Dermal Sinus

A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34)

Synonym
Spinal Bifida, Closed
Occult Spina Bifida
Spina Bifida Occulta
Dermal Sinus

Excerpt	Reference
"The congenital dermal sinus is an abnormal epithelium-lined sinus tract between the skin surface and deeper tissues."	( Kara, NN, 2003)

Excerpt	Reference
"Spina bifida occulta affected L4 in four children, L5 in 12 children, S1 in 26 children and S2 in one child."	( Choi, EK; Han, SW; Im, YJ; Lee, MJ; Lee, YS; Shin, SH, 2013)

Excerpt	Reference
"Surgical treatment of congenital dermal sinuses was accompanied with, in general, excellent results."	( Aryan, HE; Chen, JC; Farin, A; Granville, R; Jandial, R; Levy, ML, 2006)
"We examined whether the existence of spina bifida occulta or ultrasonographic bladder abnormalities was related to the outcome of treatment for primary nocturnal enuresis in children."	( Miyazato, M; Nishijima, S; Ogawa, Y; Owan, T; Sugaya, K, 2007)
"The presence of lumbar spina bifida occulta and ultrasonographic bladder abnormalities was related to the outcome of treatment for primary nocturnal enuresis in children, suggesting that spinal radiography and vesical ultrasonography may be useful predictive tests."	( Miyazato, M; Nishijima, S; Ogawa, Y; Owan, T; Sugaya, K, 2007)
"Total excision of dermal sinus tract, dermoid cyst, and the intramedullary abscess by means of a L2-S3 laminectomy, followed by antibiotic therapy resulted in good functional recovery."	( Cekinmez, M; Erdogan, B; Sener, L; Tufan, K, 2008)
"However, the effect of spina bifida occulta on the response to nocturnal enuresis treatment is controversial."	( Choi, EK; Han, SW; Im, YJ; Lee, MJ; Lee, YS; Shin, SH, 2013)
"The presence of spina bifida occulta significantly affects the response to treatment in patients with nocturnal enuresis."	( Choi, EK; Han, SW; Im, YJ; Lee, MJ; Lee, YS; Shin, SH, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	106 (65.03)	23.3326
1990's	26 (15.95)	12.5806
2000's	16 (9.82)	18.1394
2010's	15 (9.20)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
methane	low	1	0
salicylic acid	low	2	0
cytosine	low	1	0
nitrates	low	1	0
nitrous oxide	low	2	0
thymine	low	1	0
vanilmandelic acid	low	1	0
2,4,5-trichlorophenoxyacetic acid	low	1	0
phenytoin	low	1	0
baclofen	low	1	0
bupivacaine	low	1	0
carbamazepine	low	1	0
clonidine	low	1	0
diazepam	low	1	0
valproic acid	low	28	0
fentanyl	low	1	0
lidocaine	low	2	0
imipramine	low	1	0
isoflurane	low	1	0
ketamine	low	1	0
leflunomide	low	1	0
loperamide	low	1	0
metronidazole	low	3	0
muscimol	low	1	0
oxybutynin	medium	2	1
phenoxybenzamine	low	1	0
propofol	low	1	0
propranolol	low	1	0
sevoflurane	low	1	0
thalidomide	low	2	0
thyroxine	low	1	0
bromodeoxyuridine	low	1	0
methicillin	low	1	0
methylene blue	low	1	0
medroxyprogesterone acetate	low	1	0
ethylene oxide	low	2	0
isoprene	low	1	0
1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt	low	1	0
isoxazoles	low	1	0
bicuculline	low	1	0
medroxyprogesterone	low	1	0
congo red	low	1	0
vancomycin	low	1	0
technetium	low	1	0
cadmium	low	1	0
barium sulfate	low	1	0
calcium sulfate	low	1	0
cadmium sulfate	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
4-methoxyamphetamine	low	1	0
etoposide	low	1	0
substance p	low	1	0
propiconazole	low	1	0
fomesafen	low	3	0
cephalosporin c	low	1	0
homocysteine	low	1	0
beta-lactams	low	1	0
ertapenem	low	1	0
moxifloxacin	low	1	0
metrizamide	low	7	0
tretinoin	low	7	0
retinol	low	4	0
bromochloroacetic acid	low	3	0
isomethyleugenol	low	1	0
enclomiphene	medium	1	1
ethylenethiourea	low	1	0
phenylephrine hydrochloride	low	2	0
deamino arginine vasopressin	medium	3	1
cefotaxime	low	2	0
selenium	low	1	0
gadolinium dtpa	low	1	0
ro13-9904	low	2	0
piperidines	low	1	0
ascorbic acid	low	1	0
salicylates	low	1	0
warfarin	low	1	0
vitamin b 12	low	2	0
technetium tc 99m medronate	low	2	0
acyclovir	low	1	0
hypoxanthine	low	1	0
folic acid	medium	9	4
trypan blue	low	4	0
concanavalin a	low	2	0

