Favism

Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.

Synonym
Favism

Excerpt	Reference
"Favism is an acute hemolytic anemia triggered by ingestion of fava beans in genetically susceptible subjects with severe deficiency of glucose-6-phosphate dehydrogenase (G6PD) activity."	( Benatti, U; Carafoli, E; Damonte, G; De Flora, A; Forteleoni, G; Guida, L; Melloni, E; Meloni, T; Sdraffa, A, 1992)
"Favism is an acute hemolysis occurring in glucose-6-phosphate dehydrogenase (G6PD)-deficient (Mediterranean variant) individuals after intake of fava beans."	( Arese, P; Baker, MA; Bosia, A; Pescarmona, G; Turrini, F, 1984)
"Favism is an acute hemolytic anemia known to occur in susceptible individuals who ingest fava beans."	( Jollow, DJ; McMillan, DC, 1999)
"Favism is an acute anemic crisis that can occur in susceptible individuals who ingest fava beans."	( Bolchoz, LJ; Jollow, DJ; McMillan, DC, 2001)
"Patients with favism are always Glucose-6-phosphate dehydrogenase (G6PD)-deficient, but not all G6PD-deficient individuals develop hemolysis as a result of fava beans consumption."	( El-Sokkary, AM; Osman, HG; Sabry, AM; Zahran, FM, 2013)
"Favism is an acute hemolytic syndrome caused by the ingestion of fava bean (FB) in glucose 6-phosphate dehydrogenase (G6PD) deficient individuals."	( Cai, W; Du, G; Li, S; Wei, X; Xiao, M; Zhou, C, 2018)
"Favism is a metabolic disease and this study aimed to compare between olive oil and almond oil to ameliorate blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology in favism rats."	( El-Attar, MA; Koriem, KMM, 2022)
"Favism is a hemolytic disease due to the ingestion of fava beans in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency."	( Beretta, A; Cena, H; Manuelli, M, 2023)

Excerpt	Reference
"In conclusion, anise oil pretreatment into favism-induced rats decreased the favism disorders, and this effect was related to the anethole ingredient of the oil."	( Arbid, MS; El-Gendy, NF; Koriem, KM, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	144 (80.45)	23.3326
1990's	14 (7.82)	12.5806
2000's	7 (3.91)	18.1394
2010's	11 (6.15)	28.8240
2020's	3 (1.68)	9.53

Drug	Relationship Strength	Studies	Trials
carbon monoxide	low	1	0
lactic acid	medium	1	1
glycerol	low	1	0
hydrogen cyanide	low	1	0
hydrogen	low	1	0
dihydroxyphenylalanine	low	5	0
pyridoxine	low	1	0
thiamine	low	2	0
uracil	low	6	0
uric acid	medium	1	1
phenytoin	low	2	0
antipyrine	low	1	0
aspirin	low	4	0
dapsone	low	1	0
deferoxamine	low	3	0
isoniazid	low	2	0
neostigmine	low	1	0
aminosalicylic acid	low	2	0
phenobarbital	low	1	0
phenylbutazone	low	1	0
primaquine	low	13	0
salicylamide	low	1	0
sulfadiazine	low	1	0
sulfamethoxypyridazine	low	1	0
sulfanilamide	low	2	0
chloramphenicol	low	1	0
aspartic acid	low	1	0
cyanides	low	4	0
aminopyrine	low	3	0
uridine	low	10	0
levodopa	low	4	0
methylene blue	low	3	0
aniline	low	1	0
lactose	low	1	0
isoleucine	low	1	0
benzidine	low	2	0
phenylhydrazine	low	2	0
n(1)-acetylphenylhydrazine	low	1	0
sodium cyanide	low	1	0
diphenhydramine hydrochloride	low	1	0
fusarium	low	1	0
pamaquine	low	1	0
malondialdehyde	low	4	0
d-alpha tocopherol	low	1	0
streptomycin	low	1	0
mercury	low	1	0
chromium	low	1	0
transferrin	low	2	0
glucose, (beta-d)-isomer	low	16	0
1,7-phenanthroline	low	1	0
isouramil	low	7	0
convicine	low	10	0
fibrinogen	low	1	0
cortisone	low	2	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
n-acetylneuraminic acid	low	2	0
dithioerythritol	low	1	0
quinidine	low	1	0
sodium arsenite	low	1	0
dipyrone	low	1	0
anethole	low	1	0
glycosides	low	8	0
phenylthiourea	low	3	0
nadp	low	15	0
1,1-diphenyl-2-picrylhydrazyl	low	1	0
4-hydroxyisoleucine	low	1	0
bilirubin	low	10	0
vitamin k semiquinone radical	low	1	0
beta carotene	low	1	0
diamide	low	1	0
arsenic	low	1	0
selenium	low	1	0
beta-escin	low	1	0
nitrofurantoin	low	1	0
calcimycin	low	1	0
acid phosphatase	low	7	0
nad	low	5	0
tannins	low	1	0
calpain	low	3	0
heme	low	3	0
ascorbic acid	low	7	0
dicumarol	low	1	0
warfarin	low	2	0
rome	low	3	0
diospyros	low	1	0
exudates	low	1	0
rifampin	low	1	0
vicine	low	15	0
divicine	low	18	0
pyrimidinones	low	31	0

