Astigmatism

Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed)

Synonym
Astigmatism

Excerpt	Reference
"Although astigmatism is prevalent during early infancy, the influence of astigmatism on early refractive development is unclear."	( Hung, LF; Kee, CS; Qiao-Grider, Y; Roorda, A; Smith, EL, 2004)
"Astigmatism is the most common ametropia found in humans and is often associated with large spherical ametropias."	( Hung, LF; Kee, CS; Qiao-Grider, Y; Ramamirtham, R; Smith, EL, 2005)
"Irregular astigmatisms are frequently encountered in these patients and is commonly associated with high degrees of hyperopia or myopia."	( Abukhudair, A; Alhindi, N; Alsubhi, AH; Alsulami, A; Morfeq, H; Seraj, H, 2023)

Excerpt	Reference
"Astigmatism has been suggested to be an important factor in the production and/or progression of myopia."	( Chen, MS; Ho, TC; Hou, PK; Lin, LL; Shih, YF; Wang, PC, 1994)

Excerpt	Reference
"Mean astigmatism in affected eyes was 1."	( Herlihy, EP; Kelly, JP; Perkins, JA; Sidbury, R; Weiss, AH, 2016)

Excerpt	Reference
"The average amount of pretreatment astigmatism was 2."	( Blei, F; Ceisler, E; Furlan, L; Kodsi, SR; Schwartz, SR; Steele, M, 2007)
"Eighteen eyes were treated for regular astigmatism and 26 eyes were treated for irregular astigmatism after penetrating keratoplasty."	( Alessio, G; La Tegola, MG; Sborgia, C, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	116 (23.87)	23.3326
1990's	55 (11.32)	12.5806
2000's	121 (24.90)	18.1394
2010's	144 (29.63)	28.8240
2020's	50 (10.29)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	1	1
glycerol	low	1	0
hydrogen carbonate	low	1	0
pyridoxine	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
acetaminophen	medium	3	3
ciprofloxacin	low	2	0
cyclopentolate	medium	12	1
cyproheptadine	low	1	0
diclofenac	medium	3	1
erythrosine	low	6	0
fluorouracil	low	3	0
flurbiprofen	medium	1	1
gabapentin	medium	1	1
halothane	low	1	0
ibuprofen	medium	1	1
indomethacin	medium	1	1
2-propanol	medium	82	6
ketoconazole	low	1	0
ketorolac	medium	2	1
ofloxacin	low	4	0
propranolol	low	3	0
gatifloxacin	medium	2	1
thiotepa	low	1	0
tolmetin	medium	1	1
tropicamide	medium	6	1
mitomycin	medium	35	9
prednisolone	medium	11	3
prednisolone acetate	medium	5	2
prednisone	low	2	0
fluprednisolone	low	1	0
pilocarpine	low	4	0
biguanides	low	1	0
chloramphenicol	low	1	0
phenylephrine	low	4	0
methylene blue	low	1	0
methionine	low	1	0
mannitol	low	1	0
valine	low	1	0
ethylene oxide	low	1	0
perflutren	low	1	0
triamcinolone acetonide	low	2	0
methylmethacrylate	medium	6	3
fluocortolone	low	2	0
benactyzine	low	1	0
methysergide	low	1	0
betamethasone	low	4	0
fluorometholone	low	5	0
homocystine	low	2	0
chenodeoxycholic acid	low	1	0
echothiophate iodide	low	1	0
gentian violet	low	2	0
hydroxyethyl methacrylate	medium	2	1
vancomycin	low	1	0
fluorescein	low	6	0
vantocil	low	1	0
enbucrilate	medium	1	1
molybdenum	medium	1	1
neon	low	1	0
titanium	medium	3	3
argon	low	1	0
cadmium	low	1	0
helium	low	1	0
holmium	low	2	0
yttrium	low	2	0
chromates	low	1	0
fluorine	low	1	0
triamcinolone	low	4	0
cefazolin	low	1	0
tobramycin	low	3	0
vecuronium bromide	low	1	0
propiconazole	low	12	0
fomesafen	low	5	0
itraconazole	low	1	0
bromfenac	low	1	0
propamidine isethionate	low	1	0
triazoles	low	1	0
nipradilol	medium	1	1
ketorolac tromethamine	medium	2	1
nicotine	low	1	0
nsc-172755	low	1	0
cobalt	medium	1	1
yttrium radioisotopes	low	1	0
vitamin b 6	low	1	0
5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)fluorescein	low	1	0
diprofos	low	1	0
tamsulosin	low	1	0
nepafenac	medium	1	1
moxifloxacin	medium	1	1
atropine	medium	14	4
cortisone	low	1	0
glycogen	low	1	0
elastin	low	1	0
difluprednate	low	1	0
riboflavin	medium	32	2
phenylthiourea	low	1	0
cystine	low	1	0
alpha-chymotrypsin	low	1	0
amphotericin b	medium	1	1
isotretinoin	low	1	0
codeine	medium	1	1
phenylephrine hydrochloride	low	2	0
oxycodone	medium	1	1
clobetasol	low	1	0
silicon	low	2	0
strontium radioisotopes	low	2	0
tetrodotoxin	low	1	0
cholestanol	low	1	0
chlorhexidine	low	1	0
scopolamine hydrobromide	low	1	0
cellulose	medium	2	1
thimerosal	low	1	0
methylcellulose	low	2	0
ascorbic acid	medium	3	3
transforming growth factor beta	low	1	0
saxitoxin	low	1	0
balafilcon a	low	1	0
cyclosporine	medium	2	1
thromboplastin	low	1	0
chondroitin sulfates	low	1	0
exudates	low	3	0
acyclovir	low	4	0
valacyclovir	low	1	0
eye	medium	121	1