Protein Targets (872)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
SMAD family member 2	10	0	0	10
SMAD family member 3	10	0	0	10
AR protein	34	0	0	34
retinoid X nuclear receptor alpha	17	0	0	17
estrogen-related nuclear receptor alpha	32	0	0	32
farnesoid X nuclear receptor	13	0	0	13
pregnane X nuclear receptor	22	0	0	22
estrogen nuclear receptor alpha	35	0	0	35
peroxisome proliferator-activated receptor delta	15	0	0	15
peroxisome proliferator activated receptor gamma	21	0	0	21
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
thyroid hormone receptor beta isoform a	12	0	0	12
thyroid hormone receptor beta isoform 2	22	0	0	22
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
Androgen receptor	0	5	0	5
5-hydroxytryptamine receptor 2C	0	3	1	4
5-hydroxytryptamine receptor 2A	0	3	1	5
5-hydroxytryptamine receptor 1A	0	11	3	15
5-hydroxytryptamine receptor 1B	0	7	1	8
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	8	1	9
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	1	0	1
thioredoxin reductase	13	0	0	13
phosphopantetheinyl transferase	9	0	0	9
GLS protein	8	0	0	8
TDP1 protein	30	0	0	30
Smad3	3	0	0	3
thyroid stimulating hormone receptor	10	0	0	10
EWS/FLI fusion protein	9	0	0	9
arylsulfatase A	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
activating transcription factor 6	14	0	0	14
Histone H2A.x	10	0	0	10
Bloom syndrome protein isoform 1	11	0	0	11
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	20	0	0	20
Solute carrier family 22 member 1	0	7	0	9
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	6	0	6
Bile salt export pump	0	24	0	24
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	7	1	8
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Canalicular multispecific organic anion transporter 1	0	14	0	15
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	27	0	0	27
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
glucocorticoid receptor [Homo sapiens]	23	0	0	23
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	19	0	0	19
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
heat shock protein beta-1	11	0	0	11
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	12	0	0	12
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	14	0	0	14
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	9	0	0	9
GLI family zinc finger 3	25	0	0	25
thioredoxin glutathione reductase	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
IDH1	11	0	0	11
chromobox protein homolog 1	14	0	0	14
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	24	0	0	24
lethal factor (plasmid)	2	0	0	2
Polyphenol oxidase 2	0	2	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	3	8
Spike glycoprotein	14	0	1	15
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
ATAD5 protein, partial	6	0	0	6
NFKB1 protein, partial	1	0	0	1
regulator of G-protein signaling 4	5	0	0	5
67.9K protein	3	0	0	3
D(1A) dopamine receptor	5	0	0	5
cytochrome P450 3A4 isoform 1	8	0	0	8
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	8	7	3	18
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	8	7	3	18
Gamma-aminobutyric acid receptor subunit delta	8	7	3	18
Gamma-aminobutyric acid receptor subunit gamma-2	8	7	4	19
Gamma-aminobutyric acid receptor subunit alpha-5	8	7	3	18
Gamma-aminobutyric acid receptor subunit alpha-3	8	7	3	18
Gamma-aminobutyric acid receptor subunit gamma-1	8	7	3	18
Gamma-aminobutyric acid receptor subunit alpha-2	8	7	3	18
Gamma-aminobutyric acid receptor subunit alpha-4	8	7	3	18
Gamma-aminobutyric acid receptor subunit gamma-3	8	7	3	18
Gamma-aminobutyric acid receptor subunit alpha-6	8	7	3	18
Gamma-aminobutyric acid receptor subunit alpha-1	8	7	4	19
Gamma-aminobutyric acid receptor subunit beta-3	8	7	3	18
Gamma-aminobutyric acid receptor subunit beta-2	8	7	4	19
GABA theta subunit	8	7	3	18
Gamma-aminobutyric acid receptor subunit epsilon	8	7	3	18
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
ATP-dependent phosphofructokinase	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	7	4	11
Gamma-aminobutyric acid receptor subunit beta-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	3	10
Gamma-aminobutyric acid receptor subunit beta-3	0	7	3	10
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	2	8
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
thyroid stimulating hormone receptor	10	0	0	10
Cellular tumor antigen p53	24	0	0	24
Nuclear receptor ROR-gamma	6	1	1	8
interleukin 8	4	0	0	4
pregnane X receptor	6	0	0	6
Microtubule-associated protein tau	9	0	0	9
progesterone receptor	15	0	0	15
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
cellular tumor antigen p53 isoform a	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	8	0	0	8
muscarinic acetylcholine receptor M1	9	0	0	9
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Beta-lactamase	10	0	0	10
USP1 protein, partial	11	0	0	11
mitogen-activated protein kinase 1	6	0	0	6
Vpr	3	0	0	3
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	5	0	7
Potassium voltage-gated channel subfamily H member 2	0	8	0	9
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Albumin	0	1	5	7
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	2	0	3
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	2
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase VIM-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
caspase 7, apoptosis-related cysteine protease	6	0	0	6
estrogen receptor 2 (ER beta)	11	0	0	11
caspase-3	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
thyrotropin-releasing hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
vitamin D3 receptor isoform VDRA	5	0	0	5
nuclear receptor ROR-gamma isoform 1	8	0	0	8
Caspase-2	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
Chain A, Cruzipain	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2D6	8	0	0	8
Beta-1 adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	4	0	0	4
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-2A adrenergic receptor	0	6	3	10
Alpha-1B adrenergic receptor	0	11	1	12
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	5	3	9
D	0	3	0	3