Protein Targets (725)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
geminin	24	0	0	24
lamin isoform A-delta10	19	0	0	19
Guanine nucleotide-binding protein G	5	0	0	5
Chain A, Ferritin light chain	5	0	0	5
Luciferase	9	0	0	9
interleukin 8	9	0	0	9
thioredoxin reductase	11	0	0	11
15-lipoxygenase, partial	5	0	0	5
RAR-related orphan receptor gamma	14	0	0	14
GLS protein	12	0	0	12
GLI family zinc finger 3	19	0	0	19
thyroid stimulating hormone receptor	15	0	0	15
estrogen receptor 2 (ER beta)	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	22	0	0	22
pregnane X nuclear receptor	17	0	0	17
estrogen nuclear receptor alpha	33	0	0	33
G	9	0	0	9
peroxisome proliferator-activated receptor delta	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
activating transcription factor 6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform a	8	0	0	8
thyroid hormone receptor beta isoform 2	16	0	0	16
histone deacetylase 9 isoform 3	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Glutamate receptor 2	9	0	0	9
Nicotinate phosphoribosyltransferase	0	4	0	4
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
ORF73	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
Microtubule-associated protein tau	14	0	0	14
thioredoxin glutathione reductase	5	0	0	5
Smad3	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Carbonic anhydrase 1	0	11	0	14
Carbonic anhydrase 2	0	11	1	15
Tyrosine-protein phosphatase non-receptor type 1	0	0	1	1
AR protein	27	0	0	27
aldehyde dehydrogenase 1 family, member A1	24	0	0	24
glucocorticoid receptor [Homo sapiens]	19	0	0	19
Steroid C26-monooxygenase	0	0	1	1
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
ATAD5 protein, partial	5	0	0	5
USP1 protein, partial	9	0	0	9
67.9K protein	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	15
Bile salt export pump	0	24	0	24
Cytochrome P450 2C9	0	9	0	9
Cytochrome P450 2J2	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	14	0	14
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	7	0	0	7
IDH1	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	7	0	0	7
Polyphenol oxidase 2	0	4	0	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	4	0	4
Alpha-2B adrenergic receptor	0	1	1	2
Spike glycoprotein	5	1	1	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
phosphopantetheinyl transferase	8	0	0	8
arylsulfatase A	6	0	0	6
Bloom syndrome protein isoform 1	9	0	0	9
cytochrome P450 2C19 precursor	4	0	0	4
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
Carbonic anhydrase 4	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	3	0	0	3
EWS/FLI fusion protein	6	0	0	6
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	11	0	0	11
DNA polymerase kappa isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	2
Adenosine receptor A2a	0	1	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	10	2	0	12
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
pregnane X receptor	4	0	0	4
aryl hydrocarbon receptor	8	0	0	8
thyroid stimulating hormone receptor	5	0	0	5
Histone H2A.x	6	0	0	6
cellular tumor antigen p53 isoform a	4	0	0	4
rac GTPase-activating protein 1 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	1	0	11
Gamma-aminobutyric acid receptor subunit beta-1	10	1	0	11
Gamma-aminobutyric acid receptor subunit delta	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-2	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-3	10	1	0	11
UDP-glucuronosyltransferase 1A4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-2	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-4	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-3	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-6	10	1	0	11
Gamma-aminobutyric acid receptor subunit beta-3	10	1	0	11
Gamma-aminobutyric acid receptor subunit beta-2	10	1	0	11
GABA theta subunit	10	1	0	11
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	10	1	0	11
TDP1 protein	14	0	0	14
core protein, partial	0	1	0	1
peripheral myelin protein 22	6	0	0	6
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Solute carrier organic anion transporter family member 1B1	0	6	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, Cruzipain	3	0	0	3
vitamin D3 receptor isoform VDRA	7	0	0	7
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	3	0	0	3
Inositol monophosphatase 1	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acid sphingomyelinase	1	0	0	1
endonuclease IV	6	0	0	6
glp-1 receptor, partial	4	0	0	4
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	2	0	0	2
TSHR protein	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
regulator of G-protein signaling 4	6	0	0	6
nonstructural protein 1	3	0	0	3