Protein Targets (920)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	21	0	0	21
USP1 protein, partial	10	0	0	10
TDP1 protein	33	0	0	33
vitamin D3 receptor isoform VDRA	13	0	0	13
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	10	0	0	10
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
geminin	21	0	0	21
DNA polymerase kappa isoform 1	9	0	0	9
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	0	2	4
Fatty acid-binding protein, intestinal	0	5	2	7
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	17	0	0	17
RAR-related orphan receptor gamma	32	0	0	32
GLI family zinc finger 3	31	0	0	31
AR protein	46	0	0	46
aldehyde dehydrogenase 1 family, member A1	22	0	0	22
retinoic acid nuclear receptor alpha variant 1	33	0	0	33
retinoid X nuclear receptor alpha	25	0	0	25
estrogen nuclear receptor alpha	45	0	0	45
peroxisome proliferator-activated receptor delta	17	0	0	17
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
activating transcription factor 6	16	0	0	16
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform a	13	0	0	13
heat shock protein beta-1	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	33	0	0	33
lamin isoform A-delta10	21	0	0	21
Voltage-dependent calcium channel gamma-2 subunit	21	0	0	21
Glutamate receptor 2	21	0	0	21
ATAD5 protein, partial	9	0	0	9
GLS protein	10	0	0	10
Microtubule-associated protein tau	10	0	0	11
Smad3	8	0	0	8
thyroid stimulating hormone receptor	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
progesterone receptor	22	0	0	22
EWS/FLI fusion protein	17	0	0	17
estrogen-related nuclear receptor alpha	34	0	0	34
peroxisome proliferator activated receptor gamma	21	0	0	21
aryl hydrocarbon receptor	22	0	0	22
chromobox protein homolog 1	18	0	0	18
thyroid hormone receptor beta isoform 2	24	0	0	24
peripheral myelin protein 22	12	0	0	12
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	5	1	15
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	22
Solute carrier family 22 member 6	0	4	0	5
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Bile salt export pump	0	6	0	6
Bile salt export pump	0	32	0	32
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	4	0	5
Prostaglandin G/H synthase 1	0	9	0	10
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	13	0	14
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2C9	0	11	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	9	5	1	15
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	9	5	1	15
Gamma-aminobutyric acid receptor subunit gamma-2	9	5	2	16
UDP-glucuronosyltransferase 1-6	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	9	5	1	15
Gamma-aminobutyric acid receptor subunit alpha-3	9	5	1	15
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	4
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	8	0	8
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	9	5	1	15
Gamma-aminobutyric acid receptor subunit alpha-2	9	5	1	15
Gamma-aminobutyric acid receptor subunit alpha-4	9	5	1	15
Gamma-aminobutyric acid receptor subunit gamma-3	9	5	1	15
Gamma-aminobutyric acid receptor subunit alpha-6	9	5	1	15
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	9	1	11
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	9	0	0	9
Cytochrome P450 2J2	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	9	5	2	16
Gamma-aminobutyric acid receptor subunit beta-3	9	5	1	15
Gamma-aminobutyric acid receptor subunit beta-2	9	5	2	16
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	9	5	1	15
Canalicular multispecific organic anion transporter 1	0	19	0	19
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	9	5	1	15
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	10	0	0	10
arylsulfatase A	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	28	0	0	28
Bloom syndrome protein isoform 1	12	0	0	12
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Solute carrier family 22 member 1	0	6	0	9
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	5	0	6
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	5
Thymidine kinase	0	1	0	1
Chain A, Cruzipain	10	0	0	10
interleukin 8	7	0	0	7
glucocorticoid receptor [Homo sapiens]	35	0	0	35
farnesoid X nuclear receptor	22	0	0	22
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
tumor necrosis factor	3	0	0	3
Cytochrome P450 2C19	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	14	0	16
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	12	0	0	12
thioredoxin glutathione reductase	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
IDH1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
lethal factor (plasmid)	7	0	0	7
Polyphenol oxidase 2	0	3	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	3
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	3	0	3
Alpha-2B adrenergic receptor	0	11	3	15
Spike glycoprotein	14	0	0	14
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
pregnane X nuclear receptor	25	0	0	25
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	8	0	8
Muscarinic acetylcholine receptor M2	0	13	3	19
