ascorbic-acid and Facial-Dermatoses

High recurrence has previously been reported in the treatment of melasma with low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminium garnet (QS-Nd:YAG) laser. On the other hand, the efficacy and safety of the QS-Nd:YAG laser plus microneedling with vitamin C have not been evaluated in patients with mixed-type melasma.. Sixteen patients with recalcitrant dermal- or mixed-type melasma were included in the study. One side of patients' face was treated with QS-Nd:YAG laser plus microneedling with vitamin C (Group A) and the other side with QS-Nd:YAG laser alone (Group B) for four sessions at four-week intervals. Melasma Area Severity Index (MASI) scores and clinician's evaluation of clinical response were assessed monthly.. Group A had a significantly lower mean MASI score and better treatment response than Group B according to clinician's evaluation. According to MASI scores, in Group B, two patients had a good response while 12 were unresponsive to treatment. Good or very good improvement was reported by 10 patients in Group A and three patients in Group B. Adverse effects and recurrence rates were similar in Groups A and B (31.3 and 43.8%, respectively).. QS-Nd:YAG increases the blood circulation in the dermis, thereby enhancing the mechanical effect of microneedling to promote the penetration of vitamin C.. Vitamin C application with microneedling immediately after treatment with QS-Nd:YAG laser is a promising adjunctive method for the treatment of recalcitrant melasma.

Topics: Adult; Antioxidants; Ascorbic Acid; Combined Modality Therapy; Cosmetic Techniques; Double-Blind Method; Erythema; Facial Dermatoses; Female; Humans; Hyperpigmentation; Hypopigmentation; Lasers, Solid-State; Male; Melanosis; Middle Aged; Needles; Quality of Life; Recurrence; Retreatment; Severity of Illness Index

Periorbital Melanosis (POM) is a very common esthetic condition, yet there is no definite treatment modality. Topical therapy is the mainstay of treatment which includes chemical peels, vitamin C, and other depigmenting agents.. To compare clinical efficacy, safety, and tolerability of 20% glycolic acid peels, 15% lactic acid peels, and topical 20% vitamin C in treatment of constitutional type of POM in Indian patients.. Ninety patients of constitutional POM were enrolled for 12 weeks. The patients were distributed into three groups. One-third of patients underwent 3-weekly GA peel, another one-third underwent 3-weekly lactic peel, and rest applied vitamin C daily. Clinical improvement was assessed objectively using POM grading. Patient's and physicians global assessment along with patient's global tolerance was also evaluated.. More than 50% improvement in POM was observed in 73.34% of patients on GA peel, 56.67% on lactic peel, and 26.67% on vitamin C. On comparing improvement with respect to duration of therapy, GA peel was significantly more effective than lactic peel from 12 weeks onward, while it was more effective than vitamin C from 6 weeks onward. Lactic peel was more effective than vitamin C from 6 weeks onward. Physician and patient global assessment was excellent with glycolic peel followed by lactic peel and vitamin C. The incidence of adverse effect was maximum with GA peel followed by lactic peel and vitamin C.. Glycolic peel was best among the three modalities, although it was associated with increased rate of side effects.

Topics: Administration, Cutaneous; Adult; Antioxidants; Ascorbic Acid; Chemexfoliation; Eye; Facial Dermatoses; Female; Glycolates; Humans; Keratolytic Agents; Lactic Acid; Male; Melanosis; Prospective Studies; Time Factors; Treatment Outcome; Young Adult

