Page last updated: 2024-11-08

meso-dihydroguaiaretic acid

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Description

meso-dihydroguaiaretic acid : A lignan that is 2,3-dimethylbutane substituted by 2-methoxyphenol groups at positions 1 and 4 respectively. It has been isolated from the bark of Machilus robusta. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Machilusgenus[no description available]LauraceaeA family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.[MeSH]

Cross-References

ID SourceID
PubMed CID476856
CHEMBL ID430464
CHEBI ID68169
SCHEMBL ID974725
MeSH IDM0516132

Synonyms (36)

Synonym
4-[(2s,3r)-4-(4-hydroxy-3-methoxy-phenyl)-2,3-dimethyl-butyl]-2-methoxy-phenol
meso-dihydroguaiaretic acid
meso-1,4-bis-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutane
4-[(2s,3r)-4-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol
MLS002473306
smr001397390
meso-dihyroguaiareticacid
mesodihydroguaiaretic acid
chebi:68169 ,
CHEMBL430464
HMS2202B04
4,4'-dihydroxy-3,3'-dimethoxylignan
4,4'-[(2r,3s)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)
SCHEMBL974725
phenol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis[2-methoxy-, (r*,s*)-
guaiacol, 4,4'-(2,3-dimethyltetramethylene)di-, meso-
4,4'-((2r,3s)-2,3-dimethylbutane-1,4-diyl)bis(2-methoxyphenol)
66322-34-7
phenol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis(2-methoxy-, (r*,s*)-
S81Z40PSJ4 ,
dihydroguaiaretic acid, meso-
rel-4,4'-((2r,3s)-2,3-dimethyl-1,4-butanediyl)bis(2-methoxyphenol)
phenol, 4,4'-((2r,3s)-2,3-dimethyl-1,4-butanediyl)bis(2-methoxy-, rel-
unii-s81z40psj4
AKOS028109653
2,2'-dimethoxy-4,4'-[rel-(2r,3s)-2,3-dimethylbutane- 1,4-diyl]diphenol
Q27136661
rel-4,4'-((2r,3s)-2,3-dimethylbutane-1,4-diyl)bis(2-methoxyphenol)
DTXSID301019954 ,
4-[(2r,3s)-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-methylbutyl]-2-methoxyphenol
HY-N6087
CS-0032514
F82185
MS-24966
dihydroguaiareticacid
dtxcid201477814
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
lignanAny phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an "e".
guaiacolsAny phenol carrying an additional methoxy substituent at the ortho-position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency79.43280.631035.7641100.0000AID504339
acid sphingomyelinaseHomo sapiens (human)Potency112.202014.125424.061339.8107AID504937
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
TDP1 proteinHomo sapiens (human)Potency21.04410.000811.382244.6684AID686978; AID686979
Smad3Homo sapiens (human)Potency35.48130.00527.809829.0929AID588855
67.9K proteinVaccinia virusPotency6.72940.00018.4406100.0000AID720579; AID720580
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency10.32250.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency28.18383.548119.542744.6684AID743266
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency79.43280.425612.059128.1838AID504891
gemininHomo sapiens (human)Potency20.59620.004611.374133.4983AID624296
VprHuman immunodeficiency virus 1Potency56.23411.584919.626463.0957AID651644
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency28.18386.309660.2008112.2020AID720709
Alpha-synucleinHomo sapiens (human)Potency17.78280.56239.398525.1189AID652106
Guanine nucleotide-binding protein GHomo sapiens (human)Potency1.12201.995325.532750.1187AID624287
TAR DNA-binding protein 43Homo sapiens (human)Potency11.22021.778316.208135.4813AID652104
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency79.43283.981146.7448112.2020AID720708
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (122)

Processvia Protein(s)Taxonomy
angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 3Homo sapiens (human)
signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 3Homo sapiens (human)
associative learningRap guanine nucleotide exchange factor 3Homo sapiens (human)
Rap protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of actin cytoskeleton organizationRap guanine nucleotide exchange factor 3Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
intracellular signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of GTPase activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of angiogenesisRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of protein export from nucleusRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of stress fiber assemblyRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusionRap guanine nucleotide exchange factor 3Homo sapiens (human)
establishment of endothelial barrierRap guanine nucleotide exchange factor 3Homo sapiens (human)
cellular response to cAMPRap guanine nucleotide exchange factor 3Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 3Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 3Homo sapiens (human)
calcium ion homeostasisAlpha-synucleinHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIAlpha-synucleinHomo sapiens (human)
microglial cell activationAlpha-synucleinHomo sapiens (human)
positive regulation of receptor recyclingAlpha-synucleinHomo sapiens (human)