polyprotein	2	0	0	2
Parkin	2	0	0	2
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	5	0	0	5
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
glucokinase regulatory protein	2	0	0	2
huntingtin isoform 2	2	0	0	2
mitogen-activated protein kinase 1	5	0	0	5
flap endonuclease 1	6	0	0	6
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
DNA damage-inducible transcript 3 protein	0	1	0	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
nuclear receptor ROR-gamma isoform 1	4	0	0	4
Vpr	2	0	0	2
survival motor neuron protein isoform d	7	0	0	7
streptokinase A precursor	0	0	3	3
neuropeptide S receptor isoform A	3	0	0	3
Rap guanine nucleotide exchange factor 3	4	0	0	4
Amyloid-beta precursor protein	1	2	0	4
Alpha-synuclein	3	1	0	4
D(1A) dopamine receptor	1	0	0	1
TAR DNA-binding protein 43	6	0	0	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
ATP-dependent phosphofructokinase	6	0	0	6
farnesoid X nuclear receptor	6	0	0	6
peroxisome proliferator activated receptor gamma	11	0	0	11
heat shock protein beta-1	5	0	0	5
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cellular tumor antigen p53	12	0	0	12
Cytochrome P450 3A4	0	5	0	5
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
PPM1D protein	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Alpha-2C adrenergic receptor	0	1	0	1
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
dopamine D1 receptor	3	0	0	3
progesterone receptor	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
M-phase phosphoprotein 8	4	0	0	4
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase	0	4	0	5
Carbonic anhydrase 15	0	2	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
cytochrome P450 2C9 precursor	4	0	0	4
muscleblind-like protein 1 isoform 1	4	0	0	4
Bile salt export pump	0	7	0	7
Dihydrofolate reductase	0	4	0	5
Histamine H2 receptor	7	0	0	7
5-hydroxytryptamine receptor 6	0	1	0	1
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
NAD	0	1	0	1
Cholinesterase	0	5	0	5
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Integrase	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 6	0	5	0	6
Carbonic anhydrase 5A, mitochondrial	0	3	0	5
Carbonic anhydrase 7	0	2	0	3
Carbonic anhydrase 9	0	3	0	4
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Cytochrome P450 1A2	0	3	0	3
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	4
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
pyruvate kinase	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Carbonic anhydrase 12	0	1	0	2
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Carbonic anhydrase 3	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
phosphoglycerate kinase	2	0	0	2
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
Apoptotic peptidase activating factor 1	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
caspase-3	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	3	0	4
Cholinesterase	0	2	0	2
Estrogen receptor	0	0	1	1
60 kDa chaperonin	0	3	0	3
Estrogen receptor beta	0	0	1	1
10 kDa chaperonin	0	3	0	3
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Cytochrome P450 2D6	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Histone acetyltransferase KAT8	0	1	0	1
Chain A, PROTEIN (CATECHOL OXIDASE)	0	1	0	1
Tyrosinase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Gamma-aminobutyric acid	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Chloroquine resistance transporter	0	1	0	1
Pyridoxal kinase	0	0	0	1
Chain A, Beta-lactamase	4	0	0	4
Solute carrier family 22 member 1	0	4	0	6
Solute carrier organic anion transporter family member 1A4	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Solute carrier family 22 member 1	0	3	0	4
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Solute carrier family 22 member 2	0	3	0	3
DNA-directed RNA polymerase subunit beta	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Albumin	0	0	2	2
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
GALC protein	1	0	0	1
Stromelysin-1	0	0	1	1
Androgen receptor	0	1	0	1
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
Aurora kinase A	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Endothelin-1 receptor	0	1	0	1
Protease	0	2	1	3
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Protein argonaute-2	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
NFKB1 protein, partial	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	4	0	4
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Albumin	0	0	1	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (179)

Protein Targets (725)

Favism

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (179)

Drugs Studied (109)

Protein Targets (725)