 6-phosphofructokinase, platelet typeHomo sapiens (human)Kd30.000011
ATP-dependent RNA helicase DDX1Homo sapiens (human)Kd30.000011
ATP-dependent RNA helicase DDX3XHomo sapiens (human)Kd30.000011
ATP-dependent RNA helicase DDX42Homo sapiens (human)Kd30.000011
Atypical kinase COQ8A, mitochondrialHomo sapiens (human)Kd30.000011
Aurora kinase AHomo sapiens (human)Kd30.000011
Aurora kinase BHomo sapiens (human)Kd30.000011
Beta-adrenergic receptor kinase 1Homo sapiens (human)Kd30.000011
BMP-2-inducible protein kinaseHomo sapiens (human)Kd30.000011
Bone morphogenetic protein receptor type-1AHomo sapiens (human)Kd30.000011
Bone morphogenetic protein receptor type-1BHomo sapiens (human)Kd30.000011
Bone morphogenetic protein receptor type-2Homo sapiens (human)Kd30.000011
Breakpoint cluster region proteinHomo sapiens (human)Kd30.000011
Calcium/calmodulin-dependent protein kinase kinase 2Homo sapiens (human)Kd30.000011
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)Kd30.000011
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)Kd30.000011
Calcium/calmodulin-dependent protein kinase type IVHomo sapiens (human)Kd30.000011
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)Kd30.000011
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)Kd30.000011
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)Kd30.000011
cAMP-dependent protein kinase type II-alpha regulatory subunitHomo sapiens (human)Kd30.000011
Casein kinase I isoform alphaHomo sapiens (human)Kd30.000011
Casein kinase I isoform deltaHomo sapiens (human)Kd30.000011
Casein kinase I isoform epsilonHomo sapiens (human)Kd30.000012
Casein kinase I isoform gamma-1Homo sapiens (human)Kd30.000011
Casein kinase I isoform gamma-2Homo sapiens (human)Kd30.000011
Casein kinase I isoform gamma-3Homo sapiens (human)Kd30.000011
Casein kinase II subunit alpha'Homo sapiens (human)Kd30.000011
Cell division cycle 7-related protein kinaseHomo sapiens (human)Kd30.000011
cGMP-dependent protein kinase 1 Homo sapiens (human)Kd30.000012
Chromodomain-helicase-DNA-binding protein 4Homo sapiens (human)Kd30.000011
Citron Rho-interacting kinaseHomo sapiens (human)Kd30.000011
Cyclin-dependent kinase 1Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 10Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 12Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 13Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 16Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 17Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 2Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 3Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 4Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 6Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 7Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 9Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase-like 5Homo sapiens (human)Kd30.000011
Cyclin-dependent-like kinase 5 Homo sapiens (human)Kd30.000011
Cyclin-G-associated kinaseHomo sapiens (human)Kd30.000011
Cysteine--tRNA ligase, cytoplasmicHomo sapiens (human)Kd30.000011
Cytochrome c1, heme protein, mitochondrialHomo sapiens (human)Kd30.000011
dCTP pyrophosphatase 1Homo sapiens (human)Kd30.000011
Delta(24)-sterol reductaseHomo sapiens (human)Kd30.000011
Deoxycytidine kinaseHomo sapiens (human)Kd30.000011
Discoidin domain-containing receptor 2Homo sapiens (human)Kd30.000011
DNA replication licensing factor MCM4Homo sapiens (human)Kd30.000011
DNA topoisomerase 2-alphaHomo sapiens (human)Kd30.000011
DNA topoisomerase 2-betaHomo sapiens (human)Kd30.000011
DnaJ homolog subfamily A member 1Homo sapiens (human)Kd30.000011
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)Kd30.000011
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)Kd30.000011
Dual specificity mitogen-activated protein kinase kinase 3Homo sapiens (human)Kd30.000011
Dual specificity mitogen-activated protein kinase kinase 5Homo sapiens (human)Kd30.000011
Dual specificity mitogen-activated protein kinase kinase 6Homo sapiens (human)Kd30.000012
Dual specificity protein kinase CLK1Homo sapiens (human)Kd30.000011
Dual specificity protein kinase CLK2Homo sapiens (human)Kd30.000011
Dual specificity protein kinase CLK4Homo sapiens (human)Kd30.000011
Dual specificity protein kinase TTKHomo sapiens (human)Kd30.000012
Dual specificity testis-specific protein kinase 1Homo sapiens (human)Kd30.000011
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)Kd30.000011
Dynamin-like 120 kDa protein, mitochondrialHomo sapiens (human)Kd30.000011