positive regulation of neurotransmitter secretionAlpha-synucleinHomo sapiens (human)
negative regulation of protein kinase activityAlpha-synucleinHomo sapiens (human)
fatty acid metabolic processAlpha-synucleinHomo sapiens (human)
neutral lipid metabolic processAlpha-synucleinHomo sapiens (human)
phospholipid metabolic processAlpha-synucleinHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
mitochondrial membrane organizationAlpha-synucleinHomo sapiens (human)
adult locomotory behaviorAlpha-synucleinHomo sapiens (human)
response to xenobiotic stimulusAlpha-synucleinHomo sapiens (human)
response to iron(II) ionAlpha-synucleinHomo sapiens (human)
regulation of phospholipase activityAlpha-synucleinHomo sapiens (human)
negative regulation of platelet-derived growth factor receptor signaling pathwayAlpha-synucleinHomo sapiens (human)
regulation of glutamate secretionAlpha-synucleinHomo sapiens (human)
regulation of dopamine secretionAlpha-synucleinHomo sapiens (human)
synaptic vesicle exocytosisAlpha-synucleinHomo sapiens (human)
synaptic vesicle primingAlpha-synucleinHomo sapiens (human)
regulation of transmembrane transporter activityAlpha-synucleinHomo sapiens (human)
negative regulation of microtubule polymerizationAlpha-synucleinHomo sapiens (human)
receptor internalizationAlpha-synucleinHomo sapiens (human)
protein destabilizationAlpha-synucleinHomo sapiens (human)
response to magnesium ionAlpha-synucleinHomo sapiens (human)
negative regulation of transporter activityAlpha-synucleinHomo sapiens (human)
response to lipopolysaccharideAlpha-synucleinHomo sapiens (human)
negative regulation of monooxygenase activityAlpha-synucleinHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationAlpha-synucleinHomo sapiens (human)
response to type II interferonAlpha-synucleinHomo sapiens (human)
cellular response to oxidative stressAlpha-synucleinHomo sapiens (human)
SNARE complex assemblyAlpha-synucleinHomo sapiens (human)
positive regulation of SNARE complex assemblyAlpha-synucleinHomo sapiens (human)
regulation of locomotionAlpha-synucleinHomo sapiens (human)
dopamine biosynthetic processAlpha-synucleinHomo sapiens (human)
mitochondrial ATP synthesis coupled electron transportAlpha-synucleinHomo sapiens (human)
regulation of macrophage activationAlpha-synucleinHomo sapiens (human)
positive regulation of apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of neuron apoptotic processAlpha-synucleinHomo sapiens (human)
positive regulation of endocytosisAlpha-synucleinHomo sapiens (human)
negative regulation of exocytosisAlpha-synucleinHomo sapiens (human)
positive regulation of exocytosisAlpha-synucleinHomo sapiens (human)
regulation of long-term neuronal synaptic plasticityAlpha-synucleinHomo sapiens (human)
synaptic vesicle endocytosisAlpha-synucleinHomo sapiens (human)
synaptic vesicle transportAlpha-synucleinHomo sapiens (human)
positive regulation of inflammatory responseAlpha-synucleinHomo sapiens (human)
regulation of acyl-CoA biosynthetic processAlpha-synucleinHomo sapiens (human)
protein tetramerizationAlpha-synucleinHomo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosolAlpha-synucleinHomo sapiens (human)
neuron apoptotic processAlpha-synucleinHomo sapiens (human)
dopamine uptake involved in synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of dopamine uptake involved in synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of serotonin uptakeAlpha-synucleinHomo sapiens (human)
regulation of norepinephrine uptakeAlpha-synucleinHomo sapiens (human)
negative regulation of norepinephrine uptakeAlpha-synucleinHomo sapiens (human)
excitatory postsynaptic potentialAlpha-synucleinHomo sapiens (human)
long-term synaptic potentiationAlpha-synucleinHomo sapiens (human)
positive regulation of inositol phosphate biosynthetic processAlpha-synucleinHomo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathwayAlpha-synucleinHomo sapiens (human)
response to interleukin-1Alpha-synucleinHomo sapiens (human)
cellular response to copper ionAlpha-synucleinHomo sapiens (human)
cellular response to epinephrine stimulusAlpha-synucleinHomo sapiens (human)
positive regulation of protein serine/threonine kinase activityAlpha-synucleinHomo sapiens (human)
supramolecular fiber organizationAlpha-synucleinHomo sapiens (human)
negative regulation of mitochondrial electron transport, NADH to ubiquinoneAlpha-synucleinHomo sapiens (human)
positive regulation of glutathione peroxidase activityAlpha-synucleinHomo sapiens (human)
positive regulation of hydrogen peroxide catabolic processAlpha-synucleinHomo sapiens (human)
regulation of synaptic vesicle recyclingAlpha-synucleinHomo sapiens (human)
regulation of reactive oxygen species biosynthetic processAlpha-synucleinHomo sapiens (human)
positive regulation of protein localization to cell peripheryAlpha-synucleinHomo sapiens (human)
negative regulation of chaperone-mediated autophagyAlpha-synucleinHomo sapiens (human)