Melasma is a common acquired hypermelanosis that is difficult to treat. Several chemical peeling agents were used in treatment of melasma. Topical vitamin C was also used with minimal side effects.. To compare the effect of 20% trichloroacetic acid (TCA) peel alone vs. 20% TCA peel combined with topical 5% ascorbic acid in cases of epidermal melasma.. Thirty women with bilateral epidermal melasma (Fitzpatrick skin types III and IV) were divided into two groups (A and B, 15 patients each). Before therapy, digital photography and a melasma area and severity index (MASI) score were done for each patient. Groups A and B were primed for 2 weeks before TCA peel. Group B also applied 5% ascorbic acid topically once daily; 20% TCA peel was done for all patients weekly until clearance of melasma or for a maximum of six peels. Group B continued to use 5% ascorbic acid topically in between peels and during the 16-week follow-up period. Patients were assessed at the end of peeling sessions and at the end of follow-up by photography, MASI score, and a global evaluation by the patient.. Group B compared with group A showed a significant decrease in MASI score at the end of TCA peels (P < 0.001) and at the end of the 16-week follow-up period (P < 0.003). Global evaluation showed that 13 patients (87%) in group B improved or maintained their improvement compared with only 10 patients (67%) in group A.. Topical ascorbic acid combined with 20% TCA peel in melasma improves the results and helps in maintaining the response to therapy.

Topics: Administration, Cutaneous; Adult; Ascorbic Acid; Chemexfoliation; Dermatologic Agents; Drug Administration Schedule; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Melanosis; Middle Aged; Severity of Illness Index; Treatment Outcome; Tretinoin; Trichloroacetic Acid

Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Ascorbic Acid; Dermatitis, Allergic Contact; Erythema; Etanercept; Facial Dermatoses; Female; Humans; Immunosuppressive Agents; Methotrexate; Patch Tests; Skin Cream

Ascorbic acid is a substance with confirmed anti-free-radical properties. It triggers the collagen synthesis, has a depigmenting effect and seals blood vessels. All these properties have a significant effect of the skin's appearance. The characteristic traits of capillary skin include telangiectasias as well as erythema, which might consolidate in the future, along with the feeling of burning and increased skin sensitivity.. Study and evaluation of selected parameters of capillary skin after the application of 5% vitamin C concentrate throughout the period of 6 weeks with the use of instrumental tests and questionnaires.. The research was conducted on a group of 30 women ranging from 30 to 60 years of age with capillary skin indicating visible signs of erythematous plaques. The concentrate was applied once a day. Analyses of skin conditions were conducted four times: before the launch of the research D(0), after two 2D(14), after four 4D(28), and after 6 D(42) weeks of application. The research was conducted with the use of Mexameter MPA equipment, which was used to measure changes in the intensity of erythematous plaques. The depth of wrinkles was measured by PRIMOS system (two times D0 and 6D(42). The research also used VISIA system which allowed to perform visual and numeral skin analyses. Each research was finalized with a questionnaire which provided a subjective evaluation of the examined product among participants.. Significant reduction in erythema has been widely recorded. After 2 weeks, erythema dropped by 9%. After 4 weeks, it decreased by 16% and by 21% after 6 weeks. The concentrate's efficiency in diminishing erythematous plaques was confirmed by photographs generated by VISIA photograph system. Thanks to PRIMOS, decrease in both depth and volume of nasolabial folds was recorded in 87% of participants after 6 weeks of research.. 5% vitamin C concentrate is effective in treating capillary and photograph-aging skin. It decreases erythema and telangiectasias as well as triggers the shallowing of skin wrinkles.

Topics: Adult; Antioxidants; Ascorbic Acid; Erythema; Facial Dermatoses; Female; Humans; Middle Aged; Patient Satisfaction; Skin Aging; Surveys and Questionnaires; Telangiectasis

Topics: Ascorbic Acid; Cosmetics; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Humans; Middle Aged; Patch Tests; Skin Lightening Preparations

Topics: Ascorbic Acid; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Humans; Middle Aged; Molecular Structure; Patch Tests; Skin Absorption; Skin Lightening Preparations

A case of Chediak-Higashi syndrome is reported in a four-year-old boy who presented with recurrent chest infection, partial albinism, hyperpigmentation of the extremities and presence of giant granules in leucocytes and melanocytes in the skin. Parental consanguinity was present. Though uncommon, hyperpigmentation of sun exposed areas may be the initial symptom in Chediak-Higashi syndrome.

Topics: Anti-Bacterial Agents; Arm; Ascorbic Acid; Blood Transfusion; Chediak-Higashi Syndrome; Child, Preschool; Combined Modality Therapy; Facial Dermatoses; Fatal Outcome; Humans; Hyperpigmentation; Leg; Male