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	5	1	6
Amine oxidase [flavin-containing] A	0	4	0	4
Alpha-2C adrenergic receptor	0	5	1	6
Alpha-2A adrenergic receptor	0	5	1	6
Alpha-1D adrenergic receptor	0	8	1	9
Alpha-1D adrenergic receptor	0	2	2	5
D(1B) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	0	1	1
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	3	0	3
Delta-type opioid receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	2	3	6
Alpha-1B adrenergic receptor	0	1	2	4
Alpha-1A adrenergic receptor	0	11	2	13
Histamine H2 receptor	8	1	0	10
5-hydroxytryptamine receptor 7	0	5	0	5
D(2) dopamine receptor	0	3	1	4
Mu-type opioid receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
Nischarin	0	1	0	1
Luciferase	9	0	0	9
aryl hydrocarbon receptor	8	0	0	8
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Amyloid-beta precursor protein	0	6	0	6
Beta-lactamase	0	0	0	1
Beta-galactosidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Gamma-aminobutyric acid	0	2	0	2
glp-1 receptor, partial	8	0	0	8
G	13	0	0	13
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
ATP-dependent translocase ABCB1	0	6	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
cytochrome P450 2C9, partial	13	0	0	13
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Epidermal growth factor receptor	0	1	0	1
Estrogen receptor	0	3	1	4
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	10	0	10
Muscarinic acetylcholine receptor M2	0	5	2	8
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	4	0	4
Adenosine receptor A3	0	5	1	6
Cytochrome P450 2D6	0	4	1	5
Muscarinic acetylcholine receptor M1	0	5	1	7
Beta-3 adrenergic receptor	0	4	1	5
Muscarinic acetylcholine receptor M3	0	5	1	6
Substance-K receptor	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	10	1	11
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	7	1	8
C-8 sterol isomerase	0	1	0	1
D(3) dopamine receptor	0	7	0	7
Alpha-synuclein	4	2	0	6
5-hydroxytryptamine receptor 2B	0	12	1	13
5-hydroxytryptamine receptor 6	0	5	1	6
Sodium-dependent dopamine transporter	0	7	0	7
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	10	0	10
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	3	0	0	3
Taste receptor type 2 member 38	0	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase iota isoform a (long)	7	0	0	7
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A4	0	4	1	6
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	4
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	4
Glutamate receptor ionotropic, NMDA 2B	0	3	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	4
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	3	0	4
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
D(2) dopamine receptor	0	5	1	6
D(4) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	3	0	3
Mu-type opioid receptor	0	5	2	7
Delta-type opioid receptor	0	5	2	7
Kappa-type opioid receptor	0	5	1	6
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
acid sphingomyelinase	1	0	0	1
glucocerebrosidase	2	0	0	2
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
GALC protein	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
Acetylcholinesterase	0	2	0	2
Carbonic anhydrase 12	0	2	0	2
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Genome polyprotein	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Caspase-7	1	0	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Cholinesterase	0	2	0	2
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Purine nucleoside phosphorylase	0	0	1	2
Snq2p	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Solute carrier family 22 member 2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium-dependent noradrenaline transporter	0	1	0	1
Cytochrome P450 1A2	0	2	1	4
Prostaglandin G/H synthase 1	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Histamine H1 receptor	0	1	0	1
Cytochrome P450 2C19	0	3	1	5
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	1	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Solute carrier family 22 member 2	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transporter	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
Fumarate hydratase	3	0	0	3
PPM1D protein	4	0	0	4
Thrombopoietin	2	0	0	2
nonstructural protein 1	5	0	0	5
polyprotein	3	0	0	3
Parkin	4	0	0	4
P53	1	0	0	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
neuropeptide S receptor isoform A	4	0	0	4
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
flap endonuclease 1	7	0	0	7
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
15-lipoxygenase, partial	3	0	0	3
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Menin	0	1	0	1
Cocaine esterase	0	3	0	3
Transmembrane protease serine 2	0	0	1	1
Beta-2 adrenergic receptor	0	4	1	5
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Histamine H2 receptor	0	4	0	4
Nociceptin receptor	0	1	0	1
Calmodulin	0	1	1	2
Angiopoietin-1 receptor	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
PINK1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Sex hormone-binding globulin	0	0	1	1
Progesterone receptor	0	2	1	3
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	0	1	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Estrogen receptor beta	0	1	1	2
Solute carrier family 22 member 8	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
DNA polymerase eta isoform 1	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	2
D-amino-acid oxidase	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
endonuclease IV	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Beta-1 adrenergic receptor	0	2	1	4
D(1A) dopamine receptor	0	1	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	2	0	2
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Histone deacetylase 3	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
D-alanyl-D-alanine dipeptidase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (163)

Protein Targets (872)

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Synonyms(4)

Research Excerpts

Overview

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Treatment

Research

Studies (163)

Drugs Studied (106)

Protein Targets (872)