regulation of presynapse assemblyAlpha-synucleinHomo sapiens (human)
amyloid fibril formationAlpha-synucleinHomo sapiens (human)
synapse organizationAlpha-synucleinHomo sapiens (human)
chemical synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
adaptive immune responseRap guanine nucleotide exchange factor 4Homo sapiens (human)
G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
calcium-ion regulated exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of synaptic vesicle cycleRap guanine nucleotide exchange factor 4Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
protein domain specific bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 3Homo sapiens (human)
fatty acid bindingAlpha-synucleinHomo sapiens (human)
phospholipase D inhibitor activityAlpha-synucleinHomo sapiens (human)
SNARE bindingAlpha-synucleinHomo sapiens (human)
magnesium ion bindingAlpha-synucleinHomo sapiens (human)
transcription cis-regulatory region bindingAlpha-synucleinHomo sapiens (human)
actin bindingAlpha-synucleinHomo sapiens (human)
protein kinase inhibitor activityAlpha-synucleinHomo sapiens (human)
copper ion bindingAlpha-synucleinHomo sapiens (human)
calcium ion bindingAlpha-synucleinHomo sapiens (human)
protein bindingAlpha-synucleinHomo sapiens (human)
phospholipid bindingAlpha-synucleinHomo sapiens (human)
ferrous iron bindingAlpha-synucleinHomo sapiens (human)
zinc ion bindingAlpha-synucleinHomo sapiens (human)
lipid bindingAlpha-synucleinHomo sapiens (human)
oxidoreductase activityAlpha-synucleinHomo sapiens (human)
kinesin bindingAlpha-synucleinHomo sapiens (human)
Hsp70 protein bindingAlpha-synucleinHomo sapiens (human)
histone bindingAlpha-synucleinHomo sapiens (human)
identical protein bindingAlpha-synucleinHomo sapiens (human)
alpha-tubulin bindingAlpha-synucleinHomo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
tau protein bindingAlpha-synucleinHomo sapiens (human)
phosphoprotein bindingAlpha-synucleinHomo sapiens (human)
molecular adaptor activityAlpha-synucleinHomo sapiens (human)
dynein complex bindingAlpha-synucleinHomo sapiens (human)
cuprous ion bindingAlpha-synucleinHomo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein-macromolecule adaptor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
small GTPase bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Processvia Protein(s)Taxonomy
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
cortical actin cytoskeletonRap guanine nucleotide exchange factor 3Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
microvillusRap guanine nucleotide exchange factor 3Homo sapiens (human)
endomembrane systemRap guanine nucleotide exchange factor 3Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 3Homo sapiens (human)
lamellipodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
filopodiumRap guanine nucleotide exchange factor 3Homo sapiens (human)
extracellular exosomeRap guanine nucleotide exchange factor 3Homo sapiens (human)
platelet alpha granule membraneAlpha-synucleinHomo sapiens (human)
extracellular regionAlpha-synucleinHomo sapiens (human)
extracellular spaceAlpha-synucleinHomo sapiens (human)
nucleusAlpha-synucleinHomo sapiens (human)
cytoplasmAlpha-synucleinHomo sapiens (human)
mitochondrionAlpha-synucleinHomo sapiens (human)
lysosomeAlpha-synucleinHomo sapiens (human)
cytosolAlpha-synucleinHomo sapiens (human)
plasma membraneAlpha-synucleinHomo sapiens (human)
cell cortexAlpha-synucleinHomo sapiens (human)
actin cytoskeletonAlpha-synucleinHomo sapiens (human)
membraneAlpha-synucleinHomo sapiens (human)
inclusion bodyAlpha-synucleinHomo sapiens (human)
axonAlpha-synucleinHomo sapiens (human)
growth coneAlpha-synucleinHomo sapiens (human)
synaptic vesicle membraneAlpha-synucleinHomo sapiens (human)
perinuclear region of cytoplasmAlpha-synucleinHomo sapiens (human)
postsynapseAlpha-synucleinHomo sapiens (human)
supramolecular fiberAlpha-synucleinHomo sapiens (human)
protein-containing complexAlpha-synucleinHomo sapiens (human)
cytoplasmAlpha-synucleinHomo sapiens (human)
axon terminusAlpha-synucleinHomo sapiens (human)
neuronal cell bodyAlpha-synucleinHomo sapiens (human)
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
cytosolRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (72)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID385124Antiviral activity against HIV1 in human C8166 cells assessed as prevention of virus-induced cytopathic effect2008Journal of natural products, Apr, Volume: 71, Issue:4
Lignans from Kadsura angustifolia.