EKC/KEOPS complex subunit TP53RKHomo sapiens (human)Kd30.000011
Electron transfer flavoprotein subunit betaHomo sapiens (human)Kd30.000011
Elongation factor Tu, mitochondrialHomo sapiens (human)Kd30.000011
Ephrin type-A receptor 1Homo sapiens (human)Kd30.000011
Ephrin type-A receptor 2Homo sapiens (human)Kd30.000011
Ephrin type-A receptor 4Homo sapiens (human)Kd30.000011
Ephrin type-A receptor 5Homo sapiens (human)Kd30.000011
Ephrin type-A receptor 7Homo sapiens (human)Kd30.000011
Ephrin type-B receptor 2Homo sapiens (human)Kd30.000011
Ephrin type-B receptor 3Homo sapiens (human)Kd30.000011
Ephrin type-B receptor 4Homo sapiens (human)Kd30.000011
Ephrin type-B receptor 6Homo sapiens (human)Kd30.000011
Epidermal growth factor receptorHomo sapiens (human)Kd30.000011
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)Kd30.000011
Eukaryotic peptide chain release factor GTP-binding subunit ERF3BHomo sapiens (human)Kd30.000011
Eukaryotic translation initiation factor 2-alpha kinase 1Homo sapiens (human)Kd30.000011
Exosome RNA helicase MTR4Homo sapiens (human)Kd30.000011
Ferrochelatase, mitochondrialHomo sapiens (human)Kd30.000011
Fibroblast growth factor receptor 1Homo sapiens (human)Kd30.000011
Focal adhesion kinase 1Homo sapiens (human)Kd30.000011
G protein-coupled receptor kinase 6Homo sapiens (human)Kd30.000011
General transcription and DNA repair factor IIH helicase subunit XPDHomo sapiens (human)Kd30.000011
Glycine--tRNA ligaseHomo sapiens (human)Kd30.000011
Glycogen phosphorylase, brain formHomo sapiens (human)Kd30.000011
Glycogen phosphorylase, liver formHomo sapiens (human)Kd30.000011
Glycogen synthase kinase-3 alphaHomo sapiens (human)Kd30.000011
Glycogen synthase kinase-3 betaHomo sapiens (human)EC5025.906733
Glycogen synthase kinase-3 betaHomo sapiens (human)Kd30.000011
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC500.239411
GTP-binding nuclear protein RanHomo sapiens (human)Kd30.000011
Heme oxygenase 2Homo sapiens (human)Kd30.000011
High affinity nerve growth factor receptorHomo sapiens (human)Kd30.000011
Inhibitor of nuclear factor kappa-B kinase subunit epsilonHomo sapiens (human)Kd30.000011
Inosine-5'-monophosphate dehydrogenase 2Homo sapiens (human)Kd30.000011
Insulin receptorHomo sapiens (human)Kd30.000011
Insulin-like growth factor 1 receptorHomo sapiens (human)Kd30.000011
Interleukin-1 receptor-associated kinase 1Homo sapiens (human)Kd30.000011
Interleukin-1 receptor-associated kinase 3Homo sapiens (human)Kd30.000011
Interleukin-1 receptor-associated kinase 4Homo sapiens (human)Kd30.000011
Isoleucine--tRNA ligase, mitochondrialHomo sapiens (human)Kd30.000011
LIM domain kinase 1Homo sapiens (human)Kd30.000011
LIM domain kinase 2Homo sapiens (human)Kd30.000011
Long-chain-fatty-acid--CoA ligase 5Homo sapiens (human)Kd30.000011
Macrophage-stimulating protein receptorHomo sapiens (human)Kd30.000011
MAP kinase-activated protein kinase 2Homo sapiens (human)Kd30.000011
MAP kinase-activated protein kinase 5Homo sapiens (human)Kd30.000011
MAP/microtubule affinity-regulating kinase 3Homo sapiens (human)Kd30.000011
MAP/microtubule affinity-regulating kinase 4Homo sapiens (human)Kd30.000011
Maternal embryonic leucine zipper kinaseHomo sapiens (human)Kd30.000011
Membrane-associated progesterone receptor component 1Homo sapiens (human)Kd30.000011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)Kd30.000011
MidasinHomo sapiens (human)Kd30.000011
Misshapen-like kinase 1Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 1Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 10Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 11Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 14Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 15Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 3 Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 7Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 8Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase 9Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 1Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 11Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 2Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 20Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 3Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 4Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 5Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase 6Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase kinase 1Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase kinase 2Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase kinase 3Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase kinase 4Homo sapiens (human)Kd30.000011
