cleistanthins

Any of the lignans with a 9-aryl-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl glycoside skeleton originally isolated from Cleistanthus collinus, a toxic deciduous shrub. While all parts of the plant are poisonous, the leaves in particular are used as a suicide poison by young women in rural parts of southern India. Cleistanthins A and B have been particularly associated with the toxicity of the plant, with cleistanthin A being more potent than cleistanthin B.

ChEBI ID: 84406

Members (2)

Member	Definition	Role
cleistanthin	A member of the class of cleistanthins that is the 4-O-3,4-di-O-methyl-beta-D-xylopyranoside of 1,3-dihydronaphtho[2,3-c]furan-4-ol which is substituted by an oxo group at position 1, methoxy groups at positions 6 and 7, and a 1,3-benzodioxol-5-yl group at position 9. It is one of the toxic principles in Cleistanthus collinus.	cleistanthin A
cleistanthin b	A member of the class of cleistanthins that is cleistanthin A in which the 3,4-di-O-methyl-D-xylopyranosyl group is replaced by a beta-D-glucopyranosyl group.	cleistanthin B

Research

Studies (29)

Timeframe	Studies, Drugs in This Class (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (17.24)	18.2507
2000's	8 (27.59)	29.6817
2010's	11 (37.93)	24.3611
2020's	5 (17.24)	2.80

Study Types

Publication Type	Studies, Drugs in This Class (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.88%)	6.00%
Case Studies	3 (8.82%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (85.29%)	84.16%