AID1304222Growth inhibition of Italian ryegrass assessed as reduction in root growth at 1 mM after 5 days2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1304215Antifungal activity against Colletotrichum lagenarium assessed as mycelial colony growth levels at 0.25 mM after 5 days by caliper analysis2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID313421Antioxidant activity against LDL-oxidation assessed as conjugated diene formation lag time at 1.0 uM2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1464074Antibacterial activity against Staphylococcus aureus2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID1304219Antibacterial activity against Salmonella choleraesuis subsp. choleraesuis JCM 6977 after 24 hrs by 2 fold dilution method2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID46498Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 10 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID1304214Antifungal activity against Bipolaris oryzae assessed as mycelial colony growth levels at 0.25 mM after 3 days by caliper analysis2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID46501Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 30 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID46500Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 20 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID1155650Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1304218Antibacterial activity against Listeria denitrificans JCM 11481 after 24 hrs by 2 fold dilution method2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1464072Antibacterial activity against multidrug-resistant Mycobacterium tuberculosis2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID1155649Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 2 uM after 24 hrs by MTT assay relative to control2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1541175Cytotoxicity against mouse RAW264.7 cells assessed as effect on cell viability at 10 uM by CCK-8 assay2019Journal of natural products, 11-22, Volume: 82, Issue:11
Lignans from
AID1155648Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 0.4 uM after 24 hrs by MTT assay relative to control2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1304225Selectivity index, ratio of IC50 for fall armyworm sf9 cells to IC50 for Cytotoxicity against human HeLa cells2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID46497Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 100 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID1464091Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as inhibition of mycobacterial growth incubated for 2 weeks by MABA method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID1304211Antilarvicidal activity against Culex pipiens larvae after 24 hrs2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1304221Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID429824Cytotoxicity against human C8166 cells by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
AID1304216Antibacterial activity against Bacillus subtilis subsp. subtilis NBRC 13719 after 24 hrs by 2 fold dilution method2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1464093Antimycobacterial activity against isoniazid/rifampicin/streptomycin-resistant Mycobacterium tuberculosis G133 assessed as inhibition of mycobacterial growth incubated for 2 weeks by MABA method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID46502Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 3 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID313419Antioxidant activity assessed as inhibition of LDL-oxidation at 20 uM by TBARS assay2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1304217Antibacterial activity against Staphylococcus aureus subsp. aureus NBRC 14462 after 24 hrs by 2 fold dilution method2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID313424Antioxidant activity assessed as inhibition of copper-mediated LDL-oxidation at 10 uM by relative electrophoretic mobility method2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1155647Neuroprotective activity against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells assessed as cell viability at 0.08 uM after 24 hrs by MTT assay relative to control2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID313427Antioxidant activity against LDL-oxidation in human THP1 cells assessed as malondialdehyde level per mg of LDL protein at 1 uM2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1155643Antioxidant activity assessed as 150 uM DPPH free radical scavenging activity under dark condition after 30 mins by microplate reader analysis2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1464087Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID313428Antioxidant activity against LDL-oxidation in human THP1 cells assessed as malondialdehyde level per mg of LDL protein at 5 uM2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1304220Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1304226Selectivity index, ratio of IC50 for fall armyworm Sf9 cells to IC50 for Cytotoxicity against human HL60 cells2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1464071Antibacterial activity against methicillin-resistant Staphylococcus aureus2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID385126Selectivity index, Ratio of EC50 for HIV1 to CC50 for human C8166 cells2008Journal of natural products, Apr, Volume: 71, Issue:4
Lignans from Kadsura angustifolia.