Muscarinic acetylcholine receptor M4	0	10	1	13
Muscarinic acetylcholine receptor M1	0	8	1	12
Muscarinic acetylcholine receptor M3	0	7	1	11
Muscarinic acetylcholine receptor M4	0	8	1	12
Muscarinic acetylcholine receptor M5	0	7	1	11
Muscarinic acetylcholine receptor M5	0	10	1	13
Muscarinic acetylcholine receptor M2	0	8	2	14
Muscarinic acetylcholine receptor M1	0	12	4	19
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M3	0	10	2	14
Alpha-1D adrenergic receptor	0	8	2	11
5-hydroxytryptamine receptor 2C	0	8	1	9
Muscarinic acetylcholine receptor M4	0	2	0	2
Histamine H2 receptor	8	0	0	9
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
cytochrome P450 2D6	17	0	0	17
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
pregnane X receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	2	21
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
thyroid stimulating hormone receptor	10	0	0	10
Cellular tumor antigen p53	30	0	0	30
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Luciferase	17	0	0	17
apical membrane antigen 1, AMA1	2	0	0	2
Solute carrier family 15 member 1	0	3	0	4
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
SMAD family member 2	14	0	0	14
SMAD family member 3	14	0	0	14
caspase 7, apoptosis-related cysteine protease	6	0	0	6
caspase-3	6	0	0	6
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Alpha-2A adrenergic receptor	0	12	4	17
Vitamin D3 receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	7	4	12
Retinoic acid receptor RXR-alpha	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
TAR DNA-binding protein 43	13	0	0	13
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
G	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Interferon beta	20	0	0	20
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	14	0	0	14
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	14	0	0	14
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
PAX8	0	0	0	1
glp-1 receptor, partial	9	0	0	9
15-lipoxygenase, partial	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	16	0	0	16
67.9K protein	9	0	0	9
glucocerebrosidase	4	0	0	4
Parkin	4	0	0	4
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	3	0	0	3
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	4	0	0	4
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	5	0	0	5
huntingtin isoform 2	8	0	0	8
mitogen-activated protein kinase 1	5	0	0	5
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	0	4
protein AF-9 isoform a	0	0	0	2
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	2
bcl-2-related protein A1	0	1	0	1
nuclear receptor ROR-gamma isoform 1	8	0	0	8
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	4
Integrin beta-3	4	0	0	4
72 kDa type IV collagenase	0	1	0	1
Integrin alpha-IIb	4	0	0	4
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	3	0	0	3
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
Multidrug and toxin extrusion protein 1	0	5	0	5
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	12	0	0	12
Spermine oxidase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	4
DNA gyrase subunit A	0	4	0	8
DNA gyrase subunit B	0	4	0	8
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	3	0	5
DNA topoisomerase 2-alpha	0	1	0	6
DNA gyrase subunit A	0	2	0	4
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	3	0	5
DNA gyrase subunit A	0	4	0	6
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	5
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	1	2
Mu-type opioid receptor	0	6	3	9
Delta-type opioid receptor	0	5	2	7
Kappa-type opioid receptor	0	5	2	7
Mu-type opioid receptor	0	1	1	2
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
endonuclease IV	5	0	0	5
dopamine D1 receptor	3	0	0	3
regulator of G-protein signaling 4	10	0	0	10
peripheral myelin protein 22 isoform 1	5	0	0	5
survival motor neuron protein isoform d	7	0	0	7
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Fumarate hydratase	6	0	0	6
PPM1D protein	4	0	0	4
polyprotein	6	0	0	6
D(1A) dopamine receptor	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	9	0	0	9
chaperonin GroEL	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
5-hydroxytryptamine receptor 2C	0	1	0	1
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	8	1	9
5-hydroxytryptamine receptor 2A	0	3	0	3
D	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	6	1	8
Endothelin receptor type B	0	1	0	1
D(1A) dopamine receptor	0	7	1	8
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium-dependent noradrenaline transporter	0	4	1	5
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	6	0	6
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	8	1	9
5-hydroxytryptamine receptor 1B	0	6	0	6
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	5	0	5
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	1	4
Histamine H1 receptor	0	2	1	3
D(3) dopamine receptor	0	7	0	7
UDP-glucuronosyltransferase 1A3	0	0	0	4
5-hydroxytryptamine receptor 2B	0	8	1	9
5-hydroxytryptamine receptor 6	0	6	1	7
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Histone-lysine N-methyltransferase SETD7	0	2	0	2