Mitogen-activated protein kinase kinase kinase kinase 5Homo sapiens (human)Kd30.000011
Mitotic checkpoint serine/threonine-protein kinase BUB1Homo sapiens (human)Kd30.000012
Multifunctional protein ADE2Homo sapiens (human)Kd30.000011
Myosin light chain kinase 3Homo sapiens (human)Kd30.000011
Myosin light chain kinase, smooth muscleHomo sapiens (human)Kd30.000011
Myosin-14Homo sapiens (human)Kd30.000012
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Homo sapiens (human)Kd30.000011
Non-receptor tyrosine-protein kinase TNK1Homo sapiens (human)Kd30.000011
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)Kd30.000011
NUAK family SNF1-like kinase 2Homo sapiens (human)Kd30.000011
Nucleolar GTP-binding protein 1Homo sapiens (human)Kd30.000011
Obg-like ATPase 1Homo sapiens (human)Kd30.000011
PAS domain-containing serine/threonine-protein kinaseHomo sapiens (human)Kd30.000011
Peroxisomal acyl-coenzyme A oxidase 1Homo sapiens (human)Kd30.000011
Peroxisomal acyl-coenzyme A oxidase 3Homo sapiens (human)Kd30.000011
Phenylalanine--tRNA ligase beta subunitHomo sapiens (human)Kd30.000011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaHomo sapiens (human)Kd30.000011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoformHomo sapiens (human)Kd30.000011
Platelet-derived growth factor receptor betaHomo sapiens (human)Kd30.000011
Probable ATP-dependent RNA helicase DDX6Homo sapiens (human)Kd30.000011
Protein kinase C alpha typeHomo sapiens (human)Kd30.000011
Protein kinase C beta typeHomo sapiens (human)Kd30.000011
Protein kinase C delta typeHomo sapiens (human)Kd30.000011
Protein kinase C iota typeHomo sapiens (human)Kd30.000012
Protein kinase C theta typeHomo sapiens (human)Kd30.000011
Protein-tyrosine kinase 2-betaHomo sapiens (human)Kd30.000012
Protein-tyrosine kinase 6Homo sapiens (human)Kd30.000011
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)Kd30.000011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)Kd30.000011
Putative heat shock protein HSP 90-beta 2Homo sapiens (human)Kd30.000011
Pyridoxal kinaseHomo sapiens (human)Kd30.000012
Rab-like protein 3Homo sapiens (human)Kd30.000011
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)Kd30.000011
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)Kd30.000011
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)Kd30.000011
Ras-related protein Rab-10Homo sapiens (human)Kd30.000011
Ras-related protein Rab-27AHomo sapiens (human)Kd30.000011
Ras-related protein Rab-6AHomo sapiens (human)Kd30.000011
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)Kd0.480022
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)Kd30.000011
Receptor-interacting serine/threonine-protein kinase 3Homo sapiens (human)Kd10.070033
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)Kd30.000011
Rho-associated protein kinase 1Homo sapiens (human)Kd30.000011
Rho-associated protein kinase 2Homo sapiens (human)Kd30.000011
Ribosomal protein S6 kinase alpha-1Homo sapiens (human)Kd30.000011
Ribosomal protein S6 kinase alpha-3Homo sapiens (human)Kd30.000011
Ribosomal protein S6 kinase alpha-4Homo sapiens (human)Kd30.000011
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)Kd30.000011
Ribosomal protein S6 kinase alpha-6Homo sapiens (human)Kd30.000011
Ribosomal protein S6 kinase beta-1Homo sapiens (human)Kd30.000011
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)Kd30.000011
RNA cytidine acetyltransferaseHomo sapiens (human)Kd30.000011
S-adenosylmethionine synthase isoform type-2Homo sapiens (human)Kd30.000011
Septin-9Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 10Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 16Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 24Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 26Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 38-likeHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase 4Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase A-RafHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase B-rafHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Chk1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase D2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase D3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase ICKHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase LATS1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase MARK2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase MRCK alphaHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase MRCK betaHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase MRCK gammaHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase N1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase N2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase N3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Nek1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Nek2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase Nek3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase Nek9Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase NLKHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase PAK 2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase PAK 4Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase PAK 6Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase pim-1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase PLK4Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase SIK2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase SIK3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase STK11Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase TAO1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase TAO2Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase TAO3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase TBK1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase ULK1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase ULK3Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens (human)Kd30.000011
Serine/threonine-protein kinase/endoribonuclease IRE2Homo sapiens (human)Kd30.000011
Signal recognition particle receptor subunit alphaHomo sapiens (human)Kd30.000011
STE20-like serine/threonine-protein kinase Homo sapiens (human)Kd30.000011
STE20-related kinase adapter protein alphaHomo sapiens (human)Kd30.000011
Structural maintenance of chromosomes protein 1AHomo sapiens (human)Kd30.000011
Structural maintenance of chromosomes protein 2Homo sapiens (human)Kd30.000011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialHomo sapiens (human)Kd30.000011
TGF-beta receptor type-1Homo sapiens (human)Kd30.000011
TGF-beta receptor type-2Homo sapiens (human)Kd30.000011
Thyroid hormone receptor-associated protein 3Homo sapiens (human)Kd30.000011
TRAF2 and NCK-interacting protein kinaseHomo sapiens (human)Kd30.000011
Tyrosine--tRNA ligase, cytoplasmicHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase ABL1Homo sapiens (human)Kd30.000011
Tyrosine-protein kinase ABL2Homo sapiens (human)Kd30.000011
Tyrosine-protein kinase BTKHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase CSKHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase FerHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase Fes/FpsHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase FRKHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase FynHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase HCKHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase JAK1Homo sapiens (human)Kd30.000011
Tyrosine-protein kinase LckHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase LynHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase MerHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase SYKHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase TecHomo sapiens (human)Kd30.000011
Tyrosine-protein kinase YesHomo sapiens (human)Kd30.000011
U5 small nuclear ribonucleoprotein 200 kDa helicaseHomo sapiens (human)Kd30.000011
Uncharacterized protein FLJ45252Homo sapiens (human)Kd30.000011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialHomo sapiens (human)Kd30.000011
Wee1-like protein kinaseHomo sapiens (human)Kd30.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
CDK5Homo sapiens (human)AC505.559011
Cyclin-dependent kinase 1Homo sapiens (human)ID501.867524
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)Homo sapiens (human)AC505.559011
dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)AC503.106011
FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)Mycobacterium tuberculosis H37RvAC5089.100011
G2/mitotic-specific cyclin-B1Homo sapiens (human)ID501.867524
G2/mitotic-specific cyclin-B2Homo sapiens (human)ID501.867524
G2/mitotic-specific cyclin-B3Homo sapiens (human)ID501.867524