AID313426Antioxidant activity assessed as inhibition of apoB100 fragmentation at 10 uM by SDS-PAGE method2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1304223Growth inhibition of Italian ryegrass assessed as reduction in shoot growth at 1 mM after 5 days2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID46503Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 60 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID1155644Antioxidant activity assessed as 300 uM DPPH free radical scavenging activity under dark condition after 30 mins by microplate reader analysis2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID1541174Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay2019Journal of natural products, 11-22, Volume: 82, Issue:11
Lignans from
AID468191Antiinflammatory activity in rat PMNC assessed as inhibition of platelet activating factor-induced beta-glucuronidase release at 10 uM treated 15 mins before PAF by spectrophotometry2009Journal of natural products, Dec, Volume: 72, Issue:12
Chemical constituents of the bark of Machilus wangchiana and their biological activities.
AID429826Selectivity index, ratio of CC50 for human C8166 cells to EC50 for HIV1 3B2009Journal of natural products, Jun, Volume: 72, Issue:6
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
AID313420Antioxidant activity against LDL-oxidation by TBARS assay2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID313425Antioxidant activity assessed as inhibition of apoB100 fragmentation at 20 uM by SDS-PAGE method2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID46496Inhibitory activity against HIV Tat-regulated Transactivation in COS cells.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID46499Compound tested for inhibition of HIV Tat-regulated Transactivation in COS cells at a concentration of 1 uM.1998Journal of medicinal chemistry, Jul-30, Volume: 41, Issue:16
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.
AID1464092Antimycobacterial activity against isoniazid/rifampicin/ethambutol-resistant Mycobacterium tuberculosis G122 assessed as inhibition of mycobacterial growth incubated for 2 weeks by MABA method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID1304212Antifungal activity against Alternaria alternata assessed as mycelial colony growth at 0.25 mM after 3 days by caliper analysis2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1155645Antioxidant activity assessed as reduction of TPTZ-Fe3+ to TPTZ-Fe2+ after 5 mins by FRAP assay2014Journal of natural products, Jun-27, Volume: 77, Issue:6
Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties.
AID385125Cytotoxicity against human C8166 cells by MTT assay2008Journal of natural products, Apr, Volume: 71, Issue:4
Lignans from Kadsura angustifolia.
AID429825Antiviral activity against HIV1 3B in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity2009Journal of natural products, Jun, Volume: 72, Issue:6
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
AID313423Antioxidant activity assessed as inhibition of copper-mediated LDL-oxidation at 20 uM by relative electrophoretic mobility method2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
AID1304224Cytotoxicity against fall armyworm Sf9 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1464094Selectivity index, ratio of IC50 for cytotoxicity against African green monkey Vero cells to MIC for Mycobacterium tuberculosis H37Rv ATCC 272942017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID1304213Antifungal activity against Fusarium solani assessed as mycelial colony growth levels at 0.25 mM after 3 days by caliper analysis2016Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13
Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
AID1464073Antibacterial activity against Bacillus subtilis2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
AID1464075Antibacterial activity against Listeria denitrificans2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's5 (35.71)29.6817
2010's7 (50.00)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.71 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.23 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]