Transporter	0	3	1	5
Aldo-keto reductase family 1 member B10	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	5
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	2	0	2
Cytochrome c oxidase subunit 2	0	2	0	2
Fatty acid-binding protein, liver	0	5	0	5
Albumin	0	7	6	13
Interleukin-8	0	3	0	3
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Prostaglandin G/H synthase 2	0	4	0	5
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Prostaglandin G/H synthase 2	0	5	0	5
Prostaglandin G/H synthase 2	0	4	0	5
Prostaglandin G/H synthase 1	0	5	0	6
Carbonic anhydrase 4	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Chain A, Beta-lactamase	5	0	0	5
neuropeptide S receptor isoform A	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
hypothetical protein, conserved	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
thyrotropin-releasing hormone receptor	5	0	0	5
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
ATP-dependent phosphofructokinase	7	0	0	7
large T antigen	0	2	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	2	3	2	8
Neuronal acetylcholine receptor subunit beta-2	2	3	2	8
Androgen receptor	0	5	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Thrombopoietin	1	0	0	1
nonstructural protein 1	3	0	0	3
Vpr	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	4	0	4
Amyloid-beta precursor protein	1	2	0	3
Thymidylate synthase	0	1	0	1
Aromatase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
histone deacetylase 9 isoform 3	5	0	0	5
Acid-sensing ion channel 3	0	2	0	2
Aldo-keto reductase family 1 member C4	0	2	0	2
Aldo-keto reductase family 1 member C3	0	4	0	4
Aldo-keto reductase family 1 member C2	0	2	0	2
Acid-sensing ion channel 1	0	2	0	2
Aldo-keto reductase family 1 member C1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
luciferase	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
60 kDa chaperonin	0	2	0	2
Adenosine receptor A3	0	5	1	6
60 kDa heat shock protein, mitochondrial	0	3	0	3
Alpha-1B adrenergic receptor	0	8	1	9
Substance-K receptor	0	4	0	4
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Adenosine receptor A2a	0	3	1	4
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	9	1	10
10 kDa heat shock protein, mitochondrial	0	3	0	3
Fatty-acid amide hydrolase 1	1	1	0	2
Inositol monophosphatase 1	4	0	0	4
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Leukotriene B4 receptor 1	1	0	0	1
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	3	0	3
Leukotriene B4 receptor 2	1	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Carbonic anhydrase	0	1	0	1
NFKB1 protein, partial	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	4
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
Caspase-1	0	2	0	3
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	2	0	2
Caspase-3	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Phospholipase A2, major isoenzyme	0	2	0	2
Procathepsin L	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Androgen receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Thromboxane-A synthase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Olfactory receptor 51E2	0	1	0	1
GALC protein	3	0	0	3
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Translocator protein	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	1	3
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	5	1	6
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
DNA polymerase III, partial	1	0	0	1
alpha-galactosidase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
STE24	0	0	0	1
Trypsin	0	0	0	1
Acetylcholinesterase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	2	2	4
Beta-3 adrenergic receptor	0	2	2	4
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	3	1	5
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	3	2	5
Alpha-2C adrenergic receptor	0	2	2	4
Alpha-2A adrenergic receptor	0	2	2	4
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	4	5	10
Alpha-1B adrenergic receptor	0	3	4	8
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain A, PROTEIN (CATECHOL OXIDASE)	0	1	0	1
Tyrosinase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Muscarinic acetylcholine receptor DM1	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
heat shock protein 90, putative	0	0	0	2
Beta-1 adrenergic receptor	0	1	1	3
5-hydroxytryptamine receptor 1A	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	3
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
caspase-1 isoform alpha precursor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Caspase-7	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Nrf2	1	0	0	1
toll-like receptor 9	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
neurotensin receptor type 1	0	0	1	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Protein Rev	0	0	1	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (486)

Protein Targets (920)

Astigmatism

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (486)

Drugs Studied (139)

Protein Targets (920)